WO2014146598A1 - Appareil de lyophilisation - Google Patents

Appareil de lyophilisation Download PDF

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Publication number
WO2014146598A1
WO2014146598A1 PCT/CN2014/073827 CN2014073827W WO2014146598A1 WO 2014146598 A1 WO2014146598 A1 WO 2014146598A1 CN 2014073827 W CN2014073827 W CN 2014073827W WO 2014146598 A1 WO2014146598 A1 WO 2014146598A1
Authority
WO
WIPO (PCT)
Prior art keywords
freeze
chamber
drying
cold trap
plate
Prior art date
Application number
PCT/CN2014/073827
Other languages
English (en)
Chinese (zh)
Inventor
李兴波
潘宝峰
翁宽
许海兵
康峰
Original Assignee
楚天科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 楚天科技股份有限公司 filed Critical 楚天科技股份有限公司
Publication of WO2014146598A1 publication Critical patent/WO2014146598A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B5/00—Drying solid materials or objects by processes not involving the application of heat
    • F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
    • F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing

Definitions

  • the invention mainly relates to the field of food and medical packaging machinery, and particularly relates to a lyophilizer.
  • the freeze-drying box and the cold trap of the traditional freeze-drying machine generally adopt a split structure, and are arranged side by side horizontally, that is, the freeze-drying box and the cold trap are two independent containers, between the two It is connected by a pipe connection and has an independent on-off valve.
  • the lyophilizer has the following disadvantages: 1.
  • the freeze-drying box and the cold trap are connected by a connecting pipe, and the connecting pipe needs to open a large hole in the lyophilizing box and the cold trap, and the large flange is connected and connected, and the connecting pipe is to be connected and connected in the middle.
  • the freeze-drying box and the cold trap are two independent containers arranged horizontally side by side, and the manufacturing cost is high. It takes up a lot of space and is inconvenient to assemble and transport.
  • the technical problem to be solved by the present invention is to provide a lyophilizer with simple structure, low cost, small space occupation and low risk of pollution in view of the deficiencies of the prior art.
  • the present invention adopts the following technical solutions:
  • a lyophilizer comprising a lyophilization chamber and a cold trap chamber, wherein the lyophilization chamber is provided with a support plate and a plurality of lyophilized plate layers above the support plate, wherein the support plate is connected to the lyophilization chamber for use a lifting drive member for driving the lifting plate and the lyophilized plate layer, wherein the lyophilization chamber is located above the cold trap chamber, and the lyophilization chamber and the cold trap chamber are communicated through a through hole provided at a bottom of the lyophilization chamber.
  • the cold trap chamber or lyophilization chamber is provided with a seal for covering the through hole to isolate the freeze dry chamber from the cold trap chamber.
  • the lyophilization chamber and the cold trap chamber are separated by an integral cavity, and the integral cavity is provided with a partition separating the whole cavity into a lyophilization chamber and a cold trap chamber, and the through hole is opened on the partition plate.
  • the partitions are arranged horizontally.
  • the lifting drive member is mounted on the lyophilization chamber or the cold trap chamber, the sealing member is a support plate, and the bottom of the support plate is provided with a sealing ring for contacting and engaging with the partition plate.
  • the bottom of the cold trap chamber is provided with a drain port.
  • a coil for cooling is provided in the cold trap chamber.
  • the support plate When the lyophilized plate is laminated, the support plate is lowered to the bottom of the lyophilization chamber and covers the through hole to support the lyophilized layer Support.
  • the lifting and lowering driving member When the lifting and lowering driving member is disposed on the cold trap cavity, and the supporting plate is lowered to the bottom of the freeze-drying chamber and covers the through hole, the lifting and lowering driving member drives the supporting plate to be pressed against the periphery of the through hole.
  • the upper limit plate is disposed above the top layer of the lyophilized layer.
  • the lifting drive member is disposed on the lyophilization chamber, the sealing member is a sealing plate disposed in the cold trap cavity or the freeze-drying chamber, and the cold trap cavity is provided with a sealing driving member for driving the sealing plate.
  • the sealing driving member drives the sealing plate to be pressed against the periphery of the through hole.
  • the lower end surface of the baffle When the sealing plate is disposed in the cold trap cavity, the lower end surface of the baffle is provided with a sealing ring that is in contact with the sealing plate; when the sealing plate is disposed in the freeze-drying cavity, the upper end surface of the baffle is provided with a sealing plate Contact mating seals.
  • the support plate When the lyophilized plate is laminated, the support plate is lowered to the bottom of the lyophilization chamber to support the lyophilized layer.
  • the lyophilizer of the invention has a lyophilization chamber located above the cold trap chamber, which has a compact structure and a small occupied space;
  • the lyophilizer of the present invention has a lyophilization chamber communicated with the cold trap chamber through the through hole, and can be covered by the support plate to close the lyophilization chamber and the cold trap chamber, so the freeze-dry chamber
  • the switching between the cold trap chamber and the cold trap chamber can be realized by the support plate and the lifting drive member, and it is no longer necessary to provide independent on-off valves and valve cylinders, thereby simplifying the structure, reducing the cost, and avoiding the risk of contamination caused by the valve cylinders, and Optimize the design, manufacture, acceptance, cost control, control procedures, etc. of the freeze dryer;
  • the lyophilizer of the present invention wherein the lyophilization chamber and the cold trap chamber are separated by a whole cavity, the space can be compressed, the manufacturing material is saved, and the lyophilization chamber and the cold trap chamber can share the inlet and outlet pipes, the safety valve and Drainage port.
  • the lyophilizer according to the present invention wherein the lifting drive member is disposed on the cold trap cavity, and when the support plate is lowered to the bottom of the freeze-drying chamber and covers the through hole, the lifting drive member applies a downward pulling force to the support plate.
  • the plate is driven to be pressed around the periphery of the through hole to obtain a better sealing and isolation effect, and the pressure rise of the freeze-drying chamber can be measured more accurately, and the lyophilization is accurately determined.
  • the sealing member is a sealing plate disposed in the cold trap cavity or the freeze-drying cavity, and when the sealing plate covers the through hole, the sealing plate is driven to press the sealing plate against the periphery of the through hole, thereby A better sealing effect can be obtained, which can more accurately measure the pressure rise of the freeze-drying chamber and accurately determine whether the freeze-drying is sufficient.
  • FIG. 1 is a schematic structural view of a first embodiment of the present invention when a freeze-drying chamber and a cold trap chamber are in a connected state.
  • FIG. 2 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 1 of the present invention.
  • FIG 3 is a schematic structural view of the embodiment 2 of the present invention when the freeze-drying chamber and the cold trap chamber are in a connected state.
  • FIG. 4 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 2 of the present invention.
  • FIG. 5 is a schematic structural view of the third embodiment of the present invention when the freeze-drying chamber and the cold trap chamber are in an isolated state.
  • 6 is a schematic view showing the structure of the lyophilization chamber and the cold trap chamber in an isolated state according to Embodiment 3 of the present invention. Legend: 1. Freeze-drying chamber; 2. Support plate; 3. Freeze-dried plate layer; 4. Lifting drive member; 5. Cold trap cavity; 6. Partition; 7. Drainage port; 8. Coil; Through hole; 10, sealing ring; 11, sealing plate; 12, sealing drive member; 13, upper limit plate.
  • the lyophilizer of the present invention comprises a lyophilization chamber 1 and a cold trap chamber 5, and a coil 8 for cooling is provided in the cold trap chamber 5; a slab 2 is provided in the lyophilization chamber 1 and is located
  • the lyophilized plate layer 3 above the support plate 2 is provided with a lifting drive member 4 for driving the support plate 2 and the lyophilized plate layer 3 to be lifted and lowered.
  • the lifting drive member 4 in the embodiment is a cylinder. .
  • the support plate 2 and each lyophilized plate layer 3 are lowered by the lifting drive member 4, so that each lyophilized plate
  • the layers 3 are pressed against each other to press the plug on the bottle completely into the mouth of the bottle; the support 2 is lowered to the bottom of the freeze-drying chamber 1 to support the freeze-dried layer 3.
  • the freeze-drying chamber 1 is located above the cold trap chamber 5, and the freeze-drying chamber 1 and the cold trap chamber 5 are connected by a through hole 9 provided at the bottom of the freeze-drying chamber 1; as shown in Fig. 2, when the support plate 2 is driven by the lift When the member 4 is driven down to the bottom of the freeze-drying chamber 1, the through hole 9 can be covered to isolate the freeze-drying chamber 1 from the cold trap chamber 5.
  • the freeze-drying chamber 1 and the cold trap chamber 5 are separated by a whole cavity, and the whole chamber is provided with a partition 6 separating the whole cavity into the freeze-drying chamber 1 and the cold trap chamber 5, and the partition plate 6 is laterally It is arranged such that the lyophilization chamber 1 and the cold trap chamber 5 are arranged one above the other, and the through hole 9 is opened on the partition plate 6.
  • the support plate 2 can be driven by the lifting and lowering drive member 4 to descend to the bottom of the freeze-drying chamber 1 to be in contact with the partition plate 6.
  • the hole 9 is covered.
  • the support plate 2 can be used for supporting the freeze-dried plate layer 3 during the plugging, and can also serve as a valve for the freeze-drying chamber 1 to open and close with the cold trap chamber 5; the lifting and lowering drive member 4 can be used for driving when the plug is pressed.
  • the power can also be driven as a valve for the lyophilization chamber 1 and the cold trap chamber 5 to open and close.
  • the partitions 6 are horizontally arranged to facilitate better contact engagement with the partitions 6 when the support 2 is lowered to the bottom of the freeze-drying chamber 1.
  • the bottom of the support plate 2 is provided with a sealing ring 10 for contact engagement with the partition plate 6 to ensure the reliability of the isolation and to provide proper cushioning when the support plate 2 is in contact with the partition plate 6.
  • the bottom of the cold trap chamber 5 is provided with a drain port 7; during operation, the condensed water generated by the freeze-drying chamber 1 and the cold trap chamber 5 is discharged from the drain port 7.
  • this embodiment is basically the same as Embodiment 1, except that the seal is in this embodiment.
  • a lower portion of the cold trap chamber 5 is provided with a sealing driving member 12 for driving the sealing plate 11, and when the sealing plate 11 covers the through hole 9, the sealing driving member 12 applies the sealing plate 11
  • the upward lifting force drives the sealing plate 11 to be pressed against the periphery of the through hole 9, thereby obtaining a better sealing isolation effect, and can more accurately measure the pressure rise of the freeze-drying chamber 1, and accurately determine whether the lyophilization is sufficient (freeze dryer) Mainly to evaporate the water in the mixture in the bottle, seal the freeze-drying chamber 1 before the plugging, and measure the pressure rise of the freeze-drying chamber 1.
  • the lower end surface of the partition plate 6 is provided with a sealing ring 10 which is in contact with the sealing plate 11 to further improve the sealing effect.
  • the upper end surface of the partition plate 6 is provided with a sealing ring 10 that is in contact with the sealing plate 11.
  • the support 2 is lowered onto the partition 6 at the bottom of the freeze-drying chamber 1 to support the lyophilized ply 3, and the lyophilized ply 3 is pressed against the stopper.
  • this embodiment is basically the same as the first embodiment except that: in this embodiment, the lifting drive member 4 is disposed at the bottom of the cold trap cavity 5, and when the support plate 2 is lowered to the freeze-drying chamber 1 When the bottom portion covers the through hole 9, the lifting driving member 4 applies a downward pulling force to the supporting plate 2 to drive the supporting plate 2 to be pressed around the periphery of the through hole 9, thereby obtaining a better sealing isolation effect, which can be more accurately measured.
  • the pressure rise of the freeze-drying chamber 1 accurately determines whether the lyophilization is sufficient.
  • an upper limit plate 13 is disposed above the top lyophilized layer 3, and when the lifting drive 4 drives the support 2 to move upward until the uppermost bottle moves to the upper limit by the upper limit plate 13, all The tampon of the bottle.
  • the lifting and lowering drive member 4 is a hydraulic push rod, and the cylinder portion of the hydraulic push rod is located in the cold trap chamber 5, so that the telescopic length of the push rod can be shortened, and the smoothing action of the plugging operation can be ensured.
  • the cylinder of the hydraulic push rod is disposed outside the cold trap chamber 5, so that the occupation of the volume of the cold trap chamber 5 by the hydraulic push rod can be reduced, so that the cold trap chamber 5 can be appropriately reduced, and the space occupied by the whole machine can be reduced.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Drying Of Solid Materials (AREA)
  • Freezing, Cooling And Drying Of Foods (AREA)

Abstract

L'invention concerne un appareil de lyophilisation, comprenant une chambre de lyophilisation (1) et une chambre de piège à froid (5). La chambre de lyophilisation (1) est dotée d'une plaque de support (2) et de multiples couches de plaque de lyophilisation (3) situées au-dessus de la plaque de support (2); la plaque de support (2) est reliée à un composant d'entraînement de levage (4) destiné à soulever ladite plaque de lyophilisation (2), et la couche de plaque de lyophilisation (3); la chambre de lyophilisation (1) est située au-dessus de couches de plaque de lyophilisation (5), et communique avec ladite chambre de piège à froid (5) via un trou traversant (9) agencé sur la partie inferieure de la chambre de lyophilisation (1); et la chambre de piège à froid (5) ou la chambre de lyophilisation (1) est équipée d'un joint pour recouvrir le trou traversant (9) afin de séparer la chambre de lyophilisation (1) de la chambre de piège à froid (5). L'appareil de lyophilisation présente une structure simple, un prix abordable, un faible encombrement et un risque de pollution réduit.
PCT/CN2014/073827 2013-03-21 2014-03-21 Appareil de lyophilisation WO2014146598A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN201310091950.5 2013-03-21
CN 201310091950 CN103123206A (zh) 2013-03-21 2013-03-21 一种冻干机
CN201410102030.3A CN103900352B (zh) 2013-03-21 2014-03-19 一种冻干机
CN201410102030.3 2014-03-19
CN201410102024.8 2014-03-19
CN201410102024.8A CN103900351B (zh) 2013-03-21 2014-03-19 冻干机

Publications (1)

Publication Number Publication Date
WO2014146598A1 true WO2014146598A1 (fr) 2014-09-25

Family

ID=48454276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2014/073827 WO2014146598A1 (fr) 2013-03-21 2014-03-21 Appareil de lyophilisation

Country Status (2)

Country Link
CN (5) CN103123206A (fr)
WO (1) WO2014146598A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112325571A (zh) * 2020-11-09 2021-02-05 上海东富龙制药设备制造有限公司 一种用于冻干机的可升降的翻板板层***

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CN103123206A (zh) * 2013-03-21 2013-05-29 楚天科技股份有限公司 一种冻干机
CN103365318B (zh) * 2013-07-12 2016-02-24 楚天科技股份有限公司 一种冻干机板层温度智能控制方法及***
CN103615871A (zh) * 2013-11-05 2014-03-05 无锡凯夫制药有限公司 一种改进的冻干机结构
CN105091507B (zh) * 2015-08-26 2017-11-21 楚天科技股份有限公司 一种冷冻干燥机
CN105258458B (zh) * 2015-10-15 2018-03-09 楚天科技股份有限公司 一种板层可升降可倾斜的冻干机
CN105258459B (zh) * 2015-11-04 2017-06-16 楚天科技股份有限公司 一种板层可升降可倾斜的冻干机
CN108571863A (zh) * 2017-03-13 2018-09-25 天津东江食品股份有限公司 用于冻干机的冻干箱的密封圈
CN108645121B (zh) * 2018-08-08 2024-07-09 天津迦楠制药设备有限公司 一种原料药冷冻干燥机的板层***
CN110030801A (zh) * 2019-04-08 2019-07-19 上海东富龙科技股份有限公司 一种全密闭自动进出料型原料真空冷冻干燥设备
CN110044172B (zh) * 2019-05-08 2020-07-31 宁波新芝冻干设备股份有限公司 用于冻干机的物料放置架
CN113091400A (zh) * 2021-04-30 2021-07-09 楚天科技股份有限公司 冻融机的冻融方法及冻融机
CN114459211B (zh) * 2022-01-22 2023-04-07 上海田枫实业有限公司 一种冻干机
CN114392580B (zh) * 2022-03-24 2022-07-05 广东盈峰科技有限公司 一种冷阱装置
CN114877632B (zh) * 2022-06-01 2023-06-23 浙江正艺玩具有限公司 一种木制品加工用木材烘干装置

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EP2320184A1 (fr) * 2008-07-10 2011-05-11 Ulvac, Inc. Dispositif et procédé de lyophilisation
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112325571A (zh) * 2020-11-09 2021-02-05 上海东富龙制药设备制造有限公司 一种用于冻干机的可升降的翻板板层***

Also Published As

Publication number Publication date
CN203869422U (zh) 2014-10-08
CN103900351B (zh) 2016-05-11
CN103900351A (zh) 2014-07-02
CN103900352A (zh) 2014-07-02
CN203837417U (zh) 2014-09-17
CN103900352B (zh) 2016-03-23
CN103123206A (zh) 2013-05-29

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