WO2014205074A3 - Devices, compositions and methods for imaging with raman scattering - Google Patents
Devices, compositions and methods for imaging with raman scattering Download PDFInfo
- Publication number
- WO2014205074A3 WO2014205074A3 PCT/US2014/042936 US2014042936W WO2014205074A3 WO 2014205074 A3 WO2014205074 A3 WO 2014205074A3 US 2014042936 W US2014042936 W US 2014042936W WO 2014205074 A3 WO2014205074 A3 WO 2014205074A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- raman scattering
- bond
- edited
- imaging
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N2021/653—Coherent methods [CARS]
- G01N2021/655—Stimulated Raman
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/974,992 US11408892B2 (en) | 2013-06-18 | 2015-12-18 | Devices, compositions and methods for imaging with raman scattering |
US15/927,463 US20180372632A1 (en) | 2013-06-18 | 2018-03-21 | Devices, compositions and methods for imaging with raman scattering |
US16/717,634 US11408894B2 (en) | 2013-06-18 | 2019-12-17 | Devices, compositions and methods for imaging with Raman scattering |
US17/027,515 US20210068663A1 (en) | 2013-06-18 | 2020-09-21 | Devices, compositions and methods for imaging with raman scattering and for super-multiplex vibrational imaging |
US17/882,938 US20230128716A1 (en) | 2013-06-18 | 2022-08-08 | Devices, compositions and methods for imaging with raman scattering |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361836235P | 2013-06-18 | 2013-06-18 | |
US61/836,235 | 2013-06-18 | ||
US201461946296P | 2014-02-28 | 2014-02-28 | |
US61/946,296 | 2014-02-28 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/974,992 Continuation-In-Part US11408892B2 (en) | 2013-06-18 | 2015-12-18 | Devices, compositions and methods for imaging with raman scattering |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014205074A2 WO2014205074A2 (en) | 2014-12-24 |
WO2014205074A3 true WO2014205074A3 (en) | 2016-02-04 |
Family
ID=52105496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2014/042936 WO2014205074A2 (en) | 2013-06-18 | 2014-06-18 | Devices, compositions and methods for imaging with raman scattering |
Country Status (1)
Country | Link |
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WO (1) | WO2014205074A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11408892B2 (en) | 2013-06-18 | 2022-08-09 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering |
WO2019183348A1 (en) * | 2018-03-21 | 2019-09-26 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering and for super-multiplex vibrational imaging |
WO2014205074A2 (en) * | 2013-06-18 | 2014-12-24 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering |
CN107741417B (en) * | 2017-09-28 | 2019-11-08 | 上海氘峰医疗器械有限公司 | A kind of method that cell biological processes are quickly detected in original position |
CN111491629A (en) | 2017-11-22 | 2020-08-04 | 康塞特医药品公司 | Deuterated analogs of D-serine and uses thereof |
CN111912826B (en) * | 2020-06-22 | 2024-03-01 | 上海氘峰医疗科技有限公司 | Method for evaluating efficacy of antitumor drug at cellular level |
Citations (7)
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US20030178561A1 (en) * | 2000-10-04 | 2003-09-25 | Tokudia Neda | Nondestructive reading method for isotopic label |
US20050250795A1 (en) * | 1997-02-10 | 2005-11-10 | Medivir Ab | Synthesis of acyclic nucleoside derivatives |
US20070134733A1 (en) * | 2003-07-10 | 2007-06-14 | Parallax Biosystems, Inc. | Raman signature probes and their use in the detection and imaging of molecular processes and structures |
US20090166560A1 (en) * | 2006-10-26 | 2009-07-02 | The Board Of Trustees Of The Leland Stanford Junior University | Sensing of biological molecules using carbon nanotubes as optical labels |
US20090176199A1 (en) * | 2007-12-14 | 2009-07-09 | Lee Wai-Nang P | Method of isotope labeling and determining protein synthesis, quantitation and protein expression |
US20090214515A1 (en) * | 2005-11-30 | 2009-08-27 | Holzman Thomas F | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
WO2014205074A2 (en) * | 2013-06-18 | 2014-12-24 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering |
-
2014
- 2014-06-18 WO PCT/US2014/042936 patent/WO2014205074A2/en active Application Filing
Patent Citations (7)
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---|---|---|---|---|
US20050250795A1 (en) * | 1997-02-10 | 2005-11-10 | Medivir Ab | Synthesis of acyclic nucleoside derivatives |
US20030178561A1 (en) * | 2000-10-04 | 2003-09-25 | Tokudia Neda | Nondestructive reading method for isotopic label |
US20070134733A1 (en) * | 2003-07-10 | 2007-06-14 | Parallax Biosystems, Inc. | Raman signature probes and their use in the detection and imaging of molecular processes and structures |
US20090214515A1 (en) * | 2005-11-30 | 2009-08-27 | Holzman Thomas F | Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins |
US20090166560A1 (en) * | 2006-10-26 | 2009-07-02 | The Board Of Trustees Of The Leland Stanford Junior University | Sensing of biological molecules using carbon nanotubes as optical labels |
US20090176199A1 (en) * | 2007-12-14 | 2009-07-09 | Lee Wai-Nang P | Method of isotope labeling and determining protein synthesis, quantitation and protein expression |
WO2014205074A2 (en) * | 2013-06-18 | 2014-12-24 | The Trustees Of Columbia University In The City Of New York | Devices, compositions and methods for imaging with raman scattering |
Non-Patent Citations (4)
Title |
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FU ET AL.: "Quantitative Chemical Imaging with Multiplex Stimulated Raman Scattering Microscopy", J AM CHEM SOC., vol. 134, 29 February 2012 (2012-02-29), pages 3623 - 3626, XP055133192, DOI: doi:10.1021/ja210081h * |
HUANG ET AL.: "A Noncoding, Regulatory Mutation Implicates HCFC1 in Nonsyndromic Intellectual Disability", AM J HUM GENET., vol. 91, 5 October 2012 (2012-10-05), pages 694 - 702 * |
SAAR ET AL.: "Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering", SCIENCE, vol. 330, 3 December 2010 (2010-12-03), pages 1368 - 1370, XP055053264, DOI: doi:10.1126/science.1197236 * |
WEI ET AL.: "Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy", PNAS, vol. 110, no. 28, 24 June 2013 (2013-06-24), pages 11226 - 11231 * |
Also Published As
Publication number | Publication date |
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WO2014205074A2 (en) | 2014-12-24 |
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