WO2015070693A1 - 眼睛温度的测量与分析***、接收分析装置及其方法 - Google Patents

眼睛温度的测量与分析***、接收分析装置及其方法 Download PDF

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Publication number
WO2015070693A1
WO2015070693A1 PCT/CN2014/089274 CN2014089274W WO2015070693A1 WO 2015070693 A1 WO2015070693 A1 WO 2015070693A1 CN 2014089274 W CN2014089274 W CN 2014089274W WO 2015070693 A1 WO2015070693 A1 WO 2015070693A1
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Prior art keywords
eye
temperature
analyzing
signal
measuring
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PCT/CN2014/089274
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English (en)
French (fr)
Inventor
赖弘基
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赖弘基
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Priority claimed from CN201310571720.9A external-priority patent/CN104586348A/zh
Application filed by 赖弘基 filed Critical 赖弘基
Priority to EP14861945.5A priority Critical patent/EP3069652B1/en
Publication of WO2015070693A1 publication Critical patent/WO2015070693A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6821—Eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
    • G01K13/00—Thermometers specially adapted for specific purposes
    • G01K13/20—Clinical contact thermometers for use with humans or animals

Definitions

  • the present invention relates to an eye temperature measuring and analyzing system, a receiving analyzing device and a method thereof, and more particularly to a system, an analyzing device and a method thereof for analyzing and determining the surface temperature of an eye.
  • the surface temperature of the eye is the state of the muscles or layers of the eye that respond to the eyeball, so it can be used as an important indicator of eye health or disease.
  • the ocular surface temperature will increase.
  • ciliary muscle spasm causes myopia, which causes the ocular surface temperature to rise.
  • the amount of tears flowing to the ocular surface is reduced, which causes the ocular surface temperature to decrease. Therefore, an increase or decrease in ocular surface temperature can be used to determine whether the eye is healthy, close to the lesion, or has developed a lesion.
  • DM Maurice and ASMushin in the paper "Production of Myopia in Rabbits by Raised Body-Temperature and Increased Intraocular Pressure" (The Lancet; November 26, 1966, pp. 1160-1162), indicate that when the temperature of young rabbits rises to At 41-43 ° C, after about 30 minutes, the rabbit's dioptres will reach -0.75 or more.
  • the reason for myopia is that the refractive power of the eye is so great that parallel rays parallel to the visual axis converge in front of the retina and cannot form a clear image on the retina. Furthermore, changes in the visual axis are also positively correlated with eye temperature.
  • this paper also proves the correlation between eye temperature and myopia or eyeball changes.
  • the temperature of the eyeball rises, the sphere itself expands.
  • the surrounding tissue of the eyeball is more resistant to swelling, so the expansion is transmitted to the bottom of the eyeball. Under this improper deformation, the eyeball caused a long eyeball with a long visual axis.
  • US Patent No. 2012/0245444 proposes a biochip wearable contact lens for detecting a specific chemical concentration in a pre-corneal (tear) membrane.
  • US Patent No. 2010/0234717, US 2013/0041245, and PCT International Patent No. WO 03/001991 propose a contact lens in combination with an electronic pressure sensor for measuring the pressure in the eye.
  • few patents or documents suggest that contact lenses combined with electronic temperature sensors to measure the surface temperature of the eye, and there is a lack of relevant technical information on the use of contact lenses with temperature measurement functions to judge eye health or lesions.
  • eye medical or vision correction requires a system and method for judging eye health or lesions, which can be widely used in preventive medicine and corrective monitoring.
  • the object of the present invention is to provide an eye temperature measuring and analyzing system, a receiving analyzing device and a method thereof, which are capable of analyzing and judging whether an eye is healthy, close to a lesion or has developed a lesion by recording data of the surface temperature of the eye, so that Used in preventive medicine and corrective monitoring.
  • the present invention provides a system for measuring and analyzing eye temperature, comprising:
  • An eye temperature measuring device placed on the surface of the eyeball comprising:
  • a temperature sensing component that generates an electrical signal based on the surface temperature of the eye
  • a signal transmitting component that converts the electrical signal into a wireless signal
  • a receiving analysis device comprising:
  • An analyzing unit analyzes and determines whether the surface temperature of the eye is normal according to the wireless signal.
  • the eye temperature measuring device further comprises an antenna that transmits the wireless signal to the outside.
  • An eye temperature measurement and analysis system as described above, wherein the antenna generates electrical power by inductive coupling of external electromagnetic waves to supply the temperature sensing component and the signal transmitting component.
  • the other antenna includes an external antenna that relays the wireless signal.
  • the wireless signal is a signal compliant with radio frequency, Bluetooth or WiFi.
  • an eye temperature measurement and analysis system as described above, wherein the analysis unit is based on a temperature value of the surface of the eye, a difference between temperature values at two time points, or an average value of temperature values at successive time points Or its changes to determine if the eye has a lesion.
  • the difference between the nighttime temperature of the surface temperature of the eye and the daytime temperature is lower than the lower limit, it is judged that the eye has no nearsightedness or pseudonymity.
  • the occurrence of myopia Where the difference is between the lower limit value and the upper limit value, it is determined that the eye may have myopia or pseudo myopia. Wherein, if the difference is greater than the upper limit value, it is determined that the eye has myopia or pseudo myopia.
  • the difference in temperature value measured between the two time points of the eye is lower than the lower limit value, it is judged that the eye should have dry eye syndrome.
  • the temperature value measured at the two time points is that the eye surface temperature is measured again after the eye opening is opened, and the eye surface temperature is measured again between 6 and 10 seconds after the measurement, and the eyelid is between the two measurements. Keep on opening.
  • the difference in temperature value measured between the two time points of the eye is between 0.2 ° C and 0.4 ° C, it is judged that the eye may have dry eye syndrome.
  • the difference in temperature value measured between the two time points of the eye is greater than 0.4 ° C, the probability of occurrence of dry eye syndrome in the eye is determined to be low.
  • the eye temperature measuring and analyzing system as described above, wherein the receiving analyzing device is a computer to which a specific software or application is installed, a tablet computer, a smart phone or a smart watch.
  • the signal receiving unit comprises:
  • a mobile inquiry unit that provides power required by the signal transmission component and the temperature sensing component, and receives the wireless signal to generate a radio frequency signal
  • a data receiving unit receives the radio frequency signal for conversion to data having an eye surface temperature.
  • the analysis unit is a computer.
  • thermosensor component is a plurality of loop lines, special application ICs or microelectromechanical components disposed on a surface of the contact lens.
  • the eye temperature measuring and analyzing system as described above, wherein the eye temperature measuring device is a contact lens having a temperature measuring function.
  • the eye temperature measuring and analyzing system as described above, wherein the eye temperature measuring device is placed on the surface of the eyeball and inside the eyelid to measure the temperature of the eye, and the size thereof does not cover the pupil.
  • the invention further provides a receiving and analyzing device for eye temperature, comprising:
  • a signal receiving unit that receives a wireless signal, wherein the wireless signal includes data of an eye surface temperature
  • An analyzing unit analyzes and determines whether the surface temperature of the eye is normal according to the wireless signal.
  • the eye temperature receiving and analyzing device as described above, wherein the analyzing unit is based on a temperature value of an eye surface, a difference between temperature values at two time points, or an average value of temperature values at a plurality of consecutive time points or a change thereof
  • the analyzing unit is based on a temperature value of an eye surface, a difference between temperature values at two time points, or an average value of temperature values at a plurality of consecutive time points or a change thereof
  • the eye temperature receiving and analyzing device as described above, wherein when the difference in temperature value measured between the two time points of the eye is lower than the lower limit value, it is judged that the eye should have dry eye syndrome.
  • the temperature value measured at the two time points is that the eye surface temperature is measured again after blinking open the eyelid and the skin surface temperature is measured again between 6 and 10 seconds after the measurement, and the eyelid is between the two measurements. Keep on opening.
  • the difference in temperature value measured between the two time points of the eye is between 0.2 ° C and 0.4 ° C, it is judged that the eye may have dry eye syndrome.
  • the probability of occurrence of dry eye syndrome in the eye is determined to be low.
  • the signal receiving unit comprises:
  • a mobile interrogation unit that receives the wireless signal to generate a radio frequency signal
  • a data receiving unit receives the radio frequency signal for conversion to data having an eye surface temperature.
  • the analysis unit is a computer.
  • the eye temperature receiving and analyzing device as described above, wherein the receiving analyzing device is a computer to which a specific software or application is installed, a tablet computer, a smart phone or a smart watch.
  • the invention provides a method for measuring and analyzing eye temperature, which comprises the following steps:
  • the wireless signal it is analyzed and judged whether the surface temperature of the eye is normal.
  • the method for measuring and analyzing eye temperature as described above, wherein the step of analyzing and judging comprises, according to a temperature value of the eye, a difference between temperature values at two time points, or a temperature value at successive time points.
  • Figure 1 is a line graph of the difference in daytime and nighttime temperature of the surface of the pseudo-myopia group and the normal vision group in Table 1;
  • Figure 2 is a schematic view of the eye temperature measuring device of the present invention.
  • Figure 3 is a schematic view of the eye temperature measuring device of Figure 2 attached to the surface of the eye;
  • Figure 4 is a schematic illustration of the eye temperature measurement and analysis system of the present invention.
  • Figure 5 is a schematic illustration of another embodiment of the eye temperature measurement and analysis system of the present invention.
  • Figure 6 is a flow chart of a method for measuring and analyzing eye temperature of the present invention.
  • Figure 7 is a schematic view of another embodiment of the eye temperature measuring device of the present invention.
  • Figure 8 is a schematic illustration of the eye temperature measuring device of Figure 7 attached to the surface of the eye.
  • an increase or decrease in ocular surface temperature can be used to determine if the eye is healthy, close to the lesion, or has developed a lesion.
  • the ciliary muscle tendon causes myopia and increases the temperature of the ocular surface.
  • Table 1 below shows data for measuring the surface temperature of the eye in the pseudo-myopia group and the normal vision group.
  • the medical literature also points out that when the body temperature rises (high fever) or the surface temperature of the eye is staring at something (book, TV, computer, mobile phone, etc.) for a short distance, especially for a short distance and for a long time, It will cause the ciliary muscle to be in a state of high tension for a long time, and the eye temperature will increase due to the presence of such high tension. Although the ciliary muscles are used excessively during the day, the ciliary muscles gradually relax when sleeping at night, so the temperature should slowly drop. On the other hand, since the eyelids are tightly closed during sleep, the release of heat is hindered, that is, the temperature of the eyeball is still not easy or even impossible to fall.
  • the posture of the body changes (for example, lying flat)
  • the posture of the eyeball changes, and the pressure around the vitreous of the eyeball is increased, and the high temperature and high pressure are transmitted from the inside to the bottom of the eyeball. Therefore, it is easy to cause the length of the eyeball to be longer in the direction of the visual axis.
  • the length of the visual axis of the eyeball continues to grow, so that imaging is formed before the retina, that is, myopia occurs.
  • Fig. 1 is a line graph showing the difference in daytime and nighttime temperature of the eye surface of the pseudomyopia group and the normal vision group in Table 1. It can be clearly seen from the figure that the difference in nighttime and daytime temperature of the surface of the pseudomyopia group is large, that is, the nighttime temperature on the surface of the eye is significantly higher. In contrast, the normal eyesight group's eye surface night The difference between the temperature and the daytime is small, that is, the nighttime temperature on the surface of the eye is slightly higher. Therefore, it is possible to analyze and judge whether the eye is healthy, close to the lesion, or has developed lesions by recording data on the surface temperature of the eye, so it can be used for preventive medicine and corrective monitoring.
  • the present invention is not limited to the judgment of myopia, dry eye syndrome or other eye symptoms exhibiting temperature changes can be applied to the embodiments of the present invention, or the conditions of the respective embodiments can be appropriately changed in accordance with the magnitude and direction of the temperature change.
  • Figure 1 is a measurement of the surface temperature of the eyes of two groups of people during the day and night.
  • the present invention can also be used to measure the average difference of the surface temperature of the same person during the day and night, or to measure the same person for a long time.
  • the foregoing embodiment does not limit the present invention, and a difference value or an average value of the eye surface temperature for a long time or a short time can be applied to the present invention.
  • an increase or decrease in ocular surface temperature can be used to determine if the eye is healthy, close to the lesion, or has developed a lesion.
  • dry eye syndrome can cause significant changes in ocular surface temperature due to insufficient secretion of tears.
  • Table 2 below shows data on the measured surface temperature of the eye in patients with dry eye and those without dry eye.
  • Tc The eye surface temperature is measured again at the 6th second (or any time point selected between 6th and 10th seconds) after the To measurement, and the eyelid is continuously opened between the two measurements.
  • Td is the difference between To and Tc.
  • the difference in the Td of the dry eye group is significantly lower than that of the group without the dry eye. Therefore, this fact can be used as a basis for judging the occurrence of dry eye syndrome, and the criterion can be listed as follows: When the difference value Td is less than 0.2 ° C, the eye should be considered to have dry eye syndrome; when the difference value Td is between 0.2 At °C ⁇ 0.4 °C, it may be considered that the eye may have a risk of dry eye syndrome; when the difference value is greater than 0.4 °C, the incidence of dry eye syndrome in the eye may be considered to be low.
  • the present invention is not limited by this embodiment, and another criterion can be directly determined by using a single value of the temperature value To or Tc. Or a change in the curve formed by multiple temperature values To or Tc (sudden, sudden, increasing or decreasing) or a change in slope to determine different criteria. In fact, the content of the judgment criteria and the way of determining should be changed with different eye symptoms.
  • the eye temperature measuring device of this embodiment is a contact lens 20 having a temperature measuring function, but the invention is not limited thereto, and may be any wearing device placed on the surface of the eyeball to measure the temperature of the eye.
  • the contact lens 20 mainly comprises a transparent substrate 21, a temperature sensing component (or temperature sensing circuit) 22, an antenna 23 and a signal transmitting component 24.
  • the material of the transparent substrate 21 may be a silicone hydrogel (for example, HEMA). Because of its high oxygen permeability and hydrophilicity, it can improve the comfort of the loader and is suitable for long-term wear.
  • the material of the transparent substrate 21 may also be other transparent polymer materials, and is not limited by this embodiment.
  • the antenna 23 can transmit a wireless signal to the outside, and can also be used to receive external energy, for example, an inductive link or an inductive coupling effect is generated by the radio frequency signal or other electromagnetic waves, thereby generating a power supply temperature.
  • the energy supply device that emits radio frequency signals or other electromagnetic waves can be placed in the headscarf or placed in a pocket, or integrated into other portable devices (eg, mobile phones, Bluetooth headsets, etc.).
  • the present embodiment is not limited thereto, and a microelectromechanical (MEMS) battery may be disposed on the surface or inside of the transparent substrate 21.
  • MEMS microelectromechanical
  • an external antenna may be attached around the eyes (such as the eyelids), so that the signal can be transmitted and enhanced, so that the signal receiver can be clearer at a distance. received.
  • a plurality of ring-shaped lines capable of sensing temperature are coated on the surface of the transparent substrate 21 with the center of the contact lens 20 as a common center.
  • the loop line may be a plurality of circular loop lines, polygonal loop lines or irregular loop lines.
  • the temperature sensing component 22 can be a special application IC (Application-Specific IC; ASIC) or a micro-electromechanical (MEMS) component, or a nano-ply (PECO) grade chemical, metallic or biological material.
  • a test component that can be used to measure temperature or reaction temperature changes.
  • the signal transmitting component 24 can convert an electrical signal (such as a voltage signal or a current signal) generated by the temperature sensing component 22 into a radio frequency (RF) signal and transmit the wireless signal to the outside through the antenna 23.
  • RF radio frequency
  • the present invention is not limited to converting an electrical signal into a radio frequency (RF) signal, and can also be converted into a signal of a prescribed type such as Bluetooth or WiFi.
  • the antenna 23 is a plurality of loop lines coated on the surface of the transparent substrate 21 and peripheral to the temperature sensing unit 22, and the wireless signal conforming to the communication protocol can be transmitted to the outside.
  • FIG 3 is a schematic illustration of the eye temperature measuring device of Figure 2 attached to the surface of the eye.
  • the temperature sensing component with the loop line 22 and the antenna 23 are arranged in the non-visual light-receiving area, so that the light entering the pupil is not blocked, and it can be worn not only during nighttime sleep but also during daytime activities.
  • the contact lens 20 with the temperature measuring function can be worn for a long time in normal life or work, and the subject does not need to be limited to the temperature measuring tool and can only reside in the tested area, for example, in the prior art.
  • the front of the infrared thermometer is used, so it is convenient for activity, sleep or long-term measurement, thus increasing the accuracy of the judgment result.
  • System 40 includes a contact lens 20, a mobile interrogation unit 41, a data receiving unit 42, and a computer 43.
  • the mobile inquiry unit 41 wirelessly supplies the power required by the signal transmission unit 24 and the temperature sensing unit 22 via the ring-shaped sensing circuit 411, and receives a wireless signal including the eye surface temperature data from the antenna 23 of the contact lens 20. And demodulating the wireless signal to obtain the electrical signal, and then performing analog to digital conversion on the electrical signal to obtain a digital data related to the electrical signal, and then converting and converting the digital data into a
  • the carrier is used to obtain a radio frequency signal.
  • the data receiving unit 42 wirelessly receives the radio frequency signal from the mobile interrogation unit 41, and demodulates the radio frequency signal to obtain the digital data related to the electrical signal.
  • the computer 43 stores a table of digital data and eye surface temperature correspondence, and is electrically connected to the data receiving unit 42 to receive the digital data, and according to the table to obtain an eye surface temperature, which is displayed and stored.
  • the computer 43 can analyze and store the stored eye surface temperature data and determine whether the eye surface temperature is normal. For example, the difference between nighttime and daytime temperature on the surface of the eye (see Table 1) can be used to determine whether there is myopia or pseudomyopia; when the difference is less than 0.1 °C, the eye can be considered as no myopia; when the difference is At 0.1 ° C ⁇ 0.3 ° C, the eye may be considered to have myopia; when the difference is greater than 0.3 ° C, then the eye should be considered to have myopia.
  • Table 1 the difference between nighttime and daytime temperature on the surface of the eye
  • the result of the pre-open judgment may be displayed on the screen of the computer 43 or in the color of the indicator light of the data receiving unit 42, for example, green represents no myopia, yellow represents the presence of myopia, and red represents the occurrence of myopia.
  • the present invention is not limited by the judgment criteria of the above embodiments, and can be determined according to the actual eye surface temperature and different symptoms.
  • the mobile inquiry unit 41, the data receiving unit 42, and the data analysis judgment (which is the responsibility of the computer 43 in this embodiment) can be integrated into a receiving analysis device, which can be a computer on which a specific software or application is installed.
  • a receiving analysis device can be a computer on which a specific software or application is installed.
  • a tablet computer, a smart phone or a smart watch may also incorporate or embed the ring-shaped sensing circuit 411 with such devices.
  • FIG. 5 is a schematic illustration of another embodiment of the eye temperature measurement and analysis system of the present invention.
  • the system 50 uses the mobile phone 51 or the desktop computer 52 as a receiving and analyzing device.
  • the receiving and analyzing device includes at least a signal receiving unit and an analyzing unit.
  • the signal receiving unit receives the wireless signal sent by the contact lens 20, and the analyzing unit Analyze and judge the surface temperature of the eye according to the wireless signal None is normal.
  • Figure 6 is a flow chart of a method of measuring and analyzing eye temperature of the present invention.
  • the present invention provides a method for measuring and analyzing eye temperature, comprising the steps of: measuring the surface temperature of the eye through a contact lens having a temperature measuring function as shown in step 61; transmitting the wireless signal as shown in step 62; The surface temperature data; as shown in step 63, the wireless signal is received; as shown in step 64, and the surface temperature of the eye is analyzed and determined based on the wireless signal.
  • Fig. 7 is a schematic view of another embodiment of the eye temperature measuring device of the present invention, when the eye temperature measuring device 70 of this embodiment is worn on the surface of the eyeball, the pupil is not covered.
  • the apparatus of this embodiment can also be applied to the aforementioned eye temperature measurement and analysis system, that is, it can accept the power supply of the mobile inquiry unit 41 and transmit the wireless signal containing the eye surface temperature data.
  • the eye temperature measuring device 70 mainly includes a substrate 71, a temperature sensing component (or temperature sensing circuit) 72, an antenna 73, and a signal transmitting component 74.
  • the material of the substrate 71 of the present embodiment may be a silicone hydrogel polyester or a polyacrylamide, which is suitable for materials which are fully penetrating, semi-transparent or completely impervious to light.
  • the substrate 71 may also be made of other polymer materials, and soft or hard materials (for example, polysiloxane polymer, polymethyl methacrylate, which needs to be formed in accordance with the curvature of the eyeball) may not be implemented.
  • the antenna 73 can transmit a wireless signal to the outside, and can also be used to receive external energy.
  • the antenna 73 is inductively coupled or inductively coupled by a radio frequency signal or other electromagnetic waves to generate an electrical energy supply temperature sensing component 72.
  • the power required by the signal transmitting component 74 can be disposed on the surface of the substrate 71, and the generated electric energy can directly supply the electric power required for the temperature sensing component 72 and the signal transmission component 74.
  • the eye temperature measuring device 70 Since the eye temperature measuring device 70 is placed in the eyelid (see Fig. 8), its area may be limited, so that the number or size of cycles of the antenna 73 is also limited. In order to compensate for the signal strength of the antenna 73 may not be sufficient, an external antenna may be attached around the eyes (such as the eyelids), so that the signal can be transmitted and enhanced, so that the signal receiver can be clearer at a distance. received.
  • a plurality of ring-shaped lines ie, the temperature sensing component 72
  • the loop line may be a plurality of circles.
  • the temperature sensing component 72 can be an application-specific IC (ASIC) or a micro-electromechanical (MEMS) component, or a nano-ply (PECO) grade chemical, metal or biomaterial.
  • a test component that can be used to measure temperature or reaction temperature changes.
  • the signal transmitting component 74 can convert an electrical signal (eg, a voltage signal or a current signal) generated by the temperature sensing component 72 into a radio frequency (RF) signal and transmit the wireless signal to the outside through the antenna 73.
  • RF radio frequency
  • the present invention is not limited to converting an electrical signal into a radio frequency (RF) signal, and can also be converted into a signal of a prescribed type such as Bluetooth or WiFi.
  • the antenna 73 is applied to the surface of the substrate 71 and at the temperature sense A plurality of loop circuits on the periphery of the component 72 can transmit a wireless signal conforming to the communication protocol to the outside.
  • Figure 8 is a schematic illustration of the attachment of the eye temperature measuring device of the present invention to the surface of the eye.
  • the substrate 71 may be made of an opaque material because it is located in the non-visual light receiving region, that is, no need is needed. Consider whether it will block the light entering the pupil, not only when you sleep at night, but also for simultaneous measurements during daytime activities.
  • the shape of the substrate 71 may be a half-moon shape or a rectangular shape as shown in the figure to facilitate placement on the inner side of the eyelid.
  • the eye temperature measuring and analyzing system, the receiving analyzing device and the method thereof of the present invention utilize the state of the surface temperature of the eye to reflect the state of each muscle or layer of the eyeball, and make it an important index representing eye health or lesions. It can be used for preventive medicine and corrective monitoring by recording data on the surface temperature of the eye to analyze and judge whether the eye is healthy, close to the lesion, or has developed lesions.

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Abstract

一种眼睛温度的测量与分析***（40），包含一眼睛温度测量装置及一接收分析装置。眼睛温度测量装置包括一温度感测组件（22）及一信号传送组件（24）；温度感测组件（22）测量眼睛表面温度的数据，通过信号传送组件（24）向外部传送无线信号。接收分析装置包含一信号接收单元（42）及一分析单元（43），信号接收单元（42）接收来自信号传送组件（24）的无线信号，分析单元（43）根据所述无线信号分析及判断眼睛表面温度是否正常。

Description

眼睛温度的测量与分析***、接收分析装置及其方法 技术领域
本发明是关于一种眼睛温度的测量与分析***、接收分析装置及其方法，尤其是关于一种用于分析及判断眼睛表面温度的***、分析装置及其方法。
背景技术
眼睛的表面温度是反应眼球的各部肌肉或各层组织的状态，故可作为代表眼睛健康或病变的一种重要指标。当眼睛处于发炎或是有肌肉调节紧张(痉挛)时，眼表温度就会增高，例如：睫状肌痉挛造成近视眼，会使得眼表温度升高。然而，对于干眼症患者而言，在眼睑开合之间，因为泪液流到眼表的数量减少，会导致眼表温度降低。因此，眼表温度的升高或降低可用于判断眼睛是否健康、接近病变或已发生病变。
D.M.Maurice及A.S.Mushin于所撰论文“Production of Myopia in Rabbits by Raised Body-Temperature and Increased Intraocular Pressure”(The Lancet；November 26,1966,pp.1160-1162)中指出：当年轻兔子的体温升到41-43℃时，维持大约30分钟后，兔子的屈光度数(dioptres)就会达到－0.75以上。近视的原因就是眼睛屈光能力太大，致使平行于视轴的平行光线汇聚在视网膜前，不能在视网膜上形成清晰的成像。再者，视轴的变化也与眼球温度有正相关。因睫状肌的痉挛可能会刺激眼球视轴的拉长，从而形成无法逆转的真性近视，就本篇论文亦证明眼球温度和近视或眼球变化的关联性。当眼球的温度上升，球体本身就会膨胀。又眼球周边组织抵抗膨胀的力量较强，因此该膨胀就传往眼球底部发展。眼球在这种不当变形下，日积月累就造成了一个视轴较长的眼球。
又Tien-Chun Chang,等所撰论文“Application of digital infrared thermal imaging in determining inflammatory state and follow-up effect of methylprednisolone pulse therapy in patients with Graves’ophthalmopathy”(Graefes Arch Clin Exp Ophthalmol；2008,246 vol.,pp.45-49)中指出：针对葛雷夫氏症(Graves’)以计算机化远红外线热影像测量局部的温度，并能有效协助观察并记录眼球的发炎程度。另，hyang-Rong Shih等所撰论文“The application of temperature measurement of the eyes by digital infrared thermal imaging as a prognostic factor of methylprednisolone pulse therapy for Graves’ophthalmopathy”(Acta Ophthalmologica；2010 vol.88,pp.164-159)可得知：在大剂量类固醇治疗后眼睛温度平均来说会下降，温度下降的程度与治疗前的眼睛温度成正相 关。此等研究显示远红外线热影像的温度测量有助于预测大剂量类固醇治疗甲状腺眼病变的效果。
此外，因为不同用途的电子组件不断微型化，针对可戴式或嵌入式医用(或矫正)装置整合该等电子组件的应用也越来越多。例如：美国专利US2012/0245444提出一种结合生物芯片可戴式隐形眼镜，用以侦测角膜前(泪)膜中的特定化学物质浓度。又美国专利US2010/0234717、US2013/0041245及PCT国际专利WO03/001991提出一种隐形眼镜结合电子压力传感器，用以测量眼睛内压力。然鲜少专利或文献提出隐形眼镜结合电子温度传感器以测量眼睛的表面温度，更缺乏相关前案有公开使用具温度测量功能的隐形眼镜以判断眼睛健康或病变的技术内容。
综上所述，眼睛医疗或视力矫正亟需要一种能判断眼睛健康或病变的***及方法，由此可以广泛用于预防医学及矫正监测。
发明的公开
本发明的目的是提供一种眼睛温度的测量与分析***、接收分析装置及其方法，其是通过记录眼睛表面温度的数据，从而分析并判断眼睛是否健康、接近病变或已发生病变，故能用于预防医学及矫正监测。
为达上述目的，本发明提供一种眼睛温度的测量与分析***，包含：
一眼睛温度测量装置，置于眼球表面，包括：
一温度感测组件，根据眼睛表面温度产生电气信号；及
一信号传送组件，将该电气信号转换为无线信号；以及
一接收分析装置，包括：
一信号接收单元，接受该无线信号；及
一分析单元，根据该无线信号分析及判断该眼睛表面温度是否正常。
如前所述的眼睛温度的测量与分析***，其中，该眼睛温度测量装置另包含一天线，该天线向外部传送该无线信号。
如前所述的眼睛温度的测量与分析***，其中，该天线通过外部的电磁波形成电感耦合而产生电力，以供应该温度感测组件及该信号传送组件。其中，其另包含一外部天线，该外部天线会转传该无线信号。
如前所述的眼睛温度的测量与分析***，其中，该无线信号是符合射频、蓝牙或WiFi所规定的信号。
如前所述的眼睛温度的测量与分析***，其中，该分析单元是根据该眼睛表面的一温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化以判断眼睛是否有病变的发生。其中，当该眼睛的表面温度的夜间温度与日间温度的差异低于一下限值，则判断眼睛无近视或假性 近视的发生。其中，该差异介于该下限值及一上限值之间，则判断眼睛可能有近视或假性近视的发生。其中，该差异大于该上限值，则判断眼睛有近视或假性近视的发生。
如前所述的眼睛温度的测量与分析***，其中，当该眼睛的两时间点间测量的温度值差异低于一下限值，则判断眼睛应有干眼症的发生。其中，该两时间点测量的温度值是在眨眼打开眼睑立即测量眼睛表面温度及该次测量后的第6至10秒之间再次测量眼睛表面温度，且于该两次测量之间该眼睑是持续张开。其中，当该眼睛的两时间点间测量的温度值差异介于0.2℃至0.4℃之间时，则判断眼睛可能有干眼症的发生。其中，当该眼睛的两时间点间测量的温度值差异大于0.4℃时，则判断眼睛发生干眼症的机率低。
如前所述的眼睛温度的测量与分析***，其中，该接收分析装置是一已安装特定软件或应用程序的计算机、一平板计算机、一智能型手机或一智能型手表。
如前所述的眼睛温度的测量与分析***，其中，该信号接收单元包括:
一移动式询答单元，提供该信号传送组件及该温度感测组件所需的电力，并接收该无线信号以产生射频信号；以及
一数据接收单元，接受该射频信号以转换为具有眼睛表面温度的数据。其中，该分析单元是一计算机。
如前所述的眼睛温度的测量与分析***，其中，该温度感测组件是设于隐形眼镜的表面上的多个环状线路、特殊应用IC或微机电组件。
如前所述的眼睛温度的测量与分析***，其中，该眼睛温度测量装置是一具有温度测量功能的隐形眼镜。
如前所述的眼睛温度的测量与分析***，其中，该眼睛温度测量装置是置于眼球表面及眼睑内侧以测量眼睛的温度，且其尺寸未覆盖瞳孔。
本发明另提供一种眼睛温度的接收分析装置，包含：
一信号接收单元，接受一无线信号，其中该无线信号包括眼睛表面温度的数据；以及
一分析单元，根据该无线信号分析及判断该眼睛表面温度是否正常。
如前所述的眼睛温度的接收分析装置，其中，该分析单元是根据眼睛表面的温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化以判断眼睛是否有病变的发生。其中，当该眼睛的表面温度的夜间温度与日间温度的差异低于一下限值，则判断眼睛无近视或假性近视的发生。其中，该差异介于该下限值及一上限值之间，则判断眼睛可能有近视或假性近视的发生。其中，该差异大于该上限值，则判断眼睛有近视或假性近视的发生。
如前所述的眼睛温度的接收分析装置，其中，当该眼睛的两时间点间测量的温度值差异低于一下限值，则判断眼睛应有干眼症的发生。其中，该两时间点测量的温度值是于眨眼打开眼睑立即测量眼睛表面温度及该次测量后的第6至10秒之间再次测量眼睛表面温度，且于该两次测量之间该眼睑是持续张开。其中，当该眼睛的两时间点间测量的温度值差异介于0.2℃至0.4℃之间时，则判断眼睛可能有干眼症的发生。其中，当该眼睛的两时间点间测量的温度值差异大于0.4℃时，则判断眼睛发生干眼症的机率低。
如前所述的眼睛温度的接收分析装置，其中，该信号接收单元包括:
一移动式询答单元，接收该无线信号以产生射频信号；以及
一数据接收单元，接受该射频信号以转换为具有眼睛表面温度的数据。其中，该分析单元是一计算机。
如前所述的眼睛温度的接收分析装置，其中，该接收分析装置是一已安装特定软件或应用程序的计算机、一平板计算机、一智能型手机或一智能型手表。
本发明提供一种眼睛温度的测量与分析方法，其包含下列步骤：
通过一置于眼球表面的眼睛温度测量装置测量眼睛的表面温度；
以无线信号传送该表面温度的数据；
接受该无线信号；以及
根据该无线信号分析及判断该眼睛的表面温度是否正常。
如前所述的眼睛温度的测量与分析方法，其中，该无线信号是符合射频、蓝牙或WiFi所规定的信号。
如前所述的眼睛温度的测量与分析方法，其中，该分析及判断的步骤近一步包括根据眼睛的一温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化，以判断眼睛是否有病变的发生。其中，该差异低于一下限值，则判断眼睛应有或应无病变的发生。其中，该差异介于该下限值及一上限值之间，则判断眼睛可能有病变的发生。其中，该差异大于该上限值，则判断眼睛应有或应无病变的发生。
附图的简要说明
图1是表一中假性近视群及正常视力群的眼睛表面日间与夜间温度差异的折线图；
图2是本发明眼睛温度测量装置的示意图；
图3是图2的眼睛温度测量装置附着于眼睛表面的示意图；
图4是本发明眼睛温度的测量与分析***的示意图；
图5是本发明眼睛温度的测量与分析***的另一实施例的示意图；
图6是本发明眼睛温度的测量与分析方法的流程图；
图7是本发明眼睛温度测量装置的另一实施例的示意图；
图8是图7的眼睛温度测量装置附着于眼睛表面的示意图。
主要组件符号说明：
20   隐形眼镜
21   透明基材
22   温度感测组件
23   天线
24   信号传送组件
30   眼球
40   ***
41   移动式询答单元
42   数据接收单元
43   计算机
411  环状感应回路
50   ***
51   手机
52   桌上型计算机
61～64  步骤
70   眼睛温度测量装置
71   基材
72   温度感测组件
73   天线
74   信号传送组件
实现本发明的最佳方式
为展示的简化和清晰，附图展示了总体的构造方式，并且众所周知的特征和技术的描述和细节可以略去以避免使本发明不必要地模糊。另外，附图中的要素不必按照大小绘制。例如，附图中的一些要素的大小相对于其它要素可以被放大以帮助改善对本发明的实施方式的理解。在不同附图中的相同参考数字表示相同的要素。
说明书和权利要求中的用语“包含”、“包括”和“具有”以及其任何变化形式旨在覆盖非排他性的包括，以便包括一系列要素的程序、方法、***、对象、装置、或设备不必限制于那些要素，而是可以包括未清楚地列出或这 样的程序、方法、***、项目、装置、或设备固有的其它要素。
如前所述，眼表温度的升高或降低可用于判断眼睛是否健康、接近病变或已发生病变。尤其是睫状肌痉挛会造成近视眼，并使得眼表温度升高。下列表一显示假性近视群及正常视力群的测量眼睛表面温度的数据。
表一
Figure PCTCN2014089274-appb-000001
医学文献亦指出：当身体温度上升(发高烧)或是眼睛表面温度会因为眼睛短距离盯着某物(书本、电视、计算机及手机等)，尤其短距离及长时间注视于一目标物，会导致睫状肌长期处于高张力的状态，由于此种高张力的存在使得眼球温度随着增加。虽然白天长时间的睫状肌过度使用，但在晚上睡觉时，睫状肌会渐渐松弛，故温度应该会慢慢下降。另一方面，因为睡觉时眼睑会紧闭，故造成热量向外释放受到阻碍，亦即眼球温度仍不容易或甚至无法下降。同时，在睡觉时，因为身体的姿势改变(例如平躺)，眼球的姿势也随着改变，造成眼球的玻璃体周边的压力更为升高，高温及高压就由内部传导到眼球底部的部位。故易造成眼球在视轴方向的长度变长。因日复一日相同问题一再发生，眼球的视轴长度就不断变长，从而使得成像形成在视网膜之前，亦即就产生近视。
图1是表一中假性近视群及正常视力群的眼睛表面日间与夜间温度差异的折线图。由图可清楚得知假性近视群的眼睛表面夜间与日间温度的差异较大，亦即其眼睛表面的夜间温度明显较高。反观，正常视力群的眼睛表面夜 间与日间温度的差异较小，亦即其眼睛表面的夜间温度略高一点。因此，可以通过记录眼睛表面温度的数据，从而分析并判断眼睛是否健康、接近病变或已发生病变，故能用于预防医学及矫正监测。本发明不仅限于近视眼的判断，干眼症或其它呈现温度变化的眼睛症状亦可应用于本发明的各实施例，或因应温度变化的幅度及方向适当改变各实施例的条件。图1是两群人于日间与夜间进行眼睛表面温度的测量，本发明亦可以用于长时间测量同一人在日间与夜间的眼睛表面温度的差异平均值，或长时间测量同一人于每日相同时间点的眼睛表面温度的最大变化值或平均值，或特定时段眼睛表面温度或是特定时段平均温度的差异及变化。前述实施例并不限制本发明，长时间或短时间眼睛表面温度的差异值或平均值都可以应用于本发明。
如前所述，眼表温度的升高或降低可用于判断眼睛是否健康、接近病变或已发生病变。尤其是干眼症因眼泪分泌不足会造成使得眼表温度的明显改变。下列表二显示干眼症患者群及无干眼症者群的测量眼睛表面温度的数据。
表二
Figure PCTCN2014089274-appb-000002
To：眨眼打开眼睑立即测量眼睛表面温度。
Tc：于To测量后的第6秒(或第6秒至第10秒之间选定任一时间点)再次测量眼睛表面温度，且于该两次测量之间眼睑是持续张开。
Td：是To和Tc的差异值。
由表二所载数值可知，干眼症患者群的差异值Td明显较无干眼症者群的差异值Td低。因此可以通过此一事实作为判断干眼症发生的基础，并可列出判断准则如下：当该差异值Td小于0.2℃时，可认为眼睛应有干眼症；当该差异值Td介于0.2℃～0.4℃时，可认为眼睛可能有干眼症的发生风险；当该差异值大于0.4℃时，则可认为眼睛发生干眼症的机率低。本发明不受此实施例的限制，也可直接利用温度值To或Tc的单一数值定出另一判断准则， 或是多次温度值To或Tc所形成的曲线的变化(突增、突减、递增或递减)或斜率变化定出不同的判断准则。实际上应随不同眼睛症状而改变判断准则的内容及决定方式。
图2是本发明眼睛温度测量装置的示意图。此实施例的眼睛温度测量装置是一具有温度测量功能的隐形眼镜20，但本发明不以此为限制，可以是置于眼球表面以测量眼睛温度的任何配戴装置。该隐形眼镜20主要包含一透明基材21、一温度感测组件(或温度感测电路)22、一天线23及一信号传送组件24。透明基材21的材料可为硅水胶(silicone hydrogel，例如：HEMA)，因具有高透氧率与亲水性等优点，故能提高配载者的舒适性，并适合长时间配戴。透明基材21的材料亦可以是其它透明的高分子材料，并不受此实施例的限制。该天线23可以向外部发送无线信号，亦可以用于接受外部能量，例如：通过射频信号或其它电磁波使得天线23形成电感耦合(inductive link或inductive coupling)效应，从而产生电能供应温该度感测组件22及信号传送组件24所需的电力。另外，发出射频信号或其它电磁波的供能装置可以设置于头巾内或摆放于口袋中，或是整合至其它携带型装置(例如：手机、蓝芽耳机等)内。但本实施例不以此为限制，亦可以将一微机电(MEMS)的电池设于该透明基材21表面或内部。
由于受限于隐形眼镜20的面积，该天线23的循环数或尺寸亦相当受限制。为能补偿将该天线23的信号强度可能会不足够，可以于眼睛周围(例如眼眶)另黏贴一外部天线，故可将信号转传并加强，以利较远处的信号接收器可清楚接收到。
为了长期观察眼球在白天与/或睡眠时的温度变化，在透明基材21表面以隐形眼镜20的中心为共同中心，涂布数个能感测温度的环状线路(即温度感测组件22)，该环状线路可以是多个圆形环状线、多边形环状线或不规则环状线。该温度感测组件22可以是特殊应用IC(Application-Specific IC；ASIC)或是微机电(MEMS)组件，或以奈米、匹克(PECO)等级的化学材料、金属材料或生物材料形成的感测组件，能用来测量温度或反应温度变化。又该信号传送组件24可以将温度感测组件22所产生的电气信号(例如电压信号或电流信号)转换为射频(RF)信号，并通过天线23向外部传送无线信号。但本发明不限于将电气信号转换为射频(RF)信号，亦可以转换为蓝牙(Bluetooth)或WiFi等所规定型式的信号。类似前所述的环状线路，天线23是涂布于透明基材21表面并在该温度感测组件22***的多个环状线路，可以将符合通信协议的无线信号向外部发送。
图3是图2的眼睛温度测量装置附着于眼睛表面的示意图。如图所示，当受测者将隐形眼镜20置于眼球30表面，因该具环状线路的温度感测组件 22及天线23是设在非视觉受光区域，故不会挡住进入瞳孔的光线，不仅夜间睡眠时可以配戴，也适合在日间活动时配戴而同步测量。此种具有温度测量功能的隐形眼镜20可以于正常生活或工作中长时配戴，受测者不需要受限于温度测量工具而只能驻留于受测区域，例如：位于现有技术所使用的红外线测温计的前方，故方便于活动、睡眠或长时间的测量，从而增加判断结果的正确性。
图4是本发明眼睛温度的测量与分析***的示意图。***40包含一隐形眼镜20、一移动式询答单元(mobile interrogation unit)41、一数据接收单元42和一计算机43。该移动式询答单元41通过环状感应回路411以无线方式提供该信号传送组件24及温度感测组件22所需的电力，并从隐形眼镜20的天线23接收包括眼睛表面温度数据的无线信号，并将该无线信号进行解调变以得到该电气信号，进而将该电气信号进行模拟至数字转换以得到一相关于该电气信号的数字数据，再将该数字数据进行调变转换载于一载波上以得到一射频信号。该数据接收单元42从该移动式询答单元41以无线接收该射频信号，并将该射频信号进行解调变以得到该相关于该电气信号的数字数据。计算机43内存一数字数据与眼睛表面温度对应表，且电连接于该数据接收单元42以接收该数字数据，并据以查表以得到一眼睛表面温度，并予以显示和储存。
计算机43可以分析及所储存的眼睛表面温度数据，并判断该眼睛表面温度是否正常。例如：可利用眼睛表面夜间与日间温度的差异(参见表一)判断是否有近视或假性近视发生；当该差异值小于0.1℃时，可认为眼睛无近视的疑虑；当该差异值介于0.1℃～0.3℃时，可认为眼睛可能有近视；当该差异值大于0.3℃时，则可认为眼睛应有近视。前开判断的结果可以显示于计算机43屏幕上，或以数据接收单元42的指示灯的颜色呈现，例如：绿色代表无近视的疑虑、黄色代表可能有近视的存在及红色代表有近视的发生。本发明不受上述实施例的判断标准限制，可依照实际眼睛表面温度及不同症状而决定。
该移动式询答单元41、数据接收单元42及数据分析判断(本实施例是由计算机43负责)可以整合为一接收分析装置，该接收分析装置可以是一已安装特定软件或应用程序的计算机、平板计算机、智能型手机或智能型手表，也可将环状感应回路411与该等装置结合或内嵌入该等装置。
图5是本发明眼睛温度的测量与分析***的另一实施例的示意图。***50是使用手机51或桌上型计算机52作为接收分析装置，该接收分析装置至少包含一信号接收单元及一分析单元，该信号接收单元接受隐形眼镜20发出的无线信号，且该分析单元会根据该无线信号分析及判断该眼睛表面温度是 否正常。
图6是本发明眼睛温度的测量与分析方法的流程图。本发明提供一种眼睛温度的测量与分析方法，其包含下列步骤：如步骤61所示，通过一具有温度测量功能的隐形眼镜测量眼睛的表面温度；如步骤62所示，以无线信号传送该表面温度的数据；如步骤63所示，接受该无线信号；如步骤64所示，以及根据该无线信号分析及判断该眼睛的表面温度是否正常。
相较于图3的隐形眼镜20，图7是本发明眼睛温度测量装置的另一实施例的示意图，当此实施例的眼睛温度测量装置70被配戴于眼球表面时，并未覆盖瞳孔。另，此实施例的装置亦可应用于前述眼睛温度的测量与分析***中，亦即能接受移动式询答单元41的电力供应并传送含有眼睛表面温度数据的无线信号。该眼睛温度测量装置70主要包含一基材71、一温度感测组件(或温度感测电路)72、一天线73及一信号传送组件74。本实施例的基材71的材料可为硅水胶(silicone hydrogel)聚酯(polyester)或聚丙烯酰胺，可让光线全穿透、半穿透或完全不穿透的材料均适合。基材71亦可以是其它高分子材料制成，软质或硬质材料(例如：聚硅氧聚合物、聚甲基丙烯酸甲酯，需配合眼球弧度成型)均可，然并不受此实施例的限制。该天线73可以向外部发送无线信号，亦可以用于接受外部能量，例如：通过射频信号或其它电磁波使得天线73形成电感耦合(inductive link或inductive coupling)效应，从而产生电能供应温度感测组件72及信号传送组件74所需的电力。另外，可于基材71表面设置一微型电池，其所产生电能可直接供应温该度感测组件72及信号传送组件74所需的电力。
由于眼睛温度测量装置70是置于眼睑内(参见图8)，因此其面积可能会受到限制，从而该天线73的循环数或尺寸亦受限。为能补偿将该天线73的信号强度可能会不足够，可以于眼睛周围(例如眼眶)另黏贴一外部天线，故可将信号转传并加强，以利较远处的信号接收器可清楚接收到。
为了长期观察眼球在白天与/或睡眠时的温度变化，在基材71表面涂布数个能感测温度的环状线路(即温度感测组件72)，该环状线路可以是多个圆形环状线、多边形环状线或不规则环状线。该温度感测组件72可以是特殊应用IC(Application-Specific IC；ASIC)或是微机电(MEMS)组件，或以奈米、匹克(PECO)等级的化学材料、金属材料或生物材料形成的感测组件，能用来测量温度或反应温度变化。又该信号传送组件74可以将温度感测组件72所产生的电气信号(例如电压信号或电流信号)转换为射频(RF)信号，并通过天线73向外部传送无线信号。但本发明不限于将电气信号转换为射频(RF)信号，亦可以转换为蓝牙(Bluetooth)或WiFi等所规定型式的信号。类似前所述的环状线路，天线73是涂布于基材71表面并在该温度感 测组件72***的多个环状线路，可以将符合通信协议的无线信号向外部发送。
图8是本发明眼睛温度测量装置附着于眼睛表面的示意图。如图所示，当受测者将眼睛温度测量装置70置于眼球30表面及眼睑(下眼睑或上眼睑)内侧，因位于非视觉受光区域故基材71可选用不透明材料，亦即不需考虑是否会挡住进入瞳孔的光线，不仅夜间睡眠时可以配戴，也适合在日间活动时配戴而同步测量。基材71的形状可以如图所示的半月型或长方形，以利置于眼睑内侧。
本发明的技术内容及技术特点已公开如上，然而熟悉本项技术的人士仍可能基于本发明的教示及公开而作种种不背离本发明精神的替换及修饰。因此，本发明的保护范围应不限于实施例所揭示者，而应包括各种不背离本发明的替换及修饰，并为权利要求所涵盖。
工业应用性
本发明的眼睛温度的测量与分析***、接收分析装置及其方法，利用眼睛的表面温度是反应眼球的各部肌肉或各层组织的状态，使其作为代表眼睛健康或病变的一种重要指标，通过记录眼睛表面温度的数据，从而分析并判断眼睛是否健康、接近病变或已发生病变，故能用于预防医学及矫正监测。

Claims (37)

  1. 一种眼睛温度的测量与分析***，其特征在于，包含：
    一眼睛温度测量装置，是置于眼球表面，包括：
    一温度感测组件，根据眼睛表面温度产生电气信号；及
    一信号传送组件，将该电气信号转换为无线信号；以及
    一接收分析装置，包括：
    一信号接收单元，接受该无线信号；及
    一分析单元，根据该无线信号分析及判断该眼睛是否正常。
  2. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该眼睛温度测量装置另包含一天线，该天线向外部传送该无线信号。
  3. 如权利要求2所述的眼睛温度的测量与分析***，其特征在于，该天线通过外部的电磁波形成电感耦合而产生电力，以供应该温度感测组件及该信号传送组件。
  4. 如权利要求2所述的眼睛温度的测量与分析***，其特征在于，其另包含一外部天线，该外部天线会转传该无线信号。
  5. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该无线信号是符合射频、蓝牙或WiFi所规定的信号。
  6. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该分析单元是根据该眼睛表面的一温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化以判断眼睛是否有病变的发生。
  7. 如权利要求6所述的眼睛温度的测量与分析***，其特征在于，当该眼睛的表面温度的夜间温度与日间温度的差异低于一下限值，则判断眼睛无近视或假性近视的发生。
  8. 如权利要求7所述的眼睛温度的测量与分析***，其特征在于， 该差异介于该下限值及一上限值之间，则判断眼睛可能有近视或假性近视的发生。
  9. 如权利要求8所述的眼睛温度的测量与分析***，其特征在于，该差异大于该上限值，则判断眼睛有近视或假性近视的发生。
  10. 如权利要求6所述的眼睛温度的测量与分析***，其特征在于，当该眼睛的两时间点间测量的温度值差异低于一下限值，则判断眼睛应有干眼症的发生。
  11. 如权利要求10所述的眼睛温度的测量与分析***，其特征在于，该两时间点测量的温度值是在眨眼打开眼睑立即测量眼睛表面温度及该次测量后的第6至10秒之间再次测量眼睛表面温度，且于该两次测量之间该眼睑是持续张开。
  12. 如权利要求11所述的眼睛温度的测量与分析***，其特征在于，当该眼睛的两时间点间测量的温度值差异介于0.2℃至0.4℃之间时，则判断眼睛可能有干眼症的发生。
  13. 如权利要求12所述的眼睛温度的测量与分析***，其特征在于，当该眼睛的两时间点间测量的温度值差异大于0.4℃时，则判断眼睛发生干眼症的机率低。
  14. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该接收分析装置是一已安装特定软件或应用程序的计算机、一平板计算机、一智能型手机或一智能型手表。
  15. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该信号接收单元包括:
    一移动式询答单元，提供该信号传送组件及该温度感测组件所需的电力，并接收该无线信号以产生射频信号；以及
    一数据接收单元，接受该射频信号以转换为具有眼睛表面温度的数 据。
  16. 如权利要求15所述的眼睛温度的测量与分析***，其特征在于，该分析单元是一计算机。
  17. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该温度感测组件是设于该眼睛温度测量装置的表面上的多个环状线路、特殊应用IC或微机电组件。
  18. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该眼睛温度测量装置是一具有温度测量功能的隐形眼镜。
  19. 如权利要求1所述的眼睛温度的测量与分析***，其特征在于，该眼睛温度测量装置是置于眼球表面及眼睑内侧以测量眼睛的温度，且其尺寸未覆盖瞳孔。
  20. 一种眼睛温度的接收分析装置，其特征在于，包含：
    一信号接收单元，接受一无线信号，其中该无线信号是包括眼睛表面温度的数据；以及
    一分析单元，根据该无线信号分析及判断该眼睛是否正常。
  21. 如权利要求20所述的眼睛温度的接收分析装置，其特征在于，该分析单元是根据眼睛表面的温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化以判断眼睛是否有病变的发生。
  22. 如权利要求21所述的眼睛温度的接收分析装置，其特征在于，当该眼睛的表面温度的夜间温度与日间温度的差异低于一下限值，则判断眼睛无近视或假性近视的发生。
  23. 如权利要求22所述的眼睛温度的接收分析装置，其特征在于，该差异介于该下限值及一上限值之间，则判断眼睛可能有近视或假性近视的发生。
  24. 如权利要求23所述的眼睛温度的接收分析装置，其特征在于， 该差异大于该上限值，则判断眼睛有近视或假性近视的发生。
  25. 如权利要求21所述的眼睛温度的接收分析装置，其特征在于，当该眼睛的两时间点间测量的温度值差异低于一下限值，则判断眼睛应有干眼症的发生。
  26. 如权利要求25所述的眼睛温度的接收分析装置，其特征在于，该两时间点测量的温度值是于眨眼打开眼睑立即测量眼睛表面温度及该次测量后的第6至10秒之间再次测量眼睛表面温度，且于该两次测量之间该眼睑是持续张开。
  27. 如权利要求26所述的眼睛温度的接收分析装置，其特征在于，当该眼睛的两时间点间测量的温度值差异介于0.2℃至0.4℃之间时，则判断眼睛可能有干眼症的发生。
  28. 如权利要求27所述的眼睛温度的接收分析装置，其特征在于，当该眼睛的两时间点间测量的温度值差异大于0.4℃时，则判断眼睛发生干眼症的机率低。
  29. 如权利要求20所述的眼睛温度的接收分析装置，其特征在于，该信号接收单元包括:
    一移动式询答单元，接收该无线信号以产生射频信号；以及
    一数据接收单元，接受该射频信号以转换为具有眼睛表面温度的数据。
  30. 如权利要求29所述的眼睛温度的接收分析装置，其特征在于，该分析单元是一计算机。
  31. 如权利要求20所述的眼睛温度的接收分析装置，其特征在于，该接收分析装置是一已安装特定软件或应用程序的计算机、一平板计算机、一智能型手机或一智能型手表。
  32. 一种眼睛温度的测量与分析方法，其特征在于，包含下列步骤：
    通过一置于眼球表面的眼睛温度测量装置测量眼睛的表面温度；
    以无线信号传送该表面温度的数据；
    接受该无线信号；以及
    根据该无线信号分析及判断该眼睛是否正常。
  33. 如权利要求32所述的眼睛温度的测量与分析方法，其特征在于，该无线信号是符合射频、蓝牙或WiFi所规定的信号。
  34. 如权利要求32所述的眼睛温度的测量与分析方法，其特征在于，该分析及判断的步骤近一步包括根据眼睛的一温度值、于两时间点的温度值间差异或于连续多个时间点的温度值的平均值或其变化，以判断眼睛是否有病变的发生。
  35. 如权利要求34所述的眼睛温度的测量与分析方法，其特征在于，该差异低于一下限值，则判断眼睛应有或应无病变的发生。
  36. 如权利要求35所述的眼睛温度的测量与分析方法，其特征在于，该差异介于该下限值及一上限值之间，则判断眼睛可能有病变的发生。
  37. 如权利要求36所述的眼睛温度的测量与分析方法，其特征在于，该差异大于该上限值，则判断眼睛应有或应无病变的发生。
PCT/CN2014/089274 2013-11-15 2014-10-23 眼睛温度的测量与分析***、接收分析装置及其方法 WO2015070693A1 (zh)

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