WO2015051337A3 - Methods of treating gastrointestinal disorders - Google Patents
Methods of treating gastrointestinal disorders Download PDFInfo
- Publication number
- WO2015051337A3 WO2015051337A3 PCT/US2014/059190 US2014059190W WO2015051337A3 WO 2015051337 A3 WO2015051337 A3 WO 2015051337A3 US 2014059190 W US2014059190 W US 2014059190W WO 2015051337 A3 WO2015051337 A3 WO 2015051337A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- gastrointestinal disorders
- treating gastrointestinal
- treating
- decreased
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present disclosure is directed to a method of treating a gastrointestinal disorder associated with decreased enteric nerve cell survival and colonic cell motility.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361886913P | 2013-10-04 | 2013-10-04 | |
US61/886,913 | 2013-10-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015051337A2 WO2015051337A2 (en) | 2015-04-09 |
WO2015051337A3 true WO2015051337A3 (en) | 2015-11-19 |
Family
ID=52779310
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/059190 WO2015051337A2 (en) | 2013-10-04 | 2014-10-03 | Methods of treating gastrointestinal disorders |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015051337A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10519207B2 (en) | 2015-06-12 | 2019-12-31 | Georgia State University Research Foundation, Inc. | Compositions and methods for treating opioid tolerance |
CN106800597B (en) * | 2015-11-26 | 2021-07-16 | 上海佳文英莉生物技术有限公司 | Protein for neutralizing pro-apoptosis necrosis antibody and application thereof |
US20190085394A1 (en) * | 2015-12-14 | 2019-03-21 | Parkinson's Institute | Refining diagnosis and treatment of complex multi-symptom neurological disorders |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060258604A1 (en) * | 2005-05-10 | 2006-11-16 | Warren Strober | Compositions and methods for the treatment of inflammatory bowel disease utilizing NF-kappaB decoy polynucleotides |
US20080108684A1 (en) * | 2005-07-01 | 2008-05-08 | Ajinomoto Co., Inc. | Therapeutic agent for inflammatory bowel disease and tnf-alfa production inhibitor |
US20080187509A1 (en) * | 2000-03-02 | 2008-08-07 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-alpha related disorders |
US20080269123A1 (en) * | 2006-04-03 | 2008-10-30 | Rong Li | Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases |
US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
-
2014
- 2014-10-03 WO PCT/US2014/059190 patent/WO2015051337A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080187509A1 (en) * | 2000-03-02 | 2008-08-07 | Xencor, Inc. | Pharmaceutical compositions for the treatment of TNF-alpha related disorders |
US20060258604A1 (en) * | 2005-05-10 | 2006-11-16 | Warren Strober | Compositions and methods for the treatment of inflammatory bowel disease utilizing NF-kappaB decoy polynucleotides |
US20080108684A1 (en) * | 2005-07-01 | 2008-05-08 | Ajinomoto Co., Inc. | Therapeutic agent for inflammatory bowel disease and tnf-alfa production inhibitor |
US20080269123A1 (en) * | 2006-04-03 | 2008-10-30 | Rong Li | Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases |
US20090069247A1 (en) * | 2006-10-06 | 2009-03-12 | Blake Paterson | Use of tight junction antagonists to treat inflammatory bowel disease |
Non-Patent Citations (2)
Title |
---|
CHANDRASEKHARAN ET AL.: "Targeted Deletion of Neuropeptide Y (NPY) Modulates Experimental Colitis", PLOS ONE, vol. 3, no. 10, 1 October 2008 (2008-10-01), pages 1 - 11, XP002686674, ISSN: 1932-6203 * |
CHANDRASEKHARAN ET AL.: "TNF alpha Inhibitors Attenuate N europe ptide Y (NPY) Expression in the Murine Enteric Nervous System", IMPLICATIONS IN INFLAMMATION AND COLONIC MOTILITY, vol. 18, December 2012 (2012-12-01), pages S93, XP055237213, Retrieved from the Internet <URL:http://journals.lww.com/ibdjournal/Citation/2012/12001/TNF8_Inhibitors_Attenuate_Neuropeptide_Y_NPY_.229.aspx> [retrieved on 20150225] * |
Also Published As
Publication number | Publication date |
---|---|
WO2015051337A2 (en) | 2015-04-09 |
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