WO2014190331A3 - Nanophotonic raman spectroscopy biosensors - Google Patents

Nanophotonic raman spectroscopy biosensors Download PDF

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Publication number
WO2014190331A3
WO2014190331A3 PCT/US2014/039457 US2014039457W WO2014190331A3 WO 2014190331 A3 WO2014190331 A3 WO 2014190331A3 US 2014039457 W US2014039457 W US 2014039457W WO 2014190331 A3 WO2014190331 A3 WO 2014190331A3
Authority
WO
WIPO (PCT)
Prior art keywords
disclosed
monitoring
glucose
ultra
raman spectroscopy
Prior art date
Application number
PCT/US2014/039457
Other languages
French (fr)
Other versions
WO2014190331A2 (en
Inventor
Michal Lipson
Christopher PHARE
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of WO2014190331A2 publication Critical patent/WO2014190331A2/en
Publication of WO2014190331A3 publication Critical patent/WO2014190331A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0256—Compact construction
    • G01J3/0259—Monolithic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N2021/653—Coherent methods [CARS]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Methods, systems, and devices are disclosed for implementing an ultra-sensitive micro-Raman spectrometer based on high confinement nanometer-scale photonic structures, which can enhance the sensitivity while maintaining an extremely compact size. In one aspect, a portable, ultra-sensitive, chip-scale system for performing sensing and identification on liquid and gaseous samples based on Raman spectroscopy is disclosed. The disclosed chip-scale system can be especially useful for biosensing including glucose sensing and monitoring (e.g., finding concentrations of glucose in complex body fluids like blood, urine, or saliva). For example, in implementations for glucose monitoring, the disclosed technology can make an impact that not only provides relief from the typical required "finger prick" for blood sampling, but also provides an easy-to-use device that diabetics and other people in need of glucose monitoring (and eventually other types of monitoring) can use.
PCT/US2014/039457 2013-05-23 2014-05-23 Nanophotonic raman spectroscopy biosensors WO2014190331A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361826978P 2013-05-23 2013-05-23
US61/826,978 2013-05-23

Publications (2)

Publication Number Publication Date
WO2014190331A2 WO2014190331A2 (en) 2014-11-27
WO2014190331A3 true WO2014190331A3 (en) 2015-03-12

Family

ID=51934370

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/039457 WO2014190331A2 (en) 2013-05-23 2014-05-23 Nanophotonic raman spectroscopy biosensors

Country Status (1)

Country Link
WO (1) WO2014190331A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108225555A (en) * 2016-12-15 2018-06-29 中国科学院苏州纳米技术与纳米仿生研究所 The integrated package of detection chip and terahertz waveguide
WO2019032735A1 (en) 2017-08-08 2019-02-14 Massachusetts Institute Of Technology Miniaturized fourier-transform raman spectrometer systems and methods
US11041759B2 (en) 2018-06-28 2021-06-22 Massachusetts Institute Of Technology Systems and methods for Raman spectroscopy
IT201800009753A1 (en) * 2018-10-24 2020-04-24 Specto Srl Device and method for the spectroscopic analysis of scattered light
GB2580652A (en) * 2019-01-21 2020-07-29 Res & Innovation Uk Infrared spectrometer
US10983003B2 (en) 2019-02-11 2021-04-20 Massachusetts Institute Of Technology High-performance on-chip spectrometers and spectrum analyzers
US20220178831A1 (en) * 2019-04-25 2022-06-09 The Penn State Research Foundation Graphene Hybrids for Biological and Chemical Sensing
CN112683879B (en) * 2020-12-22 2023-03-17 山东大学 Polymer-based multielement surface enhanced Raman detection substrate and preparation method thereof
CN113418902B (en) * 2021-03-23 2023-10-13 重庆大学 On-chip Raman detection system
CN113238065A (en) * 2021-04-19 2021-08-10 吴志洪 Full-automatic detection device and detection method for trace drugs in sewage

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060228259A1 (en) * 2005-04-12 2006-10-12 Chromodex Inc. Joint-diagnostic spectroscopic and biosensor meter
US20070247620A1 (en) * 2006-04-21 2007-10-25 Tae-Woong Koo Apparatus and method for imaging with surface enhanced coherent anti-stokes raman scattering (SECARS)
US20080129997A1 (en) * 2006-12-01 2008-06-05 3M Innovative Properties Company Optical sensing methods
US20100007876A1 (en) * 2008-04-14 2010-01-14 General Electric Company Hollow-core waveguide-based raman systems and methods
US20120287429A1 (en) * 2011-05-13 2012-11-15 Katholieke Universiteit Leuven, K.U. Leuven R&D Waveguide-Integrated Plasmonic Resonator for Integrated SERS Measurements

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060228259A1 (en) * 2005-04-12 2006-10-12 Chromodex Inc. Joint-diagnostic spectroscopic and biosensor meter
US20070247620A1 (en) * 2006-04-21 2007-10-25 Tae-Woong Koo Apparatus and method for imaging with surface enhanced coherent anti-stokes raman scattering (SECARS)
US20080129997A1 (en) * 2006-12-01 2008-06-05 3M Innovative Properties Company Optical sensing methods
US20100007876A1 (en) * 2008-04-14 2010-01-14 General Electric Company Hollow-core waveguide-based raman systems and methods
US20120287429A1 (en) * 2011-05-13 2012-11-15 Katholieke Universiteit Leuven, K.U. Leuven R&D Waveguide-Integrated Plasmonic Resonator for Integrated SERS Measurements

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Publication number Publication date
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