WO2015097255A2 - Dispositif d'accès vasculaire polyvalent - Google Patents

Dispositif d'accès vasculaire polyvalent Download PDF

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Publication number
WO2015097255A2
WO2015097255A2 PCT/EP2014/079256 EP2014079256W WO2015097255A2 WO 2015097255 A2 WO2015097255 A2 WO 2015097255A2 EP 2014079256 W EP2014079256 W EP 2014079256W WO 2015097255 A2 WO2015097255 A2 WO 2015097255A2
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Prior art keywords
vascular access
access device
catheter
sensor
functional element
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PCT/EP2014/079256
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English (en)
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WO2015097255A3 (fr
Inventor
Eric Chevalier
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Eric Chevalier
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Publication of WO2015097255A2 publication Critical patent/WO2015097255A2/fr
Publication of WO2015097255A3 publication Critical patent/WO2015097255A3/fr

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    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
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Definitions

  • the present invention relates to vascular access device for the infusion of fluids into a patient and/or withdrawal of fluids from the patient and, more specifically, to vascular access ports or central venous catheter with sensing functionality.
  • Implantable vascular access ports are used extensively in the medical field to facilitate the performance of recurrent therapeutic tasks.
  • a typical access port comprises a needle-impenetrable housing having a fluid reservoir that is sealed by a needle penetrable septum.
  • the access port also includes an outlet stem which projects from the housing and provides a fluid passageway that communicates with the fluid reservoir. The outlet stem is used to couple the housing to a catheter.
  • the vascular access port is attached to the proximal end of the catheter. The distal end of the catheter is placed into a vessel.
  • the access port is generally implanted subcutaneously at a location that is easily accessible.
  • a non-coring needle e.g., a Huber needle
  • a feed line may be used to access the implanted vascular access port, by penetrating the septum, to deliver a desired medication.
  • bodily fluids can be withdrawn from the location where the distal end of the catheter is placed.
  • Many conventional access ports in use contain a single fluid reservoir through which medication can be delivered to a patient. With a dual reservoir access port, it is possible to use one lumen to deliver medication to a patient and use a second lumen to withdraw blood samples for testing. In fact, some medical institutions have policies that require that one lumen of an implantable port is dedicated for infusion and the other is dedicated solely for the withdrawal of blood samples.
  • a conventional dual reservoir access port typically comprises a port base having a pair of separate reservoirs formed therein: a medial fluid reservoir and a lateral fluid reservoir. Each of the fluid reservoirs has a corresponding access opening that is sealed by an individual septum. The individual septa are secured in place by a cap that engages the port base. In some other designs, a single septum (e.g., compound septum) can be used to seal both reservoirs.
  • a single septum e.g., compound septum
  • a subcutaneous pocket is first created to receive and house the access port. This is done by making an incision in the skin of the patient at the intended implantation site for the access port. The access port is then inserted beneath the skin through the incision. The outlet stem of the access port is usually received within the pocket last, after the proximal end of the access port is placed in the subcutaneous pocket. A catheter is then coupled to the outlet stem of the access port.
  • a vascular access device for use with a catheter that is to be inserted in a patient, comprising: a port assembly having a housing, at least one septum for infusion by needle, at least one chamber associated with the at least one septum, and a discharge end for a discharge stem affixed thereat for connection with a catheter proximal end, the discharge end having at least one passageway there through associated with the at least one chamber and associated with at least one respective lumen of the catheter for establishing fluid communication between the at least one chamber and a respective lumen, and at least one sensing element integrating at least one electroresponsive material which is configured to react to at least a first signal from a transmitter
  • a vascular access device for use with a catheter that is to be inserted in a patient, comprising:a port assembly having a housing, at least one septum for infusion by needle, at least one chamber associated with the at least one septum, and a discharge end for a discharge stem affixed thereat for connection with a catheter proximal end, the discharge end having at least one passageway there through associated with the at least one chamber and associated with a respective lumen of the catheter for establishing fluid communication between the at least one chamber and a respective lumen wherein a part or the whole surface of the said chamber, and/or the said discharge end, and/or the said catheter are micro-structured in order to decrease the platelet accumulation leading to blood clotting.
  • a vascular access device for use with a catheter that is to be inserted in a patient, comprising : a port assembly having a housing, at least one septum for infusion by needle, at least one chamber associated with the at least one septum, and a discharge end for a discharge stem affixed thereat for connection with a catheter proximal end, the discharge end having at least one passageway there through associated with the at least one chamber and associated with a respective lumen of the catheter for establishing fluid communication between the at least said one chamber and a respective lumen.
  • the port further comprises at least one electroresponsive material integrating in at least one sensing element which is configured to react to at least a first signal from a transmitter
  • a vascular access device that is to be inserted in a patient, comprising : a catheter and at least one functional element fixed to said catheter wherein the functional element further integrating at least one electroresponsive material.
  • vascular access device with a cylindrical geometry comprising coated
  • electroresponsive materials and deposited electrodes to active wirelessly and axially and/or radially surface acoustic waves.
  • a vascular access device for use with a catheter that is to be inserted in a patient, comprising: a port assembly having a housing, at least one septum for infusion by needle, at least one chamber associated with the at least one septum, and a discharge end for a discharge stem affixed thereat for connection with a catheter proximal end, the discharge end having at least one passageway there through associated with the at least one chamber and associated with a respective lumen of the catheter for establishing fluid communication between the at least one chamber and a respective lumen wherein a part or the whole surface of the said chamber, and/or the said discharge end, and/or the said catheter are microstructured in order to decrease the platelet accumulation leading to blood clotting
  • an implantable medical device comprising a surface acoustic wave sensor wherein the input port of the said sensor, comprised of metal electrodes deposited or photodesigned on a piezoelectric crystal, launches a
  • microstructured coating or the microstructured piezoelectric surface When cells such as platelets are in contact with the microstructured surfaces the surface acoustic waves, defined in term of amplitude, frequency, phase, and/or pulse sequence - generate via mechanotransduction processing specific cellular signal(s) internally and/or externally to the cells.
  • a method of delivering at least one agent to an area associated with a subject comprising: incorporating said agent into a plurality of liposomes, to create loaded liposomes; linking said loaded liposomes to a piezoelectric material; and generating surface acoustic waves from interdigited transducer, thus rupturing said liposomes and thus delivering said agent to the area.
  • these aims are achieved by a plurality of SAW devices implemented on a common substrate.
  • the piezoelectric respective materials are deposited on specific areas of the substrate, and an insulator material coated on the common substrate allows to absorb the surface acoustic waves generated by the interdigited transducer.
  • the said plurality of SAW devices further comprising interaction regions.
  • these aims are achieved by a method of drug delivery using a plurality of SAW devices wherein at least one coded signal selects the appropriate SAW device between the plurality in order to release by surface acoustic waves the desired liposomes which are linked to the said SAW device.
  • a reader sends at least one input signal to the said sensing element and/or said functional element embedded in the said vascular access device; any output signal from the said sensing element and/or the said functional element is converted in an information, and communicated via a server, such as telemedicine, to the physician, and/or the nurse and/or the patient in order to warn and/or perform a diagnostic and/or eventually apply treatment.
  • a server such as telemedicine
  • these aims are achieved by a method using an implantable medical device integrating a surface acoustic wave sensor wherein the input part of the said sensor, comprised of metal electrodes deposited or photodesigned on a piezoelectric crystal, launches a mechanical acoustic wave into the piezoelectric material and the acoustic wave propagates through the substrate interacting with a microstructured coating or a microstructured piezoelectric surface of the said device.
  • the surface acoustic waves defined in term of amplitude, frequency, phase, and/or pulse sequence - generate via mechanotransduction processing specific cellular signal(s) internally and/or externally to the cells
  • the electroresponsive material is operating as a wireless sensor being configured to measure parameters related to the delivery of chemotherapy, fluids, medications, and/or the clotting of said catheter or the deposits inside said chamber
  • said electroresponsive material is a piezoelectric material.
  • the said electroresponsive material is a part of a surface acoustic wave tag allowing the identification of the said vascular access port, e.g. thanks to encoding design.
  • the vascular access device further comprises a RFID tag.
  • the RFID tag might be arranged in the sensing element or the functional element of the said vascular access device.
  • the RFID tag may allow identification of the said vascular access device.
  • the vascular access device further comprising wireless flow sensor and/or wireless biofilm growth sensor. [0033] In one embodiment, providing coating on said surface in order to enhance the said hemo-compatibility of the said port
  • the sensing element is operating as a wireless sensor being configured to measure parameters related to the delivery of chemotherapy, fluids, medications, and/or the clotting of said catheter or the deposits inside the chamber.
  • the sensing element and/or the functional element incorporating at least one electroresponsive material operates a sensor based on surface acoustic wave technology.
  • the sensing element and/or the functional element is a biosensor with chemical functionalization.
  • the sensing element or the functional element is a pressure sensor.
  • the sensing element and/or the functional element can be removable from the said vascular access device.
  • the sensing element can be flexible and/or stretchable.
  • the functional element comprises at least one sensor preferentially wireless, to perform monitoring or measurement of key parameters such as pressure and/or deposited mass, and/or flowrate.
  • the functional element integrates surface acoustic wave technology for sensing and/or actuating function.
  • the sensing element and/or the functional element are provided by an embedded battery in the said device.
  • a microstructured surface is directly linked to the electroresponsive material.
  • the functional element can be integrated in a port with or without the sensing element.
  • a wireless sensor system that will interrogate multiple sensors simultaneously integrated in the said device.
  • the sensor information can be obtained via post processing of the received signal.
  • any signal from the sensing element and/or the functional element is converted in an information, clinically relevant, and communicated via a server to the physician, and/or the nurse, and/or the patient in order to perform a diagnostic and eventually apply
  • At least one surface active dopant is administered to the said liposomes to enhance its responses to the surface acoustic waves.
  • an identification tag is associated to each interaction region integrating liposomes such that a specified delivery of liposomes and/or the active agents to the environment of said devices is ensured by the surface acoustic waves.
  • a multiplexer reader is associated to a plurality of SAW devices allowing the selection of a specific SAW
  • interaction region in order to perform action(s) such as: sensing the environment, and/or identification, and/or surface acoustic wave release, and/or biofilm desorption and/or cell adhesion limitation.
  • the common substrate and then
  • piezoelectric materials and electrodes have a cylindrical geometry.
  • the plurality of SAW devices are associated with a reading system comprising: a microprocessor communicatively coupled to a system bus; a memory communicatively coupled to said system bus; at least one Identification reading device communicatively coupled to said system bus; at least one antenna being electrically coupled to a multiplexing circuit; wherein said multiplexing circuit is configured to electrically couple each antenna to said RFID reading device by using at least one time division method or one frequency division method; wherein said antenna are configured to receive Identification signals from a plurality of SAW devices disposed within a radio frequency range of said antenna; and wherein said reading system is configured to store in said memory a plurality of responses received from said plurality of SAW devices.
  • the said electroresponsive material is linked to a deformable membrane subjected to environment constraints.
  • the said device comprising at least one surface acoustic wave device which integrates a plurality of interaction regions or delay line areas.
  • the vascular access device comprises an implantable chamber communicating with a passageway to the lumen of a connected implantable catheter wherein a pulsatile blood flow property such as blood pressure is measured or monitored by the sensing element and/or the functional element.
  • the vascular access device comprises at least one electroresponsive material without sensing element(s) and/or functional element(s).
  • Figure 1 shows a cross-section of an embodiment of a vascular access device according to the prior art
  • Figure 2 shows three-dimensional view of two embodiments of vascular access device according to the prior art
  • Figure 3 shows three-dimensional view of a central venous catheter as vascular access device according to the prior art
  • Figure 4a depicts one embodiment of a vascular access device integrating at least one sensor
  • Figure 4b depicts a one embodiment of a vascular access device integrating at least one sensor
  • Figure 5 shows a representation of the distal part of a catheter integrating a functional structure
  • Figure 6 shows a part of a vascular access device integrating materials and electrodes to active wirelessly and axially a surface acoustic wave (SAW) technology
  • Figure 7 shows a part of a vascular access device integrating materials and electrodes to active wirelessly and radially a surface acoustic wave (SAW) technology
  • Figure 8 shows a schematic of a wireless sensor system that will interrogate multiple sensors simultaneously.
  • the sensor information can be obtained via post processing of the received signal;
  • Figure 9 shows a vascular access device in two status:
  • Figure 10 is a representation of a vascular access device
  • Figure 1 1 shows a schematic representation of an e-healthcare application according the present invention
  • Figure 12a shows structures of surface acoustic wave device integrating microstructured surface in the interaction region
  • Figure 12a shows structures of surface acoustic wave device integrating microstructured surface in the interaction region
  • Figure 13 shows a structure of a surface acoustic wave device incorporating liposomes
  • Figure 14 shows a plurality of SAW device on a common substrate
  • Figure 1 5 depicts a schematic representation of a SAW-responsive liposome (60); and Fig 16 depicts a representation of a circular design of a surface acoustic wave device.
  • FIG. 1 shows a cross-section of an embodiment of a vascular access device according to the state of the art comprising a port 1 and a catheter 5.
  • the port 1 is a small medical appliance that is configured to be installed beneath the skin.
  • the port 1 comprises an optional housing 1 a, a chamber 2, a septum 3 and an interface 4.
  • the chamber 2 is preferably arranged in the housing 1 a, wherein at least one side of the chamber 2 is limited by the septum 3.
  • the housing 1 a encloses the chamber 2 from all sides except in the region of the septum 3.
  • the housing 1 a is rigid or made of a material with a small elasticity which maintains the rough form of the port 1 .
  • the housing 1 a is not penetrable by a needle.
  • the septum 3 is arranged and/or configured such that it separates the chamber 2 from the outside and/or it can be penetrated from the outside by a needle.
  • the interface 4 connects the chamber 2 with a channel 5b of the catheter 5.
  • the interface 4 is preferably established by the housing 1 a, which in the shown embodiment connects a stem with the chamber 2 by a fluid channel.
  • the desired catheter can be mounted on the stem by a male-female plugging mechanism.
  • any other connection mechanism is possible for the interface 4.
  • the catheter is not exchangeable on the interface 4 and the catheter is integrally formed with the interface 4 of the port 1 .
  • the port 1 forms a bowl as chamber 2 whose opening on the top is covered by the septum 3.
  • the lower part of the bowl preferably the lowest part of the bowl, exits in a fluid channel leading to the stem as interface 4.
  • the design is similar to a tobacco pipe.
  • the inner surface of the chamber 2 and/or the outlet can be coated by specific materials to enhance hemo-compatibility and prevent clotting.
  • the catheter 5 comprises a fluid channel 5b formed by the catheter walls 5a between a proximal and a distal end of the catheter 5.
  • the catheter 5 is connected on the proximal end to the interface 4.
  • the chamber 2 is in fluid connection with the fluid channel 5a.
  • the distal end of the catheter 5 is configured to be arranged in a vein or a vessel of a body.
  • the inner surface of the catheter 5, i.e. the fluid channel 5a can be coated by specific materials to enhance hemo-compatibility and prevent clotting.
  • a vascular access device is implanted under the skin of a patient in order to inject drugs or any other fluid with a needle through the skin and the septum 3 in the chamber 2 from which the drugs or any other fluids can enter in the vein or other vessel.
  • the implanted vascular access device can be used to extract a blood or body fluid from the vein or vessel through the catheter 5, the chamber 2 connected via a needle penetrating the skin and the septum 3. This allows to inject fluids and/or to extract samples many times with less discomfort for the patient than a more typical " needle stick" .
  • Ports are used mostly to treat hematology and oncology patients, and recently ports have been adapted also for hemodialysis patients. The port is usually inserted in the upper chest, just below the clavicle or collar bone, leaving the patient's hands free.
  • Figure 2 shows in the top a three-dimensional view of the vascular access device 1 of Fig. 1 .
  • Fig. 2 shows further a second vascular access device with two chambers 2 formed in the housing 1 a and
  • FIG. 3 shows a picture of another type of vascular access device of the prior art which is a central venous catheter. Also this embodiment comprises a catheter 5 which at least partly is implanted/inserted in a patient's body, more exactly implanted/inserted in a vessel or vein of the body.
  • the invention will be explained with ports, but will not be restricted to those and can be used for any other type of catheter for access indications like central venous catheter, peripheral venous catheter, etc. .
  • a vascular access device according to the invention comprises a catheter 5 (e.g. one of the vascular access devices described above) and a sensor and/or a functional element. Examples for such vascular access device with a catheter 5 are described in detail in Fig. 1 to 3 and the repeated description is omitted. In the following, the sensor and the functional element will be described in detail.
  • the senor detects a parameter for an occlusion in or around the vascular access device.
  • a parameter for an occlusion in the channel 5b or at the distal opening of the channel 5b or at any part of the vascular access device being in fluid connection with the channel 5b is detected.
  • a parameter could be for example the blood pressure. If the blood pressure is measured at the sensor and an occlusion occurs between the sensor and the distal opening of the channel 5b, the blood pressure signal will change and an occlusion could be detected.
  • any other parameter for measuring an occlusion could be used. It is also possible to detect other parameters than those for occlusion, e.g.
  • parameters related to the delivery of chemotherapy, fluids, medications, and/or the clotting of said catheter (5a) or the deposits inside the chamber (3) could be the pressure, the temperature, the flowrate, the deposit mass or clotting mass or the viscosity of fluids. All those parameters could give an indication, if there is a problem in the vascular access device.
  • the sensor detects a chemical or biological element in the vascular access device. This allows to survey implanted vascular access devices online without the necessity to implant extra sensors.
  • the sensor and/or the functional element could comprise an optional antenna for sending the detected parameter wirelessly and/or for activation of the sensor and/or functional element.
  • the sensor is activated and powered by the reception of a wireless/radio signal. This has the advantage that the vascular access device does not need a battery which is complex and could be also dangerous for the patient's body. However, the vascular access device could have also an embedded battery.
  • the sensor and/or the functional element comprises an electroresponsive material which reacts in response to a received electric signal and/or sends a signal in response to a detection event.
  • the electroresponsive material is a piezoelectric material which generates acoustic waves in response to a received signal and/or sends a signal in response to a received acoustic wave.
  • This is preferably realized by an interdigital transducer.
  • the senor comprises a chip including the at least one interdigital transducer and an antenna.
  • the piezoelectric material of the interdigital transducer directly on the vascular access device, e.g. on the catheter 5.
  • the coating could be applied directly on the outer or inner cylindrical geometry of the catheter.
  • Electrodes preferably interdigital electrodes are printed or deposited and etched on said piezoelectric film.
  • the sensor and/or functional element induces an acoustic wave, preferably a surface or bulk acoustic wave, and detects the acoustic wave in order to detect said parameter.
  • the acoustic wave is induced by the reception of a radio signal and the detection of the induced acoustic wave induces again a radio signal.
  • Fig. 6 and 7 show embodiments for sensors and/or functional elements arranged on the catheter 5 based on acoustic wave technology. In Fig.
  • a first interdigital transducer 1 1 receives a radio signal which induces a surface/bulk acoustic wave on the catheter 5.
  • a second interdigital transducer 12 detects the surface/bulk acoustic wave and sends it via a second antenna to a controller for detecting the parameter from the received surface/bulk acoustic wave and/or for controlling the surface/bulk acoustic wave for treatment reasons (e.g. ultrasound treatment).
  • the interdigital transducer 1 1 is arranged such that the principal direction of the surface/bulk acoustic wave is the direction of the longitudinal axis of the catheter 5.
  • Fig. 7 shows a similar arrangement, wherein the interdigital transducer 1 1 is arranged such that the principal direction of the
  • the senor and/or the senor are arranged in one embodiment of the invention.
  • the functional element can be removable from the vascular access device.
  • the sensor can be flexible and/or stretchable.
  • the sensor and/or the functional element is configured to allow identification of the vascular access device. This could be realized by an RFID-tag. Alternatively, this could be realized by an interdigital transducer whose feedback signal identifies the vascular access device. The identification could be performed independently for different parts of the vascular access device, e.g. port and catheter, or for different sensors and/or functional elements of the vascular access device.
  • the functional element could for example release something, e.g. a drug.
  • the functional element could also be incorporated in the sensor, maybe on the same chip.
  • the functional element could be a biosensor with a chemical/biological functionalization.
  • the functional element and/or the sensor is passive: it comprises to a microstructured surface and/or specific coating (such as heparin coating) allowing at least the limitation or the preventing of clotting, e.g. in the distal area 9 of the catheter 5.
  • the pattern of the microstructured surface is designed or adjusted according to characteristic parameters of blood cells (platelets%) and/or to mechanotransduction mechanisms of the blood cells. This could be achieved a coating/structuring being configured to decrease the platelet accumulation leading to blood clotting.
  • the functional element and/or sensor is active: it comprises at least one sensor preferentially wireless, to perform monitoring or measurement of key parameters such as pressure and/or deposit mass (fibrin...), and/or flowrate.
  • the Figure 12a shows an embodiment of a microstructured region 17 between two interdigital transducers 1 1 and 12 as explained in Fig. 6 and 7.
  • the interdigital transducer 1 1 When the interdigital transducer 1 1 is activated, the surface acoustic wave propagates interacting with the microstructured region 17 or the microstructured piezoelectric surface.
  • the surface acoustic waves defined in term of amplitude, frequency, and/or pulse sequence - generate via mechanotransduction processing specific cellular signal(s) internally and/or externally to the cells.
  • Fig. 12b shows an embodiment as in Fig. 12a, wherein the microstructured region 18 is achieved by material removal e.g. by etching.
  • the vascular access device further comprising coating (such as heparin coating) on the said
  • the functional element uses acoustic wave technology. Specific surface/bulk acoustic waves allow the limitations of cell adhesion and/or cell aggregation, and/or the limitations of biofilm
  • Liposomes or phospholipid vesicles, with one or up to few lipid bilayers, have been recognized as a potential drug delivery vehicle for three decades. Depending on the drug of interest, liposomes can serve as a controlled release carrier or simply as a biocompatible solubilizing vehicle for poorly soluble agents. Because of their size, which typically ranges in mean diameter from 50 to 250 nm for the systemically administered vesicles, liposomes display some unique pharmacokinetic characteristics. Like this, a functional element could be achieved which releases something.
  • Figure 13 depicts a device for a method of delivering an agent to an area associated with functional element or sensor. First said agent is
  • loaded liposomes 40 incorporated into a plurality of liposomes, to create loaded liposomes 40.
  • Said loaded liposomes 40 are linked to a piezoelectric material 42.
  • a bulk/surface acoustic wave is created in the zone of the linked and loaded liposomes 40, e.g. from interdigited transducer 1 1 and/or 12, thus rupturing said liposomes (40) and thus delivering said agent to the area.
  • agent or drug delivery could act as part of dedicated treatment such as chemotherapy, and/or anti-clotting processing.
  • a surface active dopant is administered to the said liposomes to enhance its responses to the surface acoustic waves.
  • the figure 1 5 shows the process of releasing the agent.
  • a liposome 40 is exposed to a locally oscillating ultrasonic field propagating on a piezoelectric structure 42.
  • Gas bubble nuclei may be formed in the hydrophobic or hydrophilic region of the lipid bilayer. These nuclei grow until they permeate the membrane, forming a transient pore through which the drug 44 is released.
  • Fig. 4a shows a vascular access device with a port 1 as described in Fig. 1 comprising a sensor 6 and a sensor 7 like the sensor described before.
  • the sensor 6 is arranged in the chamber 2.
  • the sensor 6 is arranged in the housing 1 a, more exactly in the bottom of the chamber 2.
  • This has the advantage that the septum 3 is made of silicon which does not influence the radio signal of the wireless communication of the sensor 6.
  • the housing 1 a is often made of metal like titanium which could influence the radio signal to and/from the sensor 6.
  • a second sensor 7 is arranged in the interface 4 of the housing 1 a of the port 1 .
  • Both sensors 6 and 7 could measure a pressure, e.g. the blood pressure in order to detect an occlusion. Each sensor or the sensors 6 and 7 could perform a differential type pressure measurement. It is also possible that e.g. sensor 6 measures one parameter for detecting a certain problem and the element 7 is a functional element configured to perform a treatment against the detected certain problem after its detection. The problem could be for example clotting and the functional element 7 could release a drug against clotting.
  • Figure 5 shows another embodiment of a catheter 5 of a vascular access device, e.g. a central or peripheral venous catheter.
  • the catheter 5 integrating in its distal part 9 a sensor or a functional element 10.
  • the sensor and/or functional element 10 could be realized as shown in Fig. 6 or 7. But other realizations are possible.
  • Fig. 8 represents a catheter 5 comprising a wireless sensor system that will interrogate multiple sensors/functional elements 13 and 14 simultaneously.
  • the sensor information can be obtained via post processing of the received signal.
  • Fig. 9a shows an embodiment of a vascular access device as described in Fig. 1 comprising additionally a sensor 6 arranged here in the chamber 2.
  • the pulsatile flow property is sensitive to the distal part 9 of the catheter 5 of the catheter through the channel (or lumen) 5b up to the chamber 2.
  • the pulsatile signal 1 5 which can be a blood pressure is measured or monitored by the sensor 6. If there is a continuity between the distal part 9 and the chamber 2, i.e. a fluid connection, the pulsatile flow property can be extracted everywhere along the line. If there is an obstruction 16 as shown in Fig. 9b, the signal from at the sensor (for example the pressure) must be different. The difference could be in phase, frequency, amplitude, etc..
  • Fig. 10 shows a similar arrangement as in Fig. 9a and 9b. Here a second sensor and/or a functional element 16 is arranged at the distal part of the catheter 5.
  • any signal from a sensor or a functional element is processed, e.g. to information clinically relevant, and the processed information is communicated, preferably via a server, to the responsible medical stuff, like the physician and/or the nurse, and/or to the patient in order to perform a diagnostic and eventually apply treatment.
  • a server e.g. to the responsible medical stuff, like the physician and/or the nurse, and/or to the patient in order to perform a diagnostic and eventually apply treatment.
  • Such communication architecture is depicted in the figure 1 1 . It is clear that the processing of the detected signal in the sensor and/or functional element could be performed in the sensor and/or functional element, the vascular access device, the server, any device between the named, or a combination of them.
  • the figure 14 shows, in a preferred embodiment of the
  • a plurality of surface acoustic wave (SAW) devices implemented on a common substrate 50.
  • the piezoelectric materials 53 and 54 are deposited on specific areas of the substrate 50, and an insulator material 52 coated on the common substrate 50 allows to absorb the surface acoustic waves generated by the interdigited transducers 55.
  • the advantage is that in each interactive region linked to the materials various configuration or functionalization is possible: a mixing of encoding for identification, sensing areas for sensor functions such as the integration of a membrane for a pressure sensor.
  • each interaction region of the plurality SAW devices further integrates a plurality of liposomes.
  • Each interaction region could have different liposomes (different number of lipid layer, different active agents embedded inside the said liposomes).
  • the invention allows a specified delivery of liposomes and/or the active agents to its environment thanks to the surface acoustic wave release mechanism.
  • the specified delivery of liposomes could be triggered by a specific frequency, and/or a specific pulse sequence, and/or signal phase, and/or a singulation type protocol.
  • a method of drug delivery is to send at least one coded signal to select the convenient SAW device between the plurality of SAW devices where the convenient liposomes must be released from it.
  • a multiplexer reader is associated to a plurality of SAW device allowing the selection of a specific SAW interaction region in order to perform action(s) such as:
  • the common substrate 50 could have a cylindrical geometry.
  • Fig. 16 shows the design of the electrodes 70 and the reflector 71 of an interdigital transducer.
  • the electrodes are shaped circular or elliptic.

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Abstract

L'invention concerne un dispositif d'accès vasculaire comprenant un cathéter (5), caractérisé par un capteur et/ou un élément fonctionnel (6, 7) destinés à recevoir ou transmettre un signal radio sans fil.
PCT/EP2014/079256 2013-12-23 2014-12-23 Dispositif d'accès vasculaire polyvalent WO2015097255A2 (fr)

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EP3630230A4 (fr) * 2017-05-21 2020-12-30 Oncodisc, Inc. Orifice de perfusion de médicament implantable de faible hauteur avec localisation électronique, surveillance physiologique et transfert de données
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CN108601892B (zh) * 2015-12-11 2021-03-02 塞拉Ip股份公司 用于向患者输送流体和/或从患者抽取流体的流体接口装置
EP3630230A4 (fr) * 2017-05-21 2020-12-30 Oncodisc, Inc. Orifice de perfusion de médicament implantable de faible hauteur avec localisation électronique, surveillance physiologique et transfert de données
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