WO2015091653A3 - Means and methods for treating a pruritus-like skin-disease - Google Patents

Means and methods for treating a pruritus-like skin-disease Download PDF

Info

Publication number
WO2015091653A3
WO2015091653A3 PCT/EP2014/078230 EP2014078230W WO2015091653A3 WO 2015091653 A3 WO2015091653 A3 WO 2015091653A3 EP 2014078230 W EP2014078230 W EP 2014078230W WO 2015091653 A3 WO2015091653 A3 WO 2015091653A3
Authority
WO
WIPO (PCT)
Prior art keywords
pruritus
treating
methods
disease
skin
Prior art date
Application number
PCT/EP2014/078230
Other languages
French (fr)
Other versions
WO2015091653A2 (en
Inventor
Karin Loser
Verena KUPAS
Original Assignee
Westfaelische Wilhelms-Universitaet Muenster
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Westfaelische Wilhelms-Universitaet Muenster filed Critical Westfaelische Wilhelms-Universitaet Muenster
Priority to EP14827190.1A priority Critical patent/EP3083670A2/en
Publication of WO2015091653A2 publication Critical patent/WO2015091653A2/en
Publication of WO2015091653A3 publication Critical patent/WO2015091653A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/20—Animal model comprising regulated expression system
    • A01K2217/206—Animal model comprising tissue-specific expression system, e.g. tissue specific expression of transgene, of Cre recombinase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0368—Animal model for inflammation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present application relates to a non-human transgenic animal developing a pruritus-like skin disease and/or a pathological eye phenotype, characterized by epidermal overexpression of 4-1BB. The animal model allows for screening for agents useful for treating pruritus-like skin disease. Accordingly, the present application provides means and methods for treating pruritus-like skin disease.
PCT/EP2014/078230 2013-12-17 2014-12-17 Means and methods for treating a pruritus-like skin-disease WO2015091653A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP14827190.1A EP3083670A2 (en) 2013-12-17 2014-12-17 Means and methods for treating a pruritus-like skin-disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361916993P 2013-12-17 2013-12-17
US61/916,993 2013-12-17

Publications (2)

Publication Number Publication Date
WO2015091653A2 WO2015091653A2 (en) 2015-06-25
WO2015091653A3 true WO2015091653A3 (en) 2015-10-08

Family

ID=52347276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2014/078230 WO2015091653A2 (en) 2013-12-17 2014-12-17 Means and methods for treating a pruritus-like skin-disease

Country Status (2)

Country Link
EP (1) EP3083670A2 (en)
WO (1) WO2015091653A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018121787A1 (en) * 2016-12-30 2018-07-05 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric cd137
CN108424928B (en) 2016-12-30 2021-03-16 百奥赛图(北京)医药科技股份有限公司 Preparation method and application of humanized gene modified animal model

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (en) 1984-08-15 1986-03-07 Res Dev Corp Of Japan Chimera monoclonal antibody and its preparation
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (en) 1984-12-04 1986-06-21 Teijin Ltd Expression of hybrid antibody gene
JPS63501765A (en) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング　インコ−ポレ−テッド Antibody gene module assembly, antibodies produced thereby, and uses
EP1575672A2 (en) 2002-12-16 2005-09-21 Herbert Schwarz Use of cd137 antagonists for the treatment of tumors
EP2279003A4 (en) 2008-05-01 2013-04-03 Gtc Biotherapeutics Inc An anti-cd137 antibody as an agent in the treatment of inflammatory conditions

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JANG IHN K ET AL: "Human 4-1BB (CD137) signals are mediated by TRAF2 and activated nuclear factor-kappaB", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 242, no. 3, 26 January 1998 (1998-01-26), pages 613 - 620, XP055176796, ISSN: 0006-291X *
KUPAS, V ET AL.: "Cutaneous 4-1BB/4-1BB ligand signaling is involved in the development of a pruritus-like skin disease", EXPERIMENTAL DERMATOLOGY, vol. 22, no. 3, P147, 14 March 2013 (2013-03-14), pages e24 - e25, XP002737352 *
YASUSHI KURAISHI: "Potential New Therapeutic Targets for Pathological Pruritus", BIOLOGICAL & PHARMACEUTICAL BULLETIN, vol. 36, no. 8, 1 January 2013 (2013-01-01), pages 1228 - 1234, XP055177105, ISSN: 0918-6158, DOI: 10.1248/bpb.b13-00343 *

Also Published As

Publication number Publication date
EP3083670A2 (en) 2016-10-26
WO2015091653A2 (en) 2015-06-25

Similar Documents

Publication Publication Date Title
IL275092A (en) Methods for treating crohn's disease using an anti-il23 antibody
FR2955253B1 (en) COSMETIC METHOD FOR MODIFYING THE APPEARANCE OF THE CONTOUR OF THE EYE.
MX2015016029A (en) Heterocyclic compounds as pest control agents.
EP3035790A4 (en) Non-invasive automatic monitoring of pet animal's core temperature
BR112014005752A2 (en) platform for implantable tissues and organs produced by tissue engineering and methods for their production
EP2678434A4 (en) Genetically modified animals and methods for making the same
EP2863736A4 (en) Genetically modified animals and methods for making the same
HRP20130830T1 (en) A water-in-oil type emulsion for treating a disease of the eye
WO2012149412A3 (en) Anti-endoglin (cd105) antibodies, immunoconjugates, and uses thereof
EP3320773A4 (en) Non-human animal having human cd3 gene substituted for endogenous cd3 gene
ZA201404500B (en) Methods for diagnosing alzheimer's disease
EP2978446A4 (en) Methods and agents for treating alzheimer's disease
SG11201600813VA (en) Method for producing anterior eye segment tissue
UY34553A (en) PERINDOPRILE L-ARGININE SALT PREPARATION PROCEDURE
HK1186660A1 (en) A water-in-oil type emulsion for treating a disease of the eye
WO2017066796A3 (en) Modulators of telomere disease
DK201300530A (en) Vaccine relating to Pancreas disease in fish
EP3086846A4 (en) Diagnosing and treating alzheimer's disease
GB2535318B (en) Fishing lure
GB2489200B (en) Animal halter
FR2998139B1 (en) IMPROVED INTERJECTIVE BOXER TRICOTE AND METHOD FOR PREPARING THE SAME
WO2015091653A3 (en) Means and methods for treating a pruritus-like skin-disease
EP2791676A4 (en) Methods for diagnosing alzheimer's disease
EA201590232A1 (en) ANIMAL MODEL OF CRABBE'S DISEASE
WO2014152917A3 (en) Physiological ligands for gpr139

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14827190

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2014827190

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2014827190

Country of ref document: EP