WO2015050957A3 - Treatments for systemic lupus erythematosus - Google Patents
Treatments for systemic lupus erythematosus Download PDFInfo
- Publication number
- WO2015050957A3 WO2015050957A3 PCT/US2014/058576 US2014058576W WO2015050957A3 WO 2015050957 A3 WO2015050957 A3 WO 2015050957A3 US 2014058576 W US2014058576 W US 2014058576W WO 2015050957 A3 WO2015050957 A3 WO 2015050957A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lupus erythematosus
- systemic lupus
- treatments
- elf4
- bankl
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
Abstract
The disclosure involves the identification of the Eukaryotic initiation factor 4 (elF4) machinery as a downstream effector of the B-cell scaffold protein with ankyrin repeats 1 (Bankl )-mediated regulation of IL-6 expression. Thus, methods for treating patients suffering from autoimmune diseases such as systemic lupus erythematosus by targeting elF4 function are provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361885859P | 2013-10-02 | 2013-10-02 | |
US61/885,859 | 2013-10-02 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2015050957A2 WO2015050957A2 (en) | 2015-04-09 |
WO2015050957A8 WO2015050957A8 (en) | 2015-09-11 |
WO2015050957A3 true WO2015050957A3 (en) | 2015-11-12 |
Family
ID=52779279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/058576 WO2015050957A2 (en) | 2013-10-02 | 2014-10-01 | Treatments for systemic lupus erythematosus |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015050957A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2874561T3 (en) | 2014-09-17 | 2021-11-05 | Celgene Car Llc | MK2 inhibitors and their uses |
CN105902533B (en) * | 2016-05-23 | 2018-04-20 | 浙江省医学科学院 | Purposes of the compound cercosporamide in immunopotentiator is prepared |
US11602524B2 (en) | 2019-12-02 | 2023-03-14 | New York University | Selective inhibition of T Follicular Helper cells for treatment of autoimmune disorders |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090148462A1 (en) * | 2005-10-13 | 2009-06-11 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
US20130209543A1 (en) * | 2011-11-23 | 2013-08-15 | Intellikine Llc | Enhanced treatment regimens using mtor inhibitors |
US20130209578A1 (en) * | 2010-08-11 | 2013-08-15 | Universite De Montreal | Combinatory Cancer Treatment |
-
2014
- 2014-10-01 WO PCT/US2014/058576 patent/WO2015050957A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090148462A1 (en) * | 2005-10-13 | 2009-06-11 | Human Genome Sciences, Inc. | Methods and compositions for use in treatment of patients with autoantibody positive disease |
US20110224223A1 (en) * | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
US20130209578A1 (en) * | 2010-08-11 | 2013-08-15 | Universite De Montreal | Combinatory Cancer Treatment |
US20130209543A1 (en) * | 2011-11-23 | 2013-08-15 | Intellikine Llc | Enhanced treatment regimens using mtor inhibitors |
Non-Patent Citations (3)
Title |
---|
GROLLEAU ET AL.: "Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients.", J CLIN INVEST., vol. 106, no. 12, 2000, pages 1561 - 1568, XP055235484 * |
LOPEZ-PELAEZ ET AL.: "Cot/tpl2-MKK1/2-Erk1/2 controls mTORC1-mediated mRNA translation in Toll-like receptor-activated macrophages", MOL BIOL CELL ., vol. 23, no. 15, August 2012 (2012-08-01), pages 2982 - 2992, XP055235483 * |
WU ET AL.: "BANK1 controls CpG-induced IL -6 secretion via a p38 and MNK1/2/eIF4E translation initiation pathway.", J IMMUNOL., vol. 191, no. 12, December 2013 (2013-12-01), pages 6110 - 6, XP055235488, DOI: doi:10.4049/jimmunol.1301203 * |
Also Published As
Publication number | Publication date |
---|---|
WO2015050957A8 (en) | 2015-09-11 |
WO2015050957A2 (en) | 2015-04-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2023008686A (en) | Modulatory polynucleotides. | |
WO2016011306A3 (en) | Terminal modifications of polynucleotides | |
EP3538548A4 (en) | Il-2 variants for the treatment of autoimmune diseases | |
EP3469522A4 (en) | Accelerator for deep neural networks | |
EP3465550A4 (en) | Accelerator for deep neural networks | |
MX2018014154A (en) | Modulatory polynucleotides. | |
WO2016011222A3 (en) | Circular polynucleotides | |
EP3229734A4 (en) | Accommodative, curvature-changing intraocular lenses | |
MX2021008663A (en) | Improved il-6 antibodies. | |
EP3522332A4 (en) | Charger | |
EP3665544A4 (en) | Database engine | |
EP3378442A4 (en) | Improved accommodative intraocular lens | |
EP3331345A4 (en) | Hedge trimmer | |
ZA201608079B (en) | Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain | |
EP3433563A4 (en) | Holster | |
EP3629910A4 (en) | Seizure onset zone localization | |
EP3313927A4 (en) | Dilithium initiators | |
EP3455350A4 (en) | Combination prime: boost therapy | |
WO2015050957A3 (en) | Treatments for systemic lupus erythematosus | |
WO2017035319A8 (en) | Methods for treatment of polycystic kidney disease | |
EP3432821A4 (en) | Surgical platform supported by multiple arms | |
WO2017103280A9 (en) | Intravesical therapy for bladder cancer | |
EP3525570A4 (en) | Line trimmer | |
WO2016086022A3 (en) | Heteroaromatic imidazolyl compounds and methods for treating cancer | |
WO2016081701A3 (en) | CDDO-Me AS A THERAPY FOR LUPUS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14850884 Country of ref document: EP Kind code of ref document: A2 |
|
DPE1 | Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101) | ||
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 14850884 Country of ref document: EP Kind code of ref document: A2 |