WO2014145002A3 - Low molecular weight silk compositions and stabilizing silk compositions - Google Patents

Low molecular weight silk compositions and stabilizing silk compositions Download PDF

Info

Publication number
WO2014145002A3
WO2014145002A3 PCT/US2014/029636 US2014029636W WO2014145002A3 WO 2014145002 A3 WO2014145002 A3 WO 2014145002A3 US 2014029636 W US2014029636 W US 2014029636W WO 2014145002 A3 WO2014145002 A3 WO 2014145002A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
molecular weight
low molecular
silk
silk compositions
Prior art date
Application number
PCT/US2014/029636
Other languages
French (fr)
Other versions
WO2014145002A2 (en
Inventor
David L. Kaplan
Jonathan A. KLUGE
Fiorenzo G. Omenetto
Original Assignee
Trustees Of Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51538404&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2014145002(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to US14/775,200 priority Critical patent/US20160046679A1/en
Priority to EP22188893.6A priority patent/EP4180448A1/en
Priority to EP18163799.2A priority patent/EP3412682B1/en
Priority to KR1020237003679A priority patent/KR20230021768A/en
Priority to KR1020157029775A priority patent/KR102457668B1/en
Priority to JP2016503176A priority patent/JP6457482B2/en
Priority to EP14763730.0A priority patent/EP2970411B1/en
Priority to AU2014233480A priority patent/AU2014233480B2/en
Priority to CA2905090A priority patent/CA2905090C/en
Priority to KR1020217038630A priority patent/KR20210149207A/en
Application filed by Trustees Of Tufts College filed Critical Trustees Of Tufts College
Publication of WO2014145002A2 publication Critical patent/WO2014145002A2/en
Publication of WO2014145002A3 publication Critical patent/WO2014145002A3/en
Priority to US15/068,083 priority patent/US11376329B2/en
Priority to AU2018260835A priority patent/AU2018260835B2/en
Priority to AU2020220142A priority patent/AU2020220142B2/en
Priority to US17/829,271 priority patent/US20240082405A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
    • C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Insects & Arthropods (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present disclosure provides certain silk-fibroin compositions with particular characteristics and/or properties. In some embodiments, the disclosure provides low molecular weight compositions. In some embodiments, the disclosure provides silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, the disclosure provides low molecular weight silk fibroin compositions that comprise an active (e.g., a biological) agent or component. In some embodiments, an active agent is stabilized in a silk composition, e.g., for a period of time and/or against certain conditions or events. In some embodiments, a component present in a silk fibroin composition may be subject to analysis and/or characterization. In some embodiments, a component present in a silk fibroin composition may be recovered from the composition.
PCT/US2014/029636 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions WO2014145002A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
AU2014233480A AU2014233480B2 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
KR1020217038630A KR20210149207A (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
CA2905090A CA2905090C (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
KR1020237003679A KR20230021768A (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
EP22188893.6A EP4180448A1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
JP2016503176A JP6457482B2 (en) 2013-03-15 2014-03-14 Low molecular weight silk composition and stabilization of silk composition
EP14763730.0A EP2970411B1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
US14/775,200 US20160046679A1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
EP18163799.2A EP3412682B1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
KR1020157029775A KR102457668B1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
US15/068,083 US11376329B2 (en) 2013-03-15 2016-03-11 Low molecular weight silk compositions and stabilizing silk compositions
AU2018260835A AU2018260835B2 (en) 2013-03-15 2018-11-06 Low molecular weight silk compositions and stabilizing silk compostions
AU2020220142A AU2020220142B2 (en) 2013-03-15 2020-08-20 Low molecular weight silk compositions and stabilizing silk compostions
US17/829,271 US20240082405A1 (en) 2013-03-15 2022-05-31 Low Molecular Weight Silk Compositions and Stabilizing Silk Compositions

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361792161P 2013-03-15 2013-03-15
US61/792,161 2013-03-15
US201361830950P 2013-06-04 2013-06-04
US61/830,950 2013-06-04
US201361883732P 2013-09-27 2013-09-27
US61/883,732 2013-09-27
US201361909687P 2013-11-27 2013-11-27
US61/909,687 2013-11-27

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/775,200 A-371-Of-International US20160046679A1 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions
US15/068,083 Continuation US11376329B2 (en) 2013-03-15 2016-03-11 Low molecular weight silk compositions and stabilizing silk compositions

Publications (2)

Publication Number Publication Date
WO2014145002A2 WO2014145002A2 (en) 2014-09-18
WO2014145002A3 true WO2014145002A3 (en) 2015-01-29

Family

ID=51538404

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2014/029636 WO2014145002A2 (en) 2013-03-15 2014-03-14 Low molecular weight silk compositions and stabilizing silk compositions

Country Status (8)

Country Link
US (2) US20160046679A1 (en)
EP (3) EP4180448A1 (en)
JP (4) JP6457482B2 (en)
KR (3) KR20210149207A (en)
AU (3) AU2014233480B2 (en)
CA (2) CA2905090C (en)
ES (1) ES2935659T3 (en)
WO (1) WO2014145002A2 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10035920B2 (en) * 2012-11-27 2018-07-31 Tufts University Biopolymer-based inks and use thereof
US11376329B2 (en) 2013-03-15 2022-07-05 Trustees Of Tufts College Low molecular weight silk compositions and stabilizing silk compositions
EP3052203A4 (en) 2013-09-30 2017-08-23 Silk Therapeutics Inc. Silk protein fragment compositions and articles manufactured therefrom
US10513802B2 (en) 2013-11-08 2019-12-24 Tufts University Peptide-based nanofibrillar materials
CN104592375A (en) * 2014-12-16 2015-05-06 苏州丝美特生物技术有限公司 Method for preparing fibroin microspheres by using polyethylene glycol
CN107105724B (en) 2014-08-20 2021-02-26 蚕丝科技有限公司 Fibroin-derived protein compositions
CN113564927A (en) 2014-12-02 2021-10-29 丝绸医疗公司 Silk performance garments and products and methods of making same
WO2016115159A1 (en) * 2015-01-12 2016-07-21 Silk Therapeutics, Inc. Preserved silk protein fragment compositions and articles
US10166315B2 (en) * 2015-05-04 2019-01-01 Nanofiber Solutions, Inc. Chitosan-enhanced electrospun fiber compositions
KR20180072664A (en) 2015-07-14 2018-06-29 실크 테라퓨틱스, 인코퍼레이티드 Silk performance garments and products and their manufacturing methods
WO2017106631A1 (en) 2015-12-18 2017-06-22 Tufts University Silk solution purification system, concentrating system, and methods thereof
CN108699260A (en) * 2016-01-29 2018-10-23 国立研究开发法人理化学研究所 Formed body and its manufacturing method and the method for making the crystallinity of formed body improve
US20190031843A1 (en) * 2016-01-29 2019-01-31 Riken Molded Article, Production Method for Same, and Method for Improving Toughness of Molded Article
AU2017243878B2 (en) * 2016-03-31 2021-09-09 Deakin University Improved silk fibroin glycerol membranes
WO2017200659A2 (en) 2016-04-08 2017-11-23 Cornell University A method to enhance wound healing using silk-derived protein
EP3496662A4 (en) * 2016-08-12 2019-10-30 Silk Technologies Ltd. Silk-derived protein for treating inflammation
WO2018081805A1 (en) 2016-10-31 2018-05-03 Sofregen Medical, Inc. Compositions comprising low molecular weight silk fibroin fragments and plasticizers
CN106564997B (en) * 2016-11-14 2020-04-03 西南交通大学 Water purification element, preparation method of water purification element and water purifier
CN109996805B (en) * 2016-11-29 2023-03-28 丝芭博株式会社 Protein composition, method for producing same, and method for improving thermal stability
JP7495707B2 (en) * 2016-12-27 2024-06-05 Ｓｐｉｂｅｒ株式会社 Protein Recovery Method
US20200054796A1 (en) * 2017-02-21 2020-02-20 Trustees Of Tufts College Silk Fibroin Tracheal Stent
US11390988B2 (en) 2017-09-27 2022-07-19 Evolved By Nature, Inc. Silk coated fabrics and products and methods of preparing the same
US20210236644A1 (en) 2017-11-10 2021-08-05 Cocoon Biotech Inc. Ocular applications of silk-based products
US11684588B2 (en) * 2018-02-26 2023-06-27 Fidia Farmaceutici S.P.A. Multilayer composite material
US20210085598A1 (en) 2018-04-03 2021-03-25 Vaxess Technologies, Inc. Microneedle comprising silk fibroin applied to a dissolvable base
EP3830576A2 (en) 2018-07-27 2021-06-09 Vaxess Technologies, Inc. Polymer-based biospecimen collection devices and uses thereof
WO2020054873A1 (en) * 2018-09-14 2020-03-19 Ｓｐｉｂｅｒ株式会社 Method for producing fibroin solution and method for producing protein molded body
WO2020117368A2 (en) * 2018-10-10 2020-06-11 Trustees Of Tufts College Compression and heat-assisted production of silk-based materials
US20200178576A1 (en) * 2018-12-10 2020-06-11 Cambridge Crops, Inc. Compositions and methods for polymer based shelf life extension
WO2020158946A1 (en) * 2019-01-31 2020-08-06 Ｓｐｉｂｅｒ株式会社 Modified fibroin solution, and method for producing modified fibroin molding
KR102223544B1 (en) * 2019-05-16 2021-03-05 대한민국(농촌진흥청장) Method for Separating Sericin Protein for Preventing or Treating Bone Diseases and Uses Thereof
CA3142608A1 (en) 2019-06-04 2020-12-10 Cocoon Biotech Inc. Silk-based products, formulations, and methods of use
EP3986488A4 (en) * 2019-06-20 2023-07-19 Trustees of Tufts College Adhesive composition and method of making and using the same
WO2021055903A1 (en) * 2019-09-20 2021-03-25 Evolved By Nature, Inc. Edible silk and methods of making and using thereof
US11738174B2 (en) 2019-10-15 2023-08-29 Sofregen Medical, Inc. Delivery devices for delivering and methods of delivering compositions
CN110540404B (en) * 2019-10-17 2022-06-10 广州润虹医药科技股份有限公司 Calcium phosphate bone cement with hollow through structure, preparation method and application thereof
CN110841070A (en) * 2019-11-29 2020-02-28 苏州丝美特生物技术有限公司 Silk fibroin-based material loaded with active ingredients and preparation and application thereof
TW202144386A (en) 2020-02-12 2021-12-01 美商保爾特紡織品公司 Recombinant silk solids and films
WO2022026495A1 (en) * 2020-07-28 2022-02-03 University Of Georgia Research Foundation, Inc. Antimicrobial silk nanoparticles and methods for making and using the same
KR102194995B1 (en) * 2020-09-16 2020-12-28 장혜란 stabilization compoation of improved dried humoral diagnosis and its opplication method
CN114903809A (en) * 2021-02-08 2022-08-16 李和伟 Single-matrix freeze-dried excipient, preparation method thereof and freeze-dried preparation for beautifying and protecting skin
US11976196B2 (en) 2021-04-14 2024-05-07 Cambridge Crops, Inc. Silk packaging applications
WO2022246342A1 (en) 2021-05-21 2022-11-24 Cambridge Crops, Inc. d/b/a Mori Systems and methods for manufacturing a silk fibroin solution and powders containing silk fibroin
US11864569B2 (en) 2021-08-16 2024-01-09 Cambridge Crops, Inc. Systems and methods for improving the performance of cereal using a silk fibroin solution and powders containing silk fibroin
WO2023201183A1 (en) * 2022-04-15 2023-10-19 Unm Rainforest Innovations Well-controlled electrospun nanostructures and methods thereof
CN114870066A (en) * 2022-04-21 2022-08-09 田耿家 Functional dressing for treating chronic wound surface, preparation and preparation method thereof
WO2023250117A2 (en) 2022-06-24 2023-12-28 Vaxess Technologies, Inc. Applicator for medicament patch
CN115192777B (en) * 2022-07-15 2023-11-17 江西理工大学南昌校区 Degradable hydroxyapatite/levorotatory polylactic acid alveolar bone implant and preparation method thereof
WO2024081733A2 (en) * 2022-10-11 2024-04-18 Trustees Of Tufts College Silk coating of reeds of instruments
CN118085685A (en) * 2024-04-23 2024-05-28 山东孚日宣威新材料科技有限公司 Solvent-free marine heavy-duty anti-corrosion and anti-fouling coating material and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035124A2 (en) * 2001-10-25 2003-05-01 University Of Connecticut Fibroin compositions and methods of making the same
US20110305765A1 (en) * 2008-11-21 2011-12-15 Board Of Regents, The University Of Texas System Preparation and methodology of silk fibroin nanoparticles
US20120070427A1 (en) * 2009-06-01 2012-03-22 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
WO2012145739A1 (en) * 2011-04-21 2012-10-26 Trustees Of Tufts College Compositions and methods for stabilization of active agents

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US387413A (en) 1888-08-07 Wire fence
US3270960A (en) 1964-09-11 1966-09-06 Sperry Rand Corp Fluid sensor
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3832253A (en) 1973-03-21 1974-08-27 Baxter Laboratories Inc Method of making an inflatable balloon catheter
JPS6041043B2 (en) * 1980-06-11 1985-09-13 一丸フアルコス株式会社 Skin cosmetics containing solubilized silk peptides
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4667014A (en) 1983-03-07 1987-05-19 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
CA1200416A (en) 1983-05-13 1986-02-11 Societe Des Produits Nestle S.A. Food process
US4806355A (en) 1983-06-06 1989-02-21 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US5263992A (en) 1986-10-17 1993-11-23 Bio-Metric Systems, Inc. Biocompatible device with covalently bonded biocompatible agent
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
EP0330134A1 (en) 1988-02-25 1989-08-30 Akzo Nobel N.V. Modified cellulose for biocompatible dialysis membranes IV, and method for its preparation
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5015476A (en) 1989-08-11 1991-05-14 Paravax, Inc. Immunization implant and method
US5270419A (en) 1990-01-19 1993-12-14 Nova Pharmaceutical Corporation Polyanhydrides of oligomerized unsaturated aliphatic acids
US5245012A (en) 1990-04-19 1993-09-14 The United States Of America As Represented By The Secretary Of The Army Method to achieve solubilization of spider silk proteins
JPH04167172A (en) 1990-10-31 1992-06-15 Nec Corp Vector processor
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
JPH0670702A (en) * 1992-08-27 1994-03-15 Shinano Kenshi Kk Production of silk powder
JPH06292595A (en) * 1993-04-05 1994-10-21 Kiyoshi Hirabayashi Production of low-molecular weight fibroin
JPH0767686A (en) * 1993-09-06 1995-03-14 Shinano Kenshi Co Ltd Production of silk fibroin peptide having low molecular weight
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
EP0848754A1 (en) 1995-08-22 1998-06-24 Richard M. Basel Cloning methods for high strength spider silk proteins
US5576881A (en) 1995-08-29 1996-11-19 Lucent Technologies Inc. Multi-frequency optical signal source having reduced distortion and crosstalk
US5855613A (en) 1995-10-13 1999-01-05 Islet Sheet Medical, Inc. Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
US5814328A (en) 1997-01-13 1998-09-29 Gunasekaran; Subramanian Preparation of collagen using papain and a reducing agent
AU7486798A (en) 1997-05-12 1998-12-08 Metabolix, Inc. Polyhydroxyalkanoates for (in vivo) applications
US5932552A (en) 1997-11-26 1999-08-03 Keraplast Technologies Ltd. Keratin-based hydrogel for biomedical applications and method of production
JP4074923B2 (en) * 1997-12-25 2008-04-16 エンザミンインターナショナル株式会社 Purified silk fibroin solution and method for producing the same
US5902800A (en) 1998-03-27 1999-05-11 Glenpharma Dextran formulations and method for treatment of inflammatory joint disorders
NZ508815A (en) 1998-05-29 2005-02-25 Sugen Inc Pyrrole substituted 2-indolinone protein kinase inhibitors
US6302848B1 (en) 1999-07-01 2001-10-16 Sonotech, Inc. In vivo biocompatible acoustic coupling media
US6103255A (en) 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6267776B1 (en) 1999-05-03 2001-07-31 O'connell Paul T. Vena cava filter and method for treating pulmonary embolism
US6325810B1 (en) 1999-06-30 2001-12-04 Ethicon, Inc. Foam buttress for stapling apparatus
US6310188B1 (en) 2000-01-24 2001-10-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for producing chitin or chitosan
JP4638735B2 (en) 2002-06-24 2011-02-23 タフツ ユニバーシティー Silk biomaterial and method of using the same
US20030235546A1 (en) 2002-06-24 2003-12-25 Jairajh Mattai Cool and dry antiperspirant stick
JP3851928B2 (en) * 2002-10-07 2006-11-29 独立行政法人農業生物資源研究所 Modified silk powder with excellent cell viability, its production method and use thereof
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
JP3906924B2 (en) * 2003-02-28 2007-04-18 独立行政法人農業生物資源研究所 Extraction and utilization of cell growth peptides from silk proteins
US7115388B2 (en) * 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
JP4698596B2 (en) 2003-04-10 2011-06-08 タフツ ユニバーシティー Concentrated aqueous silk fibroin solutions and their use
WO2005123114A2 (en) 2004-06-11 2005-12-29 Trustees Of Tufts College Silk-based drug delivery system
WO2006062685A2 (en) 2004-11-11 2006-06-15 Affymax, Inc. Novel peptides that bind to the erythropoietin receptor
US7960509B2 (en) 2005-01-14 2011-06-14 Trustees Of Tufts College Fibrous protein fusions and use thereof in the formation of advanced organic/inorganic composite materials
US9290579B2 (en) 2005-04-20 2016-03-22 Trustees Of Tufts College Covalently immobilized protein gradients in three-dimensional porous scaffolds
GB2435646A (en) 2006-03-01 2007-09-05 Spin Tec Engineering Gmbh Apparatus and method of extraction of an arthropod gland
WO2008118133A2 (en) 2006-09-26 2008-10-02 Trustees Of Tufts College Silk microspheres for encapsulation and controlled release
AU2008260156B2 (en) 2007-05-29 2013-10-31 Trustees Of Tufts College Method for silk fibroin gelation using sonication
WO2009100280A2 (en) 2008-02-07 2009-08-13 Trustees Of Tufts College 3-dimensional silk hydroxyapatite compositions
US8206774B2 (en) 2008-03-13 2012-06-26 Trustees Of Tufts College Diazonium salt modification of silk polymer
WO2010042798A2 (en) 2008-10-09 2010-04-15 Trustees Of Tufts College Modified silk films containing glycerol
US8501172B2 (en) 2008-09-26 2013-08-06 Trustees Of Tufts College pH-induced silk gels and uses thereof
EP2349366B1 (en) 2008-09-26 2013-08-28 Trustees Of Tufts College Active silk muco-adhesives, silk electrogelation process, and devices
WO2010057142A2 (en) 2008-11-17 2010-05-20 Trustees Of Tufts College Surface modification of silk fibroin matrices with poly(ethylene glycol) useful as anti adhesion barriers and anti thrombotic materials
CN101445546B (en) * 2008-12-31 2011-09-28 苏州大学 Preparation for tussore silk fibroin solution and concentration method thereof
CA2789009C (en) 2009-02-12 2017-03-21 Trustees Of Tufts College Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
CA2791580C (en) 2009-03-04 2017-12-05 Trustees Of Tufts College Silk fibroin systems for antibiotic delivery
AU2010271238A1 (en) 2009-07-10 2012-02-09 Trustees Of Tufts College Bioengineered silk protein-based nucleic acid delivery systems
US8728498B2 (en) 2009-07-14 2014-05-20 Trustees Of Tufts College Electrospun silk material systems for wound healing
WO2011011347A2 (en) 2009-07-21 2011-01-27 Trustees Of Tufts College Functionalization of silk material by avidin-biotin interaction
WO2011041395A2 (en) 2009-09-29 2011-04-07 Trustees Of Tufts College Silk nanospheres and microspheres and methods of making same
JP5889199B2 (en) * 2009-11-30 2016-03-22 アーエムシルク ゲーエムベーハー Silk particles for controlled and sustained delivery of compounds
WO2011109691A2 (en) 2010-03-05 2011-09-09 Trustees Of Tufts College Silk-based ionomeric compositions
CN103181025A (en) 2010-04-12 2013-06-26 塔夫茨大学 Silk electronic components
WO2012031144A2 (en) 2010-09-01 2012-03-08 Trustees Of Tufts College Silk fibroin and polyethylene glycol-based biomaterials
JP2012082174A (en) * 2010-10-13 2012-04-26 Iwate Univ Method of separating fibroin and sericin in cricula cocoon layer, and fibroin and sericin obtained by the method
JP2015508104A (en) 2012-02-22 2015-03-16 トラスティーズ オブ タフツ カレッジ Compositions and methods for the delivery of therapeutic agents to the eye

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003035124A2 (en) * 2001-10-25 2003-05-01 University Of Connecticut Fibroin compositions and methods of making the same
US20110305765A1 (en) * 2008-11-21 2011-12-15 Board Of Regents, The University Of Texas System Preparation and methodology of silk fibroin nanoparticles
US20120070427A1 (en) * 2009-06-01 2012-03-22 Trustees Of Tufts College Vortex-induced silk fibroin gelation for encapsulation and delivery
WO2012145739A1 (en) * 2011-04-21 2012-10-26 Trustees Of Tufts College Compositions and methods for stabilization of active agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LEE ET AL.: "A combination graft of low-molecular-weight silk fibroin with Choukroun platelet-rich fibrin for rabbit calvarial defect'", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY, AND ENDODONTOLOGY, vol. 109, no. 5, 2010, pages E33 - E38, XP027032509 *
PRITCHARD ET AL.: "Silk fibroin biomaterials for controlled release drug delivery", EXPERT OPINION ON DRUG DELIVERY, vol. 8, no. 6, 2011, pages 797 - 811, XP008174796 *

Also Published As

Publication number Publication date
JP2021080277A (en) 2021-05-27
JP6457482B2 (en) 2019-01-23
WO2014145002A2 (en) 2014-09-18
EP3412682B1 (en) 2022-08-31
CA2905090C (en) 2022-10-25
JP2018168198A (en) 2018-11-01
CA3172969A1 (en) 2014-09-18
JP2023174942A (en) 2023-12-08
JP2016517443A (en) 2016-06-16
AU2018260835B2 (en) 2020-05-21
ES2935659T3 (en) 2023-03-09
US20240082405A1 (en) 2024-03-14
KR20230021768A (en) 2023-02-14
CA2905090A1 (en) 2014-09-18
KR20150131329A (en) 2015-11-24
AU2014233480A1 (en) 2015-08-27
EP4180448A1 (en) 2023-05-17
AU2014233480B2 (en) 2018-08-09
KR102457668B1 (en) 2022-10-21
JP7257112B2 (en) 2023-04-13
AU2020220142A1 (en) 2020-12-10
EP2970411A2 (en) 2016-01-20
EP2970411B1 (en) 2018-05-09
KR20210149207A (en) 2021-12-08
AU2020220142B2 (en) 2023-06-01
EP2970411A4 (en) 2016-10-19
AU2018260835A1 (en) 2018-11-22
US20160046679A1 (en) 2016-02-18
EP3412682A1 (en) 2018-12-12

Similar Documents

Publication Publication Date Title
AU2018260835A1 (en) Low molecular weight silk compositions and stabilizing silk compostions
MX2019005192A (en) Selectively substituted quinoline compounds.
MX2018002999A (en) Stable inoculant compositions and methods for producing same.
MY172926A (en) Tetrahydropyrazolopyrimidine compounds
MX363708B (en) Selectively substituted quinoline compounds.
MX2015015421A (en) Acc inhibitors and uses thereof.
MX2015015417A (en) Acc inhibitors and uses thereof.
EP2778259A3 (en) Metal cleaning compositions including a chloro-fluoro-alkene solvent and method thereof
CL2017001139A1 (en) Antibiotic compositions
BR112014015908A2 (en) composition
MX2015001958A (en) Improved compositions of substantially spherical particles.
SG10201811454WA (en) Materials and methods for controlling infections
WO2012058211A3 (en) Quinazoline derivatives, compositions, and uses related thereto
EA201492011A1 (en) ANHATIC PHARMACEUTICAL FORMULATIONS FOR LOCAL APPLICATION
WO2014086982A3 (en) Stable metal compounds, their compositions and methods of their use
MX349265B (en) Rheology modified low foaming liquid antimicrobial compositions and methods of use thereof.
EA201490024A1 (en) FILLED SILICONE COMPOSITIONS, THEIR RECEPTION AND APPLICATION
EP3452056A4 (en) Glycogen and phytoglycogen nanoparticles as immunosuppressive compounds, and compositions and methods of use thereof
MX2021003835A (en) Pongamia compositions, methods of preparing and analyzing thereof, and uses thereof.
WO2013057310A3 (en) Hybridization compositions and methods
EP3006434A4 (en) Novel compound derived from plant of genus quamoclit and composition containing same as active ingredient for preventing or treating diabetes
WO2014133811A3 (en) Compounds from invasive salvinias and methods of using the same
MX2016011572A (en) Organic acid antimicrobial compositions.
IN2014KN02877A (en)
WO2015073418A3 (en) Methods and assays for factor viii activity

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2014233480

Country of ref document: AU

Date of ref document: 20140314

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2905090

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2016503176

Country of ref document: JP

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 20157029775

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2014763730

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 14763730

Country of ref document: EP

Kind code of ref document: A2