WO2015098047A1 - 生体情報測定装置 - Google Patents
生体情報測定装置 Download PDFInfo
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- WO2015098047A1 WO2015098047A1 PCT/JP2014/006288 JP2014006288W WO2015098047A1 WO 2015098047 A1 WO2015098047 A1 WO 2015098047A1 JP 2014006288 W JP2014006288 W JP 2014006288W WO 2015098047 A1 WO2015098047 A1 WO 2015098047A1
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- light
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- diffraction grating
- optical path
- biological information
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
- A61B5/14552—Details of sensors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
- A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
Definitions
- the present invention relates to a biological information measuring apparatus that non-invasively measures biological information such as blood glucose level using light.
- This type of apparatus generally includes a first optical system that guides light from a light source to a measurement target, a second optical system that guides light reflected from the measurement target, and a reflection guided by the second optical system.
- a spectroscopic optical system that splits the light; a light receiving element that receives the split light; and a reference signal optical system for obtaining a reference signal for calibration.
- JP 2006-87913 A JP 2002-65465 A JP 2007-259967 A JP 2012-191969 A
- the biological information measuring device as described above is made compact and portable, the user can measure the blood glucose level at any time, which is considered very convenient. Further, if the size is reduced, there is an advantage that it can be easily incorporated into other health care devices such as an existing body composition meter.
- the light receiving element as the main component is composed of an array type sensor, and it is still insufficient in terms of miniaturization.
- the present invention has been made in consideration of the above points, and provides a biological information measuring apparatus capable of downsizing the apparatus configuration without degrading measurement accuracy.
- One aspect of the biological information measuring device of the present invention is: A light source; A first optical path for guiding light emitted from the light source to a measurement target; A second optical path for guiding reflected light reflected from the measurement object; A rotating diffraction grating that splits the reflected light guided from the second optical path; A light receiving element for receiving the spectrum from the rotating diffraction grating; In place of the measurement object, a reflecting member that reflects light incident from the first optical path and emits the light to the second optical path; It comprises.
- the present invention it is possible to realize a biological information measuring apparatus capable of downsizing the apparatus configuration without reducing the measurement accuracy.
- FIG. 1 Schematic which shows the whole structure of the biological information measuring device which concerns on embodiment Diagram for explaining diffraction operation of rotating diffraction grating
- FIG. 1 A plan view showing an external configuration of a MEMS device provided with a rotating diffraction grating
- the figure which shows the change of the magnitude
- Sectional drawing which shows the structural example of a reflection member
- FIG. 1 is a schematic diagram showing the overall configuration of a biological information measuring apparatus according to an embodiment of the present invention.
- the biological information measuring apparatus 100 irradiates the subject 10 with near-infrared light and analyzes the reflected light in order to noninvasively measure the blood glucose level of the subject 10 to be measured as biological information. It is like that.
- the biological information measuring device 100 generates near-infrared rays by the light source 101.
- the light source 101 includes an LED (Light-Emitting-Diode), a halogen lamp, or a xenon lamp.
- the light from the light source 101 is condensed by the condenser lens 103 after passing through the pinhole 102.
- the condensed light enters the light-emitting side optical fiber 105 from the light incident body 104.
- One end of the light emission side optical fiber 105 is connected to the light incident body 104, while the other end of the light emission side optical fiber 105 is connected to the measurement probe 106.
- the pinhole 102 is not essential and may be omitted.
- the measurement probe 106 is provided at a position where the tip can contact the surface of the skin of the subject 10, or a position where the measurement probe 106 can face the skin in the very vicinity of the skin.
- the light returning to the measurement probe 106 is emitted from the light emitting body 108 via the light receiving side optical fiber 107.
- the light emitted from the light emitting body 108 is collimated by the lens system 109 and then enters the rotating diffraction grating 110.
- the absorption intensity of near-infrared light in the body is greatly influenced by the presence of glucose, and thus the glucose concentration in the body, that is, the blood sugar level is measured by measuring the absorption intensity.
- the rotating diffraction grating 110 rotates as indicated by an arrow a in the figure.
- the incident surface of the rotary diffraction grating 110 is a mirror surface, and reflects incident light. That is, the rotating diffraction grating 110 rotates so that the incident angle on the mirror surface changes.
- the light reflected by the rotating diffraction grating 110 passes through the slit 121 and then enters the photodetector (PD) 122.
- the light reception signal obtained by photoelectric conversion by the PD 122 is output to the arithmetic unit 130 via the analog-digital conversion circuit (A / D conversion) 123.
- the arithmetic device 130 is a device such as a personal computer or a smartphone having an analysis program, and obtains biological information such as a blood glucose level from the received light signal by executing the analysis program.
- the optical system of the biological information measuring apparatus 100 is accommodated in the case 124.
- An opening 125 for allowing light to pass between the measurement probe 106 and the subject 10 is formed at a position corresponding to the measurement probe 106 in the case 124.
- the opening 125 is not essential and may be omitted.
- FIG. 2 is a diagram for explaining the diffraction operation of the rotating diffraction grating 110.
- the rotating diffraction grating 110 is in the rotational position as shown in FIG. 2A, the ⁇ 1 component is incident on the PD 122 by reflecting the ⁇ 1 component of the incident light in the direction of the slit 121.
- the rotating diffraction grating 110 is in the rotational position as shown in FIG. 2B
- the ⁇ 2 component is incident on the PD 122 by reflecting the ⁇ 2 component of the incident light in the direction of the slit 121.
- the ⁇ 3 component is incident on the PD 122 by reflecting the ⁇ 3 component of the incident light in the direction of the slit 121.
- the rotating diffraction grating 110 is configured to split incident light by inputting light having a wavelength corresponding to the rotation angle to the PD 122.
- the photodetector (PD) 122 is not an array sensor but a single sensor as compared with the case where a fixed diffraction grating is used. It is possible to use a light receiving element having a light receiving surface. As a result, since the photodetector 122 having a simple configuration can be used, the cost can be reduced accordingly. Further, as compared with the case where a fixed diffraction grating is used, it is not necessary to provide a space for spectroscopy between the diffraction grating and the photodetector 122, so that the apparatus can be reduced in size accordingly.
- a movable part of MEMS is a mirror surface, and a diffraction grating is formed on the mirror surface. That is, the rotating diffraction grating 110 has a grating formed on the mirror surface of the MEMS mirror.
- FIG. 3 is a plan view showing an external configuration of the MEMS device 200 provided with the rotating diffraction grating 110.
- the MEMS device 200 includes a drive unit 201 configured by a drive circuit, an actuator, and the like, a rotating diffraction grating 110, a fixed frame 202, a movable frame 203, and beam portions 204 and 205.
- the drive unit 201 has a fixed frame 202 in addition to the function of driving the rotary diffraction grating 110, and serves as a base for the rotary diffraction grating 110.
- the beam portion 204 is composed of two beams 204a and 204b.
- the two beams 204 a and 204 b are provided so as to bridge the two opposing edge portions of the movable frame 203 and the fixed frame 202. Thereby, the movable frame 203 is suspended from the fixed frame 202 by the beams 204a and 204b.
- the beam portion 205 includes two beams 205a and 205b.
- the two beams 205 a and 205 b are provided so as to bridge the two opposing edges of the rotating diffraction grating 110 and the movable frame 203. Thereby, the rotary diffraction grating 110 is suspended from the movable frame 203 by the beams 205a and 205b.
- the rotating diffraction grating 110 rotates when the beams 204 a and 204 b are driven by the driving unit 201. Specifically, the drive unit 201 alternately changes the left and right sides of the beams 204a and 204b in the front and back direction of the paper, so that the rotating diffraction grating 110 is driven to rotate within a predetermined angle range.
- the rotating diffraction grating 110 is rotationally driven at a rotational speed of 1 to 2 [Hz].
- the rotation speed is not limited to this.
- the rotation speed may be selected according to the calculation speed of the calculation device 130 or the like.
- a driving method for driving the rotary diffraction grating 110 a piezoelectric method, an electrostatic method, an electromagnetic driving method, or the like can be used.
- the surface of the rotating diffraction grating 110 is a mirror surface, and a diffraction grating 111 is formed on the mirror surface.
- the diffraction grating 111 is formed so as to be parallel to the rotation axes of the beams 204a and 204b.
- the pitch of the diffraction grating 111 is 0.5 to 3 [ ⁇ m].
- the depth of the diffraction grating 111 is 1.5 [ ⁇ m] or more. Accordingly, the rotating diffraction grating 110 can favorably disperse near-infrared rays by rotation.
- the pitch and / or depth of the diffraction grating 111 may be selected according to the light.
- the rotating diffraction grating 110 is also driven in a direction perpendicular to the mirror surface.
- the beams 205a and 205b are simultaneously bent in the same front and back direction by the driving unit 201, so that the rotating diffraction grating 110 is driven in a direction perpendicular to the mirror surface.
- high-frequency simple vibration is performed at several tens [KHz] in a direction perpendicular to the mirror surface.
- FIGS. 4A and 4B show the change in the magnitude of the signal measured by the PD 122 when the rotational position of the rotating diffraction grating 110 is the same and the position of the rotating diffraction grating 110 is changed in the direction perpendicular to the mirror surface.
- FIG. 4A and 4B show the change in the magnitude of the signal measured by the PD 122 when the rotational position of the rotating diffraction grating 110 is the same and the position of the rotating diffraction grating 110 is changed in the direction perpendicular to the mirror surface.
- FIG. 4A and 4B shows the amount of light passing through the slit 121 changes, so that the amount of light incident on the PD 122 changes as shown in FIGS. 4A and 4B.
- the chopper signal can be superimposed on the measurement signal, and the noise component can be removed by performing lock-in amplifier detection.
- the rotating diffraction grating 110 may be rotated by driving the beams 205a and 205b. Specifically, when the beams 205a and 205b are twisted in the same direction, the rotary diffraction grating 110 is rotationally driven within a predetermined angular range.
- FIG. 5 is a diagram for explaining lock-in amplifier detection.
- FIG. 5A shows an ideal spectral spectrum without noise.
- FIG. 5B noises of various frequencies are superimposed on the actual measurement signal.
- FIG. 5C shows a spectrum when the rotating diffraction grating 110 is subjected to a single high frequency vibration at a frequency f 0 in a direction perpendicular to the mirror surface.
- the chopper signal having the frequency f 0 is superimposed on the measured signal.
- FIG. 5D shows the measurement signal after lock-in amplifier detection. Can be taken out only a signal of frequency f 0 as a DC signal (A in FIG. 5C, B). Thus, the frequency of the signals other than f 0 is removed as noise.
- the measurement light is dispersed by rotating the rotary diffraction grating 110, and the S / N of the measurement signal is obtained by causing the rotary diffraction grating 110 to vibrate at a high frequency in a direction perpendicular to the mirror surface.
- the rotary diffraction grating 110 is driven biaxially in the rotation direction and in the direction perpendicular to the mirror surface.
- the biological information measuring apparatus 100 includes a movable reflective member 140.
- the reflecting member 140 is for obtaining a reference signal for calibration.
- calibration is performed by subtracting a reference signal acquired in advance from a measurement signal in the arithmetic unit 130, thereby removing noise components caused by optical path characteristics included in the measurement signal. It is to be.
- the reflection member 140 When obtaining the reference signal, the reflection member 140 is moved to a position facing the tip of the measurement probe 106 as shown in FIG. 6A, and reflects the light emitted from the measurement probe 106 to reflect the measurement probe 106. Return to. On the other hand, when obtaining the measurement signal, the reflecting member 140 retracts from the position facing the tip of the measurement probe 106 as shown in FIG. 6B. Although omitted in FIGS. 6 and 1, a sliding mechanism such as a VCM or a stepping motor may be provided in order to move the reflecting member 140.
- FIG. 7 is a cross-sectional view showing a configuration example of the reflecting member 140.
- FIG. 7A shows an example in which the main body 141 is made of resin or the like, and the metal film 142 is formed on the reflecting surface by plating or vapor deposition.
- FIG. 7B shows an example in which the main body 143 is made of aluminum, stainless steel, or the like, and the diffuse reflection surface 144 is formed by forming irregularities such as satin on the reflection surface.
- the diffuse reflection surface 144 has a roughness approximate to the reflectance of the skin surface. By doing so, it is possible to include noise due to the skin surface in the reference signal in a pseudo manner.
- the optical path for obtaining the measurement signal and the optical path for obtaining the reference signal are common, the optical path for obtaining the reference signal is compared with the case where it is provided separately from the optical path of the measurement signal.
- the apparatus configuration can be simplified and downsized.
- the reference signal of the optical path common to the measurement signal can be obtained, the accuracy of calibration can be improved.
- the reflection member 140 When the measurement is not performed, the reflection member 140 is moved to a position that closes the opening 125 formed at a position corresponding to the measurement probe 106, thereby preventing dust from entering the optical system. That is, the reflective member 140 functions not only as a reference signal but also as a lid that closes the opening 125. As a result, the number of parts can be reduced as compared with the case where a dedicated lid is provided.
- the number of parts and the required space of the spectroscopic optical system can be reduced by separating the reflected light from the subject 10 using the rotating diffraction grating 110.
- an optical path for obtaining a measurement signal by providing a reflection member 140 that reflects the light incident from the measurement probe 106 and emits the light to the measurement probe 106;
- the optical path for obtaining the reference signal can be shared, the required space can be reduced, and the calibration accuracy can be improved.
- the spectroscopic optical system and the reference signal optical system can be reduced in size without degrading the measurement accuracy.
- the biological information measuring device 100 having a small device configuration can be realized without reducing the measurement accuracy.
- the rotating diffraction grating 110 is realized by forming the diffraction grating on the MEMS mirror, the rotating diffraction grating 110 can be reduced in size and compared with a case where the rotating diffraction grating 110 is realized by attaching the diffraction grating to an actuator such as a galvanometer. A low-cost rotating diffraction grating 110 can be realized.
- the MEMS mirror can be easily created by a so-called wafer process, it can be produced at low cost. Furthermore, since the diffraction grating 111 can be easily formed by directly forming the diffraction grating 111 on the MEMS mirror by a wafer process, an increase in cost can be suppressed. Further, since the diffraction grating is formed directly on the mirror, assembly is not necessary. However, the diffraction grating 111 may be formed by a process different from the manufacturing process of the MEMS mirror and may be attached to the MEMS mirror.
- the first optical path that guides the light emitted from the light source 101 to the measurement target and the second optical path that guides the reflected light reflected from the measurement target are connected to the optical fibers 105 and 107.
- the present invention is not limited to this, and may be realized by a spatial optical system without using the optical fibers 105 and 107.
- the biological information measuring device according to the present invention may be used for measuring biological information other than blood glucose level. It can.
- the light source 101 generates ultraviolet rays having a wavelength of 300 to 400 [ ⁇ m] and irradiates the subject 10 with the ultraviolet rays, the state of the skin surface of the subject 10 can be measured.
- the present invention can be applied to a biological information measuring apparatus that non-invasively measures biological information.
- DESCRIPTION OF SYMBOLS 10 Subject 100 Biological information measuring device 101 Light source 102 Pinhole 103 Condensing lens 104 Light incident body 105 Light emission side optical fiber 106 Probe for measurement 107 Light reception side optical fiber 108 Light emitting body 109 Lens system 110 Rotating diffraction grating 111 Diffraction grating 121 Slit 122 Photodetector (PD) 123 Analog-digital conversion circuit (AD conversion) 124 Case 125 Opening 130 Arithmetic unit 140 Reflective member 141, 143 Main body 142 Metal film 144 Diffuse reflective surface 200 MEMS device 201 Drive unit 202 Fixed frame 203 Movable frame 204, 205 Beam portion 204a, 204b, 205a, 205b Beam
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Abstract
Description
光源と、
前記光源から照射される光を測定対象に導く第1の光学経路と、
前記測定対象から反射される反射光を導く第2の光学経路と、
前記第2の光学経路より導かれた反射光を分光する回転回折格子と、
前記回転回折格子からの分光を受光する受光素子と、
前記測定対象に代わって、前記第1の光学経路から入射された光を反射して前記第2の光学経路へと出射する反射部材と、
を具備する。
100 生体情報測定装置
101 光源
102 ピンホール
103 集光レンズ
104 光入射体
105 発光側光ファイバー
106 測定用プローブ
107 受光側光ファイバー
108 光出射体
109 レンズ系
110 回転回折格子
111 回折格子
121 スリット
122 フォトディテクター(PD)
123 アナログディジタル変換回路(AD変換)
124 ケース
125 開口
130 演算装置
140 反射部材
141、143 本体
142 金属膜
144 拡散反射面
200 MEMSデバイス
201 駆動部
202 固定フレーム
203 可動フレーム
204、205 梁部
204a、204b、205a、205b 梁
Claims (6)
- 光源と、
前記光源から照射される光を測定対象に導く第1の光学経路と、
前記測定対象から反射される反射光を導く第2の光学経路と、
前記第2の光学経路より導かれた反射光を分光する回転回折格子と、
前記回転回折格子からの分光を受光する受光素子と、
前記測定対象に代わって、前記第1の光学経路から入射された光を反射して前記第2の光学経路へと出射する反射部材と、
を具備する生体情報測定装置。 - 前記回転回折格子は、
MEMS(Micro Electro Mechanical System)ミラーと、
前記MEMSミラーのミラー面に形成された回折格子と、
を有する請求項1に記載の生体情報測定装置。 - 前記回転回折格子は、
前記第2の光学経路より導かれた反射光の前記ミラー面への入射角が変化するように回転すると共に、前記ミラー面に対して垂直方向に振動する、
請求項2に記載の生体情報測定装置。 - 前記反射部材の反射面は、皮膚表面の反射率に近似するよう処理がされている、
請求項1から請求項3のいずれか一項に記載の生体情報測定装置。 - 前記第1の光学経路と、前記第2の光学経路との間には、前記第1の光学経路からの光を前記測定対象の方向に出射すると共に、前記測定対象から反射される反射光を前記第2の光学経路に入射させる測定用プローブが設けられ、
前記反射部材は、前記測定用プローブから出射される光を反射して前記測定用プローブに入射させる位置に設けられている、
請求項1から請求項3のいずれか一項に記載の生体情報測定装置。 - 前記生体情報測定装置の光学系が収容されるケースには、前記測定対象に前記光学系からの光を照射しかつ前記測定対象からの反射光を前記光学系に戻すための開口部が形成されており、
前記反射部材は、測定時には前記開口部から退避した位置に移動して前記開口部を開口状態とし、測定時以外は前記開口部を塞ぐ位置に移動する、
請求項1から請求項3のいずれか一項に記載の生体情報測定装置。
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CN201480071250.2A CN105873512A (zh) | 2013-12-27 | 2014-12-17 | 生物体信息测定装置 |
US15/107,242 US20170014057A1 (en) | 2013-12-27 | 2014-12-17 | Biological-information measurement device |
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WO2016006211A1 (ja) * | 2014-07-08 | 2016-01-14 | ミツミ電機株式会社 | 生体成分情報測定装置 |
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DE102014108424B3 (de) | 2014-06-16 | 2015-06-11 | Johann Wolfgang Goethe-Universität | Nicht-invasive Stoffanalyse |
EP3359949B1 (de) | 2015-12-09 | 2019-03-06 | Diamontech GmbH | Vorrichtung und verfahren zum analysieren eines stoffs |
CN108369182B (zh) | 2015-12-09 | 2021-10-15 | 迪亚蒙泰克股份有限公司 | 用于分析材料的装置和方法 |
JP2018054450A (ja) * | 2016-09-28 | 2018-04-05 | 花王株式会社 | 反射スペクトルの測定方法 |
CN109730693A (zh) * | 2018-12-13 | 2019-05-10 | 北京理工大学 | 一种新型管状结构三视场光学手持探头 |
CN110327058A (zh) | 2019-07-31 | 2019-10-15 | 清华大学 | 一种无创血糖仪及血糖检测方法 |
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- 2014-12-17 KR KR1020167012924A patent/KR20160102161A/ko not_active Application Discontinuation
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JP2015126789A (ja) | 2015-07-09 |
JP6387610B2 (ja) | 2018-09-12 |
CN105873512A (zh) | 2016-08-17 |
TW201524472A (zh) | 2015-07-01 |
US20170014057A1 (en) | 2017-01-19 |
KR20160102161A (ko) | 2016-08-29 |
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