WO2015080360A1 - Bioactivity index calculation method and system - Google Patents

Bioactivity index calculation method and system Download PDF

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Publication number
WO2015080360A1
WO2015080360A1 PCT/KR2014/005665 KR2014005665W WO2015080360A1 WO 2015080360 A1 WO2015080360 A1 WO 2015080360A1 KR 2014005665 W KR2014005665 W KR 2014005665W WO 2015080360 A1 WO2015080360 A1 WO 2015080360A1
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index
pulse wave
vitality
motility
calculating
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PCT/KR2014/005665
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French (fr)
Korean (ko)
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문찬곤
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(주)스마트메디칼디바이스
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Publication of WO2015080360A1 publication Critical patent/WO2015080360A1/en

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems

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  • the present invention relates to a method and system for calculating the vitality index, and to a method and system for calculating the vitality index which can calculate a more accurate vitality index through the information on the motility of blood vessels.
  • the degree of vitality of the body is calculated using only the degree of activity of sympathetic and parasympathetic, the accuracy is lowered.
  • the value of blood flow index (PI) was used to determine whether the measuring instrument accurately measured the data value at the correct position.
  • inaccurate measurement may be performed and the blood flow index may be determined in a person with peripheral circulation disorder. It was often recognized as a measurement error because it came out below the reference value.
  • the heart rate waveform was analyzed to obtain the inflection point of the acceleration pulse wave, and the change according to age was calculated as an age index, and the aging information of blood vessels could be represented using the characteristics of the waveform.
  • the stress index part there was no part reflecting the stiffness of vascular aging that occurs with age as arteriosclerosis in reflecting the stiffness of the blood due to stress caused by stress. Therefore, there is a need to correct for vascular stiffness due to arteriosclerosis with age in vascular stiffness.
  • CCTVs and alarms were installed as the main methods of patient monitoring for suicide prevention due to emotional changes such as depression of long-term inpatients, but there was a lack of direct measurement of emotional changes of patients.
  • the present invention has been made to solve the above problems, a method and system for calculating the vitality index that can measure the vitality information of the whole body using not only the activity ratio of the sympathetic nerve and parasympathetic nerve, but also the vascular mobility information. to provide.
  • the present invention in addition to looking at the degree of stress using the heart rate variability, it is possible to measure and monitor the degree of mental anxiety, and to measure the degree of reliability of the oral dictation by measuring the anxiety felt by the dictator through the low frequency range It provides a method and system for calculating the vitality index that can be measured.
  • the method for calculating a vitality index includes: (a) calculating acceleration pulse wave and heart rate variance values using blood flow measurement values of a volumetric pulse wave sensor; (b) calculating a ratio of a low frequency region that is a sympathetic nerve activation region and a high frequency region that is a parasympathetic nerve activation region through frequency conversion of the heart rate variability value; (c) calculating the motility index and peripheral blood circulation index of the blood vessel using the blood flow measurement value and the acceleration pulse wave; Computing a vitality index using the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel and the peripheral blood circulation index.
  • Step (d) may include calculating a stress index using the following formula.
  • Step (d) may include calculating an instability index (concentration index, confidence index) using the following formula.
  • the motility index of the blood vessel is
  • a and b are values at the inflection point of the acceleration pulse wave.
  • the peripheral blood circulation index can be calculated using the following formula.
  • the step of determining that the peripheral blood circulation is reduced may further include.
  • the vitality index calculation system the volumetric pulse wave measuring sensor; Acceleration pulse wave and heart rate variance values are calculated using the blood flow measurement values received from the volumetric pulse wave measurement sensor, and the ratios of the high frequency region, the low frequency region and the sympathetic nerve activation region, are sympathetic nerve activation regions through frequency conversion of the heart rate variability values.
  • Acceleration pulse wave and heart rate variance values are calculated using the blood flow measurement values received from the volumetric pulse wave measurement sensor, and the ratios of the high frequency region, the low frequency region and the sympathetic nerve activation region, are sympathetic nerve activation regions through frequency conversion of the heart rate variability values.
  • Calculate the vascular motility index and peripheral blood circulation index using the blood flow measurement value and the acceleration pulse wave calculate the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel and the peripheral blood circulation index It may include a server for calculating the vitality index by using.
  • the server may calculate a stress index using the following formula.
  • the server may calculate the instability index (concentration index, new index) using the following formula.
  • the motility index of the blood vessel is
  • the peripheral blood circulation index may be calculated using the following formula.
  • the peripheral blood circulation index is 0.5 or less
  • the motility of the vessel is maintained, but it may be determined that the peripheral blood circulation is reduced.
  • the temperature measuring sensor for measuring the room temperature and body temperature; And a humidity measuring sensor for measuring indoor humidity, and the server may determine a state of an indoor environment in which the examinee is located based on the measured values of the temperature measuring sensor and the humidity measuring sensor.
  • the server may generate an alarm sound or an alarm message to a terminal of a preset user when the subject is determined to be angina pectoris, arrhythmia, tachycardia, bradycardia, or atrial fibrillation.
  • the volumetric pulse wave sensor may be one of an earring type, an earphone type, a headband type, a wristwatch type, and a ring type.
  • the method and system for calculating the physical power index according to the present invention have the effect of measuring the vitality index more accurately by measuring vitality information of the whole body using not only the sympathetic nerve and parasympathetic activity ratio, but also the vascular mobility information. .
  • the present invention has the effect of calculating a more accurate stress index by reflecting the vascular aging index reflecting the degree of arteriosclerosis according to age when calculating the degree of stress using the heart rate variability.
  • the present invention in addition to looking at the degree of stress using the heart rate variability, it is possible to measure and monitor the degree of mental anxiety, and to measure the degree of reliability of the oral dictation by measuring the anxiety felt by the dictator through the low frequency range It has a measurable effect.
  • the present invention can monitor the status of the subject, the environmental condition of the room by having a body temperature sensor, an indoor temperature sensor, a humidity sensor, and the like, and remotely monitor the measured value using a Bluetooth Wi-Fi, and to the remote terminal It has the effect of providing an alarm or the like.
  • FIG. 1 is a schematic configuration diagram of a system for calculating the vitality index according to an embodiment of the present invention.
  • FIG. 2 is a diagram illustrating a mobile terminal 20 of the bio vitality index calculation system of FIG. 1.
  • FIG 3 is a view showing a sensor according to another embodiment applied to the system for calculating the vitality index of the present invention.
  • Figure 4 is a flow chart illustrating a method for calculating the vitality index of the present invention.
  • FIG. 5 is a diagram illustrating a screen on which a blood flow index is displayed on a screen of a mobile terminal.
  • FIG. 6 is a diagram illustrating a screen on which an autonomic balance test result is displayed on a screen of a mobile terminal.
  • FIG. 7 is a diagram illustrating a screen displaying an acceleration pulse wave test result on a screen of a mobile terminal.
  • FIG. 8 is a diagram illustrating a screen displaying a stress test result on a screen of a mobile terminal.
  • FIG. 9 is a graph showing the volumetric pulse wave and the acceleration pulse wave measured by the sensor of the system according to the present invention.
  • first, second, etc. are used herein to describe various members, regions, and / or portions, it is obvious that these members, components, regions, layers, and / or portions should not be limited by these terms. Do. These terms do not imply any particular order, up or down, or superiority, and are only used to distinguish one member, region or region from another member, region or region. Accordingly, the first member, region, or region described below may refer to the second member, region, or region without departing from the teachings of the present invention.
  • FIG. 1 is a schematic configuration diagram of a system for calculating the vitality index according to an embodiment of the present invention.
  • a bio vitality index calculation system includes a sensor 10, a mobile terminal 20, a server 30, and another terminal 40.
  • the sensor 10 may include all sensors such as a volumetric pulse wave sensor, a thermometer, a hygrometer, and the like, and may be configured as a wristwatch as shown in FIG. 1.
  • the sensor 10 may be formed in various forms such as earrings, earphones, wristwatches, rings, etc. in addition to the wristwatch.
  • the mobile terminal 20 receives the value measured by the sensor 10 using a wireless communication network such as Bluetooth, Wi-Fi, and transmits the same to the server 30 using the wireless communication network.
  • a pre-prepared application is installed in the mobile receiver 20 to display data received from the sensor 10 or the server 30 to a user (patient, subject, etc.).
  • the server 30 calculates the acceleration pulse wave and the heart rate variance value by using the value measured by the sensor 10, in particular, the blood flow measurement value received from the volumetric pulse wave measurement sensor, and activates the sympathetic nerve through frequency conversion of the heart rate variability value.
  • the low frequency region and the parasympathetic nerve activation region which are regions, calculate a ratio of the high frequency region, calculate the motility index and peripheral blood circulation index of the blood vessel using the blood flow measurement value and the acceleration pulse wave, and calculate the low frequency region and the high frequency region of the high frequency region. Ratio, the motility index with the blood and the peripheral blood circulation index is configured to calculate the vitality index.
  • the server 30 may calculate a stress index, an instability index (a concentration index, a confidence index) and the like. Specific methods and formulas will be described later.
  • the server 30 may transmit an alarm sound or an alarm message to another terminal 40 remotely through the wireless communication network.
  • the other terminal 40 may be a mobile terminal used by the family, or may be a specific terminal of a predetermined period such as a police station. If the other terminal 40 can transmit an alarm, the location is not limited and the user is not limited.
  • FIG. 2 is a diagram illustrating a mobile terminal 20 of the bio vitality index calculation system of FIG. 1.
  • the mobile terminal 20 may be provided with a dedicated application in advance to provide an interface as shown in FIG. 2, and may display data received from the sensor 10 or the server 30.
  • FIG 3 is a view showing a sensor according to another embodiment applied to the system for calculating the vitality index of the present invention.
  • the sensor 12 has an earphone shape and includes an ambient thermometer 12a, an ambient hygrometer 12b, a body temperature sensor 12c and a volumetric pulse wave sensor 12d.
  • the ambient thermometer 12a and the ambient hygrometer 12b are installed outside the ear in the shape of the earphone and serve to measure the temperature and humidity of the room where the subject is located, respectively.
  • the body temperature measuring sensor 12c is installed at the part inserted into the ear in the shape of the earphone to measure the body temperature of the subject, and the volumetric pulse wave sensor 12d is also installed at the part inserted into the ear to measure the blood flow index. .
  • the volumetric pulse wave sensor (12d) is a volumetric pulse wave method (Photoplethysmograph; PPG) is a pulse wave measuring method that can determine the heart rate activity state by measuring the blood flow through the blood vessels using the optical characteristics of the biological tissue.
  • Pulse wave is a pulsating waveform in which blood ruptures in the heart and can be measured by a change in blood flow, that is, a change in the volume of blood vessels, as a result of the relaxation and contraction of the heart.
  • Volumetric pulse wave measurement is a method of measuring pulse waves using light, and the optical sensor detects and measures changes in optical characteristics such as reflection and absorption transmittance of biological tissues when volume changes. .
  • This method is widely used because it can measure the non-invasive pulse and has the advantages of miniaturization and ease of use.
  • it is widely used in wearable sensor modules such as earphones.
  • the volumetric pulse wave sensor has a problem that the measurement signal is severely distorted when the movement is accompanied.
  • optical volumetric pulse wave sensor as a sensor for measuring the heart rate
  • all pulse rate sensors including the ECG can be used.
  • the server 30 receives a blood flow measurement value of the volumetric pulse wave sensor 12d (S100).
  • the server 30 calculates the acceleration pulse wave and the heart rate variability from the blood flow measurement value (S200).
  • the heart rate variability value is frequency-transformed (S300) to calculate the ratio LF / HF of the low frequency region and the high frequency region (S400).
  • the server 30 calculates the vascular motility index and peripheral blood circulation index using the blood flow measurement value and the acceleration pulse wave (S500), the ratio of the low frequency region and the high frequency region (LF / HF), the motility index of the blood vessels and peripheral blood
  • the vitality index is calculated using the circulation index (S600).
  • the server 30 of the present invention measures the heart rate variability using the value measured by the sensor 10, and the low frequency region (LF, for example, 0.01 to 0.08 Hz) of sympathetic activity and parasympathetic activity through frequency conversion
  • the high frequency region (HF, for example, 0.15 to 0.4 Hz) is extracted, their ratios (LF / HF) are calculated, and the values a, b, c, d, and e at the inflection points of the acceleration pulse wave are typical.
  • the stress level is typically calculated by comparing the high frequency region and the low frequency region in HRV. That is, for example, it is determined that the stress is increased when the value of the LF / HF is more than 1.5, or the stress is increased when the LF exceeds 60% by the white light rate.
  • arteriosclerosis also increases the stiffness of blood vessels.
  • the criteria for determining arteriosclerosis in accelerative pulse wave are b, c, and d, a d / a is a useful indicator for evaluating the efficacy of vasodilators, but it can be used to determine the tension of the vessel wall. As a result, age-based comparisons are necessary.
  • the present invention uses a method of obtaining (-b + c + d) / a, which is the vascular aging index of a subject, and comparing it with the vascular aging index of the same age. That is, the present invention can calculate the stress index using Equation 1 below.
  • Equation 1 a more accurate stress index can be calculated by correcting the conventional stress index according to the aging degree of blood vessels.
  • the parasympathetic nerve when the parasympathetic nerve is overactive, it is used to complain of feeling of helplessness to determine the degree of vitality of the body when the parasympathetic nerve is activated.
  • the parasympathetic nerves are activated even at rest, there is a problem that can be mistaken as lethargy with low vitality even in a stable state.
  • the present invention uses the motility index of blood vessels to solve this point.
  • Vascular motility functions to a certain degree even at rest. Therefore, by comparing the magnitude of the volumetric pulse wave at each inflection point, it is possible to determine the degree of motility of arterial blood vessels, and indirectly, to measure the vitality of the body.
  • the present invention relates to the motility index of blood vessels
  • Value can be set, peripheral blood circulation index can be calculated by the following equation (2).
  • peripheral blood flow itself is significant because these symptoms occur in peripheral arterial injury or nerve abnormality. Therefore, it is possible to determine whether the motility is good but the circulating blood flow is small and the mobility itself is a problem by comparing the magnitude and the blood flow of (a-b), the amplitude of the acceleration pulse wave representing the blood flow and motility, and thus the circulating blood flow is small.
  • Circulating blood flow helps to determine the distribution of sufficient blood in peripheral blood vessels and their function. In other words, if the blood flow in the peripheral blood vessels, the temperature of the hands and feet lowers or the skin becomes more likely to occur symptoms. Therefore, the peripheral circulating blood flow index can be calculated by comparing the circulating blood flow index and the motility of blood vessels. The clinical results showed that cold limbs developed due to peripheral circulation reduction in those whose blood flow index (PI) and
  • the server 30 determines that the motility of the vessels is maintained when the ratio between the blood flow index (PI) and
  • the present invention not only heart rate, but also the risk of angina pectoris through SDNN, RMSSD index on HRV, and confirming the drop of ST segment (part of ECG waveform) through ECG, risk of angina pectoris Over, intermittent, persistent atrial, ventricular fibrillation, arrhythmia, tachycardia, bradycardia notification function can send an alarm sound or alarm message to a preset terminal via wireless communication, such as Wi-Fi, Bluetooth.
  • wireless communication such as Wi-Fi, Bluetooth.
  • LF increases in sympathetic activity under stress and mental anxiety, and increases in attention deficit state and ADHD, which is a learning behavioral disorder. That is, concentration decreases during anger and excitement.
  • This can be used as an indirect indicator to measure the degree of concentration for learning.
  • the usual LF and 0.1Hz portion of these are measured to grasp the usual attention level, and how much appears during learning can be referred to the learning ability judgment.
  • the emotional part can be monitored using the present invention to prevent it. That is, the present invention can induce the respiratory movement through the display that counters the exhalation and inspiration, respectively, and can lower the LF (particularly, the frequency of 0.1 Hz) to obtain concentration and mental stability.
  • the average breathing rate is breathing at 3 second intervals based on 20 breaths per minute.
  • LF increases in the parasympathetic nerve, which is the vagus nerve.
  • HF is increased. Therefore, when the LF interval is low, for example, when the LF interval is low during induction of respiratory movement, the interval between inspiration and exhalation of the breath can be displayed as 6 seconds or more when the HF value is low.
  • the instability index (concentration index, confidence index) can be calculated as shown in Equation 3 below.
  • the instability index when the instability index is below 0.95, it can be determined that the instability stage has been entered.
  • the concentration index and the confidence index are below 0.90, the concentration can be judged to be decreased concentration and reliability.
  • Each of these thresholds can be graded as clinical studies progress, and decreased concentration may mean reduced memory.
  • the present invention may be provided with a sensor for measuring the body temperature and oxygen saturation in addition to measuring the heart rate, it is possible to transmit the heart rate and body temperature, oxygen saturation information to the mobile terminal (20). Therefore, the patient may monitor the body temperature with the mobile terminal 20 in an infectious disease such as a cold.
  • the present invention is provided with a temperature sensor and a humidity sensor in the sensor 12 as shown in Figure 3 so that the user can easily obtain the temperature and humidity information of the place where the patient can be easily confirmed by the mobile terminal 20. .
  • FIG. 5 shows a screen displaying a blood flow index, etc. on the screen of the mobile terminal 20
  • FIG. 6 shows a screen displaying autonomic neural balance test results on the screen of the mobile terminal 20
  • FIG. A screen displaying an acceleration pulse wave test result is displayed on a screen of the terminal 20, and a screen displaying a stress test result is displayed on a screen of the mobile terminal 20.
  • the present invention can be used in the method and system for calculating the vitality index.

Abstract

The present invention relates to a bioactivity index calculation method and system capable of measuring activity information of the whole body, using motility information of blood vessels as well as the activation rates of the sympathetic nerve and the parasympathetic nerve. The present invention can: calculate accelerated photoplethysmograph and a heart rate variability value, using a blood flow measurement value; calculate the ratio of a low-frequency domain, which is a sympathetic nerve vitalization domain, and a high-frequency domain, which is a parasympathetic nerve vitalization domain, through frequency conversion of the heart rate variability value; calculate a motility index of the blood vessels and a peripheral blood circulation index, using the blood flow measurement value and the accelerated photoplethysmograph; and calculate a bioactivity index, using the ratio of the low-frequency domain and the high-frequency domain, the motility index of the blood vessels and the peripheral blood circulation index.

Description

생체활력지수 산출 방법 및 시스템Method and system for calculating vitality index
본 발명은 생체활력지수 산출 방법 및 시스템에 관한 것으로, 혈관의 운동성 정보를 통하여 보다 정확한 생체활력지수를 산출할 수 있는 생체활력지수 산출 방법 및 시스템에 관한 것이다.The present invention relates to a method and system for calculating the vitality index, and to a method and system for calculating the vitality index which can calculate a more accurate vitality index through the information on the motility of blood vessels.
옥시미터를 통하여 산호포와도와 심박변이도를 분석하여 자율신경기능과 혈관노화정도를 평가하는 기술과 논문들이 지속적으로 발표되고 있다. 이러한 종래 기술과 논문들에는 심박의 간격과 그 변화도인 심박변이도와 심박수 표준편차, 저주파영역 및 고주파영역의 비율을 추출하여 스트레스를 측정하였다.Techniques and papers have been published to evaluate autonomic nervous system function and vascular aging by analyzing coral vesicles and heart rate variability using oximeters. In the prior art and thesis, the stress was measured by extracting the interval between the heart rate and the degree of change, the heart rate variability, the heart rate standard deviation, the low frequency region and the high frequency region.
하지만, 부교감활성이 심한 경우 무기력함을 나타내지만, 교감신경이 활성화된 경우에도 스트레스와 함께 전신피로감을 호소하는 경우가 발생한다. 따라서, 신체의 활력정도는 교감과 부교감의 활성 정도만을 이용하여 산출하게되면 정확도가 떨어지게 된다.However, when the parasympathetic activity is severe, it is shown to be lethargic, but even when the sympathetic nerve is activated, there is a case that complains of stress and systemic fatigue. Therefore, the degree of vitality of the body is calculated using only the degree of activity of sympathetic and parasympathetic, the accuracy is lowered.
또한, 기존의 측정시에는 혈류량지수(PI)의 값을 통하여 측정 기구가 정확한 위치에서 데이터 값을 정확하게 측정하는 지를 판단하였으나, 부정확한 측정이 수행될 수 있으며 또한 말초순환장애가 있는 사람에게는 혈류량지수가 기준값 이하로 나와 측정오류로 인식되는 경우가 많았다. In addition, in the conventional measurement, the value of blood flow index (PI) was used to determine whether the measuring instrument accurately measured the data value at the correct position. However, inaccurate measurement may be performed and the blood flow index may be determined in a person with peripheral circulation disorder. It was often recognized as a measurement error because it came out below the reference value.
또한, 기존에는 심박파형을 분석하여 가속도맥파의 변곡점을 구해 나이에 따른 변화를 나이지수로 산출하였으며, 파형의 특성을 이용 혈관의 노화 정보를 나타낼 수 있었다. 하지만, 스트레스 지수 부분에서는 스트레스로 발생한 긴장에 의한 혈과의 경직도 반영에 있어서 동맥경화처럼 나이가 증가함에 따라 발생하는 혈관노화에 대한 경직도 반영 부분이 없었다. 따라서, 혈관 경직도에서 나이에 따른 동맥경화로 인한 혈관경직성에 대하여 보정할 필요성이 있다.In addition, the heart rate waveform was analyzed to obtain the inflection point of the acceleration pulse wave, and the change according to age was calculated as an age index, and the aging information of blood vessels could be represented using the characteristics of the waveform. However, in the stress index part, there was no part reflecting the stiffness of vascular aging that occurs with age as arteriosclerosis in reflecting the stiffness of the blood due to stress caused by stress. Therefore, there is a need to correct for vascular stiffness due to arteriosclerosis with age in vascular stiffness.
또한, 저주파영역과 0.1Hz 부분과, 고주파 영역의 값을 통하여 불안과 주의력, 정신분열진단 관련성에 대한 연구가 있었으나, 평소와의 상태와 비교하여 현재 구술하고 있는 말의 신뢰성에 대한 판단을 하는 부분에는 적용이 없었다. In addition, there have been studies on the relationship between anxiety, attention, and schizophrenia through low-frequency, 0.1-Hz, and high-frequency values. There was no application.
또한, 장기입원환자의 우울증 같은 감정변화로 인한 자살예방에는 환자 감시방법중 주 방법으로 CCTV와 알람 등을 설치하였으나, 직접적인 환자의 감정의 변화를 측정하는 부분은 미흡했다. In addition, CCTVs and alarms were installed as the main methods of patient monitoring for suicide prevention due to emotional changes such as depression of long-term inpatients, but there was a lack of direct measurement of emotional changes of patients.
또한, 불안정도를 유도호흡을 통하여 감소시키려는 노력이 있었으며 이에 저주파영역을 이용하여 측정하였으나, 보다 효율적인 훈련을 위하여 지속적인 모니터링과 적극적인 호흡지도에 대한 연구가 미흡하였다. In addition, there was an effort to reduce instability through induction breathing, which was measured using the low frequency region, but studies on continuous monitoring and active breathing guidance were insufficient for more efficient training.
본 발명은 상기와 같은 문제점을 해결하기 위해 안출된 것으로, 교감신경과 부교감 신경의 활성 비율 뿐만 아니라, 혈관의 운동성 정보를 이용하여 전신의 활력 정보를 측정할 수 있는 생체활력지수 산출 방법 및 시스템을 제공한다.The present invention has been made to solve the above problems, a method and system for calculating the vitality index that can measure the vitality information of the whole body using not only the activity ratio of the sympathetic nerve and parasympathetic nerve, but also the vascular mobility information. to provide.
또한, 본 발명은 심박변이도를 이용하여 스트레스 정도를 살펴보는 것 이외에, 정신적 불안 정도를 측정하고 모니터링할 수 있게 하며, 저주파영역의 수치를 통하여 구술자가 말하는 동안 느끼는 불안감을 측정하여 구술의 신뢰성 정도를 측정할 수 있는 생체활력지수 산출 방법 및 시스템을 제공한다. In addition, the present invention, in addition to looking at the degree of stress using the heart rate variability, it is possible to measure and monitor the degree of mental anxiety, and to measure the degree of reliability of the oral dictation by measuring the anxiety felt by the dictator through the low frequency range It provides a method and system for calculating the vitality index that can be measured.
이를 위해 본 발명의 일실시예에 따른 생체활력지수 산출 방법은, (a) 용적맥파 측정 센서의 혈류량 측정값을 이용하여 가속도맥파와 심박변이도 값을 산출하는 단계와; (b) 상기 심박변이도 값의 주파수 변환을 통하여 교감신경 활성화 영역인 저주파 영역 및 부교감신경 활성화 영역인 고주파 영역의 비를 산출하는 단계와; (c) 상기 혈류량 측정값 및 상기 가속도 맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환 지수를 산출하는 단계와; 상기 저주파 영역 및 상기 고주파 영역의 비, 상기 혈관의 운동성 지수 및 상기 말초혈액순환 지수를 이용하여 생체활력지수를 산출하는 단계를 포함한다.To this end, the method for calculating a vitality index according to an embodiment of the present invention includes: (a) calculating acceleration pulse wave and heart rate variance values using blood flow measurement values of a volumetric pulse wave sensor; (b) calculating a ratio of a low frequency region that is a sympathetic nerve activation region and a high frequency region that is a parasympathetic nerve activation region through frequency conversion of the heart rate variability value; (c) calculating the motility index and peripheral blood circulation index of the blood vessel using the blood flow measurement value and the acceleration pulse wave; Computing a vitality index using the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel and the peripheral blood circulation index.
상기 (d) 단계는, 아래의 수식을 이용하여 스트레스 지수를 산출하는 단계를 포함할 수 있다.Step (d) may include calculating a stress index using the following formula.
Figure PCTKR2014005665-appb-I000001
Figure PCTKR2014005665-appb-I000001
상기 (d) 단계는, 아래의 수식을 이용하여 불안정지수(집중력지수, 신뢰지수)를 산출하는 단계를 포함할 수 있다.Step (d) may include calculating an instability index (concentration index, confidence index) using the following formula.
Figure PCTKR2014005665-appb-I000002
Figure PCTKR2014005665-appb-I000002
상기 혈관의 운동성 지수는 |a| 또는 |a-b|의 값일 수 있다. (이때, a, b는 상기 가속도맥파의 변곡점에서의 값)The motility index of the blood vessel is | a | Or | a-b |. Where a and b are values at the inflection point of the acceleration pulse wave.
상기 말초혈액순환지수는 아래의 수식을 이용하여 산출될 수 있다.The peripheral blood circulation index can be calculated using the following formula.
Figure PCTKR2014005665-appb-I000003
Figure PCTKR2014005665-appb-I000003
본 발명에 따른 생체활력지수 산출 방법은, 혈류량지수(PI)가 10% 이하이고, 상기 말초혈액순환지수가 0.5 이하인 경우에는 맥관의 운동성은 유지되지만, 말초혈액순환량이 감소된 것으로 판단하는 단계를 더 포함할 수 있다.In the method of calculating the vitality index according to the present invention, when the blood flow index (PI) is 10% or less and the peripheral blood circulation index is 0.5 or less, the motility of the vessel is maintained, but the step of determining that the peripheral blood circulation is reduced It may further include.
또한, 본 발명의 일실시예에 따른 생체활력지수 산출 시스템은, 용적맥파 측정 센서와; 상기 용적맥파 측정 센서로부터 수신된 혈류량 측정값을 이용하여 가속도맥파와 심박변이도 값을 산출하고, 상기 심박변이도 값의 주파수 변환을 통하여 교감신경 활성화 영역인 저주파 영역 및 부교감신경 활성화 영역인 고주파 영역의 비를 산출하고, 상기 혈류량 측정값 및 상기 가속도맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환 지수를 산출하고, 상기 저주파 영역 및 상기 고주파 영역의 비, 상기 혈관의 운동성 지수 및 상기 말초혈액순환 지수를 이용하여 생체활력지수를 산출하는 서버를 포함할 수 있다.In addition, the vitality index calculation system according to an embodiment of the present invention, the volumetric pulse wave measuring sensor; Acceleration pulse wave and heart rate variance values are calculated using the blood flow measurement values received from the volumetric pulse wave measurement sensor, and the ratios of the high frequency region, the low frequency region and the sympathetic nerve activation region, are sympathetic nerve activation regions through frequency conversion of the heart rate variability values. Calculate the vascular motility index and peripheral blood circulation index using the blood flow measurement value and the acceleration pulse wave, calculate the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel and the peripheral blood circulation index It may include a server for calculating the vitality index by using.
상기 서버는, 아래의 수식을 이용하여 스트레스 지수를 산출할 수 있다.The server may calculate a stress index using the following formula.
Figure PCTKR2014005665-appb-I000004
Figure PCTKR2014005665-appb-I000004
또한, 상기 서버는, 아래의 수식을 이용하여 불안정지수(집중력지수, 신회지수)를 산출할 수 있다.In addition, the server may calculate the instability index (concentration index, new index) using the following formula.
Figure PCTKR2014005665-appb-I000005
Figure PCTKR2014005665-appb-I000005
상기 혈관의 운동성 지수는 |a| 또는 |a-b|의 값일 수 있다. (이때, a, b는 상기 가속도맥파의 변곡점)The motility index of the blood vessel is | a | Or | a-b |. (Wherein a and b are inflection points of the acceleration pulse wave)
상기 말초혈액순환 지수는 아래의 수식을 이용하여 산출될 수 있다.The peripheral blood circulation index may be calculated using the following formula.
Figure PCTKR2014005665-appb-I000006
Figure PCTKR2014005665-appb-I000006
상기 서버는, 상기 혈류량지수(PI)가 10% 이하일때, 상기 말초혈액순환지수가 0.5 이하인 경우에는 맥관의 운동성이 유지되지만, 말초혈액순환량이 감소된 것으로 판단할 수 있다.When the blood flow index (PI) is 10% or less, when the peripheral blood circulation index is 0.5 or less, the motility of the vessel is maintained, but it may be determined that the peripheral blood circulation is reduced.
본 발명의 생체활력지수 산출 시스템은, 실내온도 및 체온을 측정하는 온도측정센서; 및 실내습도를 측정하는 습도측정센서를 더 포함하고, 상기 서버는 상기 온도측정센서 및 상기 습도측정센서의 측정값을 기초로 피검자가 위치한 실내환경 상태를 판단할 수 있다.Bio vitality index calculation system of the present invention, the temperature measuring sensor for measuring the room temperature and body temperature; And a humidity measuring sensor for measuring indoor humidity, and the server may determine a state of an indoor environment in which the examinee is located based on the measured values of the temperature measuring sensor and the humidity measuring sensor.
상기 서버는, 피검자가 협심증, 부정맥, 빈맥, 서맥, 심방세동 상태라고 판단되면 미리 설정된 사용자의 단말기에 알람음 또는 알람 메시지를 발생시킬 수 있다.The server may generate an alarm sound or an alarm message to a terminal of a preset user when the subject is determined to be angina pectoris, arrhythmia, tachycardia, bradycardia, or atrial fibrillation.
상기 용적맥파 센서는, 귀걸이형, 이어폰형, 머리띠형, 손목시계형, 반지형 중 하나일 수 있다.The volumetric pulse wave sensor may be one of an earring type, an earphone type, a headband type, a wristwatch type, and a ring type.
본 발명에 따른 신체화력지수 산출 방법 및 시스템은 교감신경과 부교감 신경의 활성 비율 뿐만 아니라, 혈관의 운동성 정보를 이용하여 전신의 활력 정보를 측정함으로써 보다 정확하게 생체활력지수를 측정할 수 있는 효과를 가진다.The method and system for calculating the physical power index according to the present invention have the effect of measuring the vitality index more accurately by measuring vitality information of the whole body using not only the sympathetic nerve and parasympathetic activity ratio, but also the vascular mobility information. .
또한, 본 발명은 심박변이도를 이용하여 스트레스 정도를 산출할 때 나이에 따른 동맥경화정도를 반영한 혈관노화지수를 반영함으로써 보다 더 정확한 스트레스 지수를 산출할 수 있는 효과를 가진다. In addition, the present invention has the effect of calculating a more accurate stress index by reflecting the vascular aging index reflecting the degree of arteriosclerosis according to age when calculating the degree of stress using the heart rate variability.
또한, 본 발명은 심박변이도를 이용하여 스트레스 정도를 살펴보는 것 이외에, 정신적 불안 정도를 측정하고 모니터링할 수 있게 하며, 저주파영역의 수치를 통하여 구술자가 말하는 동안 느끼는 불안감을 측정하여 구술의 신뢰성 정도를 측정할 수 있는 효과를 가진다.In addition, the present invention, in addition to looking at the degree of stress using the heart rate variability, it is possible to measure and monitor the degree of mental anxiety, and to measure the degree of reliability of the oral dictation by measuring the anxiety felt by the dictator through the low frequency range It has a measurable effect.
또한, 본 발명은 체온센서, 실내온도센서, 습도 센서 등을 구비함으로써 피검자의 상태, 실내의 환경 상태를 모니터링할 수 있으며, 블루투스 와이파이 등을 이용하여 원격으로 측정값을 모니터링하고, 원격의 단말에 알람 등을 제공할 수 있는 효과를 가진다.In addition, the present invention can monitor the status of the subject, the environmental condition of the room by having a body temperature sensor, an indoor temperature sensor, a humidity sensor, and the like, and remotely monitor the measured value using a Bluetooth Wi-Fi, and to the remote terminal It has the effect of providing an alarm or the like.
도 1은 본 발명의 일실시예 따른 생체활력지수 산출 시스템의 개략 구성도이다.1 is a schematic configuration diagram of a system for calculating the vitality index according to an embodiment of the present invention.
도 2는 도 1의 생체활력지수 산출 시스템의 모바일 단말기(20)를 나타내는 도면이다.FIG. 2 is a diagram illustrating a mobile terminal 20 of the bio vitality index calculation system of FIG. 1.
도 3은 본 발명의 생체활력지수 산출 시스템에 적용되는 다른 실시예에 따른 센서를 나타내는 도면이다.3 is a view showing a sensor according to another embodiment applied to the system for calculating the vitality index of the present invention.
도 4는 본 발명의 생체활력지수 산출 방법을 설명하는 순서도이다.Figure 4 is a flow chart illustrating a method for calculating the vitality index of the present invention.
도 5는 모바일 단말기의 화면에 혈류량 지수 등이 표시되는 화면을 나타내는 도면이다.5 is a diagram illustrating a screen on which a blood flow index is displayed on a screen of a mobile terminal.
도 6은 모바일 단말기의 화면에 자율신경균형도검사결과가 표시된 화면을 나타내는 도면이다. FIG. 6 is a diagram illustrating a screen on which an autonomic balance test result is displayed on a screen of a mobile terminal.
도 7은 모바일 단말기의 화면에 가속도맥파검사결과가 표시된 화면을 나타내는 도면이다.7 is a diagram illustrating a screen displaying an acceleration pulse wave test result on a screen of a mobile terminal.
도 8은 모바일 단말기의 화면에 스트레스검사결과가 표시된 화면을 나타내는 도면이다.8 is a diagram illustrating a screen displaying a stress test result on a screen of a mobile terminal.
도 9는 본 발명에 따른 시스템의 센서에서 측정된 용적맥파 및 가속도맥파의 그래프를 나타내는 도면이다.9 is a graph showing the volumetric pulse wave and the acceleration pulse wave measured by the sensor of the system according to the present invention.
이하, 첨부된 도면을 참조하여 본 발명의 바람직한 실시예를 상세히 설명하기로 한다.Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.
본 발명의 실시예들은 당해 기술 분야에서 통상의 지식을 가진 자에게 본 발명을 더욱 완전하게 설명하기 위하여 제공되는 것이며, 아래의 실시예들은 여러 가지 다른 형태로 변형될 수 있으며, 본 발명의 범위가 아래의 실시예들로 한정되는 것은 아니다. 오히려, 이들 실시예는 본 개시를 더욱 충실하고 완전하게 하며 당업자에게 본 발명의 사상을 완전하게 전달하기 위하여 제공하는 것이다.Embodiments of the present invention are provided to more fully explain the present invention to those skilled in the art, and the following embodiments may be modified in many different forms, the scope of the present invention It is not limited to the following embodiments. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the invention to those skilled in the art.
본 명세서에서 사용된 용어는 특정 실시예를 설명하기 위하여 사용되며, 본 발명을 제한하기 위한 것이 아니다. 본 명세서에서 사용된 바와 같이 단수 형태는 문맥상 다른 경우를 분명히 지적하는 것이 아니라면, 복수의 형태를 포함할 수 있다. 또한, 본 명세서에서 사용되는 "포함한다(comprise)" 및/또는 "포함하는(comprising)"은 언급한 형상들, 숫자, 단계, 동작, 부재, 요소 및/또는 이들 그룹의 존재를 특정하는 것이며, 하나 이상의 다른 형상, 숫자, 동작, 부재, 요소 및/또는 그룹들의 존재 또는 부가를 배제하는 것이 아니다. 본 명세서에서 사용되는 바와 같이, 용어 "및/또는" 은 해당 열거된 항목 중 어느 하나 및 하나 이상의 모든 조합을 포함한다.The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" may include the plural forms as well, unless the context clearly indicates otherwise. Also, as used herein, "comprise" and / or "comprising" refers to the presence of the shapes, numbers, steps, actions, members, elements, and / or groups thereof mentioned. It is not intended to exclude the presence or addition of one or more other shapes, numbers, acts, members, elements and / or groups. As used herein, the term "and / or" includes any and all combinations of one or more of the listed items.
본 명세서에서 제1, 제2 등의 용어가 다양한 부재, 영역 및/또는 부위들을 설명하기 위하여 사용되지만, 이들 부재, 부품, 영역, 층들 및/또는 부위들은 이들 용어에 의해 한정되어서는 안됨은 자명하다. 이들 용어는 특정 순서나 상하, 또는 우열을 의미하지 않으며, 하나의 부재, 영역 또는 부위를 다른 부재, 영역 또는 부위와 구별하기 위하여만 사용된다. 따라서, 이하 상술할 제1 부재, 영역 또는 부위는 본 발명의 가르침으로부터 벗어나지 않고서도 제2 부재, 영역 또는 부위를 지칭할 수 있다.Although the terms first, second, etc. are used herein to describe various members, regions, and / or portions, it is obvious that these members, components, regions, layers, and / or portions should not be limited by these terms. Do. These terms do not imply any particular order, up or down, or superiority, and are only used to distinguish one member, region or region from another member, region or region. Accordingly, the first member, region, or region described below may refer to the second member, region, or region without departing from the teachings of the present invention.
이하, 본 발명의 실시예들은 본 발명의 실시예들을 개략적으로 도시하는 도면들을 참조하여 설명한다. 도면들에 있어서, 예를 들면, 제조 기술 및/또는 공차에 따라, 도시된 형상의 변형들이 예상될 수 있다. 따라서, 본 발명의 실시예는 본 명세서에 도시된 영역의 특정 형상에 제한된 것으로 해석되어서는 아니 되며, 예를 들면, 제조상 초래되는 형상의 변화를 포함하여야 한다.Hereinafter, embodiments of the present invention will be described with reference to the drawings schematically showing embodiments of the present invention. In the drawings, for example, variations in the shape shown may be expected, depending on manufacturing techniques and / or tolerances. Thus, embodiments of the present invention should not be construed as limited to the specific shapes of the regions shown herein, but should include, for example, changes in shape resulting from manufacturing.
도 1은 본 발명의 일실시예 따른 생체활력지수 산출 시스템의 개략 구성도이다.1 is a schematic configuration diagram of a system for calculating the vitality index according to an embodiment of the present invention.
도 1을 참조하면, 본 발명의 일실시예에 따른 생체활력지수 산출 시스템은 센서(10)와, 모바일 단말기(20)와, 서버(30)와, 타 단말기(40)를 포함하여 구성된다.Referring to FIG. 1, a bio vitality index calculation system according to an embodiment of the present invention includes a sensor 10, a mobile terminal 20, a server 30, and another terminal 40.
센서(10)는 용적맥파 센서, 온도계, 습도계 등의 센서를 모두 포함하여 구성될 수 있으며, 도 1에서와 같이 손목시계형으로 구성될 수 있다. 물론, 센서(10)는 손목시계형 이외에도 귀걸이형, 이어폰형, 손목시계형, 반지형 등 다양한 형태로 형성될 수도 있음은 물론이다.The sensor 10 may include all sensors such as a volumetric pulse wave sensor, a thermometer, a hygrometer, and the like, and may be configured as a wristwatch as shown in FIG. 1. Of course, the sensor 10 may be formed in various forms such as earrings, earphones, wristwatches, rings, etc. in addition to the wristwatch.
모바일 단말기(20)는 센서(10)에서 측정된 값을 블루투스, 와이파이 등의 무선통신망을 이용하여 수신하고, 이를 무선통신망을 이용하여 서버(30)로 전송한다. 이때, 모바일 담라기(20)에는 미리 마련된 어플리케이션이 설치되어 센서(10) 또는 서버(30)로부터 수신된 데이터를 사용자(환자, 피검자 등)에게 디스플레이할 수 있다.The mobile terminal 20 receives the value measured by the sensor 10 using a wireless communication network such as Bluetooth, Wi-Fi, and transmits the same to the server 30 using the wireless communication network. In this case, a pre-prepared application is installed in the mobile receiver 20 to display data received from the sensor 10 or the server 30 to a user (patient, subject, etc.).
서버(30)는 센서(10)에서 측정된 값 특히, 용적맥파 측정 센서로부터 수신된 혈류량 측정값을 이용하여 가속도맥파와 심박변이도 값을 산출하고, 상기 심박변이도 값의 주파수 변환을 통하여 교감신경 활성화 영역인 저주파 영역 및 부교감신경 활성화 영역이 고주파 영역의 비를 산출하고, 상기 혈류량 측정값 및 상기 가속도맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환 지수를 산출하고, 상기 저주파 영역 및 상기 고주파 영역의 비, 상기 혈과의 운동성 지수 및 상기 말초혈액순환 지수를 이용하여 생체활력지수를 산출할 수 있도록 구성된다.The server 30 calculates the acceleration pulse wave and the heart rate variance value by using the value measured by the sensor 10, in particular, the blood flow measurement value received from the volumetric pulse wave measurement sensor, and activates the sympathetic nerve through frequency conversion of the heart rate variability value. The low frequency region and the parasympathetic nerve activation region, which are regions, calculate a ratio of the high frequency region, calculate the motility index and peripheral blood circulation index of the blood vessel using the blood flow measurement value and the acceleration pulse wave, and calculate the low frequency region and the high frequency region of the high frequency region. Ratio, the motility index with the blood and the peripheral blood circulation index is configured to calculate the vitality index.
서버(30)는 스트레스 지수, 불안정지수(집중력지수, 신뢰지수) 등을 산출할 수 있는데 구체적인 방법 및 수식은 후술하기로 한다. 서버(30)는 무선통신망을 통하여 원격의 타 단말기(40)에 알람음 또는 알람 메시지를 전송할 수 있다. The server 30 may calculate a stress index, an instability index (a concentration index, a confidence index) and the like. Specific methods and formulas will be described later. The server 30 may transmit an alarm sound or an alarm message to another terminal 40 remotely through the wireless communication network.
여기서, 타 단말기(40)는 가족이 사용하는 모바일 단말기이거나, 경찰서 등의 미리 설정된 기간의 특정 단말기일 수 있다. 타 단말기(40)는 알람을 전달할 수 있는 것이라면 위치가 제한되지 않으며 사용자 또한 제한되지 않는다.Here, the other terminal 40 may be a mobile terminal used by the family, or may be a specific terminal of a predetermined period such as a police station. If the other terminal 40 can transmit an alarm, the location is not limited and the user is not limited.
도 2는 도 1의 생체활력지수 산출 시스템의 모바일 단말기(20)를 나타내는 도면이다.FIG. 2 is a diagram illustrating a mobile terminal 20 of the bio vitality index calculation system of FIG. 1.
모바일 단말기(20)에는 미리 전용 애플리케이션이 설치되어 도 2에 표시된 것과 같은 인터페이스를 제공할 수 있으며, 센서(10) 또는 서버(30)로부터 수신되는 데이터들을 표시할 수 있다.The mobile terminal 20 may be provided with a dedicated application in advance to provide an interface as shown in FIG. 2, and may display data received from the sensor 10 or the server 30.
도 3은 본 발명의 생체활력지수 산출 시스템에 적용되는 다른 실시예에 따른 센서를 나타내는 도면이다.3 is a view showing a sensor according to another embodiment applied to the system for calculating the vitality index of the present invention.
센서(12)는 이어폰 형상으로 구성되고, 주변온도계(12a), 주변습도계(12b), 체온측정센서(12c) 및 용적맥파 측정센서(12d)를 포함하여 구성된다.The sensor 12 has an earphone shape and includes an ambient thermometer 12a, an ambient hygrometer 12b, a body temperature sensor 12c and a volumetric pulse wave sensor 12d.
주변온도계(12a) 및 주변습도계(12b)는 이어폰 형상에서 귀에 삽입되지 않는 외측에 설치되어 피검자아 위치하는 실내의 온도 및 습도를 각각 측정하는 역할을 한다.The ambient thermometer 12a and the ambient hygrometer 12b are installed outside the ear in the shape of the earphone and serve to measure the temperature and humidity of the room where the subject is located, respectively.
체온측정센서(12c)는 이어폰 형상에서 귀에 삽입되는 부분에 설치되어 피검자의 체온을 측정하는 역할을 하며, 용적맥파 측정센서(12d) 역시 귀에 삽입되는 부분에 설치되어 혈류량 지수를 측정하는 역할을 한다.The body temperature measuring sensor 12c is installed at the part inserted into the ear in the shape of the earphone to measure the body temperature of the subject, and the volumetric pulse wave sensor 12d is also installed at the part inserted into the ear to measure the blood flow index. .
여기서, 용적맥파 측정센서(12d)는 용적맥파 측정법(Photoplethysmograph; PPG)은 생체조직의 광학적 특성을 이용하여 혈관에 흐르는 혈류량을 측정함으로써 심박 활동 상태를 알 수 있는 맥파 측정 방법이다. 맥파는 혈액이 심장에서 파상하며 나타내는 맥동성 파형으로, 심장의 이완 수축 작용에 따라 나타나는 혈류량의 변화, 즉 혈관의 용적 변화를 통하여 측정 가능하다. 용적맥파 측정법은 빛을 이용하여 맥파를 측정하는 방법으로, 용적 변화시 나타나는 생체조직의 반사, 흡수 투과비 등의 광학적 특성의 변화를 광 센서에서 감지하여 측정하며, 이를 통해 맥박 측정을 하는 방식이다. 이 방법은 비침습적인 맥박 측정이 가능하고 소형화, 사용편의성 등의 장점을 가지고 있어 널리 사용되고 있으며 특히, 이어폰 등의 형성과 같이 착용형(wearable) 센서 모듈에 많이 이용된다. 하지만, 용적맥파 측정 센서는 움직임이 동반될 시 측정 신호가 심하게 왜곡될 수 있는 문제를 가진다.Here, the volumetric pulse wave sensor (12d) is a volumetric pulse wave method (Photoplethysmograph; PPG) is a pulse wave measuring method that can determine the heart rate activity state by measuring the blood flow through the blood vessels using the optical characteristics of the biological tissue. Pulse wave is a pulsating waveform in which blood ruptures in the heart and can be measured by a change in blood flow, that is, a change in the volume of blood vessels, as a result of the relaxation and contraction of the heart. Volumetric pulse wave measurement is a method of measuring pulse waves using light, and the optical sensor detects and measures changes in optical characteristics such as reflection and absorption transmittance of biological tissues when volume changes. . This method is widely used because it can measure the non-invasive pulse and has the advantages of miniaturization and ease of use. In particular, it is widely used in wearable sensor modules such as earphones. However, the volumetric pulse wave sensor has a problem that the measurement signal is severely distorted when the movement is accompanied.
하지만, 위에서 심박측정을 위한 센서로 광학식 용적맥파센서를 예시로 들었지만, 심전도를 포함한 모든 맥박측정센서를 사용할 수도 있음은 물론이다.However, as an example of the optical volumetric pulse wave sensor as a sensor for measuring the heart rate, of course, all pulse rate sensors including the ECG can be used.
이하에서는 도 4를 참조하며, 본 발명의 생체활력지수 시스템이 생체활력지수를 산출하는 방법을 상세히 설명하기로 한다.Hereinafter, referring to FIG. 4, a method of calculating the bioactivity index by the bioactivity index system of the present invention will be described in detail.
도 4를 참조하면, 본 발명의 일실시예에 따른 생체활력지수 산출 방법은, 서버(30)가 용적맥파 측정 센서(12d)의 혈류량 측정값을 수신한다(S100).Referring to FIG. 4, in the method for calculating a vitality index according to an embodiment of the present invention, the server 30 receives a blood flow measurement value of the volumetric pulse wave sensor 12d (S100).
다음, 서버(30)는 혈류량 측정값으로부터 가속도맥파 및 심박변이도를 산출한다(S200). 심박변이도가 산출되면, 심박변이도 값을 주파수 변환시켜(S300), 저주파 영역 및 고주파 영역의 비(LF/HF)를 산출한다(S400).Next, the server 30 calculates the acceleration pulse wave and the heart rate variability from the blood flow measurement value (S200). When the heart rate variance is calculated, the heart rate variability value is frequency-transformed (S300) to calculate the ratio LF / HF of the low frequency region and the high frequency region (S400).
서버(30)는 혈류량 측정값 및 가속도맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환지수를 산출하고(S500), 저주파 영역 및 고주파 영역의 비(LF/HF), 혈관의 운동성 지수 및 말초혈액순환지수를 이용하여 생체활력지수를 산출한다(S600) The server 30 calculates the vascular motility index and peripheral blood circulation index using the blood flow measurement value and the acceleration pulse wave (S500), the ratio of the low frequency region and the high frequency region (LF / HF), the motility index of the blood vessels and peripheral blood The vitality index is calculated using the circulation index (S600).
도 9를 참조하면, 측정된 용적맥파 및 이를 2번 미분하여 생성된 가속도맥파의 그래프를 확인할 수 있다. Referring to FIG. 9, it is possible to check a graph of the measured volume pulse wave and the acceleration pulse wave generated by differentiating it twice.
도 9의 (b)의 가속도맥파의 그래프에서 볼 수 있는이, 가속도맥파 그래프에는 5개의 변곡점이 나타나는데, a,b,c,d,e 는 각각 5개의 변곡점에서의 가속도맥파의 값을 나타낸다.As shown in the graph of the acceleration pulse wave of FIG. 9 (b), five inflection points appear in the acceleration pulse wave graph, and a, b, c, d, and e represent the values of the acceleration pulse wave at the five inflection points, respectively.
본 발명의 서버(30)는 센서(10)에서 측정된 값을 이용하여 심박변이도를 측정하고, 주파수변환을 통해 교감활성의 저주파영역(LF, 예를 들어, 0.01~0.08Hz)과 부교감활성의 고주파영역(HF, 예를 들어, 0.15~0.4Hz)을 추출하고, 이들의 비(LF/HF)를 산출하고, 가속맥파의 변곡점에서의 값 a, b, c, d, e를 통하여 통상적인 혈관노화지수 (-b+c+d)/a를 구한다.The server 30 of the present invention measures the heart rate variability using the value measured by the sensor 10, and the low frequency region (LF, for example, 0.01 to 0.08 Hz) of sympathetic activity and parasympathetic activity through frequency conversion The high frequency region (HF, for example, 0.15 to 0.4 Hz) is extracted, their ratios (LF / HF) are calculated, and the values a, b, c, d, and e at the inflection points of the acceleration pulse wave are typical. Obtain the vascular aging index (-b + c + d) / a.
스트레스 정도는 통상적으로 심박변이도(HRV)에서는 고주파영역과 저주파영역을 비교하여 산출한다. 즉, 예를 들어, LF/HF의 값이 1.5 이상시 스트레스가 증가된 것으로 판단하거나, 백불율로 LF가 60%를 넘어설 경우 스트레스가 증가된 것으로 판단한다.The stress level is typically calculated by comparing the high frequency region and the low frequency region in HRV. That is, for example, it is determined that the stress is increased when the value of the LF / HF is more than 1.5, or the stress is increased when the LF exceeds 60% by the white light rate.
스트레스가 증가하고 교감신경이 흥분될수도록 혈관의 긴장도는 증가하게 되는데, 이는 동맥혈관자체가 근육덩어리이기 때문에 자율신경의 지배를 받고 이를 교감신경 흥분시 수축을 통하여 긴장하게 되기 때문이다. 긴장하게 되면 당연히 혈관의 굵기도 감소하고 맥벽의 경직도도 증가하게 된다.In order to increase stress and excite sympathetic nerves, the tension of blood vessels increases, because arteriovascular blood vessels are muscle masses, which are controlled by autonomic nerves, which are tensioned through contraction when sympathetic nerves are excited. The tension, of course, decreases the thickness of the blood vessels and increases the stiffness of the vein wall.
하지만, 동맥경화로도 혈관의 경직도는 증가하게 된다. 가속도맥파에서 동맥경화를 판정하는 기준이 b, c, d 이지만, 이중 d/a는 혈관확장제의 효능을 살펴볼 때에 유용한 지표로, 혈관벽의 긴장성 판단에 이용될 수 있지만, 동맥경화로 인한 긴장성에도 강화되기 때문에 나이에 따른 비교가 필요하게 된다.However, arteriosclerosis also increases the stiffness of blood vessels. Although the criteria for determining arteriosclerosis in accelerative pulse wave are b, c, and d, a d / a is a useful indicator for evaluating the efficacy of vasodilators, but it can be used to determine the tension of the vessel wall. As a result, age-based comparisons are necessary.
따라서, 본 발명은 피검자의 혈관노화지수인 (-b+c+d)/a를 구하고, 동일 연령의 혈관노화지수와 비교하는 방법을 사용한다. 즉 본 발명은 아래의 수식 1을 이용하여 스트레스 지수를 산출할 수 있다.Therefore, the present invention uses a method of obtaining (-b + c + d) / a, which is the vascular aging index of a subject, and comparing it with the vascular aging index of the same age. That is, the present invention can calculate the stress index using Equation 1 below.
수학식 1
Figure PCTKR2014005665-appb-M000001
 Equation 1
Figure PCTKR2014005665-appb-M000001
상기 수학식 1과 같이 계산함으로써 통상적인 스트레스 지수를 혈관의 노화도에 따라 보정함으로써 보다 더 정확한 스트레스 지수를 산출할 수 있다.By calculating as shown in Equation 1, a more accurate stress index can be calculated by correcting the conventional stress index according to the aging degree of blood vessels.
또한, 위에서 서술 했듯이, 신체의 활력정도를 판단하기 위해서는 동맥혈관의 운동성을 살펴보는 것이 중요하다. 따라서, 종래에는 부교감신경이 과도활성 되었을 때 무력감을 호소하는 것을 이용하여 부교감 신경활성시 신체 활력정도를 판단하였다. 하지만, 안정시에도 부교감 신경이 활성화되는 경우가 있기 때문에 안정되어 있는 상태에서도 활력이 떨어지는 무기력증으로 오인될 수 있는 문제가 있었다. 본 발명은 이러한 점을 해결하기 위하여 혈관의 운동성 지수를 이용한다.In addition, as described above, to determine the degree of vitality of the body it is important to look at the motility of the arterial vessels. Therefore, in the related art, when the parasympathetic nerve is overactive, it is used to complain of feeling of helplessness to determine the degree of vitality of the body when the parasympathetic nerve is activated. However, since the parasympathetic nerves are activated even at rest, there is a problem that can be mistaken as lethargy with low vitality even in a stable state. The present invention uses the motility index of blood vessels to solve this point.
혈관의 운동성은 안정시에도 일정한 정도로 작용을 한다. 그러므로, 용적맥파의 각 변곡점에서의 크기를 비교하면 동맥혈관의 운동성의 정도를 알 수 있으며, 이를 통하여 간접적으로 신체의 활력정도를 측정할 수 있다.Vascular motility functions to a certain degree even at rest. Therefore, by comparing the magnitude of the volumetric pulse wave at each inflection point, it is possible to determine the degree of motility of arterial blood vessels, and indirectly, to measure the vitality of the body.
그러나, 말초혈관을 통한 용적맥파추출시 말초혈관에 충분한 혈류량이 통과하는 경우에만 충분한 맥파를 추출할 수 있다. 그래서 일반적인 기구에서는 말초혈류량이 일정값 이하인 경우에는 센서값을 검출하지 않으며, 센서의 위치와 눌린 압력정도에 따라 감도의 차이가 발생하고, 이로 인하여 측정값이 추출되지 않은 경우가 발생하게 된다. 예를 들어, 심박변이도(HRV) 측정 기수의 많은 수에서 혈류량지수(PI)는 혈류측정정도의 지표가 4% 이하일 때 들어오는 값을 읽지 않는다. 실제 측정에서 보면 손이 차갑거나 많이 긴장한 상태의 피검자를 측정해 보면 혈류측정정도의 지표가 4% 이하인 경우가 많다. 이 상황에서 따듯하게 하거나 안정시킨 후 다시 시행하는 방법을 사용할 수 있지만, 정상적으로 일정기간 휴식 후 측정해도 같은 경우가 발생하는 경우가 있다. 이런 경우는, 말초혈류량 자체가 적게 들어오는 경우이다.However, sufficient pulse wave can be extracted only when sufficient blood flow passes through the peripheral blood vessel during volumetric pulse extraction through the peripheral blood vessel. Therefore, in the general apparatus, when the peripheral blood flow is below a certain value, the sensor value is not detected, and a difference in sensitivity occurs according to the position of the sensor and the degree of pressure pressed, and thus a measurement value is not extracted. For example, in a large number of heart rate variability (HRV) radix readers, the blood flow index (PI) does not read incoming values when the indicator of blood flow measurement is less than 4%. In actual measurement, when measuring a cold or highly tense subject, the index of blood flow measurement is often less than 4%. In this situation, you can use warming or stabilization and then re-run. However, the same situation may occur even if the measurement is performed after a certain period of rest. In this case, the peripheral blood flow itself is low.
본 발명은 혈관의 운동성 지수로 |a| 또는 |a-b| 값으로 설정할 수 있으며, 말초혈액순환 지수는 아래의 수학식 2로 산출할 수 있다.The present invention relates to the motility index of blood vessels | a | Or | a-b | Value can be set, peripheral blood circulation index can be calculated by the following equation (2).
수학식 2
Figure PCTKR2014005665-appb-M000002
 Equation 2
Figure PCTKR2014005665-appb-M000002
따라서, 말초동맥손상이나, 신경이상에서도 이런 현상들이 발생하기 때문에 말초혈류량 자체가 의미가 있는 것이다. 그러므로, 혈류량과 운동성을 나타내는 가속도맥파의 운동폭인 (a-b)의 크기 및 혈류량을 비교하여 운동성이 좋으나 순환혈류량이 적은지, 운동성 자체가 문제가 있어 순환혈류량이 적은지 판단할 수 있다.Therefore, the peripheral blood flow itself is significant because these symptoms occur in peripheral arterial injury or nerve abnormality. Therefore, it is possible to determine whether the motility is good but the circulating blood flow is small and the mobility itself is a problem by comparing the magnitude and the blood flow of (a-b), the amplitude of the acceleration pulse wave representing the blood flow and motility, and thus the circulating blood flow is small.
순환혈류량은 말초 혈관에 충분한 혈액이 분포하고 그 기능을 판단하는데 도움이 된다. 즉, 말초혈관에 혈류량이 적다면 손발등의 온도가 내려가고 또는 피부가 건조하게 되는 증상들이 발생할 가능성이 높아지게 된다. 따라서, 순환하는 혈류량지수와 혈관의 운동성의 비교로 말초순환혈류지수를 산출할 수 있다. 임상결과, 혈류량지수(PI)와 |a-b|의 비가 0.5(PI가 10~1%, |a-b|가 10-4) 이하인 사람에게서 말초순환감소로 손발이 찬 증상이 발생하였다.Circulating blood flow helps to determine the distribution of sufficient blood in peripheral blood vessels and their function. In other words, if the blood flow in the peripheral blood vessels, the temperature of the hands and feet lowers or the skin becomes more likely to occur symptoms. Therefore, the peripheral circulating blood flow index can be calculated by comparing the circulating blood flow index and the motility of blood vessels. The clinical results showed that cold limbs developed due to peripheral circulation reduction in those whose blood flow index (PI) and | a-b | were less than 0.5 (PI was 10 ~ 1%, | a-b | was 10-4).
따라서, 본 발명에 따른 서버(30)는 혈류량지수(PI)와 |a-b|의 비가 0.5 이하인 경우에는 맥관의 운동성은 유지되나, 말초혈액순환량이 감소된 것으로 판단한다.Therefore, the server 30 according to the present invention determines that the motility of the vessels is maintained when the ratio between the blood flow index (PI) and | a-b | is less than 0.5, but the peripheral blood circulation is determined to be reduced.
또한, 본 발명은 심박 뿐만 아니라, 심박변이도(HRV) 상의 SDNN, RMSSD 지수를 통하여 협심증 위험성을 알리고, 심전도를 통하여 ST 세그먼트(segment)(심전도파형의 일부분)의 하강을 확인하여 심근허혈의 협심증 위험과, 간헐적, 지속적 심방, 심실세동, 부정맥, 빈맥, 서맥을 알림기능을 와이파이, 블루투스 등의 무선통신을 통하여 미리 설정된 단말기에 알람음 또는 알람 메시지를 전송할 수 있다.In addition, the present invention not only heart rate, but also the risk of angina pectoris through SDNN, RMSSD index on HRV, and confirming the drop of ST segment (part of ECG waveform) through ECG, risk of angina pectoris Over, intermittent, persistent atrial, ventricular fibrillation, arrhythmia, tachycardia, bradycardia notification function can send an alarm sound or alarm message to a preset terminal via wireless communication, such as Wi-Fi, Bluetooth.
또한, 상기에 서술한 것처럼 스트레스와 정신적으로 불안한 상황에서 교감활성인 저주파(LF)가 증가하고, 주의력 결핍상태, 학습행동장애인 ADHD에서도 LF가 증가하며, 이 중 특히 0.1Hz 대역의 주파수가 증가하게 된다, 즉, 분노와 흥분시에는 집중력이 감소한다. 이를 이용하여 학습을 위한 집중력 정도를 측정하는 간접지표로 사용할 수 있다. 평소의 LF와 이 중 0.1Hz 부분을 측정하여 평소의 주의력 정도를 파악하고, 학습시에 어느 정도 나타나는 가를 측정하여 이를 학습능력판단에 참고할 수 있다. In addition, as described above, LF increases in sympathetic activity under stress and mental anxiety, and increases in attention deficit state and ADHD, which is a learning behavioral disorder. That is, concentration decreases during anger and excitement. This can be used as an indirect indicator to measure the degree of concentration for learning. The usual LF and 0.1Hz portion of these are measured to grasp the usual attention level, and how much appears during learning can be referred to the learning ability judgment.
또한, 장기입원시에 환자들은 감정적으로 우울감을 느끼는 경우가 많고 이럴 경우 무기력증과 함께 자살사고, 치료의 비협조 등을 유발하게 되는 위험한 경우에 직면하게 되는 경우가 종종 있다. 이런 경우, 본 발명을 이용하여 감정적인 부분을 모니터링하여 미연에 예방할 수 있다. 즉, 본 발명은 호기와 흡기를 각각 카운터 해주는 디스플레이를 통하여 호흡운동을 유도하고, LF(특히, 0.1Hz의 주파수)를 낮추어 집중력과 정신적 안정을 얻을 수 있게 할 수 있다.In addition, during long-term hospitalization, patients often feel emotionally depressed, and in this case, they often face a dangerous case that causes suicide, incoordination of treatment, and the like, with lethargy. In this case, the emotional part can be monitored using the present invention to prevent it. That is, the present invention can induce the respiratory movement through the display that counters the exhalation and inspiration, respectively, and can lower the LF (particularly, the frequency of 0.1 Hz) to obtain concentration and mental stability.
예를 들어, 평균호흡수가 분당 20회를 기준으로 3초 간격의 호흡인데, 이를 3~6초 간격일 때는 미주신경인 부교감신경에 LF 값이 상승하고, 6초 이상이 되면 오히려 교감신경영역인 HF가 증가된다. 따라서, 호흡운동 유도시 호흡의 간격을 LF 간격이 낮을 때는 예를 들어 5초로 유도하고, HF 값이 낮을 때는 6초 이상으로 호흡의 흡기와 호기의 간격을 표시해줄 수 있다. For example, the average breathing rate is breathing at 3 second intervals based on 20 breaths per minute. At 3 to 6 second intervals, LF increases in the parasympathetic nerve, which is the vagus nerve. HF is increased. Therefore, when the LF interval is low, for example, when the LF interval is low during induction of respiratory movement, the interval between inspiration and exhalation of the breath can be displayed as 6 seconds or more when the HF value is low.
이를 이용하면, 불안정한 상태에서 LF와 0.1Hz 부위가 증가하는 것을 이용하여, 평소 말할 때 상기 주파수 영역의 크기를 측정하고, 예민한 질문에 대답시 상기 주파수 영역을 비교하여 신뢰정도를 판단할 수 있다. Using this, by using the LF and 0.1Hz region increase in an unstable state, it is possible to determine the degree of confidence by measuring the size of the frequency domain when speaking normally and comparing the frequency domain when answering sensitive questions.
이를 정리하면, 아래의 수학식 3와 같이 불안정지수(집중력지수, 신뢰지수)를 산출할 수 있다. In summary, the instability index (concentration index, confidence index) can be calculated as shown in Equation 3 below.
수학식 3
Figure PCTKR2014005665-appb-M000003
 Equation 3
Figure PCTKR2014005665-appb-M000003
구체적으로, 불안정지수가 0.95 이하시 불안정 단계에 진입하였다고 판단할 수 있으며, 집중력지수 및 신뢰지수는 0.90 이하시 집중력 감소와 신뢰도 감소로 판단할 수 있다. 이러한 각각의 기준값은 임상연구 진행으로 등급을 조절할 수 있으며, 집중력 감소는 기억력 감소를 의미할 수도 있다.Specifically, when the instability index is below 0.95, it can be determined that the instability stage has been entered. When the concentration index and the confidence index are below 0.90, the concentration can be judged to be decreased concentration and reliability. Each of these thresholds can be graded as clinical studies progress, and decreased concentration may mean reduced memory.
또한, 본 발명은 심박수를 측정하는 것과 더불어 체온과 산소포화도를 측정하는 센서를 같이 구비할 수 있으며, 심박수와 체온, 산소포화도 정보를 모바일 단말기(20)로 전송하도록 할 수 있다. 따라서, 환자는 감기와 같은 감염증에 모바일 단말기(20)로 체온 모니터링 등을 할 수 있다.In addition, the present invention may be provided with a sensor for measuring the body temperature and oxygen saturation in addition to measuring the heart rate, it is possible to transmit the heart rate and body temperature, oxygen saturation information to the mobile terminal (20). Therefore, the patient may monitor the body temperature with the mobile terminal 20 in an infectious disease such as a cold.
또한, 본 발명은 도 3에서와 같이 센서(12)에 온도센서와 습도센서를 구비함으로써 환자가 있는 곳의 온도 및 습도 정보를 획득할 수 있도록 하여 사용자가 모바일 단말기(20)로 쉽게 확인할 수 있다. In addition, the present invention is provided with a temperature sensor and a humidity sensor in the sensor 12 as shown in Figure 3 so that the user can easily obtain the temperature and humidity information of the place where the patient can be easily confirmed by the mobile terminal 20. .
도 5에는 모바일 단말기(20)의 화면에 혈류량 지수 등이 표시되는 화면이 나타나 있으며, 도 6에는 모바일 단말기(20)의 화면에 자율신경균형도검사결과가 표시된 화면이 나타나 있으며, 도 7에는 모바일 단말기(20)의 화면에 가속도맥파검사결과가 표시된 화면이 나타나 있으며, 도 8에는 모바일 단말기(20)의 화면에 스트레스검사결과가 표시된 화면이 나타나 있다. 5 shows a screen displaying a blood flow index, etc. on the screen of the mobile terminal 20, FIG. 6 shows a screen displaying autonomic neural balance test results on the screen of the mobile terminal 20, and FIG. A screen displaying an acceleration pulse wave test result is displayed on a screen of the terminal 20, and a screen displaying a stress test result is displayed on a screen of the mobile terminal 20.
이상 도면을 참조하여 본 발명의 실시 형태에 대하셔 설명하였다. 하지만, 이는 단지 본 발명을 설명하기 위한 목적에서 기술된 것이고 본 발명의 내용을 이에 한정하거나 제한하기 위하여 기술된 것은 아니다, 그러므로, 본 기술분야의 통상의 지식을 가진 자라면 이로부터 다양한 변형 및 균등한 다른 실시예를 실시하는 것이 가능할 것이다, 따라서, 본 발명의 진정한 기술적 보호범위는 첨부된 특허청구범위의 기술적 사항에 의해 정해져야 할 것이다. The embodiment of the present invention has been described above with reference to the drawings. However, this is only for the purpose of describing the present invention and is not described to limit or limit the contents of the present invention. Therefore, those skilled in the art can make various modifications and equivalents therefrom. It will be possible to implement one other embodiment, therefore, the true technical protection scope of the invention should be defined by the technical details of the appended claims.
본 발명은 생체활력지수 산출 방법 및 시스템에 사용될 수 있다. The present invention can be used in the method and system for calculating the vitality index.

Claims (15)

  1. (a) 용적맥파 측정 센서의 혈류량 측정값을 이용하여 가속도맥파와 심박변이도 값을 산출하는 단계;(a) calculating acceleration pulse wave and heart rate variance values using blood flow measurement values of the volumetric pulse wave measurement sensor;
    (b) 상기 심박변이도 값의 주파수 변환을 통하여 교감신경 활성화 영역인 저주파 영역 및 부교감신경 활성화 영역인 고주파 영역의 비를 산출하는 단계; (b) calculating a ratio of a low frequency region that is a sympathetic nerve activation region and a high frequency region that is a parasympathetic nerve activation region through frequency conversion of the heart rate variability value;
    (c) 상기 혈류량 측정값 및 상기 가속도 맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환 지수를 산출하는 단계; 및(c) calculating the motility index and peripheral blood circulation index of the blood vessel using the blood flow measurement value and the acceleration pulse wave; And
    (d) 상기 저주파 영역 및 상기 고주파 영역의 비, 상기 혈관의 운동성 지수 및 상기 말초혈액순환 지수를 이용하여 생체활력지수를 산출하는 단계를 포함하는 생체활력지수 산출 방법.and (d) calculating a vitality index using the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel, and the peripheral blood circulation index.
  2. 제 1항에 있어서,The method of claim 1,
    상기 (d) 단계는,In step (d),
    아래의 수식을 이용하여 스트레스 지수를 산출하는 단계를 포함하는 것을 특징으로 하는 생체활력지수 산출 방법.Comprising a step of calculating the stress index by using the following formula.
    Figure PCTKR2014005665-appb-I000007
    Figure PCTKR2014005665-appb-I000007
  3. 제1항에 있어서,The method of claim 1,
    상기 (d) 단계는,In step (d),
    아래의 수식을 이용하여 불안정지수(집중력지수, 신뢰지수)를 산출하는 단계를 포함하는 것을 특징으로 하는 생체활력지수 산출 방법.Comprising a step of calculating the instability index (concentration index, confidence index) using the formula below.
    Figure PCTKR2014005665-appb-I000008
    Figure PCTKR2014005665-appb-I000008
  4. 제1항에 있어서,The method of claim 1,
    상기 혈관의 운동성 지수는 |a| 또는 |a-b|의 값인 것을 특징으로 하는 생체활력지수 산출 방법.The motility index of the blood vessel is | a | Or a value of | a-b |.
    (이때, a, b는 상기 가속도맥파의 변곡점에서의 값)Where a and b are values at the inflection point of the acceleration pulse wave.
  5. 제1항에 있어서,The method of claim 1,
    상기 말초혈액순환 지수는 아래의 수식을 이용하여 산출되는 것을 특징으로 하는 생체활력지수 산출 방법.The peripheral blood circulation index is a vitality index calculation method, characterized in that calculated using the following formula.
    Figure PCTKR2014005665-appb-I000009
    Figure PCTKR2014005665-appb-I000009
  6. 제5항에 있어서,The method of claim 5,
    상기 혈류량지수(PI)가 10% 이하이고, 상기 말초혈액순환지수가 0.5 이하인 경우에는 맥관의 운동성을 유지되지만, 말초혈액순환량이 감소된 것으로 판단하는 단계를 더 포함하는 것을 특징으로 하는 생체활력지수 산출 방법.When the blood flow index (PI) is 10% or less and the peripheral blood circulation index is 0.5 or less, the motility of the vessel is maintained, but the vitality index further comprises the step of determining that the peripheral blood circulation is reduced Output method.
  7. 용적맥파 측정 센서; 및Volumetric pulse wave measuring sensor; And
    상기 용적맥파 측정 센서로부터 수신된 혈류량 측정값을 이용하여 가속도맥파와 심박변이도 값을 산출하고, 상기 심박변이도 값의 주파수 변화을 통하여 교감신경 활성화 영역인 저주파 영역 및 부교감신경 활성화 영역인 고주파 영역의 비를 산출하고, 상기 혈류량 측정값 및 상기 가속도맥파를 이용하여 혈관의 운동성 지수 및 말초혈액순환 지수를 산출하고, 상기 저주파 영역 및 상기 고주파 영역의 비, 상기 혈관의 운동성 지수 및 상기 말초혈액순환 지수를 이용하여 생체활력지수를 산출하는 서버를 포함하는 생체활력지수 산출 시스템.The acceleration pulse wave and heart rate variance values are calculated using the blood flow measurement values received from the volumetric pulse wave measurement sensor, and the ratio of the low frequency region, the sympathetic nerve activation region, and the high frequency region, the sympathetic nerve activation region, is determined by changing the frequency of the heart rate variability values. Calculate the vascular motility index and peripheral blood circulation index using the blood flow measurement value and the acceleration pulse wave, and use the ratio of the low frequency region and the high frequency region, the motility index of the blood vessel and the peripheral blood circulation index The vitality index calculation system comprising a server for calculating the vitality index.
  8. 제7항에 있어서,The method of claim 7, wherein
    상기 서버는, 아래의 수식을 이용하여 스트레스 지수를 산출하는 것을 특징으로 하는 생체활력지수 산출 시스템.The server, the vitality index calculation system, characterized in that for calculating the stress index using the following formula.
    Figure PCTKR2014005665-appb-I000010
    Figure PCTKR2014005665-appb-I000010
  9. 제7항에 있어서,The method of claim 7, wherein
    상기 서버는, 아래의 수식을 이용하여 불안정지수(집중력지수, 신뢰지수)를 산출하는 것을 특징으로 하는 생체활력지수 산출 시스템.The server, the vitality index calculation system, characterized in that for calculating the instability index (concentration index, confidence index) using the following formula.
    Figure PCTKR2014005665-appb-I000011
    Figure PCTKR2014005665-appb-I000011
  10. 제7항에 있어서,The method of claim 7, wherein
    상기 혈관의 운동성 지수는 |a| 또는 |a-b|의 값인 것을 특징으로 하는 생체활력지수 산출 시스템.The motility index of the blood vessel is | a | Or a value of | a-b |.
    (이때, a, b는 상기 가속도맥파의 변곡점에서의 값)Where a and b are values at the inflection point of the acceleration pulse wave.
  11. 제7항에 있어서,The method of claim 7, wherein
    상기 말초혈액순환 지수는 아래의 수식을 이용하여 산출되는 것을 특징으로 하는 생체활력지수 산출 시스템.The peripheral blood circulation index is a vitality index calculation system, characterized in that calculated using the following formula.
    Figure PCTKR2014005665-appb-I000012
    Figure PCTKR2014005665-appb-I000012
  12. 제11항에 있어서,The method of claim 11,
    상기 서버는, 상기 혈류량지수(PI)가 10% 이하이고, 상기 말초혈액순환지수가 0.5 이하인 경우에는 맥관의 운동성을 유지되지만, 말초혈액순환량이 감소된 것으로 판단하는 것을 특징으로 하는 생체활력지수 산출 시스템.If the blood flow index (PI) is 10% or less, and the peripheral blood circulation index is 0.5 or less, the motility of the vasculature is maintained, but the vitality index calculation is characterized in that the peripheral blood circulation is determined to be reduced. system.
  13. 제7항에 있어서,The method of claim 7, wherein
    실내온도 및 체온을 측정하는 온도측정센서; 및A temperature sensor for measuring room temperature and body temperature; And
    실내습도를 측정하는 습도측정센서를 더 포함하고,Further comprising a humidity measuring sensor for measuring the indoor humidity,
    상기 서버는 상기 온도측정센서 및 상기 습도측정센서의 측정값을 기초로 피검자가 위치한 실내환경 상태를 판단하는 것을 특징으로 하는 생체활력지수 산출 시스템.The server is a vitality index calculation system, characterized in that for determining the indoor environment state in which the subject is located based on the measured values of the temperature measuring sensor and the humidity measuring sensor.
  14. 제7항에 있어서,The method of claim 7, wherein
    상기 서버는, 피검자가 협심증, 부정맥, 빈맥, 서맥, 심방세동 상태라고 판단되면 미리 설정된 사용자의 단말기에 알람음 또는 알람 메시지를 발생시키는 것을 특징으로 하는 생체활력지수 산출 시스템.The server, when the subject is determined to be angina pectoris, arrhythmia, tachycardia, bradycardia, atrial fibrillation state, the vitality index calculation system, characterized in that for generating an alarm sound or an alarm message to the terminal of the user preset.
  15. 제7항에 있어서,The method of claim 7, wherein
    상기 용적맥파 센서는,The volumetric pulse wave sensor,
    귀걸이형, 이어폰형, 머리띠형, 손목시계형, 반지형 중 하나인 것을 특징으로 하는 생체활력지수 산출 시스템.Bio vitality index calculation system, characterized in that one of the earring type, earphone type, headband type, watch type, ring type.
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