WO2015055889A1 - A method for the production of pine bark extract to be used as a pharmaceutical, herbal or cosmetic ingredient, by using a magnesium compound - Google Patents

Abstract

The invention discloses a heat extraction method of pine bark, according to which a solvent, typically water, and a magnesium compound are used. Then the extract is decanted, if necessary also filtered, to get a red solution to be used as a pharmaceutical, herbal or cosmetic ingredient.

Description

A method for the production of pine bark extract to be used as a pharmaceutical, herbal or cosmetic ingredient, by using a magnesium compound

TECHNICAL FIELD

It is an extraction method of pine (Pinus species) bark with magnesium compound to as a pharmaceutical, herbal and cosmetic ingredient The extract can be used as a product or as a part of a product, such as absorbed into the diatomaceous earth in tablets or capsules, or ointment or gel or a cosmetic or a toner, serum ingredient or semi-finished powder in bags which are extracted by the client, such making coffee or tea.

BACKGROUND OF THE INVENTION A pine {Pinus species) is very much used an herb and its different components have long been used in the pharmaceutical, herbal and cosmetic products. Particularly, the pine bark has been used in many different ways and the extraction has made with various solvents. In many cases it has not been possible to use only water as a solvent, although it is the safest solvent. There are also many preparations where are combined pine bark with other active substances.

The Stanford University website (httpJ/ppop.stanford.edu/pinebark.html retrieved 16 October 2013) explains "Pine bark has been used as a foodstuff for thousands of years in human history. Today, pine bark extracts and other OPCs products (especially grape seed extracts) are widely consumed as a food ingredient or dietary supplement. Extensive research conducted with several formulations of pine bark extracts has established its safety and tolerability for human consumption".

Also, magnesium has been used for a long time, for example, for treating muscle cramps. The magnesium compounds contain often oxygen or can form oxygen-containing compounds when oxygen-free magnesium salt is dissolving and reacting with water. Water includes oxygen. The chemistry of magnesium is well known, for example,

(http://en. wikipedia.org/wiki/Magnesium retrieved 17 October 2013);

MgCh + Ca(OH)2→ Mg(OH)2 + CaCfe and also so a magnesium hydroxide is obtained. The patent publication US 5968517 Process for extraction of proanthocyanidins from botanical material, Kelvin Winston Duncan, Ian Alexander Gilmour (23 May 1996) is presented a hot water-based extraction method of pine bark. The patent publication CN 102038721 extract of Pinus and application thereof

^Σ -, (23 October 2009) is presented a complex extraction procedure, which lasts for 3-5 months.

The patent publication EP 2517716 Oral compositions containing botanical extracts, Diane Cummins M Harsh Trivedi (1 October 2007) is presented a composition in which at least two of the herbal active ingredients and one can be pine.

The patent publication WO 2006090953 Extraction method for antioxidants from pine trees using natural antioxidant extracts solvents and thereby Wan-Taek Han (28 February 2005) is presented different extraction solvents, such as alcohols and animal and vegetable oils.

The patent publication CN 102485209 Pycnogenol / rhEGF skin care cosmetic composition and preparation method thereof, Pingshun Yang, Zeqi Zhang (6 December 2010) is presented the pine bark extract and rbJEGP composition for skin care.

The publication Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, pycnogenol, G. Rimbach and F. Virgjli, Free Radical Biology and Medicine, Volume 27, Issues 5-6, September 1999, pages 704-724 is a review publication of many studies which have made using of Pinus maritima.

SUMMARY OF THE INVENTION

In the present invention, it is essential that the extraction of bark pine is made with magnesium compound. Even though both materials are well known in the art and used in common, the inventive is that before this has not been presented. It is inventive to get from starting materials, which are not red, to the red extract, and this has a great importance, for example in cosmetics such as cosmetic serums. A big advantage is also that the solvent can typically be water, which is safe.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

The present invention discloses an extraction of pine (Pinus) bark (Figure la). The invention is not limited to specific pine species, and the scope of the invention includes for example Pinus sylvestris, Pinus pinaster, Pinus maritima, Pinus radiate, Pinus koraiensis, Pinus pumila, Pimus luchuensis, Pinus palustris, Pinus bungeana, Pinus thunbergii, Pinus densiflora, Pinus parviflora, Pinus pentaphylla, Pinus koraiensis, Pinus pumila, Pimus luchuensis, Pinus palustris or Pinus bungeana or a mixture of these. Such in many patents of pine bark this is not used the thick outer bark of pine generally. Pine bark can be fresh or dried, and crushed to different sizes. Magnesium and magnesium compounds (Figure lc) are known. The magnesium compound can be magnesium oxide, magnesium hydroxide, magnesium carbonate, magnesium lactate, magnesium phosphate, magnesium aspartate, magnesium gluconate, magnesium carbonate, magnesium orotate, magnesium citrate, magnesium, or other, or a combination of these, or it is a part of the other, such as a talk, dolomite and magnesite. Also, magnesium can be pure magnesium and magnesium reacts typically with water.

A solvent (Figure lb) is typically water, but it can be ethanol or oil, such as animal or vegetable oil. Those skilled in the art it is known that for the oil-water mixing there are a variety of emulsifiers. The new products according to the invention are aqueous or oil- based. It can be added for example preservatives and perfumes, and these are well known to those skilled in the art and these do not involve novelty and inventive steps.

An extraction is one of the oldest methods in the chemistry. The extraction can be done in many ways, for example by supercritical fluid extraction. Generally, it is tried to use as short as possible extraction times and low temperatures, so that the active ingredients would not decompose. In the extraction there is typically 50-100 °C for 20 minutes at normal atmospheric pressure.

A decanting (Figure Id) is also a common chemical method. The decanting may be enough, depending on, for example, pine bark particle size, and if necessary it is filtered (Figure le) The resulting red solution (Figure If) can be used in many ways, for example as a part of lotion, cosmetic serum, paste, gel, nutritional supplement and pharmaceutical formulation. The final products can be liquid, such as a lotion, or solid, such as a part of tablets, capsules, or in the form of powder or spray, gel and semi-solid ointments.

The Figure 1 shows the invented extraction process, wherein in the step a) fresh or dried pine bark, typically not part of the outer thick bark b) a solvent, typically water, and c) magnesium compound / magnesium d) are mixed and heated, typically in 100 ⁰ C for 20 minutes, in step e) is decanted, if necessary filtered, to getting a red solution step f).

Examples

Example 1

The dried pine (Pinus sylvestris) bark (Figure la) , not typically a part of the outer thick bark, 10 g mixed with 101 water (Figure lb) and 1 g magnesium oxide (Figure lc), and the mixture was heated in 100 °C for 20 min. The extract is decanted (Figure Id), and the red solution (Figure If) was used as an ingredient in lotion, gel and cosmetic serum.

Without magnesium oxide it does not get the red solution.

Example 2

The dried pine {Pinus sylvestris) bark (Figure la), not typically a part of the outer thick bark, 10 g, mixed with 10 1 water (Figure lb) and 1 g magnesium hydroxide (Figure lc), and when the mixture was heated in 100 °C for 20 min. The extract was decanted (Figure Id), and the red solution (Figure If) was used as an ingredient in lotion, gel and cosmetic serum. Without magnesium hydroxide it does not get the red solution (Figure 1 ί)· Example 3

The dried pine (Pinus sylvestris) bark (Figure la) , not typically a part of the outer thick bark part, 10 g, mixed with 10 1 water (Figure lb) and 1 g magnesium carbonate (Figure 1 c), and the mixture was heated in 100 ⁰ C for 20 min. The extract is decanted (Figure Id), and the red solution (Figure If) was used as an ingredient in lotion, gel and cosmetic serum. Without magnesium carbonate it does not get the red solution. Example 4

The dried pine Pinus sylvestris) bark (Figure la), typically a part of the outer thick bark part, 10 g, mixed with 10 1 water (Figure lb) and 1 g of magnesium citrate (Figure lc), and the mixture was heated in 100 °C for 20 min. The extract is decanted (Figure Id), and the red solution (Figure 1 f), was used as an ingredient in lotion, gel and cosmetic serum. Without magnesium citrate it does not get the red solution.

Those skilled in the art know that the invention is not limited to the above described details of the embodiments, but for example, different extraction temperatures and times, and solvents, solvent mixtures and pressures are enclosed the scope of the invention. Different creams and gels are well known in the manufacture of emulsifiers, wherein the water and oil phases can be mixed and also to make micro and nanocapsules, for example, cementation. Pharmaceutical, drug and cosmetic products often contain many substances both water and oil-soluble substances, and the inner phase can be an aqueous phase and the outer phase is oil phase, or vice versa, or their multiples. The inventive ingredient can be part of another product, which may include, for example, animal and vegetable oils, seed oils, such as grape, crowberry, sea buckthorn and cloudberry seed oil, blueberry, lingonberry, mountain blueberry, menthol, anise, peach, taurine, glycerol, L-carnitine, cinnamon, omega fatty acids, cod liver oil, folic acid, calcium, zinc, ubiquinone, inulin, urine substances, such as urea and urea, ceramides, hyaluronic acid, acrylates, bergamot, chamomile, aloe vera, pantothenol, musk salvia, valerian root, silicon, herbal extracts, green tea, A, B, C, D and E-vitamins. For example, an anti-wrinkle ingredients are derivatives of vitamin A, tretinoin and tazarotene, glycolic acid and vitamin C. Depending on the product, the product has different excipients such as gel makers, such as carbomer and emulsifiers, which make emulsions of two or more liquids that are normally immiscible, for example water and oil mixture. For example, the emulsifier is cetearyl alcohol. BRIEF DESCRIPTION OF THE FIGURES

Figure 1

Pine bark (Figure la), typically not thick, outer bark is put to the solvent, (Figure lb), typically water, and add the magnesium compound (Figure lc), and the mixture is stirred and heated typically in 100 °C for 20 minutes, the resulting extract is decanted (Figure Id) and filtered (Figure le) if necessary, and so it is obtained the red solution (Figure If) which is used in the pharmaceutical, herbal and cosmetic products.

Claims

1. An extraction method of pine (Pinus) bark (Figure la) for as a pharmaceutical, herbal or cosmetic ingredient using heat extraction, solvent (Figure lb), typically water, and magnesium compound (Figure lc).

2. The method according to the claim 1 wherein the magnesium compound (Figure lc) is magnesium oxide, magnesium hydroxide, magnesium carbonate, magnesium chloride, magnesium sulfate, magnesium arsenate, magnesium, magnesium nitrate, magnesium stearate, magnesium malate, magnesium, glycinate, dolomite, magnesite or talc or their mixture.

3. The method according to the claim 1 wherein the magnesium containing compound (Figure lc) is the beginning of magnesium, which reacts with solvent (Figure lb), typically water, to form a magnesium compound.

4. The method according to the claim 1 wherein the solvent (Figure lb) is water, ethanol, ethanol aqueous solution or oil such as vegetable oil.

5. The method according to the claim 1 wherein the pine (Pinus) bark (Figure la) is on Pinus sylvestris, Pinus pinaster, Pinus maritima, Pinus radiate, Pinus koraiensis, Pinus pumila, Pinus luchuensis, Pinus palustris, Pinus bungeana, Pinus thunbergii, Pinus densiflora, Pinus parviflora, Pinus pentaphylla, Pinus koraiensis, Pinus pumila, Pimus luchuensis, Pinus palustris or Pinus bungeana or other species, or their mixture.

6. The method according to the claim 1 wherein the pine (Pinus) bark (Figure la) is fresh or dried and crushed or whole.

7. The method according to the claim 1 wherein the pine (Pinus) bark (Figure la) is typically not part of the thick outer bark of pine.

8. The method according to the claim 1 wherein the extraction the temperature is

0-100 °C and also higher than 100 °C by changing the pressure, typically 100 °C at normal atmospheric pressure.

9. The method according to the claim 1 wherein that the extraction time is 1-300 minutes, typically 20 minutes.

10. The method according to the claim 1 wherein the extract is decanted (Figure Id) and/or filtered (Figure le) separating the solids and thereby to give a red solution (Figure If).