WO2015009882A3 - Cyano derivatives and their uses - Google Patents
Cyano derivatives and their uses Download PDFInfo
- Publication number
- WO2015009882A3 WO2015009882A3 PCT/US2014/046937 US2014046937W WO2015009882A3 WO 2015009882 A3 WO2015009882 A3 WO 2015009882A3 US 2014046937 W US2014046937 W US 2014046937W WO 2015009882 A3 WO2015009882 A3 WO 2015009882A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cyano
- ethyl
- hydrazinecarbonyl
- methylguanidine
- methylthio
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Compounds inhibit Nrf2 activity for treatment of mycobacterial infection, granulomatous inflammation, tuberculosis, viral infection, or cancer include 5-((2-(2-cyano-3-methylguanidino)ethylthio)methyl)-1 H-imidazole-4carboxamide; 2-cyano-1-(2-( ( 4-hydrazinecarbonyl)-1 H-im idazol-5-yl)methylthio )ethyl-3-methylguanidine; 5-((2-(2-cyano-3-methylguanidino)ethylthio)methyl)-1 H-imidazole-2-carboxamide; 2-cyano-1-(2-((2-hydrazinecarbonyl)-1 H-imidazol-5-yl)methylthio)ethyl-3-methylguanidine; 2-cyano-1-methyl-3-(2-((4- methyl-1 H-imidazol-5-yl)methylamino)ethylguanidine; 3-( ( 2-(2-cyano-3-m ethylg uan idino) ethylth io) m ethyl)pyrazine-2-carboxamide; 6-( ( 2-(2-cyano-3-m ethylg uan idino) ethylth io) m ethyl)pyrazine-2-carboxamide; 2-cyano-1-(2-( ( 4-hydrazinecarbonyl)pyridine-2-yl) methylthio )ethyl-3-methylguanidine; and 2-cyano-1-(2-( ( 4-hydrazinecarbonyl)pyridine-3-yl) methylthio)ethyl-3-methylguanidine; or a pharmaceutically acceptable salt thereof.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361847630P | 2013-07-18 | 2013-07-18 | |
US61/847,630 | 2013-07-18 | ||
US201361891956P | 2013-10-17 | 2013-10-17 | |
US61/891,956 | 2013-10-17 | ||
US201361908215P | 2013-11-25 | 2013-11-25 | |
US61/908,215 | 2013-11-25 | ||
US201462025049P | 2014-07-16 | 2014-07-16 | |
US62/025,049 | 2014-07-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2015009882A2 WO2015009882A2 (en) | 2015-01-22 |
WO2015009882A3 true WO2015009882A3 (en) | 2015-11-12 |
Family
ID=52346842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/046937 WO2015009882A2 (en) | 2013-07-18 | 2014-07-17 | Cyano derivatives and their uses |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2015009882A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201510077D0 (en) * | 2015-06-10 | 2015-07-22 | Novabiotics Ltd | Use |
CN114394939A (en) * | 2022-01-27 | 2022-04-26 | 河北科技大学 | Synthesis method of cimetidine |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
US5541212A (en) * | 1994-01-10 | 1996-07-30 | Metatron, Inc. | Use of cimetidine for the control of retrovirus infections |
US20020077343A1 (en) * | 1998-11-17 | 2002-06-20 | David S. Garvey | H2 receptor antagonist compounds in combination with nitric oxide donors, compostions and methods of use |
US20070281906A1 (en) * | 2001-12-06 | 2007-12-06 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
US20080274104A1 (en) * | 2005-02-10 | 2008-11-06 | Arlinghaus Ralph B | Targeting a Secreted Pro-Apoptotic Factor for Cancer Therapeutics |
-
2014
- 2014-07-17 WO PCT/US2014/046937 patent/WO2015009882A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5422350A (en) * | 1992-09-10 | 1995-06-06 | Warner-Lambert Company | Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use |
US5541212A (en) * | 1994-01-10 | 1996-07-30 | Metatron, Inc. | Use of cimetidine for the control of retrovirus infections |
US20020077343A1 (en) * | 1998-11-17 | 2002-06-20 | David S. Garvey | H2 receptor antagonist compounds in combination with nitric oxide donors, compostions and methods of use |
US20070281906A1 (en) * | 2001-12-06 | 2007-12-06 | Dalton James T | Selective androgen receptor modulators for treating diabetes |
US20080274104A1 (en) * | 2005-02-10 | 2008-11-06 | Arlinghaus Ralph B | Targeting a Secreted Pro-Apoptotic Factor for Cancer Therapeutics |
Also Published As
Publication number | Publication date |
---|---|
WO2015009882A2 (en) | 2015-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP3889153A4 (en) | Pyrimidine and five-membered nitrogen heterocycle derivative, preparation method therefor, and medical uses thereof | |
MY195002A (en) | Benzoxazepin oxazolidinone compounds and methods of use | |
EP3991731A4 (en) | Pyrimidine five-membered nitrogen heterocyclic derivative, preparation method thereof and pharmaceutical use thereof | |
MX2022013950A (en) | 2-(het)aryl-substituted condensed heterocyclic derivatives as pest control agents. | |
NZ742208A (en) | Topical pharmaceutical formulations for treating inflammatory-related conditions | |
PH12018500638A1 (en) | 2-(het)aryl-substituted condensed bicyclic heterocyclic derivatives as pest control agents | |
IL272444B (en) | Phenyl and heteroaryl derivatives of (1-substituted-piperidin-4- yl)urea, salts thereof and their use for treatment of diseases | |
MX2015005949A (en) | Antiviral azasugar-containing nucleosides. | |
UA122781C2 (en) | Pesticidally active heterocyclic derivatives with sulphur containing substituents | |
MX2017000305A (en) | Pesticidally active heterocyclic derivatives with sulphur containing substituents. | |
MX2017010124A (en) | 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents. | |
MX2017009880A (en) | 2-(het)aryl-substituted condensed bicyclic heterocycle derivatives as pest control agents. | |
MX2016001011A (en) | Substituted quinazolin-4-one derivatives. | |
BRPI1012331A2 (en) | "Active substance combinations nematicides, insecticides and acaricides comprising pyridyl ethylbenzamide and insecticides." | |
WO2014188178A9 (en) | Polymyxin derivatives and their use in combination therapy together with different antibiotics | |
WO2008130021A3 (en) | Heterocyclic hydrazide compound and pesticidal use of the same | |
WO2011133521A3 (en) | Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor | |
MX2016012448A (en) | Pesticidally active heterocyclic derivatives with sulphur containing substituents. | |
AU2015211852A1 (en) | Heterocyclic sulfonamide derivative and medicine comprising same | |
WO2011005052A8 (en) | Novel arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same | |
EP2583962A4 (en) | Novel thiourea or urea derivative, preparation method thereof, and pharmaceutical composition for preventing or treating aids, containing same as active ingredient | |
MX2016005324A (en) | Pesticidal compositions and related methods. | |
WO2015009882A3 (en) | Cyano derivatives and their uses | |
EP3470415A4 (en) | 5-membered heterocycle fused with [3,4-d]pyridazinone, and manufacturing method, pharmaceutical composition, and application thereof | |
CY1119483T1 (en) | THERAPEUTIC PARTY FOR ANXIETY DISORDERS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 14826082 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 14826082 Country of ref document: EP Kind code of ref document: A2 |