WO2015035044A3 - Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY - Google Patents

Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY Download PDF

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Publication number
WO2015035044A3
WO2015035044A3 PCT/US2014/054088 US2014054088W WO2015035044A3 WO 2015035044 A3 WO2015035044 A3 WO 2015035044A3 US 2014054088 W US2014054088 W US 2014054088W WO 2015035044 A3 WO2015035044 A3 WO 2015035044A3
Authority
WO
WIPO (PCT)
Prior art keywords
dependent cell
mediated cytotoxicity
variants
improved antibody
antibody
Prior art date
Application number
PCT/US2014/054088
Other languages
French (fr)
Other versions
WO2015035044A2 (en
Inventor
Paul R. Hinton
Mengli XIONG
Veronica Juan
Original Assignee
Abbvie Biotherapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Biotherapeutics Inc. filed Critical Abbvie Biotherapeutics Inc.
Publication of WO2015035044A2 publication Critical patent/WO2015035044A2/en
Publication of WO2015035044A3 publication Critical patent/WO2015035044A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

Abstract

The present disclosure relates to polypeptide variants having modified Fc domains with improved potency and efficacy in activation of antibody-dependent cell-mediated cytotoxicity.
PCT/US2014/054088 2013-09-04 2014-09-04 Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY WO2015035044A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361873485P 2013-09-04 2013-09-04
US61/873,485 2013-09-04

Publications (2)

Publication Number Publication Date
WO2015035044A2 WO2015035044A2 (en) 2015-03-12
WO2015035044A3 true WO2015035044A3 (en) 2015-08-13

Family

ID=51542498

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/054088 WO2015035044A2 (en) 2013-09-04 2014-09-04 Fc VARIANTS WITH IMPROVED ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY

Country Status (1)

Country Link
WO (1) WO2015035044A2 (en)

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