WO2015046909A1 - Novel use of mta-based coating composition - Google Patents

Novel use of mta-based coating composition Download PDF

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Publication number
WO2015046909A1
WO2015046909A1 PCT/KR2014/008953 KR2014008953W WO2015046909A1 WO 2015046909 A1 WO2015046909 A1 WO 2015046909A1 KR 2014008953 W KR2014008953 W KR 2014008953W WO 2015046909 A1 WO2015046909 A1 WO 2015046909A1
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mta
teeth
composition
sensitive
coating composition
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PCT/KR2014/008953
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French (fr)
Korean (ko)
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최정훈
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최정훈
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Publication of WO2015046909A1 publication Critical patent/WO2015046909A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/70—Preparations for dentistry comprising inorganic additives
    • A61K6/71—Fillers
    • A61K6/76—Fillers comprising silicon-containing compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/853—Silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
    • A61K6/876—Calcium oxide

Definitions

  • the present invention relates to a novel use of the MTA (Mineral Trioxide Aggregate) -based coating composition for sensitive teeth, and more particularly, including the MTA component, when effectively applied to the outside of sensitive teeth to effectively seal the dentinal tubules on the tooth surface It relates to a composition for tooth coating which can prevent or treat the symptom of sensitive teeth.
  • MTA Mineral Trioxide Aggregate
  • irritable teeth include mechanical or chemical irritation or temperature on dentin exposed or damaged by enamel (enamel) or cervical areas of the tooth surface due to various causes such as gingivitis, high-wear toothpaste, and gum retraction due to aging.
  • external stimuli are transmitted to the dentinal tubules, which are connected to nerves, and even teeth can be difficult to develop into gum disease or tooth decay.
  • dentin tubule in dentin structure.
  • nerve cells are present at the base of the dentinal tubule.
  • the dentin is covered by enamel, which separates the dentinal tubule from the outside and the external changes are not transmitted to the nerve cell, whereas enamel is worn out by the above-mentioned causes.
  • enamel is worn out by the above-mentioned causes.
  • external stimuli are transmitted to nerve cells through the ivory tubules.
  • the present inventors have studied the technology for forming a coating layer for sealing the dentinal tubules of the tooth surface of the living teeth, the composition containing the MTA effectively seals the dentinal tubules of the tooth surface effectively prevent the symptom of dentition of sensitive teeth Or the present invention was found to be curable.
  • an object of the present invention is to provide a novel use as a composition for preventing or alleviating symptoms of the syrup of the MTA-based composition that has been previously used for pulp repair.
  • the present invention when applied to the outside of sensitive teeth effectively seals the dentinal tubules on the surface of the sensitive teeth MTA for sensitive teeth that can prevent or treat symptoms It provides a novel use of the Mineral Trioxide Aggregate-based coating composition.
  • the coating composition for preventing or treating sensitive teeth according to the present invention is safe for teeth and is applied to the outside of sensitive teeth because it uses an MTA component mainly composed of calcium silicate cement, which has been widely recognized and used for teeth. By effectively sealing the dentinal tubules on the surface of the tooth, attenuation of sensitive teeth can effectively prevent or alleviate the symptoms.
  • the present invention relates to a novel use of MTA, and specifically, it is not only used to seal the dentin in the root canal commonly used during neurotherapy, but also applied to the dentin when exposed to the outside as well as the root canal of clean living teeth.
  • the present invention relates to a tooth coating composition comprising, as an active ingredient, MTA containing calcium silicate cement as an active ingredient in order to prevent or treat sensitive teeth having an effect of sealing the tubules.
  • composition for sensitive tooth coating of the present invention uses MTA as the main substrate.
  • MTA usable in the present invention calcium silicate cement is used alone or known MTA including the same, for example, Pro Root MTA (pro Root MTA, Dentsply), MTA angelus (Angelus), orthoMTA (bioMTA) ), bioaggregate (verio dental company), biodentine (septodont company) and the like can be used, but is not limited thereto.
  • the amount of calcium silicate cement added to the composition of the present invention is not particularly limited as long as the operability is good.
  • addition amount can be suitably adjusted according to the quantity of the said calcium silicate cement.
  • the sensitive dental coating composition of the present invention is preferably prepared in the form of an ointment or toothpaste, and accordingly, various additives, for example, purified water, wetting agents, binders, flavors, sweeteners, preservatives, foaming agents, acidity regulators, surfactants , Food coloring and other active ingredients may be further included in an appropriate amount.
  • various additives for example, purified water, wetting agents, binders, flavors, sweeteners, preservatives, foaming agents, acidity regulators, surfactants , Food coloring and other active ingredients may be further included in an appropriate amount.
  • Purified water can be used to adjust the viscosity of the toothpaste or ointment.
  • Wetting agents are ingredients to prevent toothpaste or ointment from solidifying and to give the surface of the toothpaste a gloss and to give a sweetening effect depending on the type.
  • glycerin, sorbitol, xylitol, polyethylene glycols and polypropylene glycols can be used.
  • the binder is to combine the inorganic components of the toothpaste or ointment with liquid components such as purified water and humectant to prevent phase separation and increase the viscosity, and any binder may be used without limitation as long as it is a water-soluble polymer commonly used in the art. And one or more selected from methyl cellulose, sodium alginate, hydroxyethyl cellulose, arabic gum, carrageenan, xanthan gum.
  • flavors and sweeteners may be additionally used to improve taste.
  • Flavoring agents include one or more selected from peppermint oil, spearmint oil, sage, eucalyptol, methyl salicylate, herb and fruit extract, and the like, and sweeteners include sodium saccharin, xylitol, aspartame, acesulfame, stevioside And may be one or more from licorice.
  • Preservatives can help to prolong the preservation of toothpaste or ointment by preventing the contamination of microorganisms, and examples thereof include sodium benzoate and parabens.
  • foaming agent to enhance the feeling of use of the product, to help the cleaning action, and to act to easily remove foreign substances in the oral cavity by speeding up the dispersion and penetration of other active ingredients and reducing the interfacial tension.
  • foaming agent sodium lauryl sulfate, an anionic surfactant, is mainly used, and a copolymer of polyoxyethylene polyoxypropylene (poloxamer), which is a nonionic surfactant, is polyoxyethylene-cured castor oil, and polyoxy, depending on the characteristics of the formulation. Ethylene sorbitan fatty acid ester and the like can be used.
  • the composition for sensitive tooth coatings according to the present invention is safe for teeth by using MTA component mainly composed of calcium silicate cement, which has been widely used and recognized for teeth, and is only used for sealing the dentin in the root canal commonly used during neurotherapy. It is effective not to use, but to apply when the dentin is exposed not only in the root canal of the living teeth but also in the outside, thereby sealing the dentinal tubules.
  • MTA component mainly composed of calcium silicate cement, which has been widely used and recognized for teeth, and is only used for sealing the dentin in the root canal commonly used during neurotherapy. It is effective not to use, but to apply when the dentin is exposed not only in the root canal of the living teeth but also in the outside, thereby sealing the dentinal tubules.
  • MTA Mineral Trioxide Aggregate: trade name PRO ROOT MTA, Dentply Co., Ltd.
  • Test Example 1 Confirming the Effect of Syringe on Symptom Relief
  • the site of the symptom (hypersensitivity symptom) in the cervical region is cleaned by wiping with a cotton moistened with hydrogen peroxide, and then the coating composition of Example 1 is coated on the symptomatic region Buried in and applied for about 10 to 20 seconds. It was air dried and applied again two to three times.
  • the degree of ache symptoms (hypersensitivity symptoms) before and after application was determined by dividing into 0 (no symptom) to 10 (too cold to normal life), the results are shown in Table 1 below.
  • Table 1 subject Preoperative Postoperative Improvement One 8 2 Improved 2 10 7 Improved 3 10 7 Improved 4 8 6 Improved 5 3 0 Improved 6 5 2 Improved 7 3 One Improved 8 3 0 Improved 9 5 One Improved 10 5 0 Improved 11 4 0 Improved 12 8 3 Improved 13 4 2 Improved 14 5 One Improved 15 8 3 Improved 16 7 3 Improved 17 4 One Improved 18 8 5 Improved 19 7 2 Improved 20 8 2 Improved 21 6 2 Improved 22 8 2 Improved 23 7 2 Improved

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  • Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Plastic & Reconstructive Surgery (AREA)
  • Cosmetics (AREA)
  • Dental Preparations (AREA)

Abstract

The present invention relates to a novel use of a mineral trioxide aggregate (MTA)-based coating composition for sensitive teeth, and more specifically, to a teeth coating composition, containing an MTA ingredient, for preventing or treating a dental hypersensitivity symptom of sensitive teeth by effectively sealing the dentinal tubule on the surface of the teeth when coated on the outer portion of the sensitive teeth.

Description

엠티에이계 코팅 조성물의 신규한 용도New Uses of MT Coating Compositions
본 발명은 민감성 치아용 MTA (Mineral Trioxide Aggregate)계 코팅 조성물의 신규한 용도에 관한 것으로서, 더욱 상세하게는 MTA 성분을 포함하여, 민감성 치아의 외부에 도포될 경우 치아 표면의 상아세관을 효과적으로 밀폐하여 민감성 치아의 시린이 증상을 예방 또는 치료할 수 있는 치아 코팅용 조성물에 관한 것이다.The present invention relates to a novel use of the MTA (Mineral Trioxide Aggregate) -based coating composition for sensitive teeth, and more particularly, including the MTA component, when effectively applied to the outside of sensitive teeth to effectively seal the dentinal tubules on the tooth surface It relates to a composition for tooth coating which can prevent or treat the symptom of sensitive teeth.
일반적으로 과민성 치아란 치은염, 마모도 높은 치약 사용, 노령화에 따른 잇몸 퇴축 등 여러 가지 원인으로 인해 치아 표면의 에나멜질 (법랑질)이나 치경부가 마모되거나 손상되어 노출된 상아질에 기계적 또는 화학적 자극이나 온도 등의 외부 자극이 가해지는 경우에 치아가 시리거나 심지어는 통증이 유발되게 되는 치아를 말한다. 상아질이 노출되면 신경과 연결되는 상아세관에 외부 자극이 그대로 전달되면서 심지어는 양치질까지 힘들어 잇몸병 또는 충치로까지 발전할 수 있다.In general, irritable teeth include mechanical or chemical irritation or temperature on dentin exposed or damaged by enamel (enamel) or cervical areas of the tooth surface due to various causes such as gingivitis, high-wear toothpaste, and gum retraction due to aging. A tooth that is cold or even painful when an external stimulus is applied. When the dentin is exposed, external stimuli are transmitted to the dentinal tubules, which are connected to nerves, and even teeth can be difficult to develop into gum disease or tooth decay.
이러한 현상은 상아질의 구조가 상아세관이라는 통로가 형성되어 있음에 기인한다. 상아세관의 기저부에는 신경세포가 존재하는데 정상적인 상태에서는 에나멜질에 의해 상아질이 덮여 있어 상아세관과 외부가 격리되어 외부의 변화가 신경세포에 전달되지 않는데 반해 에나멜질이 상술한 원인에 의해 마모되어 상아질이 노출되면 상아세관을 통해 외부의 자극이 신경세포로 전달되게 된다.This phenomenon is due to the formation of a channel called dentin tubule in dentin structure. At the base of the dentinal tubule, nerve cells are present. In normal condition, the dentin is covered by enamel, which separates the dentinal tubule from the outside and the external changes are not transmitted to the nerve cell, whereas enamel is worn out by the above-mentioned causes. When exposed, external stimuli are transmitted to nerve cells through the ivory tubules.
치아는 특성상 재생이 되지 않기 때문에 나이가 들면서 치아가 점점 약해지므로 이러한 시린이 증상은 성인이면 누구나 겪게 될 수밖에 없는 것으로 그동안 시린이 증상을 완화하는 여러 가지 치료법이 발달하였다.Because teeth are not regenerated due to their nature, teeth become weaker as they age, so this symptomatic symptom can only be experienced by adults. Various treatments have been developed to alleviate symptomatic symptoms.
그러나 이러한 치료법의 시술은 치과에 가서 받아야 하나 일반인 입장에선 치과에 가는 것이 여간 어려운 일이 아니다. 따라서 시린이 전문 치약들이 개발되어 시판되고 있다.However, the treatment of these treatments should go to the dentist, but for the general public it is not difficult to go to the dentist. Therefore, specialized toothpastes have been developed and marketed.
이에, 본 발명자들은 생활치의 치아 표면의 상아세관의 밀봉을 위한 코팅층을 형성하는 기술에 관하여 연구한 결과, MTA를 포함하는 조성물이 치아 표면의 상아세관을 효과적으로 밀봉하여 민감성 치아의 시림 증상을 효과적으로 예방 또는 치료할 수 있음을 발견하여 본 발명을 완성하였다.Accordingly, the present inventors have studied the technology for forming a coating layer for sealing the dentinal tubules of the tooth surface of the living teeth, the composition containing the MTA effectively seals the dentinal tubules of the tooth surface effectively prevent the symptom of dentition of sensitive teeth Or the present invention was found to be curable.
상기와 같은 문제를 해결하기 위하여, 본 발명은 기존에 치수수복용으로 사용되어온 MTA계 조성물의 시린이 증상 예방 또는 완화용 조성물로서의 신규한 용도를 제공하는 것을 목적으로 한다.In order to solve the above problems, an object of the present invention is to provide a novel use as a composition for preventing or alleviating symptoms of the syrup of the MTA-based composition that has been previously used for pulp repair.
상기 목적을 달성하기 위하여, 본 발명은 MTA 성분을 포함하여, 민감성 치아의 외부에 도포될 경우 치아 표면의 상아세관을 효과적으로 밀폐하여 민감성 치아의 시린이 증상을 예방 또는 치료할 수 있는 민감성 치아용 MTA (Mineral Trioxide Aggregate)계 코팅 조성물의 신규한 용도를 제공한다.In order to achieve the above object, the present invention, including the MTA component, when applied to the outside of sensitive teeth effectively seals the dentinal tubules on the surface of the sensitive teeth MTA for sensitive teeth that can prevent or treat symptoms It provides a novel use of the Mineral Trioxide Aggregate-based coating composition.
본 발명에 따른 민감성 치아 예방 또는 치료용 코팅 조성물은 치아에 대한 적합성이 이미 인정되어 널리 사용되고 있는 규산칼슘 시멘트를 주성분으로 하는 MTA 성분을 이용하므로 치아에 안전하고, 민감성 치아의 외부에 도포될 경우, 치아 표면의 상아세관을 효과적으로 밀폐하여 민감성 치아의 시린이 증상을 효과적으로 예방 또는 완화시킬 수 있다.The coating composition for preventing or treating sensitive teeth according to the present invention is safe for teeth and is applied to the outside of sensitive teeth because it uses an MTA component mainly composed of calcium silicate cement, which has been widely recognized and used for teeth. By effectively sealing the dentinal tubules on the surface of the tooth, attenuation of sensitive teeth can effectively prevent or alleviate the symptoms.
본 발명은 MTA의 신규한 용도에 관한 것으로, 구체적으로는 흔히 신경치료 중 사용하는 근관 내 상아질의 밀폐에만 사용하는 것이 아니라 깨끗하게 살아있는 치아의 근관내 뿐만 아니라 외부에 상아질이 노출된 경우에 도포하여 상아 세관을 밀폐하는 효과를 나타내는, 민감성 치아를 예방 또는 치료하기 위하여 규산칼슘 시멘트를 주성분으로 하는 MTA를 활성성분으로서 포함하는 치아 코팅용 조성물에 관한 것이다. The present invention relates to a novel use of MTA, and specifically, it is not only used to seal the dentin in the root canal commonly used during neurotherapy, but also applied to the dentin when exposed to the outside as well as the root canal of clean living teeth. The present invention relates to a tooth coating composition comprising, as an active ingredient, MTA containing calcium silicate cement as an active ingredient in order to prevent or treat sensitive teeth having an effect of sealing the tubules.
이하, 본 발명을 보다 상세하게 설명한다. Hereinafter, the present invention will be described in more detail.
본 발명의 민감성 치아 코팅용 조성물은 주요 기재로서 MTA를 사용한다.The composition for sensitive tooth coating of the present invention uses MTA as the main substrate.
본 발명에서 사용가능한 MTA로는 규산칼슘 시멘트를 단독으로 사용하거나, 이를 포함하는 공지의 MTA, 예를 들어, 프로루트 MTA (pro Root MTA, Dentsply사), MTA angelus (Angelus사), orthoMTA (bioMTA사), bioaggregate (verio dental사), biodentine (septodont사) 등을 사용할 수 있으나, 이에 한정되지는 않는다.As MTA usable in the present invention, calcium silicate cement is used alone or known MTA including the same, for example, Pro Root MTA (pro Root MTA, Dentsply), MTA angelus (Angelus), orthoMTA (bioMTA) ), bioaggregate (verio dental company), biodentine (septodont company) and the like can be used, but is not limited thereto.
본 발명의 조성물에 첨가되는 규산칼슘 시멘트의 양은 조작성이 좋은 상태정도라면 특별히 한정되지는 않으나, 조성물 총 중량에 대하여 20 내지 80 중량%, 바람직하게는 30 내지 70 중량%인 것이 좋다.The amount of calcium silicate cement added to the composition of the present invention is not particularly limited as long as the operability is good.
또한 공지의 MTA를 사용하는 경우에는, 상기 규산칼슘 시멘트의 양에 따라 첨가량을 적절히 조절할 수 있다.In addition, when using a well-known MTA, addition amount can be suitably adjusted according to the quantity of the said calcium silicate cement.
본 발명의 민감성 치아용 코팅 조성물은 연고제 또는 치약의 형태로 제조되는 것이 바람직하며, 이에 따라, 다양한 첨가제, 예를 들어, 정제수, 습윤제, 결합제, 향료, 감미제, 방부제, 기포제, 산도 조정제, 계면활성제, 식용색소 및 기타 약효성분들을 적절한 양으로 추가로 포함할 수 있다.The sensitive dental coating composition of the present invention is preferably prepared in the form of an ointment or toothpaste, and accordingly, various additives, for example, purified water, wetting agents, binders, flavors, sweeteners, preservatives, foaming agents, acidity regulators, surfactants , Food coloring and other active ingredients may be further included in an appropriate amount.
정제수는 치약 또는 연고제의 점도를 조절하기 위하여 사용될 수 있다.Purified water can be used to adjust the viscosity of the toothpaste or ointment.
습윤제는 치약 또는 연고제가 고형화되는 것을 방지하고 치약의 표면에 윤기를 제공할 뿐만 아니라 종류에 따라 감미 효과를 주기 위한 성분으로, 예를 들어, 글리세린, 소르비톨, 자일리톨, 폴리에틸렌글리콜류 및 폴리프로필렌글리콜류로 이루어진 군에서 1개 이상을 선택하여 사용할 수 있다. Wetting agents are ingredients to prevent toothpaste or ointment from solidifying and to give the surface of the toothpaste a gloss and to give a sweetening effect depending on the type. For example, glycerin, sorbitol, xylitol, polyethylene glycols and polypropylene glycols. One or more selected from the group consisting of can be used.
결합제는 치약 또는 연고제의 무기성분과 정제수, 습윤제와 같은 액상성분을 결합시켜 상분리를 방지하고 점도를 높이기 위한 것으로, 당분야에서 통상적으로 사용하는 수용성 고분자라면 제한 없이 사용될 수 있으며, 예를 들어, 카르복시메틸 셀룰로스, 알기산 나트륨, 히드록시에틸 셀룰로스, 아라빅 검, 카라기난, 잔탄검으로부터 선택된 1종 이상을 포함할 수 있다.The binder is to combine the inorganic components of the toothpaste or ointment with liquid components such as purified water and humectant to prevent phase separation and increase the viscosity, and any binder may be used without limitation as long as it is a water-soluble polymer commonly used in the art. And one or more selected from methyl cellulose, sodium alginate, hydroxyethyl cellulose, arabic gum, carrageenan, xanthan gum.
또한 치아에 코팅시, 맛을 좋게 하기 위해 향료와 감미제를 추가로 사용할 수 있다. 향료로는 페퍼민트 오일, 스피아민트 오일, 세이지, 유칼립톨, 메틸살리실레이트, 허브 및 과일 추출물 등으로부터 선택된 1종 이상을 포함하고, 감미료로는 사카린나트륨, 자일리톨, 아스파탐, 아세설팜, 스테비오사이드, 감초산 등으로부터 1종 이상을 포함할 수 있다.In addition, when coating the teeth, flavors and sweeteners may be additionally used to improve taste. Flavoring agents include one or more selected from peppermint oil, spearmint oil, sage, eucalyptol, methyl salicylate, herb and fruit extract, and the like, and sweeteners include sodium saccharin, xylitol, aspartame, acesulfame, stevioside And may be one or more from licorice.
방부제는 미생물에 대한 오염을 방지하여 치약 또는 연고제의 보존을 장기화하는데 도움을 줄 수 있으며 대표적인 것으로 벤조산나트륨, 파라벤류 등이 있다.Preservatives can help to prolong the preservation of toothpaste or ointment by preventing the contamination of microorganisms, and examples thereof include sodium benzoate and parabens.
또한, 기포제의 사용은 제품의 사용감을 증진시키고 세정작용을 도와주며 기타 약효성분의 분산 및 침투를 신속하게 하고 계면 장력을 감소시킴으로써 구강내 이물질을 쉽게 떨어지게 하는 작용을 한다. 기포제로는 주로 음이온성 계면활성제인 라우릴황산나트륨이 사용되며 제형의 특성에 따라 보조적으로 비이온성 계면활성제인 폴리옥시에틸렌 폴리옥시프로필렌의 공중합체(폴록사머), 폴리옥시에틸렌 경화 피마자유, 폴리옥시에틸렌 소르비탄 지방산에스테르 등이 사용될 수 있다.In addition, the use of foaming agent to enhance the feeling of use of the product, to help the cleaning action, and to act to easily remove foreign substances in the oral cavity by speeding up the dispersion and penetration of other active ingredients and reducing the interfacial tension. As the foaming agent, sodium lauryl sulfate, an anionic surfactant, is mainly used, and a copolymer of polyoxyethylene polyoxypropylene (poloxamer), which is a nonionic surfactant, is polyoxyethylene-cured castor oil, and polyoxy, depending on the characteristics of the formulation. Ethylene sorbitan fatty acid ester and the like can be used.
또한, 민감성 치아에 효과가 있는 다양한 약효 성분들을 1종 이상 혼합하여 추가로 사용할 수 있다.In addition, it is possible to further use a mixture of one or more of the various active ingredients effective on sensitive teeth.
본 발명에 따른 민감성 치아 코팅용 조성물은 치아에 대한 적합성이 이미 인정되어 널리 사용되고 있는 규산칼슘 시멘트를 주성분으로 하는 MTA 성분을 이용하므로 치아에 안전하고, 흔히 신경치료 중 사용하는 근관 내 상아질의 밀폐에만 사용하는 것이 아니라 깨끗하게 살아있는 치아의 근관내 뿐만 아니라 외부에 상아질이 노출된 경우에 도포하여 상아 세관을 밀폐하는 효과를 나타내므로, 민감성 치아의 시린이 증상을 완화시키는데 효과적이다.The composition for sensitive tooth coatings according to the present invention is safe for teeth by using MTA component mainly composed of calcium silicate cement, which has been widely used and recognized for teeth, and is only used for sealing the dentin in the root canal commonly used during neurotherapy. It is effective not to use, but to apply when the dentin is exposed not only in the root canal of the living teeth but also in the outside, thereby sealing the dentinal tubules.
이하에서 본 발명을 실시예에 의거하여 보다 구체적으로 설명한다. 단, 이들 실시예는 본 발명을 예시하기 위한 것일 뿐, 본 발명이 이들만으로 한정되는 것은 아니다.Hereinafter, the present invention will be described in more detail with reference to Examples. However, these Examples are only for illustrating the present invention, the present invention is not limited to these.
[실시예]EXAMPLE
실시예 1: 민감성 치아 예방 또는 치료용 코팅 조성물의 제조Example 1 Preparation of Coating Composition for Sensitive Teeth Prevention or Treatment
MTA(Mineral Trioxide Aggregate: 상품명 PRO ROOT MTA, Dentply사)와 증류수를 섞어서 건축용 시멘트를 혼합하듯이 물: MTA= 4:6의 비율로 섞어 코팅용 조성물을 제조하였다.MTA (Mineral Trioxide Aggregate: trade name PRO ROOT MTA, Dentply Co., Ltd.) and distilled water was mixed to mix the building cement, water: MTA = 4: 6 to prepare a coating composition.
시험예 1: 시린이 증상 완화효과 확인Test Example 1: Confirming the Effect of Syringe on Symptom Relief
시린이 증상이 있는 피실험자를 대상으로, 치경부 부위에 시린 증상(지각과민 증상)이 있는 부위를 과산화수소를 적신 코튼으로 닦아서 깨끗이 한 다음, 시린 증상이 있는 부위에 상기 실시예 1의 코팅용 조성물을 코튼으로 묻혀 10 내지 20초 정도 도포하였다. 이를 에어로 건조시키고 다시 도포하는 작업을 2 내지 3회 시행하였다. 도포 전과 후에 시린증상(지각과민 증상)의 정도를 0(무증상) 내지 10(너무 시려서 정상생활 불가)으로 나누어서 확인하였으며, 그 결과를 하기 표 1에 나타내었다.For subjects with a symptom of a symptom, the site of the symptom (hypersensitivity symptom) in the cervical region is cleaned by wiping with a cotton moistened with hydrogen peroxide, and then the coating composition of Example 1 is coated on the symptomatic region Buried in and applied for about 10 to 20 seconds. It was air dried and applied again two to three times. The degree of ache symptoms (hypersensitivity symptoms) before and after application was determined by dividing into 0 (no symptom) to 10 (too cold to normal life), the results are shown in Table 1 below.
표 1
피실험자 술전 술후 개선유무
1 8 2 개선됨
2 10 7 개선됨
3 10 7 개선됨
4 8 6 개선됨
5 3 0 개선됨
6 5 2 개선됨
7 3 1 개선됨
8 3 0 개선됨
9 5 1 개선됨
10 5 0 개선됨
11 4 0 개선됨
12 8 3 개선됨
13 4 2 개선됨
14 5 1 개선됨
15 8 3 개선됨
16 7 3 개선됨
17 4 1 개선됨
18 8 5 개선됨
19 7 2 개선됨
20 8 2 개선됨
21 6 2 개선됨
22 8 2 개선됨
23 7 2 개선됨
Table 1
subject Preoperative Postoperative Improvement
One 8 2 Improved
2 10 7 Improved
3 10 7 Improved
4 8 6 Improved
5 3 0 Improved
6 5 2 Improved
7 3 One Improved
8 3 0 Improved
9 5 One Improved
10 5 0 Improved
11 4 0 Improved
12 8 3 Improved
13 4 2 Improved
14 5 One Improved
15 8 3 Improved
16 7 3 Improved
17 4 One Improved
18 8 5 Improved
19 7 2 Improved
20 8 2 Improved
21 6 2 Improved
22 8 2 Improved
23 7 2 Improved
상기 표 1에 나타난 바와 같이, 본 발명에 따른 민감성 치아용 MTA계 코팅 조성물을 시린 증상이 있는 민감성 치아의 외부에 코팅할 경우, 시린 증상을 현저히 개선함을 확인하였다.As shown in Table 1, when the MTA-based coating composition for sensitive teeth according to the present invention is coated on the outside of sensitive teeth with symptomatic symptoms, it was confirmed that the symptom was significantly improved.

Claims (3)

  1. 규산칼슘 시멘트를 포함하는 MTA (Mineral Trioxide Aggregate) 성분을 포함하고, 민감성 치아의 외부에 도포시 민감성 치아의 시린이 증상을 예방 또는 치료하기 위한 민감성 치아 코팅용 조성물. A composition for sensitive tooth coating comprising MTA (Mineral Trioxide Aggregate) component comprising calcium silicate cement, for preventing or treating symptomatic syringe of sensitive teeth when applied to the exterior of sensitive teeth.
  2. 제1항에 있어서,The method of claim 1,
    상기 조성물 내 규산칼슘 시멘트의 양은 조성물 총 중량에 대하여 20 내지 80 중량%인 것을 특징으로 하는 민감성 치아 코팅용 조성물.The amount of calcium silicate cement in the composition is a composition for sensitive tooth coating, characterized in that 20 to 80% by weight based on the total weight of the composition.
  3. 제1항에 있어서,The method of claim 1,
    상기 조성물이 치약 또는 연고제 조성물인 것을 특징으로 하는 민감성 치아용 MTA계 코팅 조성물.MTA-based coating composition for sensitive teeth, characterized in that the composition is a toothpaste or ointment composition.
PCT/KR2014/008953 2013-09-25 2014-09-25 Novel use of mta-based coating composition WO2015046909A1 (en)

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US20070009858A1 (en) * 2005-06-23 2007-01-11 Hatton John F Dental repair material
KR20100123439A (en) * 2009-05-15 2010-11-24 유준상 Root canal filler composed of mineral trioxide aggregates and fabrication method thereof
KR20120084426A (en) * 2011-01-20 2012-07-30 서울대학교산학협력단 Composition for regeneration of dentine containing odontogenic ameloblast-associated protein as an active ingredient
JP2012167033A (en) * 2011-02-10 2012-09-06 Nippon Shika Yakuhin Kk Composition for dental treatment
US20130023601A1 (en) * 2010-01-25 2013-01-24 Ogliari Fabricio Aulo Dental Composition Comprising A Calcium Source

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US20070009858A1 (en) * 2005-06-23 2007-01-11 Hatton John F Dental repair material
KR20100123439A (en) * 2009-05-15 2010-11-24 유준상 Root canal filler composed of mineral trioxide aggregates and fabrication method thereof
US20130023601A1 (en) * 2010-01-25 2013-01-24 Ogliari Fabricio Aulo Dental Composition Comprising A Calcium Source
KR20120084426A (en) * 2011-01-20 2012-07-30 서울대학교산학협력단 Composition for regeneration of dentine containing odontogenic ameloblast-associated protein as an active ingredient
JP2012167033A (en) * 2011-02-10 2012-09-06 Nippon Shika Yakuhin Kk Composition for dental treatment

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