WO2014141066A3 - Polipéptido mutado, cepa de bacterias que lo comprende y métodos para detectar diferentes cationes metálicos simultáneamente - Google Patents
Polipéptido mutado, cepa de bacterias que lo comprende y métodos para detectar diferentes cationes metálicos simultáneamente Download PDFInfo
- Publication number
- WO2014141066A3 WO2014141066A3 PCT/IB2014/059629 IB2014059629W WO2014141066A3 WO 2014141066 A3 WO2014141066 A3 WO 2014141066A3 IB 2014059629 W IB2014059629 W IB 2014059629W WO 2014141066 A3 WO2014141066 A3 WO 2014141066A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- metal cations
- different metal
- simultaneously detect
- detect different
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Polipéptido mutado, cepas que lo comprende y métodos para detectar cationes metálicos, por ejemplo Au, Cu, Ag, Hg, Pb, Cd, Co y Zn, en muestras de manera simultánea, en donde el polipéptido comprende una sustitución de serina por cisteína en la posición 77 de la SEQ ID N° 1 o SEQ ID N° 2; y en donde dicha proteína tiene actividad de regulador transcripcional, por ejemplo GolS o CueR. El polipéptido detecta los metales como cationes metálicos monovalentes y divalentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP20130100783 | 2013-03-11 | ||
ARP130100783A AR090303A1 (es) | 2013-03-11 | 2013-03-11 | Polipeptido mutado, cepa de bacterias que lo comprende y metodos para detectar diferentes cationes metalicos simultaneamente |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014141066A2 WO2014141066A2 (es) | 2014-09-18 |
WO2014141066A3 true WO2014141066A3 (es) | 2014-12-31 |
Family
ID=50680076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2014/059629 WO2014141066A2 (es) | 2013-03-11 | 2014-03-11 | Polipéptido mutado, cepa de bacterias que lo comprende y métodos para detectar diferentes cationes metálicos simultáneamente |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR090303A1 (es) |
WO (1) | WO2014141066A2 (es) |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999014597A1 (en) * | 1997-09-15 | 1999-03-25 | Vlaamse Instelling Voor Technologisch Onderzoek | Metal ion specific capacity affinity sensor |
WO2002030962A2 (en) * | 2000-10-12 | 2002-04-18 | University Of Georgia Research Foundation, Inc. | Metal binding proteins, recombinant host cells and methods |
WO2006069610A2 (en) * | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
WO2006110413A2 (en) * | 2005-03-30 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Haemophilus influenzae type b |
CN102250819A (zh) * | 2010-05-18 | 2011-11-23 | 天津工业生物技术研究所 | 高灵敏检测重金属汞的生物传感器细胞及其制造方法 |
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2013
- 2013-03-11 AR ARP130100783A patent/AR090303A1/es not_active Application Discontinuation
-
2014
- 2014-03-11 WO PCT/IB2014/059629 patent/WO2014141066A2/es active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999014597A1 (en) * | 1997-09-15 | 1999-03-25 | Vlaamse Instelling Voor Technologisch Onderzoek | Metal ion specific capacity affinity sensor |
WO2002030962A2 (en) * | 2000-10-12 | 2002-04-18 | University Of Georgia Research Foundation, Inc. | Metal binding proteins, recombinant host cells and methods |
WO2006069610A2 (en) * | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
WO2006110413A2 (en) * | 2005-03-30 | 2006-10-19 | Novartis Vaccines And Diagnostics Inc. | Haemophilus influenzae type b |
CN102250819A (zh) * | 2010-05-18 | 2011-11-23 | 天津工业生物技术研究所 | 高灵敏检测重金属汞的生物传感器细胞及其制造方法 |
Non-Patent Citations (8)
Title |
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BONTIDEAN I ET AL: "Bacterial metal-resistance proteins and their use in biosensors for the detection of bioavailable heavy metals", JOURNAL OF INORGANIC BIOCHEMISTRY, NEW YORK, NY, US, vol. 79, no. 1-4, 1 April 2000 (2000-04-01), pages 225 - 229, XP002224821, DOI: 10.1016/S0162-0134(99)00234-2 * |
CHANGELA ANITA ET AL: "Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 301, no. 5638, 5 September 2003 (2003-09-05), pages 1383 - 1387, XP002431143, ISSN: 0036-8075, DOI: 10.1126/SCIENCE.1085950 * |
DATABASE Geneseq [online] 10 December 2009 (2009-12-10), "Fumarate/malate production-related protein, SEQ:17753.", XP002729732, retrieved from EBI accession no. GSP:AXJ88351 Database accession no. AXJ88351 * |
DATABASE Geneseq [online] 4 October 2007 (2007-10-04), "H. influenzae type B polypeptide HIB0292.", XP002729731, retrieved from EBI accession no. GSP:AEL79330 Database accession no. AEL79330 * |
J. V. STOYANOV ET AL: "The Escherichia coli Copper-responsivecopA Promoter Is Activated by Gold", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 3, 22 November 2002 (2002-11-22), pages 1407 - 1410, XP055140116, ISSN: 0021-9258, DOI: 10.1074/jbc.C200580200 * |
JAN ROELOF VAN DER MEER ET AL: "Where microbiology meets microengineering: design and applications of reporter bacteria", NATURE REVIEWS MICROBIOLOGY, vol. 8, no. 7, 1 June 2010 (2010-06-01), pages 511 - 522, XP055139833, ISSN: 1740-1526, DOI: 10.1038/nrmicro2392 * |
SUSANA K CHECA ET AL: "Bacterial gold sensing and resistance", BIOMETALS, KLUWER ACADEMIC PUBLISHERS, BO, vol. 24, no. 3, 14 December 2010 (2010-12-14), pages 419 - 427, XP019900565, ISSN: 1572-8773, DOI: 10.1007/S10534-010-9393-2 * |
ZHEN MA ET AL: "Coordination Chemistry of Bacterial Metal Transport and Sensing", CHEMICAL REVIEWS, vol. 109, no. 10, 29 September 2009 (2009-09-29), pages 4644 - 4681, XP055140062, ISSN: 0009-2665, DOI: 10.1021/cr900077w * |
Also Published As
Publication number | Publication date |
---|---|
WO2014141066A2 (es) | 2014-09-18 |
AR090303A1 (es) | 2014-11-05 |
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