WO2014177978A3 - An improved process for the preparation of teriflunomide - Google Patents

An improved process for the preparation of teriflunomide Download PDF

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Publication number
WO2014177978A3
WO2014177978A3 PCT/IB2014/060966 IB2014060966W WO2014177978A3 WO 2014177978 A3 WO2014177978 A3 WO 2014177978A3 IB 2014060966 W IB2014060966 W IB 2014060966W WO 2014177978 A3 WO2014177978 A3 WO 2014177978A3
Authority
WO
WIPO (PCT)
Prior art keywords
teriflunomide
preparation
improved process
formula
provides
Prior art date
Application number
PCT/IB2014/060966
Other languages
French (fr)
Other versions
WO2014177978A2 (en
Inventor
Venkat Raman JAYARAMAN
Samir Patel
Snehal Dhol
Vishal Ray
Original Assignee
Alembic Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alembic Pharmaceuticals Limited filed Critical Alembic Pharmaceuticals Limited
Publication of WO2014177978A2 publication Critical patent/WO2014177978A2/en
Publication of WO2014177978A3 publication Critical patent/WO2014177978A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/32—Separation; Purification; Stabilisation; Use of additives
    • C07C253/34—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides an improved process for preparation of Teriflunomide of formula (I).
PCT/IB2014/060966 2013-05-02 2014-04-24 An improved process for the preparation of teriflunomide WO2014177978A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1583MU2013 2013-05-02
IN1583/MUM/2013 2013-05-02

Publications (2)

Publication Number Publication Date
WO2014177978A2 WO2014177978A2 (en) 2014-11-06
WO2014177978A3 true WO2014177978A3 (en) 2015-02-19

Family

ID=51844038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/060966 WO2014177978A2 (en) 2013-05-02 2014-04-24 An improved process for the preparation of teriflunomide

Country Status (1)

Country Link
WO (1) WO2014177978A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017103942A1 (en) * 2015-12-14 2017-06-22 Natco Pharma Ltd An improved process for the preparation of teriflunomide
WO2019186429A1 (en) * 2018-03-30 2019-10-03 Sun Pharmaceutical Industries Limited A process for the preparation of bosutinib
CN112305097A (en) * 2020-09-30 2021-02-02 辰欣药业股份有限公司 Method for detecting substances related to teriflunomide tablets
CN115838340A (en) * 2022-12-31 2023-03-24 辰欣药业股份有限公司 Preparation method of teriflunomide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365626B1 (en) * 1998-08-21 2002-04-02 Parker Hughes Institute BTK inhibitors and methods for their identification and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365626B1 (en) * 1998-08-21 2002-04-02 Parker Hughes Institute BTK inhibitors and methods for their identification and use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ELIZABETH ET AL.: "Synthesis, Structure-Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy-N-[3-methyl-4- (trifluoromethyl)phenyl]propenamide and Related Compounds", JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, 1936, pages 4608 - 4621, XP000196780, DOI: doi:10.1021/jm9604437 *
MATTHEW ET AL.: "Structure-Based Design, Synthesis, and Characterization of Inhibitors of Human and Plasmodium falciparum Dihydroorotate Dehydrogenases", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 9, 2009, pages 2683 - 2693 *

Also Published As

Publication number Publication date
WO2014177978A2 (en) 2014-11-06

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