WO2015022575A3 - A process for the preparation of gc-c agonist - Google Patents

A process for the preparation of gc-c agonist Download PDF

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Publication number
WO2015022575A3
WO2015022575A3 PCT/IB2014/001570 IB2014001570W WO2015022575A3 WO 2015022575 A3 WO2015022575 A3 WO 2015022575A3 IB 2014001570 W IB2014001570 W IB 2014001570W WO 2015022575 A3 WO2015022575 A3 WO 2015022575A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
agonist
linaclotide
coupling
solid phase
Prior art date
Application number
PCT/IB2014/001570
Other languages
French (fr)
Other versions
WO2015022575A2 (en
Inventor
Agasaladinni NAGANA GOUD
Vadlamani SURESH KUMAR
Original Assignee
Auro Peptides Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auro Peptides Ltd filed Critical Auro Peptides Ltd
Publication of WO2015022575A2 publication Critical patent/WO2015022575A2/en
Publication of WO2015022575A3 publication Critical patent/WO2015022575A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to a process for the preparation of Linaclotide by coupling of two or three suitable fragments by solid phase synthesis.
PCT/IB2014/001570 2013-08-13 2014-08-11 A process for the preparation of gc-c agonist WO2015022575A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2574CH2013 2013-08-13
IN2574CHE2013 2013-08-13

Publications (2)

Publication Number Publication Date
WO2015022575A2 WO2015022575A2 (en) 2015-02-19
WO2015022575A3 true WO2015022575A3 (en) 2015-07-02

Family

ID=51743467

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/001570 WO2015022575A2 (en) 2013-08-13 2014-08-11 A process for the preparation of gc-c agonist

Country Status (1)

Country Link
WO (1) WO2015022575A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11572386B2 (en) * 2014-09-08 2023-02-07 Auro Peptides Ltd. Process for the preparation of linaclotide
CN107001416B (en) * 2014-12-26 2021-01-15 深圳华大生命科学研究院 Conotoxin kappa-CPTx-btl 04, and preparation method and application thereof
WO2016101276A1 (en) * 2014-12-26 2016-06-30 深圳华大基因研究院 Conotoxin peptide κ-cptx-btl03, preparation method therefor, and uses thereof
WO2016101274A1 (en) * 2014-12-26 2016-06-30 深圳华大基因研究院 Conotoxin peptide κ-cptx-btl01, preparation method therefor, and uses thereof
CN106892968B (en) 2015-12-18 2021-11-05 深圳翰宇药业股份有限公司 Synthesis method of linaclotide
WO2017134687A1 (en) * 2016-02-03 2017-08-10 Cipla Limited A process for the preparation of guanylate cyclase 2c agonist
CN111732632B (en) * 2020-07-16 2021-12-21 台州吉诺生物科技有限公司 Synthesis method of linaclotide
CN112321681B (en) * 2020-10-29 2021-12-14 杭州信海医药科技有限公司 Preparation method of linaclotide
EP4194464A1 (en) 2021-12-13 2023-06-14 Chemi SPA Manufacturing process for the production of linaclotide

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020811A1 (en) * 2003-01-28 2005-01-27 Currie Mark G. Methods and compositions for the treatment of gastrointestinal disorders
WO2012118972A2 (en) * 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020811A1 (en) * 2003-01-28 2005-01-27 Currie Mark G. Methods and compositions for the treatment of gastrointestinal disorders
WO2012118972A2 (en) * 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MIRIAM GÓNGORA-BENÍTEZ ET AL: "Optimized Fmoc solid-phase synthesis of the cysteine-rich peptide linaclotide", BIOPOLYMERS, vol. 96, no. 1, 1 January 2011 (2011-01-01), pages 69 - 80, XP055047758, ISSN: 0006-3525, DOI: 10.1002/bip.21480 *

Also Published As

Publication number Publication date
WO2015022575A2 (en) 2015-02-19

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