WO2015070568A1 - 一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物及其应用 - Google Patents
一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物及其应用 Download PDFInfo
- Publication number
- WO2015070568A1 WO2015070568A1 PCT/CN2014/076332 CN2014076332W WO2015070568A1 WO 2015070568 A1 WO2015070568 A1 WO 2015070568A1 CN 2014076332 W CN2014076332 W CN 2014076332W WO 2015070568 A1 WO2015070568 A1 WO 2015070568A1
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- WIPO (PCT)
- Prior art keywords
- prothioconazole
- disease
- fluboscalid
- composition containing
- bactericidal composition
- Prior art date
Links
- 239000005825 Prothioconazole Substances 0.000 title claims abstract description 66
- MNHVNIJQQRJYDH-UHFFFAOYSA-N 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione Chemical compound N1=CNC(=S)N1CC(C1(Cl)CC1)(O)CC1=CC=CC=C1Cl MNHVNIJQQRJYDH-UHFFFAOYSA-N 0.000 title claims abstract description 65
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 239000005782 Fluopicolide Substances 0.000 title abstract description 6
- GBOYJIHYACSLGN-UHFFFAOYSA-N fluopicolide Chemical compound ClC1=CC(C(F)(F)F)=CN=C1CNC(=O)C1=C(Cl)C=CC=C1Cl GBOYJIHYACSLGN-UHFFFAOYSA-N 0.000 title abstract description 6
- 230000001954 sterilising effect Effects 0.000 title abstract 5
- 238000004659 sterilization and disinfection Methods 0.000 title abstract 5
- 241000221785 Erysiphales Species 0.000 claims abstract description 7
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 7
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000009566 rice Nutrition 0.000 claims abstract description 7
- 206010027146 Melanoderma Diseases 0.000 claims abstract description 6
- 208000031888 Mycoses Diseases 0.000 claims abstract description 5
- 241000233647 Phytophthora nicotianae var. parasitica Species 0.000 claims abstract description 4
- 230000002265 prevention Effects 0.000 claims abstract description 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000004495 emulsifiable concentrate Substances 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 241000221662 Sclerotinia Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000000839 emulsion Substances 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 claims description 5
- 239000000575 pesticide Substances 0.000 claims description 4
- 239000004562 water dispersible granule Substances 0.000 claims description 4
- 241000196324 Embryophyta Species 0.000 claims description 3
- 239000000375 suspending agent Substances 0.000 claims description 3
- PZBPHYLKIMOZPR-FIYGWYQWSA-K 2-[4-[2-[[(2r)-1-[[(4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-4-[[(2r,3r)-1,3-dihydroxybutan-2-yl]carbamoyl]-7-[(1r)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-19-yl] Chemical compound [68Ga+3].C([C@H](C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)NC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1)C1=CC=CC=C1 PZBPHYLKIMOZPR-FIYGWYQWSA-K 0.000 claims description 2
- 230000000855 fungicidal effect Effects 0.000 claims description 2
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 claims 1
- 241000223218 Fusarium Species 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 29
- 201000010099 disease Diseases 0.000 abstract description 28
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- 206010059866 Drug resistance Diseases 0.000 abstract description 2
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- 230000001934 delay Effects 0.000 abstract 1
- 230000002085 persistent effect Effects 0.000 abstract 1
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- 229940051841 polyoxyethylene ether Drugs 0.000 description 14
- 239000004480 active ingredient Substances 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- 239000002994 raw material Substances 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- 239000003921 oil Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 230000001018 virulence Effects 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- IEORSVTYLWZQJQ-UHFFFAOYSA-N 2-(2-nonylphenoxy)ethanol Chemical compound CCCCCCCCCC1=CC=CC=C1OCCO IEORSVTYLWZQJQ-UHFFFAOYSA-N 0.000 description 5
- 241000209094 Oryza Species 0.000 description 5
- 229910019142 PO4 Inorganic materials 0.000 description 5
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 5
- 229920000847 nonoxynol Polymers 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000010452 phosphate Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 241000209140 Triticum Species 0.000 description 3
- 235000021307 Triticum Nutrition 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- -1 fatty acid ethylene oxide Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- XZTJQQLJJCXOLP-UHFFFAOYSA-M sodium;decyl sulfate Chemical compound [Na+].CCCCCCCCCCOS([O-])(=O)=O XZTJQQLJJCXOLP-UHFFFAOYSA-M 0.000 description 3
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- 230000017858 demethylation Effects 0.000 description 2
- 238000010520 demethylation reaction Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229920005552 sodium lignosulfonate Polymers 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000005780 Fluazinam Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 241001329956 Nothopassalora personata Species 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 241000233679 Peronosporaceae Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000010627 Phaseolus vulgaris Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000221696 Sclerotinia sclerotiorum Species 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- HCWYXKWQOMTBKY-UHFFFAOYSA-N calcium;dodecyl benzenesulfonate Chemical compound [Ca].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 HCWYXKWQOMTBKY-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 230000008029 eradication Effects 0.000 description 1
- UZCGKGPEKUCDTF-UHFFFAOYSA-N fluazinam Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=C(Cl)C([N+]([O-])=O)=C1NC1=NC=C(C(F)(F)F)C=C1Cl UZCGKGPEKUCDTF-UHFFFAOYSA-N 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 230000028644 hyphal growth Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 1
- 244000000003 plant pathogen Species 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- QPDUQKTYZRXRBC-UHFFFAOYSA-N triazole-4-thione Chemical compound S=C1C=NN=N1 QPDUQKTYZRXRBC-UHFFFAOYSA-N 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Definitions
- the present invention relates to a bactericidal composition and its use, and more particularly to a bactericidal composition comprising prothioconazole and fluazimid as main active ingredients and uses thereof.
- prothioconazole The mechanism of action of prothioconazole is to inhibit the demethylation of the precursor of alcohol in the fungus, l-lanol or 24-methylene dihydrogen, at the 14 position, ie demethylation inhibitors (DMIs) . It not only has good systemic activity, excellent protection, treatment and eradication activity, but also has a long-lasting effect. Through a large number of field efficacy tests, the results show that prothioconazole not only has good safety to crops, but also has good anti-disease and curative effect, and has obvious yield increase. Compared with triazole-based fungicides, prothioconazole has more A broad spectrum of bactericidal activity.
- Fluopicolide molecular formula: C 14 3 ⁇ 4C1 3 F 3 N 2 0 .
- Fluazimidamide is a novel pyridinamide fungicide developed by Bayer with a unique mechanism of action. It is mainly used for the control of oomycete diseases such as downy mildew and epidemic diseases. In addition, it has certain control effects against rice blast, gray mold and powdery mildew, and has no cross-resistance with other compounds.
- An object of the present invention is to provide a bactericidal composition containing thiothiazol and fluazimid which is widely applicable, low in cost and effective in the above technical problems.
- Still another object of the present invention is to provide the bactericidal composition as a preparation for controlling fungal diseases caused by plant fungi, especially as a preparation for controlling powdery mildew, sheath blight, blight, leaf spot, rust, sclerotinia, net Application of spot disease, moiré, gray mold, black spot, brown spot, black shank, rice blast and disease drugs.
- the object of the invention is achieved by the following measures:
- a bactericidal composition containing prothioconazole and fluaziram wherein the weight ratio of prothioconazole to flufenamide is from 1 to 70: 1-50, preferably from 1 to 35: 1- 25, further preferably 1 to 10: 1-20, and most preferably 1: 2 to 6.
- both the prothioconazole and the fluazimid are 2 to 80% by weight, preferably 10 to 40% by weight of the composition.
- the bactericidal composition wherein prothioconazole and fluazimid are compounded with known auxiliaries and excipients into a pesticide-acceptable dosage form.
- auxiliaries include dispersing agents, diffusing agents, defoaming agents, wetting agents, disintegrating agents, etc., and calcium dodecyl benzene sulfonate, nonyl phenol ethoxylate, benzyl phenol polyoxygen can be used.
- the above auxiliaries, excipients and other excipients may be used singly or in combination.
- the bactericidal composition is in the form of an emulsifiable concentrate, a wettable powder, a suspending agent, a water emulsion, a microemulsion or a moisture granule.
- the bactericidal composition containing prothioconazole and flufenidamide is useful as a medicament for preparing a fungal disease-resistant fungus.
- the composition is resistant to fungal diseases such as powdery mildew, sheath blight, blight, leaf spot, rust, sclerotinia, net Spot disease, moiré, gray mold, black spot, brown spot, black shank, rice blast and disease have obvious synergistic effects, overcome and delay drug resistance, expand the spectrum of prevention, and significantly improve the control effect
- fungal diseases such as powdery mildew, sheath blight, blight, leaf spot, rust, sclerotinia, net Spot disease, moiré, gray mold, black spot, brown spot, black shank, rice blast and disease
- Reducing the cost of labor and medication (3) Replacing conventional and susceptible pesticides; (4) Lowering the cost of production and use compared with single agents; (5) Inhibiting the development of fungal resistance, The effect is significantly higher than its single dose use.
- the two active compounds can be processed into any of the acceptable dosage forms, and the preparation of the two active ingredients is described below in the specific examples, but the preparations in which the two active ingredients can be processed are not limited to the following.
- prothioconazole 10 g of fluazimid, 2 g of detergent LS (sodium p-methoxy fatty acid amino sulfonate), 4 g of diffusing agent NNO (sodium methylene bis naphthalene sulfonate), white charcoal Black 5 g, kaolin added to 100 g of the mixture was subjected to jet milling to obtain a 15% by weight wettable powder.
- detergent LS sodium p-methoxy fatty acid amino sulfonate
- diffusing agent NNO sodium methylene bis naphthalene sulfonate
- white charcoal Black 5 g, kaolin added to 100 g of the mixture was subjected to jet milling to obtain a 15% by weight wettable powder.
- prothioconazole 50 g of flufenidamide, phenethyl phenol polyoxyethylene ether phosphate 3 g, agricultural milk 33 # 2 g, nonylphenol ethoxylate lg, solvent oil 13 g, and water were added to 100 g.
- the above raw materials are conventionally formulated into an aqueous emulsion, and are mixed into a mixing kettle at a high speed to prepare a 55% prothioconazole monofluridamide aqueous emulsion.
- Phosphate 3 g agricultural milk 33 # 2 g, alkylphenol ethoxylate lg, isopropanol 10 g, and water was added to 100 g.
- the above raw materials are put into a mixing kettle by conventionally preparing a microemulsion to prepare a microemulsion having an active ingredient weight percentage of 32% prothioconazole monofluridazole.
- prothioconazole 5 g of fluazimid, 3 g of phenethyl phenol polyoxyethylene ether phosphate, agricultural milk 33 # 2 g, nonylphenol ethoxylate lg, solvent oil 13 g, and water was added to 100 g.
- the above raw materials are prepared by conventionally preparing an aqueous emulsion into a mixing kettle at a high speed to prepare a 6% prothioconazole monofluridamide aqueous emulsion.
- prothioconazole 50 g of prothioconazole, 20 g of flufenidamide, 5 g of dodecylbenzenesulfonate, 2 g of phenethylphenol polyoxyethylene ether, 2 g of castor oil polyoxyethylene ether, and solvent oil were added to 100 g.
- the above raw materials are mixed into a mixing kettle according to a conventional method for preparing an emulsifiable concentrate, and the active ingredient is 70% by weight of prothioconazole monofluridazole emulsifiable concentrate.
- prothioconazole 20g of flufenidamide, 6g of calcium dodecylbenzenesulfonate, 3g of phenethylphenol polyoxyethylene ether phosphate, 33g of agricultural milk, 2g, nonylphenol ethoxylate Lg, 10 g of isopropanol, add water to 100 g.
- the above raw materials are put into a mixing kettle by conventionally preparing a microemulsion to prepare a microemulsion having an active ingredient weight percentage of 25% prothioconazole monofluridazole.
- prothioconazole 5 g of prothioconazole, 0.5 g of fluazimid, 6 g of calcium dodecylbenzenesulfonate, 7 g of phenethylphenol polyoxyethylene ether, and a solvent oil of 100 g were weighed.
- the above raw materials are put into a mixing kettle by conventionally preparing an emulsifiable concentrate, and are prepared into an effective component weight percentage of 5.5% prothioconazole monofluridazole emulsifiable concentrate.
- prothioconazole 5 g of prothioconazole, 30 g of fluazimid, 4 g of calcium dodecylbenzenesulfonate, 4 g of phenethylphenol polyoxyethylene ether, and solvent oil were added to 100 g.
- the above raw materials are put into a mixing kettle by conventionally preparing an emulsifiable concentrate, and are prepared into an effective component weight percentage of 35% prothioconazole monofluridazole emulsifiable concentrate.
- prothioconazole 12g of flufenamide, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether, 0.15g of xanthan gum, 5g of ethylene glycol, 0.10g of ethoxylated silicate, magnesium aluminum silicate 0.5 g, made up to 100 g with water, and made into a 42% prothioconazole monofluridamide suspension with an active ingredient weight by the action of a sand mill.
- prothioconazole 5g of flufenamide, 8g of sodium lignosulfonate, 2g of sodium decyl sulfate, 5g of ammonium sulfate, 5g of polyvinyl alcohol, 2g of borax, 3g of white carbon, diatomaceous earth
- the above raw materials were prepared as water-dispersible granules to prepare a 7% by weight of prothioconazole monofluridamide aqueous dispersion granules.
- prothioconazole 13g of flufenamide, 8g of sodium lignosulfonate, 2g of sodium decyl sulfate, 5g of ammonium sulfate, 5g of polyvinyl alcohol, 2g of borax, and 28g of diatomaceous earth to make up 100g.
- the above raw materials are prepared as water-dispersible granules in an amount of 17% by weight of prothioconazole monofluridamide water-dispersible granules.
- prothioconazole 15g of flufenamide, 2g of lignin, 4g of polyoxyethylene polyoxypropylene ether, 0.15g of xanthan gum, 5g of ethylene glycol, 0.10g of siloxane, magnesium aluminum silicate 0.5 g, made up to 100 g with water, and made into a 20% prothioconazole monofluridamide suspending agent with an active ingredient weight by the action of a sand mill.
- the hyphal growth rate method was used indoors to determine the EC 5Q value of the strains of different pesticides.
- the co-toxicity coefficient calculation method was used to calculate the co-toxicity coefficient (CTC) of the mixture, and the synergistic effect of the mixture was determined.
- the specific calculation method is as follows: :
- Single dose virulence index standard pharmaceutical EC 5Q / a single dose EC 5Q X 100
- Theoretical virulence index virulence index of eight single agents X A ratio of single agent in the mixture + virulence index of B single agent X B proportion of single agent in the mixture
- Measured virulence index EC 5 o value of standard single dose / 5 of mixture. 5 . Value 100
- Co-toxicity coefficient measured virulence index / theoretical virulence index X 100
- Co-toxicity classification When CTC is greater than 120, the mixture has synergistic effect. When CTC is less than 80, it is antagonistic, and CTC is additive between 80 and 120. Instruction manual
- Table 1 Indoor bioassay results for different ratios of prothioconazole + fluazinam to Cercospora personata
- the co-toxicity coefficients of the compositions of the present invention are all greater than 120, that is, the compositions of the present invention have better synergistic effects, and the effects are better than single-agent varieties.
- Test treatment In this test, three dosages are respectively set according to the respective components, and the dosage is the mass of the effective component prothioconazole (A) and the active ingredient fluazimid (B).
- the control agents were a single pesticide 25% flufenamide ME and 5% prothioconazole ME and a blank water test.
- Test method The area of each plot is 66.7m 2 , repeated 3 times; the pre-application investigation and the post-treatment investigation efficacy method are as follows: randomly sample 5 points in the test treatment area, according to the national field test related standards for the disease Grading, calculate the effect. The test results are shown in the table below -
- the composition of the present invention has an obvious synergistic effect, the composition has excellent control effect, and the control effect is better than that of a single dose, and has application value in agricultural applications.
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Abstract
本发明公开了一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物及其应用。该杀菌组合物以丙硫菌唑和氟啶酰菌胺为主要有效成分。该杀菌组合物可应用于防治禾谷类、果树、蔬菜病害,具有较高的协同增效作用,克服和延缓了病菌的抗药性,杀菌速度快、持效期长、降低了应用成本,防治效果明显优于其单剂使用。本发明可以用于防治农作物上的真菌性病害,尤其可以用于防治白粉病、纹枯病、枯萎病、叶斑病、锈病、菌核病、网斑病、云纹病、灰霉病、黑斑病、褐斑病、黑胫病、稻瘟病和疫病,效果好于单剂使用。
Description
一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物及其应用
技术领域:
本发明涉及一种杀菌组合物及其应用,尤其是一种以丙硫菌唑和氟啶酰菌胺为主要 活性成分的杀菌组合物及其应用。
背景技术- 丙硫菌唑(Prothioconazole), 是由拜耳公司研制的新型广谱***硫酮类杀菌剂, 化 学名称: 2-(2-(1-氯环丙基) -3-(2-氯苯基 )-2-羟丙基 -1-2-二氢 -3-1,2,4-*** -3-硫代,分子式: C14H15C12N30S。 结构式如下: 说
书
丙硫菌唑的作用机理是抑制真菌中 醇的前体一一羊毛 醇或 24-亚甲基二 氢举毛醉14 位上的脱甲基化作用, 即脱甲基化抑制剂 (DMIs )。不仅具有很好的 内吸活性, 优异的保护、 治疗和铲除活性, 且持效期长。 通过大量的田间药效试 验, 结果表明丙硫菌唑对作物不仅具有良好的安全性, 防病治病效果好, 而且增 产明显, 同***类杀茵剂相比, 丙硫菌唑具有更广谱的杀菌活性。 主要用于防治 禾谷类作物如小麦、 大麦、 油菜、 花生、 水稻和豆类作物等众多病害。 几乎对所 有麦类病害都有很好的防治效果, 如小麦和大麦的白粉病、 纹枯病、 枯萎病、 叶 斑病、 锈病、 菌核病、 网斑病、 云纹病等。 还能防治油莱和花生的土传病害, 如 菌核病, 以及主要叶面病害, 如灰霉病、 黑斑病、 褐斑病、 黑胫病、 菌核病和锈 病等。
氟啶酰菌胺是由拜耳公司开发的具有独特作用机理的新型吡啶酰胺类杀菌剂。 主 要用于防治卵菌纲病害如霜霉病、 疫病等, 除此之外还对稻瘟病、 灰霉病、 白粉病等有 一定的防效, 与其他类化合物无交互抗性。
说 明 书
目前植物病菌的防治难度越来越大, 一方面, 随着种植结构的改变, 瓜果、 蔬菜等 经济作物种植面积逐步扩大,病害发生程度、发生数量均有所提高,在防治上难度加大; 另一方面,病原菌的抗性在持续的药剂选择压力下逐年上升,单剂的防治效果大打折扣, 植物病害防治面临着重大挑战。
发明内容:
本发明的目的是针对上述技术问题提供一种适用范围广、成本低、效果好的含丙硫 菌唑与氟啶酰菌胺的植物杀菌组合物。
本发明还有一个目的是提供该杀菌组合物作为制备防治植物真菌引起真菌病害药 物的应用, 尤其是作为制备防治白粉病、 纹枯病、 枯萎病、 叶斑病、 锈病、 菌核病、 网斑病、 云纹病、 灰霉病、 黑斑病、 褐斑病、 黑胫病、 稻瘟病和疫病药物的应用。
本发明的目的是通过下列措施来实现的:
一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物,所述的丙硫菌唑与氟啶酰菌胺重量比 为 1~70: 1-50, 优选为 1~35: 1-25, 进一步优选为 1~10: 1-20, 最优选为 1 : 2~6。
在本发明组合物中, 丙硫菌唑和氟啶酰菌胺二者占组合物的重量百分比为 2~80%, 优选 10-40%
所述的杀菌组合物,其中丙硫菌唑和氟啶酰菌胺与已知的助剂和赋形剂复配成农药 上允许的剂型。 这些已知的助剂有分散剂、 扩散剂、 消泡剂、 润湿剂、 崩解剂等, 可以 采用十二垸基苯磺酸钙、垸基酚聚氧乙烯醚、苄基酚聚氧乙烯醚、苯乙基酚聚氧乙烯醚、 脂肪醇聚氧乙烯醚及其类似产品、 脂肪胺聚氧乙烯醚、 脂肪酸环氧乙烷加成物、 聚氧乙 烯聚氧丙稀嵌段化合物、 蓖麻油聚氧乙烯醚、 壬基酚聚氧乙烯醚、 吐温系列、 脂肪醇聚 氧乙烯醚、 聚乙二醇系列、 磺酸盐类、 羧酸盐、 硫酸盐、 磷酸盐、 亚磷酸盐、 木质素磺 酸盐、 黄原胶、 酚甲醛缩合物、 铵盐、 季铵盐型等中的一种或多种混合, 赋形剂包括环 己酮、 二甲苯、 各种溶剂油、 水、 防冻剂 (如丙二醇)、 去离子水等。 以上助剂、 赋形 剂及其它辅料可以单用或并用。
所述的杀菌组合物, 其剂型是乳油、 可湿性粉剂、 悬浮剂、 水乳剂、 微乳剂或水分 散颗粒剂。
所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物作为制备具有防治抗性植物真菌病 害药物的应用。
所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物作为制备防治白粉病、 纹枯病、 枯 萎病、 叶斑病、 锈病、 菌核病、 网斑病、 云纹病、 灰霉病、 黑斑病、 褐斑病、 黑
说 明 书
胫病、 稻瘟病和疫病药物的应用。
本发明的有益效果:
与现有技术相比本发明的有益效果: (1 )与单剂相比, 该组合物对抗性真菌病害如 白粉病、 纹枯病、 枯萎病、 叶斑病、 锈病、 菌核病、 网斑病、 云纹病、 灰霉病、 黑斑病、褐斑病、黑胫病、稻瘟病和疫病有明显协同增效作用, 克服和延缓了抗药性, 扩大防治谱, 明显提高了防治效果; (2)减少防治用工、 用药成本; (3 )可替代常规和 易产生抗性的农药; (4)与单剂相比, 生产和使用成本降低; (5 )抑制真菌抗药性的产 生, 其效果明显高于其单剂使用。
具体实施方式:
以下结合实施例对本发明作进一步说明, 实施例中剂型的制备方法均为常规方法, 本发明所述的 "% "均为质量百分比。
两种活性化合物可以加工成允许的任意一种剂型,下面以具体的实施例说明两种有 效成分加工成的制剂, 但是该两种活性成分可以加工的制剂不仅限于以下所列。
实施例 1 :
将丙硫菌唑 5g、 氟啶酰菌胺 10g、 净洗剂 LS (对甲氧基脂肪酸胺基苯磺酸钠) 2g、 扩散剂 NNO (亚甲基双萘磺酸钠) 4g、 白炭黑 5g, 高岭土加至 100g混合物进行气流粉 碎, 制得有效成分重量百分含量为 15%可湿性粉剂。
实施例 2:
将丙硫菌唑 3g、氟啶酰菌胺 12g、十二垸基硫酸钠 3g、扩散剂 NNO 4g、 白炭黑 5g, 高岭土加至 100g混合物进行气流粉碎,制得有效成分重量百分含量为 15%可湿性粉剂。 实施例 3:
将丙硫菌唑 2g、氟啶酰菌胺 12g、十二烷基硫酸钠 3g、扩散剂 NNO 4g、 白炭黑 5g, 高岭土加至 100g混合物进行气流粉碎,制得有效成分重量百分含量为 14%可湿性粉剂。 实施例 4:
称取 5g丙硫菌唑、 50g氟啶酰菌胺、苯乙基酚聚氧乙烯醚磷酸酯 3g、农乳 33 # 2g、 垸基酚聚氧乙烯醚 lg,溶剂油 13g, 加水至 100g。将以上原料按常规配制水乳剂的方法 投入混合釜中高速混合,制成有效成分重量百分含量为 55 %丙硫菌唑一氟啶酰菌胺水乳 剂。
实施例 5:
称取 2g丙硫菌唑、 30g氟啶酰菌胺、 十二垸基苯磺酸钙 6g、 苯乙基酚聚氧乙烯醚
说 明 书
磷酸酯 3g、农乳 33 # 2g、烷基酚聚氧乙烯醚 lg, 异丙醇 10g, 加水至 100g。将以上原 料按常规配制微乳剂的方法投入混合釜中混合,制成有效成分重量百分含量为 32%丙硫 菌唑一氟啶酰菌胺微乳剂。
实施例 6:
称取 lg丙硫菌唑、 5g氟啶酰菌胺、 苯乙基酚聚氧乙烯醚磷酸酯 3g、农乳 33 # 2g、 垸基酚聚氧乙烯醚 lg,溶剂油 13g, 加水至 100g。将以上原料按常规配制水乳剂的方法 投入混合釜中高速混合, 制成有效成分重量百分含量为 6%丙硫菌唑一氟啶酰菌胺水乳 剂。
实施例 7:
称取 50g丙硫菌唑、 20g氟啶酰菌胺, 十二烷基苯磺酸麪 5g、 苯乙基酚聚氧乙烯醚 2g、 蓖麻油聚氧乙烯醚 2g、 溶剂油至 100g。 将以上原料按常规配制乳油的方法投入混 合釜中混合, 制成有效成分重量百分含量为 70%丙硫菌唑一氟啶酰菌胺乳油。
实施例 8:
称取 2g丙硫菌唑、 40g氟啶酰菌胺, 十二烷基苯磺酸钙 8g、 苯乙基酚聚氧乙烯醚 5g、溶剂油至 100g。将以上原料按常规配制乳油的方法投入混合釜中混合, 制成有效成 分重量百分含量为 42%丙硫菌唑一氟啶酰菌胺乳油。
实施例 9:
称取 5g丙硫菌唑、 20g氟啶酰菌胺、 十二垸基苯磺酸钙 6g、 苯乙基酚聚氧乙烯醚 磷酸酯 3g、农乳 33 # 2g、垸基酚聚氧乙烯醚 lg, 异丙醇 10g, 加水至 100g。将以上原 料按常规配制微乳剂的方法投入混合釜中混合,制成有效成分重量百分含量为 25 %丙硫 菌唑一氟啶酰菌胺微乳剂。
实施例 10:
称取 5g丙硫菌唑、 0.5g氟啶酰菌胺, 十二垸基苯磺酸钙 6g、 苯乙基酚聚氧乙烯醚 7g、溶剂油至 100g。将以上原料按常规配制乳油的方法投入混合釜中混合, 制成有效成 分重量百分含量为 5.5 %丙硫菌唑一氟啶酰菌胺乳油。
实施例 11 :
称取 5g丙硫菌唑、 30g氟啶酰菌胺, 十二烷基苯磺酸钙 4g、 苯乙基酚聚氧乙烯醚 4g、溶剂油至 100g。将以上原料按常规配制乳油的方法投入混合釜中混合, 制成有效成 分重量百分含量为 35 %丙硫菌唑一氟啶酰菌胺乳油。
实施例 12:
说 明 书
称取 10g丙硫菌唑、 10g氟啶酰菌胺, 木质素 2g, 聚氧乙烯聚氧丙烯醚 4g, 黄原胶
0.15g, 乙二醇 5g, 硅氧乙垸 0.10g, 硅酸镁铝 0.5g, 用水补足至 100g, 在砂磨机的作用 下制成有效成分重量百分含量为 20%丙硫菌唑一氟啶酰菌胺悬浮剂。
实施例 13 :
称取 30g丙硫菌唑、 12g氟啶酰菌胺, 木质素 2g, 聚氧乙烯聚氧丙烯醚 4g, 黄原胶 0.15g, 乙二醇 5g, 硅氧乙垸 0.10g, 硅酸镁铝 0.5g, 用水补足至 100g, 在砂磨机的作用 下制成有效成分重量百分含量为 42%丙硫菌唑一氟啶酰菌胺悬浮剂。
实施例 14:
称取 2g丙硫菌唑、 5g氟啶酰菌胺, 木质素磺酸钠 8g、十二垸基硫酸钠 2g、硫酸铵 5g, 聚乙烯醇 5g, 硼砂 2g, 白炭黑 3g、 硅藻土补足至 100g, 将以上原料按水分散颗粒 剂方法制成有效成分重量百分含量为 7 %丙硫菌唑一氟啶酰菌胺水分散颗粒剂。
实施例 15:
称取 4g丙硫菌唑、 13g氟啶酰菌胺, 木质素磺酸钠 8g、 十二垸基硫酸钠 2g、 硫酸 铵 5g, 聚乙烯醇 5g, 硼砂 2g, 硅藻土 28g补足至 100g, 将以上原料按水分散颗粒剂 方法制成有效成分重量百分含量为 17 %丙硫菌唑一氟啶酰菌胺水分散颗粒剂。
实施例 16:
称取 5g丙硫菌唑、 15g氟啶酰菌胺, 木质素 2g, 聚氧乙烯聚氧丙烯醚 4g, 黄原胶 0.15g, 乙二醇 5g, 硅氧乙垸 0.10g, 硅酸镁铝 0.5g, 用水补足至 100g, 在砂磨机的作用 下制成有效成分重量百分含量为 20%丙硫菌唑一氟啶酰菌胺悬浮剂。
室内生测试验:
在室内采用菌丝生长速率法,测定不同药剂对菌株的 EC5Q值,采用共毒系数计算方 法, 计算出混剂的共毒系数 (CTC), 确定混剂的增效性, 具体计算方法如下:
以混剂中某一单剂为标准药剂 (通常选择 EC5()较低者), 进行计算:
单剂毒力指数 =标准药剂 EC5Q/某单剂 EC5Q X 100
理论毒力指数 =八单剂的毒力指数 X A单剂在混剂中所占比例 + B单剂的毒力指数 X B单剂在混剂中所占比例
实测毒力指数 =标准单剂的 EC5o值 /混剂的 5。5。值 100
共毒系数=实测毒力指数 /理论毒力指数 X 100
共毒系数分级: CTC大于 120时混剂具有协同增效性, CTC小于 80时为拮抗, CTC 在 80- 120之间为相加作用。
说 明 书
表 1 : 丙硫菌唑 +氟啶酰菌胺不同配比对花生叶斑病菌(Cercospora personata) 的室内生 测结果
田间药效试验:
1.试验处理: 本试验根据各个成分的不同分别设三个药剂用量, 药剂用量是有效成 分丙硫菌唑(A)和有效成分氟啶酰菌胺(B )的质量和。对照药剂分别是农药单剂 25% 氟啶酰菌胺 ME和 5%丙硫菌唑 ME及空白清水试验。
2.试验方法: 每个小区面积为 66.7m2, 重复 3次; 施药前调查及防治后的调查药效 方法为: 在试验处理区内随机取样 5点, 按照国家田间试验相关标准进行病情分级, 计 算防效。 试验结果见下表-
表 2田间药效试验结果
说
书
通过田间药效结果表明, 由表 2可知, 本发明组合物具有明显的协同增效作用, 组 合物的防治效果优良, 防治效果均好于单剂品种, 在农业应用中具有应用价值。
Claims
1、 一种含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑与 氟啶酰菌胺的重量比为 1~70: 1~50。
2、 根据权利要求 1所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑与氟啶酰菌胺的重量比为 1~35: 1~25。
3、 根据权利要求 2所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑与氟啶酰菌胺的重量比为 1~10: 1~20。
4、 根据权利要求 3所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑与氟啶酰菌胺的重量比为 1 : 2-60
5、 根据权利要求 1所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑和氟啶酰菌胺二者占组合物的重量百分含量为 5.5~80%。
6、 根据权利要求 5所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的丙硫菌唑和氟啶酰菌胺二者占组合物的重量百分含量为 10~40%。
7、 根据权利要求 1所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的杀菌组合物是以丙硫菌唑和氟啶酰菌胺为主要有效成分和农药助剂、 赋型剂配 制成农药上允许的剂型。
8、 根据权利要求 7所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物, 其特征在于: 所述的剂型是乳油、 悬浮剂、 水乳剂、 可湿性粉剂、 微乳剂或水分散颗粒剂。
9、权利要求 1所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物作为制备防治抗性植 物真菌病害药物的应用。
10、 根据权利要求 9所述的含丙硫菌唑和氟啶酰菌胺的杀菌组合物作为制备防治 白粉病、 纹枯病、 枯萎病、 叶斑病、 锈病、 菌核病、 网斑病、 云纹病、 灰霉病、 黑斑病、 褐斑病、 黑胫病、 稻瘟病和疫病药物的应用。
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Publication number | Priority date | Publication date | Assignee | Title |
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CN102105053A (zh) * | 2008-07-24 | 2011-06-22 | 拜耳作物科学股份公司 | 用于可分散于水中的植物相容浓缩物的增稠剂 |
CN102395272A (zh) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | 杀真菌混合物和其用途 |
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CN102395272A (zh) * | 2009-04-15 | 2012-03-28 | 先正达参股股份有限公司 | 杀真菌混合物和其用途 |
CN103314968A (zh) * | 2013-06-09 | 2013-09-25 | 江苏辉丰农化股份有限公司 | 具有增效作用的杀菌组合物 |
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