WO2014167428A3 - Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide - Google Patents

Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide Download PDF

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Publication number
WO2014167428A3
WO2014167428A3 PCT/IB2014/059443 IB2014059443W WO2014167428A3 WO 2014167428 A3 WO2014167428 A3 WO 2014167428A3 IB 2014059443 W IB2014059443 W IB 2014059443W WO 2014167428 A3 WO2014167428 A3 WO 2014167428A3
Authority
WO
WIPO (PCT)
Prior art keywords
thioxoimidazolidin
methylbenzamide
oxo
trifluoromethyl
fluoro
Prior art date
Application number
PCT/IB2014/059443
Other languages
French (fr)
Other versions
WO2014167428A2 (en
Inventor
Dr. RAFIUDDIN
Vinod Kumar Singh
Nagnnath KOKARE
Sanjay HIRPARA
Ashok Kumar ADDANKI
Pothuraju RAJU
Akshaykant CHATURVEDI
Original Assignee
Shilpa Medicare Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shilpa Medicare Limited filed Critical Shilpa Medicare Limited
Publication of WO2014167428A2 publication Critical patent/WO2014167428A2/en
Publication of WO2014167428A3 publication Critical patent/WO2014167428A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to amorphous 4-(3-(4-cyano-3-(trifluoromethyl) phenyl)- 5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide (I) (I) and process for preparation thereof. The invention further relates to a solid dispersion of 4-(3-(4-cyano-3-(trifluoromethyl) phenyl)-5, 5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide and at least one pharmaceutically acceptable carrier. The amorphous 4-(3-(4-cyano-3-(trifluoromethyl) phenyl)-5,5-dimethyl-4-oxo-2- thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide (I) and/or its solid dispersion of the present invention can be useful in the treatment of cancer.
PCT/IB2014/059443 2013-04-10 2014-03-05 Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide WO2014167428A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1630CH2013 2013-04-10
IN1630/CHE/2013 2013-04-10

Publications (2)

Publication Number Publication Date
WO2014167428A2 WO2014167428A2 (en) 2014-10-16
WO2014167428A3 true WO2014167428A3 (en) 2015-02-19

Family

ID=51690075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2014/059443 WO2014167428A2 (en) 2013-04-10 2014-03-05 Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide

Country Status (1)

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WO (1) WO2014167428A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3725778T (en) 2012-09-11 2021-09-22 Astellas Pharma Inc Formulations of enzalutamide
UA123538C2 (en) 2014-12-05 2021-04-21 Араґон Фармасьютікалз, Інк. Anticancer compositions
ES2839128T3 (en) 2014-12-05 2021-07-05 Aragon Pharmaceuticals Inc Anticancer compositions
RU2019138248A (en) * 2017-04-28 2021-05-28 Астеллас Фарма Инк. PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION, CONTAINING ENZALUTAMIDE
CA3152909A1 (en) 2019-10-03 2021-04-08 Synthon Bv Pharmaceutical composition comprising enzalutamide

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004074350A2 (en) * 2003-02-21 2004-09-02 Hetero Drugs Limited Bicalutamide polymorphs
WO2006124118A1 (en) * 2005-05-13 2006-11-23 The Regents Of The University Of California Diarylhydantoin compounds
WO2007127010A2 (en) * 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
WO2010099238A1 (en) * 2009-02-24 2010-09-02 Medivation Prostate Therapeutics, Inc. Specific diarylhydantoin and diarylthiohydantoin compounds
WO2011106570A1 (en) * 2010-02-24 2011-09-01 Medivation Prostate Therapeutics, Inc. Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004074350A2 (en) * 2003-02-21 2004-09-02 Hetero Drugs Limited Bicalutamide polymorphs
WO2006124118A1 (en) * 2005-05-13 2006-11-23 The Regents Of The University Of California Diarylhydantoin compounds
WO2007127010A2 (en) * 2006-03-29 2007-11-08 The Regents Of The University Of California Diarylthiohydantoin compounds
WO2010099238A1 (en) * 2009-02-24 2010-09-02 Medivation Prostate Therapeutics, Inc. Specific diarylhydantoin and diarylthiohydantoin compounds
WO2011106570A1 (en) * 2010-02-24 2011-09-01 Medivation Prostate Therapeutics, Inc. Processes for the synthesis of diarylthiohydantoin and diarylhydantoin compounds

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Publication number Publication date
WO2014167428A2 (en) 2014-10-16

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