WO2014134834A1 - Composition and food comprising same and preparation method of food - Google Patents
Composition and food comprising same and preparation method of food Download PDFInfo
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- WO2014134834A1 WO2014134834A1 PCT/CN2013/072372 CN2013072372W WO2014134834A1 WO 2014134834 A1 WO2014134834 A1 WO 2014134834A1 CN 2013072372 W CN2013072372 W CN 2013072372W WO 2014134834 A1 WO2014134834 A1 WO 2014134834A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/06—Preparations for care of the skin for countering cellulitis
Definitions
- composition Composition, food containing same, and preparation method of the same
- the present invention relates to the field of health foods and cosmetics, and in particular to a composition comprising Inca fruit, and to a method of preparing the composition. Background technique
- Aging is a natural physiological phenomenon of the human body.
- the aging of the human body is obvious in the skin and body condition, and the skin gradually loses its original brightness and elasticity, and the skin color becomes dull and dull. Whether it is the normal redox reaction in the body, external stimuli, or life pressure, it will cause free radicals.
- oxidative damage not only causes damage to the true cortex matrix, collagen, and elastic fibers, but also causes skin to appear slack, wrinkles, dryness, water shortage, allergies and inflammatory reactions, and accelerates the aging process.
- the body can take a lot of antioxidants from the outside, such as vitamins [, vitamin E, carotenoids, flavonoids, melatonin and so on.
- vitamins [, vitamin E, carotenoids, flavonoids, melatonin and so on.
- Studies have shown that vitamin C and vitamin E naturally contained in plants, compared to their artificial synthesis, retain the natural state and properties of the active substance, and are more easily absorbed by the body. Therefore, when used as raw materials for health foods, cosmetics, etc., people tend to use natural vitamin C and vitamin E.
- Amy has recently chosen different skin care products and health care products to adjust.
- cosmetics and health products on the market are mainly vitamins, vitamin E, polyphenols, and collagen.
- antioxidants due to the different antioxidant effects and effects of various antioxidants, simply taking one or two of these antioxidants has very limited antioxidant effects, which cannot be fundamentally treated or prevented, nor can it be caused by the body. To the system and comprehensive antioxidant effect. Coupled with the adverse effects of many cosmetic health products on safety, these products are difficult to achieve the antioxidant, anti-aging, beauty and skin care effects consumers demand. Existing anti-oxidant and anti-aging health foods, due to a single nutritional function, can not fully absorb the active ingredients, resulting in a certain waste.
- the present invention is directed to solving at least some of the above technical problems or at least providing a useful commercial choice. To this end, it is an object of the present invention to provide a composition which has both anti-oxidation, anti-aging, cosmetic and anti-obesity effects.
- the present invention provides a composition
- a composition comprising, according to an embodiment of the present invention, 10 to 30 parts by weight of inca fruit oil; 5 to 25 parts by weight of sea buckthorn oil
- the weight ratio of ingrown fruit oil to sea buckthorn oil in the composition is (0.4-6): 1.
- the inventor of the present application based on scientific theories, after arduous creative labor and trial and error, was surprised to find out:
- the composition consisting of inca fruit oil and sea buckthorn oil has obvious synergistic effect and technical progress characteristics, and the composition of the invention has obvious effects in anti-oxidation, anti-aging and skin care, and the effect of the composition Significantly superior to the effect of a single component, with significant synergy.
- the composition preferably comprises: 16 to 24 parts by weight of inca fruit oil; and 8 to 20 parts by weight of sea buckthorn oil.
- the weight ratio of ingrown fruit oil to seabuckthorn oil in the composition is from 0.8 to 3:1.
- the composition most preferably comprises: 20 parts by weight of inca fruit oil; and 10 parts by weight of sea buckthorn oil; that is, in the most preferred combination, the optimum weight ratio of inca fruit oil to sea buckthorn oil is 2 : 1.
- the composition exerts the best anti-oxidant, anti-aging and cosmetic benefits.
- the above composition may further comprise: 50 to 65 parts by weight of glycerin; 20 to 40 parts by weight of gelatin; and 50 to 70 parts by weight of water, according to a specific embodiment of the present invention, preferably 60 parts by weight of glycerin; 25 parts by weight of gelatin; and 55 parts by weight of water.
- the composition exerts the best anti-oxidant, anti-aging and cosmetic skin care effects.
- the iPlukenetia volubilis L., Inca Peanut, sacha inchi of the present invention is a plant of the genus Euphorbiae, also known as Inca peanut, South American vine, Star vine, and Meito fruit.
- the perennial oil plant, native to the Amazon River Basin in South America, was originally transformed from the Incas to the wild, and has been used by local indigenous people for thousands of years in the Inca region of South America. When planted in the same year, the fruit can be hung.
- the seeds are rich in oil, protein, amino acids, vitamin A and vitamin E.
- Inca fruit oil contains extremely rich unsaturated fatty acids ( ⁇ -3, ⁇ -6, ⁇ -9), content of up to 92%, and contains vitamins, strontium and protein, among them The content of ⁇ and ⁇ tocopherol exceeds 2000 mg/kg.
- Such high levels of antioxidant tocopherol make the taste and quality of Inca fruit oil very stable during storage.
- Inca fruit oil is obtained after harvesting the fruit of Inca fruit, first peeling the shell, drying it, and then cold-pressing the nut with low temperature, filtering and removing impurities.
- Seabuckthorn fruit is rich in nutrients, containing various vitamins, fatty acids, trace elements, linoleic acid, seabuckthorn flavonoids, superoxide dismutase (SOD) and other biological nutrients and various amino acids required by the human body.
- sea buckthorn oil contains 206 kinds of active substances beneficial to the human body.
- biological active substances which contain a lot of vitamins, vitamin E, flavonoids, etc.
- the vitamin C content is extremely high, Every 100 grams of juice, vitamin C content can reach 825 ⁇ 1 100 mg, which is 2 ⁇ 3 times of kiwifruit. It has anti-oxidation, balances free radicals in human body, regulates immune cell activity, enhances immune function, etc. Skin, anti-wrinkle and anti-aging play a very good role, and promote wound healing.
- Inca fruit oil and the sea buckthorn oil according to the present invention are used in a reasonable ratio, wherein the biologically active substances can synergistically synergistically, significantly lowering the MDA level and increasing the SOD activity.
- Inca fruit oil and Seabuckthorn oil contains a lot of natural vitamin C and vitamin E. Both of them belong to low molecular antioxidants, which can eliminate free radicals in the body, and they have synergistic effect. Vitamin C can also reduce vitamin E which has been oxidized.
- Vitamin E circulation plays a better role; vitamin E can also promote the absorption of vitamin C and vitamin A. It can effectively eliminate free radicals in the body, eliminate pigmentation, and whiten the skin.
- the combination of vitamin C+E can help cells better absorb the nutrients of external skin care products and increase the beauty effect.
- the composition contains a large amount of natural flavonoid active ingredients, can induce antioxidant enzyme activity, inhibit the production of reactive oxygen species and hydrogen peroxide, reduce DNA oxidative damage, inhibit lipid peroxidation, and also prevent lipid peroxidation. The chain reaction that produces and blocks lipid peroxidation. Its interaction with vitamins C and E can affect each other, promote each other, and exert synergistic effects, which can exert greater antioxidant effects on the body.
- the composition contains a large amount of polyunsaturated fatty acids which also have synergistic effects with vitamins C and E.
- Vitamin E can control physiological peroxidation, which can synergistically enhance the synergistic effect between polyunsaturated fatty acids and vitamin E.
- Vitamin C can reduce the peroxidation of free radicals to polyunsaturated fatty acids and improve oxygen in the body.
- the utilization rate can improve the working ability of the body and accelerate the recovery of the body's activity. Therefore, the combination of Inca fruit oil and sea buckthorn oil, its natural active natural substance, can systematically and comprehensively eliminate various aging-causing substances in the body, significantly enhance the body's antioxidant capacity, achieve the purpose of delaying the body's aging, and also lose weight and beauty. Skin care, and delay skin wrinkles, to avoid dark spots, freckles and so on. In addition, it is effective against heart and vascular diseases as well as promoting blood circulation.
- the composition may be a functional food, a health food or a cosmetic. Therefore, it can be easily used.
- the form of the composition is not particularly limited.
- the composition is in the form of a hard capsule, a soft capsule, a tablet, a granule, a pill, an ointment, a cream, a cream or an emulsion.
- the composition can be prepared into a health food, a cosmetic or the like.
- hard capsules, soft capsules, tablets, granules, pills, ointments, creams, creams can be prepared by conventional techniques, together with auxiliaries commonly used in pharmacy.
- Agent For cosmetics with a cosmetic effect, it can be made into a medicinal ointment, cream, cream, or lotion, or moisturizing skin care oil, whitening skin cream by a conventional process, plus pharmaceutics commonly used excipients. Wait.
- the above composition can be obtained by mixing a predetermined ratio of imprinted fruit oil and sea buckthorn oil.
- the inca fruit oil is obtained by subjecting the nuts of the Inca fruit to a low temperature physical cold pressing and filtering and removing impurities
- the seabuckthorn oil is an oil which is pressed by sea buckthorn seeds (nucleus).
- the above composition can be prepared into a soft capsule according to the following method: Gelatin, glycerin, hydration gel, and tape are first prepared.
- Ink oil and sea buckthorn oil are passed through a 100 mesh stainless steel mesh, stirred and mixed to obtain a liquid, placed in a soft capsule pilling machine, filled into soft capsules, and then dried in a drum drying device to soften the soft capsule.
- the drying chamber ambient temperature and humidity (below 50%), so that the capsule shell moisture and ethanol are naturally evaporated, the drying time is not less than 20 hours, until the surface of the capsule is dry and smooth, slightly elastic, and the drying is completed.
- the unqualified soft capsules such as appearances and joints are sorted and discarded, and the selected qualified soft capsules are packaged in the form of bottles or blister sheets, that is, the finished soft capsules are obtained. This makes it easier to use in order to further exert the antioxidant and anti-aging effects of the above composition.
- the above dosage forms which can be present in the composition can be prepared according to the method of preparing the same dosage form in a pharmaceutical method, and will not be enumerated here.
- the compositions prepared according to the examples of the present invention and their dosage forms are safe to eat, and their anti-oxidation and anti-aging effects are remarkable.
- the invention provides a food product comprising the composition of the above examples.
- the form of the food is not particularly limited as long as it can be used for eating.
- the food product may be in the form of a capsule, a tablet, a granule or a granule.
- the food provided by the present invention can be used as a health food, which can be made into a pharmaceutically acceptable capsule, tablet, or granule by a conventional process. It is easy to eat, so as to be more beneficial to its antioxidant and anti-aging effects.
- the invention provides a cosmetic comprising the composition of the above examples.
- the cosmetic has the effects of anti-oxidation, delayed aging, and beauty and skin care. It will be understood that the foregoing description of the features and advantages of the compositions applies to the food product and will not be described again.
- the invention proposes a method of preparing the cosmetic of the above embodiments.
- the method comprises: heating a predetermined ratio of glyceryl monostearate, lecithin, myristic acid, polymethylphenylsiloxane, polyvinylpyrrolidone and hyaluronic acid to 90 degrees Celsius To obtain a first mixture; to add potassium sorbate and to stir evenly when the first mixture is cooled to 50 degrees Celsius; to obtain a second mixture; and to add the indica oil and sea buckthorn oil to the second mixture to obtain the cosmetic.
- the cosmetic can be prepared into different types such as an emulsion, a cream, and the like. It will be understood that the foregoing description of the features and advantages of the compositions and cosmetics applies to the method and will not be further described herein.
- the invention provides the use of a composition of the above embodiments in the preparation of a formulation for at least one of anti-oxidation, anti-aging, cosmetic and anti-obesity.
- composition of the present invention can significantly reduce the content of peroxidized lipid degradation product - malondialdehyde (MDA) in mouse serum, and significantly increase superoxide dismutase (SOD). Vitality.
- MDA peroxidized lipid degradation product - malondialdehyde
- SOD superoxide dismutase
- Vitality Experiments on the effects on the lifespan of Drosophila showed that the average lifespan and average life expectancy of male and female flies were significantly prolonged after application of the composition of the present invention. It is indicated that the composition of the invention can delay the aging process of the body and has anti-oxidation and anti-aging effects.
- the anti-oxidation anti-aging, beauty and skin care effects of the composition of the present invention were verified, and the results further confirmed that the composition of the present invention has the functions of anti-oxidation, anti-aging, beauty and skin care, and has good safety.
- composition of the invention is based on traditional medicine theory, all raw materials are taken from nature, originated from nature, safe and reliable, and the sources of raw materials are widely available, and the compatibility of the prescriptions is scientific and reasonable, unified and coordinated, the curative effect is exact, and the preparation process is simple. , Storage and application safety, low production costs.
- the invention combines the substance and function of the indica oil and the seabuckthorn oil, and systematically and comprehensively eliminates various aging-causing substances in the body, thereby not only regulating the body's metabolic balance, improving the quality of life, but also resisting oxidation.
- Free radical scavenging can significantly enhance the body's antioxidant capacity, achieve the purpose of delaying the body's aging, weight loss beauty and skin care, and delay skin wrinkles, etc., providing a new business choice for people's daily health care.
- Example 1 Soft capsule of the composition of the invention
- Preparation method 60 parts by weight of glycerin, 25 parts by weight of gelatin and 55 parts by weight of water, heating the gel, and making a tape.
- the ambient temperature and humidity (50% or less) of the drying chamber the capsule shell moisture and ethanol are naturally evaporated, and the drying time is not less than 20 hours.
- the surface of the capsule is dry and smooth, slightly elastic, and dried.
- the unqualified soft capsules such as the outer shape and the joint are sorted and discarded, and the selected qualified soft capsules are packaged in the form of a bottle or a blister board to obtain the soft capsule of the composition of the present invention.
- Example 2 Soft capsule of the composition of the invention
- Example 3 Soft gel of the composition of the present invention I Ingredients 30 parts by weight Seabuckthorn oil 5 parts by weight Glycerol 60 parts by weight Gelatin 25 parts by weight Water 55 parts by weight Preparation method: The same as Example 1.
- Example 4 Soft gel of the composition of the present invention I Ingredients 16 parts by weight Seabuckthorn oil 8 parts by weight Glycerol 55 parts by weight Gelatin 25 parts by weight Water 55 parts by weight Preparation method: The same as in Example 1.
- Example 5 Soft gel of the composition of the invention I Ingredients 24 parts by weight Seabuckthorn oil 20 parts by weight Glycerol 60 parts by weight Gelatin 30 parts by weight Water 60 parts by weight Preparation method: The same as in Example 1.
- Example 6 Soft gel of the composition of the invention I Inca fruit oil
- Example 7 Soft capsule of the composition of the invention
- Example 8 The composition of the present invention whitening skin cream
- Preparation method glyceryl monostearate, lecithin, myristic acid, polymethylphenylsiloxane, polyvinylpyrrolidone, hyaluronic acid are weighed according to the amount in the formula, and mixed, heated to 90 ° C, The material is melted and dissolved evenly. Then slowly add water to the oil phase material with stirring, continue to stir, when the temperature drops to 50 ° C, add the preservative potassium sorbate, let stand, cool to white milky skin cream, add inca fruit oil and sea buckthorn Oil, tune, that is, whitening skin cream.
- the prepared skin care product is a white-like muddy body, and the particles are uniformly dispersed and viscous. It is easy to spread on the skin, and is not irritating to the skin after use. After being placed for a few days, it does not change color, is mildewed, and is not dry.
- test article used in this example was prepared in the same manner as in Example 1.
- mice edible oil containing vitamins C and E
- 0.34, 0.67, 2.00 g/kg of the composition of the present invention were administered in three dose groups, each group of 10 male mice of 12 months old, daily oral Give the sample once, continue to give 30 do on the 31st day, take the blood, centrifuge, take serum, and determine the lipid peroxide degradation product - malondialdehyde (MDA) content and superoxide dismutase (SOD) in the serum of mice. Vitality, as well as glutathione peroxidase (GSH-Px) levels.
- MDA malondialdehyde
- SOD superoxide dismutase
- mice were fed for 30 days, the general condition was good, the coat color was smooth, the food was stable, and the weight gain was stable during the experiment period. No obvious abnormal performance was observed, and no natural death occurred. There was no significant difference between the experimental groups at the beginning, middle and end of the experiment, and the control group (P>0.05).
- the doses of the present invention were orally administered to mice in different doses.
- the MDA level in the 2.00 g/kg group was significantly lower than that in the control group (P ⁇ 0.05); the SOD activity was significantly higher than that in the control group, and the difference was statistically significant. Significance (P ⁇ 0.05); GSH-Px level was higher than the control group, the difference was not statistically significant (P>0.05).
- composition of the present invention has an antioxidant function in mice.
- Example 10 Human test of antioxidant function of the composition of the present invention
- Test article The soft capsule of this example was prepared in the same manner as in Example 3.
- Example 11 Antioxidation, anti-aging, beauty and skin care
- the soft capsules of the examples were prepared in the same manner as in Example 5.
- Trial group Take the soft capsule of this embodiment twice, 400mg each time;
- Control group 1 Take vitamin E soft capsule 2 times, each time 400mg (Beijing Tongrentang Health Pharmaceutical Co., Ltd.); Control group 2: Do not take any soft capsules or other drugs or health foods; the experimental results are shown in Table 1.
- composition of the present invention has the functions of anti-oxidation, anti-aging, beauty and skin care, and has high safety.
- the description of the terms “one embodiment”, “some embodiments”, “example”, “specific example”, or “some examples” and the like means a specific feature described in connection with the embodiment or example.
- a structure, material or feature is included in at least one embodiment or example of the invention.
- the schematic representation of the above terms does not necessarily mean the same embodiment or example.
- the particular features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples.
Abstract
Provided are a composition containing Inca fruit oil and food and cosmetics containing the composition. The composition comprises 10 to 30 parts by weight of Inca fruit oil, and 5 to 25 parts by weight of sea buckthorn oil.
Description
组合物以及包含其的食品、 该食品的制备方法 Composition, food containing same, and preparation method of the same
技术领域 Technical field
本发明属于保健食品和化妆品领域， 具体涉及一种含有印加果的组合物， 本发明还涉 及该组合物的制备方法。 背景技术 The present invention relates to the field of health foods and cosmetics, and in particular to a composition comprising Inca fruit, and to a method of preparing the composition. Background technique
衰老是人体自然的生理现象， 人体老化在皮肤及身体状况上表现明显， 肌肤会逐渐失 去原有的明亮和弹性， 肤色变得暗淡无光泽。 无论是体内正常的氧化还原反应、 外界刺激 因素、 还是生活压力等原因， 都会造成自由基的产生。 对肌肤而言， 氧化破坏不但造成真 皮层基质、 胶原蛋白、 弹性纤维受损， 更会让肌肤出现松弛、 皱纹、 干燥、 缺水、 过敏与 炎症反应， 加速人体老化进程。 Aging is a natural physiological phenomenon of the human body. The aging of the human body is obvious in the skin and body condition, and the skin gradually loses its original brightness and elasticity, and the skin color becomes dull and dull. Whether it is the normal redox reaction in the body, external stimuli, or life pressure, it will cause free radicals. For the skin, oxidative damage not only causes damage to the true cortex matrix, collagen, and elastic fibers, but also causes skin to appear slack, wrinkles, dryness, water shortage, allergies and inflammatory reactions, and accelerates the aging process.
人体可从外界摄取的抗氧化剂很多， 如维生素〔、 维生素 E、 类胡萝卜素群、 黄酮类、 褪黑素等。 研究证明， 植物中天然含有的维生素 C和维生素 E， 相对于其人工合成， 其保 持了活性物质的天然状态和属性， 更易于人体吸收。 所以， 在作为保健食品、 化妆品等原 料时， 人们更趋向于选用天然的维生素 C和维生素 E。 为了延缓衰老及老化过程， 爱美人 士近来年均选择不同的护肤品及保健品进行调补。 如市面上的化妆品、 保健品也是以维生 素〔、 维生素 E、 多酚类、 骨胶原蛋白等为主。 但由于各种抗氧化剂的抗氧化功效和作用不 尽相同， 仅仅单纯的服用其中一两种抗氧化剂， 其抗氧化效果非常有限， 不能从根本上做 成治疗或预防， 也不可能对机体起到***而全面的抗氧化作用。 再加上很多化妆品保健品 在安全性方面的不良影响， 这些产品很难达到消费者所要求的抗氧化、 延缓衰老、 美容护 肤等效果。 现有的抗氧化、 延缓衰老的保健食品， 由于营养功能单一， 有效成分不能充分 吸收， 造成一定的浪费。 The body can take a lot of antioxidants from the outside, such as vitamins [, vitamin E, carotenoids, flavonoids, melatonin and so on. Studies have shown that vitamin C and vitamin E naturally contained in plants, compared to their artificial synthesis, retain the natural state and properties of the active substance, and are more easily absorbed by the body. Therefore, when used as raw materials for health foods, cosmetics, etc., people tend to use natural vitamin C and vitamin E. In order to delay the aging and aging process, Amy has recently chosen different skin care products and health care products to adjust. For example, cosmetics and health products on the market are mainly vitamins, vitamin E, polyphenols, and collagen. However, due to the different antioxidant effects and effects of various antioxidants, simply taking one or two of these antioxidants has very limited antioxidant effects, which cannot be fundamentally treated or prevented, nor can it be caused by the body. To the system and comprehensive antioxidant effect. Coupled with the adverse effects of many cosmetic health products on safety, these products are difficult to achieve the antioxidant, anti-aging, beauty and skin care effects consumers demand. Existing anti-oxidant and anti-aging health foods, due to a single nutritional function, can not fully absorb the active ingredients, resulting in a certain waste.
然而， 目前用于抗氧化、 延缓衰老的保健品或化妆品仍有待改进。 发明内容 However, health care products or cosmetics currently used for anti-oxidation and anti-aging have yet to be improved. Summary of the invention
本发明旨在至少在一定程度上解决上述技术问题之一或至少提供一种有用的商业选择。 为此， 本发明的一个目的在于提供一种组合物， 该组合物同时具有抗氧化、 抗衰老、 美容 护肤和治疗肥胖的作用。 The present invention is directed to solving at least some of the above technical problems or at least providing a useful commercial choice. To this end, it is an object of the present invention to provide a composition which has both anti-oxidation, anti-aging, cosmetic and anti-obesity effects.
为此， 在本发明的第一方面， 本发明提出了一种组合物， 根据本发明的实施例， 该组 合物包括： 10〜30重量份的印加果油； 5〜25 重量份的沙棘油， 组合物中印加果油与沙棘油 的重量比例为 (0.4-6) ： 1。 To this end, in a first aspect of the invention, the present invention provides a composition comprising, according to an embodiment of the present invention, 10 to 30 parts by weight of inca fruit oil; 5 to 25 parts by weight of sea buckthorn oil The weight ratio of ingrown fruit oil to sea buckthorn oil in the composition is (0.4-6): 1.
本申请的发明人依据科学理论、 经过艰苦的创造性劳动和反复试验， 惊奇的发现： 由
印加果油和沙棘油组成的组合物， 具有明显的协同增效作用、 以及技术进步特征， 本发明 所述的组合物在抗氧化、 延缓衰老和美容护肤方面效果明显， 且组合物的作用效果明显优 于单一成分的效果， 具有显著的协同作用。 The inventor of the present application, based on scientific theories, after arduous creative labor and trial and error, was surprised to find out: The composition consisting of inca fruit oil and sea buckthorn oil has obvious synergistic effect and technical progress characteristics, and the composition of the invention has obvious effects in anti-oxidation, anti-aging and skin care, and the effect of the composition Significantly superior to the effect of a single component, with significant synergy.
根据本发明的实施例， 该组合物优选包括： 16〜24重量份的印加果油； 以及 8〜20 份重 量份的沙棘油。 优选组合物中印加果油与沙棘油的重量比例为 0.8〜3： 1。 由此， 可以进一 步提高该组合物用于抗氧化、 延缓衰老和美容护肤方面的效果。 According to an embodiment of the present invention, the composition preferably comprises: 16 to 24 parts by weight of inca fruit oil; and 8 to 20 parts by weight of sea buckthorn oil. Preferably, the weight ratio of ingrown fruit oil to seabuckthorn oil in the composition is from 0.8 to 3:1. Thereby, the effect of the composition for anti-oxidation, anti-aging and skin care can be further improved.
根据本发明的实施例， 该组合物最优选包括： 20重量份的印加果油； 以及 10重量份的 沙棘油； 即在最优选组合中， 印加果油与沙棘油的最佳重量比例为 2: 1。 由此， 组合物可 发挥最好的抗氧化、 延缓衰老和美容护肤效果。 According to an embodiment of the present invention, the composition most preferably comprises: 20 parts by weight of inca fruit oil; and 10 parts by weight of sea buckthorn oil; that is, in the most preferred combination, the optimum weight ratio of inca fruit oil to sea buckthorn oil is 2 : 1. Thus, the composition exerts the best anti-oxidant, anti-aging and cosmetic benefits.
根据本发明的实施例， 上述组合物还可以进一步包括： 50〜65重量份的甘油； 20〜40重 量份的明胶；以及 50〜70重量份的水，根据本发明的具体实施例，优选为 60重量份的甘油； 25重量份的明胶； 以及 55重量份的水。 由此， 组合物可发挥最好的抗氧化、 延缓衰老和美 容护肤效果。 According to an embodiment of the present invention, the above composition may further comprise: 50 to 65 parts by weight of glycerin; 20 to 40 parts by weight of gelatin; and 50 to 70 parts by weight of water, according to a specific embodiment of the present invention, preferably 60 parts by weight of glycerin; 25 parts by weight of gelatin; and 55 parts by weight of water. Thus, the composition exerts the best anti-oxidant, anti-aging and cosmetic skin care effects.
本发明所述的印加果 iPlukenetia volubilis L.， Inca Peanut, sacha inchi) 为大戟科藤本植 物， 又称印加花生、 南美油藤、 星油藤、 美藤果。 多年生油料植物， 原产南美洲亚马逊河 流域雨林， 最初由印加人变野生为家种， 在南美洲印加地区已被当地土著应用了上千年的 历史。 当年种植， 当年可挂果， 种子富含油脂、 蛋白质、 氨基酸， 还有维生素 A、 维生素 E The iPlukenetia volubilis L., Inca Peanut, sacha inchi of the present invention is a plant of the genus Euphorbiae, also known as Inca peanut, South American vine, Star vine, and Meito fruit. The perennial oil plant, native to the Amazon River Basin in South America, was originally transformed from the Incas to the wild, and has been used by local indigenous people for thousands of years in the Inca region of South America. When planted in the same year, the fruit can be hung. The seeds are rich in oil, protein, amino acids, vitamin A and vitamin E.
(生育酚）和一些其它微量元素；印加果油含有极其丰富的不饱和脂肪酸（ω-3、 ω-6、 ω-9 )， 含量高达 92 %以上， 以及含维生素 Α、 Ε和蛋白质， 其中 γ和 δ生育酚的含量超过 2000毫 克 /公斤。 如此高含量的具有抗氧化作用生育酚使得印加果油的味道和质量在储存过程中非 常的稳定。 印加果油是印加果的果实经采收后， 先脱壳成果仁， 晒干， 再将果仁经低温物 理冷搾、 过滤除杂后得到的。 (tocopherol) and some other trace elements; Inca fruit oil contains extremely rich unsaturated fatty acids (ω-3, ω-6, ω-9), content of up to 92%, and contains vitamins, strontium and protein, among them The content of γ and δ tocopherol exceeds 2000 mg/kg. Such high levels of antioxidant tocopherol make the taste and quality of Inca fruit oil very stable during storage. Inca fruit oil is obtained after harvesting the fruit of Inca fruit, first peeling the shell, drying it, and then cold-pressing the nut with low temperature, filtering and removing impurities.
沙棘果实营养丰富， 含有多种维生素、 脂肪酸、 微量元素、 亚油素、 沙棘黄酮、 超氧 化物歧化酶 （SOD ) 等多种生物营养成分和人体所需的各种氨基酸。 沙棘最有价值之一的 就是沙棘油， 沙棘油中含有 206种对人体有益的活性物质， 其中有 46种生物活性物质， 含 有大量的维生素 、 维生素 E、 黄酮等 （其中维生素 C含量极高， 每 100克果汁中， 维生 素 C含量可达到 825〜1 100毫克， 是猕猴桃的 2〜3倍） ， 具有抗氧化、 平衡人体内自由基、 调节免疫细胞活性、 增强免疫功能等作用， 可对护理皮肤， 防皱抗衰起到很好的作用， 并 有促进伤口愈合的作用。 Seabuckthorn fruit is rich in nutrients, containing various vitamins, fatty acids, trace elements, linoleic acid, seabuckthorn flavonoids, superoxide dismutase (SOD) and other biological nutrients and various amino acids required by the human body. One of the most valuable seabuckthorns is sea buckthorn oil. Seabuckthorn oil contains 206 kinds of active substances beneficial to the human body. Among them, there are 46 kinds of biological active substances, which contain a lot of vitamins, vitamin E, flavonoids, etc. (the vitamin C content is extremely high, Every 100 grams of juice, vitamin C content can reach 825~1 100 mg, which is 2~3 times of kiwifruit. It has anti-oxidation, balances free radicals in human body, regulates immune cell activity, enhances immune function, etc. Skin, anti-wrinkle and anti-aging play a very good role, and promote wound healing.
机体衰老后， 对缺血缺氧敏感， 过氧化脂质增加， 超氧化物歧化酶 （SOD ) 这一体内 消除自由基的重要酶活性下降。 本发明所述的印加果油与沙棘油以合理的比例使用， 其中 的生物活性物质可相互协同增效作用， 显著降低 MDA水平， 提高 SOD活性。 印加果油与
沙棘油含有大量的天然维生素 C和维生素 E， 两者同属低分子抗氧化物质， 均可清除体内 自由基， 且二者具有协同增效作用， 维生素 C还可以还原已经被氧化的维生素 E， 使得维 生素 E循环发挥更佳功效； 维生素 E还能促进维 C和维 A的吸收。 能够起到有效祛除体内 自由基、 祛除色斑， 美白肌肤的作用； 维生素 C+E的搭配能帮助细胞更好地吸收外部护肤 品的营养成分， 可以增加美容功效。 组合物中含有的大量天然黄酮类活性成分， 可诱导抗 氧化酶活性，抑制活性氧及氧化氢的产生，减少 DNA的氧化损伤、抑制脂质过氧化的作用， 同时还具有预防脂质过氧化的产生和阻断脂质过氧化的链式反应。 其与维生素 C和 E的作 用可相互影响、 相互促进、 发挥协同作用， 对机体起到更大的抗氧化作用。 组合物中含有 大量的多不饱和脂肪酸， 其与维生素 C和 E也具有协同作用。 其中维生素 E可控制生理过 氧化， 可使多不饱和脂肪酸和维生素 E这两种功效物质间发挥协同增效之功效； 维生素 C 可减少自由基对多不饱和脂肪酸的过氧化作用， 提高体内氧的利用率， 从而达到改善机体 工作能力， 加快机体活性恢复等作用。 故印加果油与沙棘油的组合应用， 其天然的活性天 然物质， 可***而全面的消除体内各种引起衰老的物质， 明显增强机体抗氧化能力、 达到 延缓机体衰老的目的， 还可减肥美容护肤， 并延缓皮肤皱纹， 避免产生黑斑、 雀斑等。 此 外， 对心脏、 血管疾病以及促进血液循环都具有疗效。 After aging, the body is sensitive to ischemia and hypoxia, and lipid peroxide increases. Superoxide dismutase (SOD), a major enzyme activity that eliminates free radicals in the body, decreases. The Inca fruit oil and the sea buckthorn oil according to the present invention are used in a reasonable ratio, wherein the biologically active substances can synergistically synergistically, significantly lowering the MDA level and increasing the SOD activity. Inca fruit oil and Seabuckthorn oil contains a lot of natural vitamin C and vitamin E. Both of them belong to low molecular antioxidants, which can eliminate free radicals in the body, and they have synergistic effect. Vitamin C can also reduce vitamin E which has been oxidized. Vitamin E circulation plays a better role; vitamin E can also promote the absorption of vitamin C and vitamin A. It can effectively eliminate free radicals in the body, eliminate pigmentation, and whiten the skin. The combination of vitamin C+E can help cells better absorb the nutrients of external skin care products and increase the beauty effect. The composition contains a large amount of natural flavonoid active ingredients, can induce antioxidant enzyme activity, inhibit the production of reactive oxygen species and hydrogen peroxide, reduce DNA oxidative damage, inhibit lipid peroxidation, and also prevent lipid peroxidation. The chain reaction that produces and blocks lipid peroxidation. Its interaction with vitamins C and E can affect each other, promote each other, and exert synergistic effects, which can exert greater antioxidant effects on the body. The composition contains a large amount of polyunsaturated fatty acids which also have synergistic effects with vitamins C and E. Vitamin E can control physiological peroxidation, which can synergistically enhance the synergistic effect between polyunsaturated fatty acids and vitamin E. Vitamin C can reduce the peroxidation of free radicals to polyunsaturated fatty acids and improve oxygen in the body. The utilization rate can improve the working ability of the body and accelerate the recovery of the body's activity. Therefore, the combination of Inca fruit oil and sea buckthorn oil, its natural active natural substance, can systematically and comprehensively eliminate various aging-causing substances in the body, significantly enhance the body's antioxidant capacity, achieve the purpose of delaying the body's aging, and also lose weight and beauty. Skin care, and delay skin wrinkles, to avoid dark spots, freckles and so on. In addition, it is effective against heart and vascular diseases as well as promoting blood circulation.
根据本发明的实施例， 该组合物可以为功能食品、 保健食品或化妆品。 从而， 可以方 便地进行使用。 According to an embodiment of the invention, the composition may be a functional food, a health food or a cosmetic. Therefore, it can be easily used.
根据本发明的实施例， 该组合物的形式， 并不受特别限制。 根据本发明的具体示例， 组合物呈硬胶囊、 软胶囊、 片剂、 颗粒剂、 丸剂、 软膏剂、 乳膏剂、 霜剂或乳液的形式。 由此， 便于人使用， 从而提高该组合物用于抗氧化、 延缓衰老和美容护肤方面的效果。 According to an embodiment of the present invention, the form of the composition is not particularly limited. According to a specific example of the invention, the composition is in the form of a hard capsule, a soft capsule, a tablet, a granule, a pill, an ointment, a cream, a cream or an emulsion. Thereby, it is convenient for human use, thereby improving the effects of the composition for anti-oxidation, anti-aging and skin care.
由此， 该组合物可制备成保健食品、 化妆品等。 具体的， 对于保健食品， 可以通过常 规工艺， 加上药剂学上常用的辅料， 制成药剂学上所说的硬胶囊、 软胶囊、 片剂、颗粒剂、 丸剂、 软膏剂、 乳膏剂、 霜剂。 对于具有美容护肤作用的化妆品， 通过常规工艺， 加上药 剂学上常用的辅料， 可以制成药剂学上所说的软膏剂、 乳膏剂、 霜剂、 或乳液、 或滋润护 肤油、 美白护肤霜等。 Thus, the composition can be prepared into a health food, a cosmetic or the like. Specifically, for health foods, hard capsules, soft capsules, tablets, granules, pills, ointments, creams, creams can be prepared by conventional techniques, together with auxiliaries commonly used in pharmacy. Agent. For cosmetics with a cosmetic effect, it can be made into a medicinal ointment, cream, cream, or lotion, or moisturizing skin care oil, whitening skin cream by a conventional process, plus pharmaceutics commonly used excipients. Wait.
根据本发明的实施例，上述组合物可以通过将预定比例的印加果油、沙棘油混合得到。 根据本发明的具体实施例， 印加果油是将印加果的果仁经低温物理冷搾、 过滤除杂后获得 的， 沙棘油是由沙棘种子 （果核） 压搾而成的油。 根据本发明的具体示例， 可以根据下列 方法将上述组合物制备成软胶囊： 先将明胶、 甘油、 水化胶， 制胶带。 将印加果油、 沙棘 油过 100目不锈钢筛网， 搅拌混合均匀得料液， 置于软胶囊压丸机中， 填充压制成软胶囊， 进入滚筒干燥设备进行吹风干燥， 使软胶囊硬化成型， 再经过乙醇杀菌、 擦洗丸， 通过控
制干燥室环境温度与湿度 (50 %以下)， 使胶囊囊壳水分和乙醇自然蒸发掉， 干燥时间不低于 20 小时， 至囊皮表面干燥光洁、 稍有弹性， 干燥完成。 最后将外型、 合缝等不合格的软胶 囊拣选出来弃掉， 将拣选出来的合格软胶囊采用瓶装或泡罩板等形式进行包装， 即得软胶 囊成品。 由此更加便于使用， 以便进一步发挥上述组合物的抗氧化、 抗衰老作用。 According to an embodiment of the present invention, the above composition can be obtained by mixing a predetermined ratio of imprinted fruit oil and sea buckthorn oil. According to a specific embodiment of the present invention, the inca fruit oil is obtained by subjecting the nuts of the Inca fruit to a low temperature physical cold pressing and filtering and removing impurities, and the seabuckthorn oil is an oil which is pressed by sea buckthorn seeds (nucleus). According to a specific example of the present invention, the above composition can be prepared into a soft capsule according to the following method: Gelatin, glycerin, hydration gel, and tape are first prepared. Ink oil and sea buckthorn oil are passed through a 100 mesh stainless steel mesh, stirred and mixed to obtain a liquid, placed in a soft capsule pilling machine, filled into soft capsules, and then dried in a drum drying device to soften the soft capsule. After ethanol sterilization, scrubbing pills, pass the control The drying chamber ambient temperature and humidity (below 50%), so that the capsule shell moisture and ethanol are naturally evaporated, the drying time is not less than 20 hours, until the surface of the capsule is dry and smooth, slightly elastic, and the drying is completed. Finally, the unqualified soft capsules such as appearances and joints are sorted and discarded, and the selected qualified soft capsules are packaged in the form of bottles or blister sheets, that is, the finished soft capsules are obtained. This makes it easier to use in order to further exert the antioxidant and anti-aging effects of the above composition.
根据本发明的实施例， 上述组合物可以呈现的剂型均可按照药学方法中制备相同剂型 的方法制备， 在此不再一一列举。 根据本发明实施例制备的组合物及其剂型均食用安全， 并且其抗氧化、 抗衰老作用效果明显。 According to an embodiment of the present invention, the above dosage forms which can be present in the composition can be prepared according to the method of preparing the same dosage form in a pharmaceutical method, and will not be enumerated here. The compositions prepared according to the examples of the present invention and their dosage forms are safe to eat, and their anti-oxidation and anti-aging effects are remarkable.
在本发明的第二个方面， 本发明提出了一种食品， 该食品包含上述实施例的组合物。 根据本发明的实施例， 该食品的形式并不受特别限制， 只要可以用于食用即可。 根据本发 明的具体示例， 该食品可以呈胶囊剂、 片剂、 冲剂或颗粒剂的形式。 由此， 便于人食用， 从而提高组合物的抗氧化、 延缓衰老的功效。 可以理解， 前面关于组合物特征和优点的描 述， 均适用于该食品， 在此不再赘述。 In a second aspect of the invention, the invention provides a food product comprising the composition of the above examples. According to an embodiment of the present invention, the form of the food is not particularly limited as long as it can be used for eating. According to a specific example of the invention, the food product may be in the form of a capsule, a tablet, a granule or a granule. Thereby, it is convenient for human consumption, thereby improving the anti-oxidation and anti-aging effects of the composition. It will be understood that the foregoing description of the features and advantages of the compositions applies to the food product and will not be described again.
由此， 本发明所提供的食品可以作为保健食品， 其可以通过常规工艺， 制成药剂学 上所说的胶囊剂、 片剂、 或冲剂。 由此便于食用， 以便更加利于发挥其抗氧化、 抗衰老的 功效。 Thus, the food provided by the present invention can be used as a health food, which can be made into a pharmaceutically acceptable capsule, tablet, or granule by a conventional process. It is easy to eat, so as to be more beneficial to its antioxidant and anti-aging effects.
在本发明的第三个方面， 本发明提出了一种化妆品， 该化妆品包含上述实施例的组合 物。 由此该化妆品具有抗氧化、 延迟衰老、 美容养颜护肤的功效。 可以理解， 前面关于组 合物特征和优点的描述， 均适用于该食品， 在此不再赘述。 In a third aspect of the invention, the invention provides a cosmetic comprising the composition of the above examples. Thus, the cosmetic has the effects of anti-oxidation, delayed aging, and beauty and skin care. It will be understood that the foregoing description of the features and advantages of the compositions applies to the food product and will not be described again.
在本发明的四个方面， 本发明提出了一种制备上述实施例中化妆品的方法。 根据本发 明的实施例， 该方法包括： 将预定比例的单硬脂酸甘油酯、 卵磷脂、 肉豆蔻酸、 聚甲基苯 基硅氧烷、 聚乙烯吡咯烷酮和透明质酸混合加热至 90摄氏度， 以便得到第一混合物； 将第 一混合物降温至 50摄氏度时加入山梨酸钾并搅拌均匀； 以便得到第二混合物； 将第二混合 物中加入印加果油和沙棘油， 以便得到所述化妆品。 In four aspects of the invention, the invention proposes a method of preparing the cosmetic of the above embodiments. According to an embodiment of the invention, the method comprises: heating a predetermined ratio of glyceryl monostearate, lecithin, myristic acid, polymethylphenylsiloxane, polyvinylpyrrolidone and hyaluronic acid to 90 degrees Celsius To obtain a first mixture; to add potassium sorbate and to stir evenly when the first mixture is cooled to 50 degrees Celsius; to obtain a second mixture; and to add the indica oil and sea buckthorn oil to the second mixture to obtain the cosmetic.
根据本发明的具体示例， 可以将化妆品制备成不同的类型， 例如乳液、 霜剂等。 可以 理解， 前面， 关于组合物以及化妆品的特征和优点的描述， 均适用于该方法， 在此不再赘 述。 According to a specific example of the present invention, the cosmetic can be prepared into different types such as an emulsion, a cream, and the like. It will be understood that the foregoing description of the features and advantages of the compositions and cosmetics applies to the method and will not be further described herein.
在本发明的地五个方面， 本发明提出了上述实施例组合物在制备制剂中的用途， 制剂 用于抗氧化、 抗衰老、 美容护肤和治疗肥胖的至少之一。 In five aspects of the invention, the invention provides the use of a composition of the above embodiments in the preparation of a formulation for at least one of anti-oxidation, anti-aging, cosmetic and anti-obesity.
经对小鼠抗氧化功能的动物实验表明， 本发明组合物可显著降低小鼠血清中过氧化脂 质降解产物-丙二醛 (MDA)的含量、 并显著提高超氧化物歧化酶 (SOD)的活力。 经对果蝇寿 命的影响实验表明，应用本发明组合物后，雌雄果蝇平均寿命和平均最高寿命均显著延长。 说明本发明组合物可以延缓机体衰老过程， 具有抗氧化、 抗衰老的作用。
对本发明组合物的抗氧化延缓衰老、 美容养颜护肤等作用进行验证， 结果进一步验证 了本发明组合物对人体具有抗氧化、 延缓衰老、 美容养颜护肤的功能， 且具有较好的安全 性。 Animal experiments on the antioxidant function of mice have shown that the composition of the present invention can significantly reduce the content of peroxidized lipid degradation product - malondialdehyde (MDA) in mouse serum, and significantly increase superoxide dismutase (SOD). Vitality. Experiments on the effects on the lifespan of Drosophila showed that the average lifespan and average life expectancy of male and female flies were significantly prolonged after application of the composition of the present invention. It is indicated that the composition of the invention can delay the aging process of the body and has anti-oxidation and anti-aging effects. The anti-oxidation anti-aging, beauty and skin care effects of the composition of the present invention were verified, and the results further confirmed that the composition of the present invention has the functions of anti-oxidation, anti-aging, beauty and skin care, and has good safety.
本发明的有益效果在于： The beneficial effects of the invention are:
1、 本发明所述组合物以传统医药理论为基础， 所有原料取于自然、 源于天然、 安全可 靠， 且原料来源广泛易得， 组方配伍科学合理、 统一协调， 疗效确切， 制备工艺简单， 贮 运和应用安全， 生产成本低廉。 1. The composition of the invention is based on traditional medicine theory, all raw materials are taken from nature, originated from nature, safe and reliable, and the sources of raw materials are widely available, and the compatibility of the prescriptions is scientific and reasonable, unified and coordinated, the curative effect is exact, and the preparation process is simple. , Storage and application safety, low production costs.
2 、 本发明将印加果油和沙棘油的物质及其功能合为一体， 可***而全面的消除体内 各种引起衰老的物质， 既能整体调理身体代谢平衡， 提高生活质量， 又能抗氧化清除自由 基， 能明显增强机体抗氧化能力、 达到延缓机体衰老的目的， 还可减肥美容护肤， 并延缓 皮肤皱纹等， 为人们日常保健提供了新的商业选择。 2. The invention combines the substance and function of the indica oil and the seabuckthorn oil, and systematically and comprehensively eliminates various aging-causing substances in the body, thereby not only regulating the body's metabolic balance, improving the quality of life, but also resisting oxidation. Free radical scavenging can significantly enhance the body's antioxidant capacity, achieve the purpose of delaying the body's aging, weight loss beauty and skin care, and delay skin wrinkles, etc., providing a new business choice for people's daily health care.
本发明的优点将在下面的描述中部分给出， 部分将从下面的描述中变得明显， 或通过 本发明的实践了解到。 具体实施方式 The advantages of the invention will be set forth in part in the description which follows. detailed description
下面实施例是对本发明的进一步说明，而不是限制本发明的保护范围。需要说明的是， 除非明确指出， 下面实施例中所采用的原材料均为市售可得的。 The following examples are intended to further illustrate the invention and are not intended to limit the scope of the invention. It should be noted that the raw materials used in the following examples are commercially available unless explicitly stated.
实施例 1 : 本发明组合物软胶囊 Example 1 : Soft capsule of the composition of the invention
印加果油 20重量份 Inca fruit oil 20 parts by weight
沙棘油 10重量份 Seabuckthorn oil 10 parts by weight
甘油 60重量份 Glycerin 60 parts by weight
明胶 25重量份 Gelatin 25 parts by weight
水 55重量份 Water 55 parts by weight
制备方法： 60重量份的甘油、 25重量份的明胶和 55重量份的水， 加热化胶， 制胶带。 称取印加果油 20重量份、沙棘油 10重量份，过 100目不锈钢筛网， 搅拌混合均匀得料液， 置于软胶囊压丸机中， 填充压制成软胶囊， 进入滚筒干燥设备进行吹风干燥， 使软胶囊硬 化成型， 再经过乙醇杀菌、 擦洗丸， 通过控制干燥室环境温度与湿度 (50 %以下)， 使胶囊囊 壳水分和乙醇自然蒸发掉， 干燥时间不低于 20 小时， 至囊皮表面干燥光洁、 稍有弹性， 干 燥完成。 最后将外型、 合缝等不合格的软胶囊拣选出来弃掉， 将拣选出来的合格软胶囊采 用瓶装或泡罩板等形式进行包装， 即得本发明组合物的软胶囊成品。 Preparation method: 60 parts by weight of glycerin, 25 parts by weight of gelatin and 55 parts by weight of water, heating the gel, and making a tape. Weigh 20 parts by weight of Inca fruit oil, 10 parts by weight of sea buckthorn oil, pass through 100 mesh stainless steel screen, stir and mix to obtain the liquid, put it into soft capsule press machine, fill it into soft capsule, and enter the drum drying equipment to blow Dry, soften the soft capsule, and then sterilize and scrub the pellet by ethanol. By controlling the ambient temperature and humidity (50% or less) of the drying chamber, the capsule shell moisture and ethanol are naturally evaporated, and the drying time is not less than 20 hours. The surface of the capsule is dry and smooth, slightly elastic, and dried. Finally, the unqualified soft capsules such as the outer shape and the joint are sorted and discarded, and the selected qualified soft capsules are packaged in the form of a bottle or a blister board to obtain the soft capsule of the composition of the present invention.
实施例 2: 本发明组合物软胶囊 Example 2: Soft capsule of the composition of the invention
印加果油 10重量份
沙棘油 Inca fruit oil 10 parts by weight Sea buckthorn oil
甘油 Glycerin
明胶 Gelatin
水 Water
制备方法: 同实施例 1。 Preparation method: Same as Example 1.
实施例 3: 本发明组合物软胶 I 印加果油 30重量份 沙棘油 5重量份 甘油 60重量份 明胶 25重量份 水 55重量份 制备方法: 同实施例 1。 Example 3: Soft gel of the composition of the present invention I Ingredients 30 parts by weight Seabuckthorn oil 5 parts by weight Glycerol 60 parts by weight Gelatin 25 parts by weight Water 55 parts by weight Preparation method: The same as Example 1.
实施例 4: 本发明组合物软胶 I 印加果油 16重量份 沙棘油 8重量份 甘油 55重量份 明胶 25重量份 水 55重量份 制备方法: 同实施例 1。 Example 4: Soft gel of the composition of the present invention I Ingredients 16 parts by weight Seabuckthorn oil 8 parts by weight Glycerol 55 parts by weight Gelatin 25 parts by weight Water 55 parts by weight Preparation method: The same as in Example 1.
实施例 5: 本发明组合物软胶 I 印加果油 24重量份 沙棘油 20重量份 甘油 60重量份 明胶 30重量份 水 60重量份 制备方法: 同实施例 1。 Example 5: Soft gel of the composition of the invention I Ingredients 24 parts by weight Seabuckthorn oil 20 parts by weight Glycerol 60 parts by weight Gelatin 30 parts by weight Water 60 parts by weight Preparation method: The same as in Example 1.
实施例 6: 本发明组合物软胶 I 印加果油 Example 6: Soft gel of the composition of the invention I Inca fruit oil
沙棘油 Sea buckthorn oil
甘油 Glycerin
明胶
制备方法： 同实施例 1。 Gelatin Preparation method: Same as Example 1.
实施例 7: 本发明组合物软胶囊 Example 7: Soft capsule of the composition of the invention
印加果油 10重量份 Inca fruit oil 10 parts by weight
沙棘油 15重量份 Seabuckthorn oil 15 parts by weight
甘油 50重量份 Glycerin 50 parts by weight
明胶 40重量份 Gelatin 40 parts by weight
水 70重量份 70 parts by weight of water
制备方法： 同实施例 1。 Preparation method: Same as Example 1.
实施例 8: 本发明组合物美白护肤霜 Example 8: The composition of the present invention whitening skin cream
印加果油 20重量份 Inca fruit oil 20 parts by weight
沙棘油 10重量份 Seabuckthorn oil 10 parts by weight
单硬脂酸甘油酯 20重量份 Glyceryl monostearate 20 parts by weight
卵磷脂 5重量份 Lecithin 5 parts by weight
肉豆蔻酸 15重量份 Myristic acid 15 parts by weight
聚甲基苯基硅氧烷 3重量份 Polymethylphenylsiloxane 3 parts by weight
聚乙烯吡咯烷酮 3重量份 Polyvinylpyrrolidone 3 parts by weight
透明质酸 3重量份 Hyaluronic acid 3 parts by weight
山梨酸钾 1重量份 Potassium sorbate 1 part by weight
制备方法： 按配方中的量分别称取单硬脂酸甘油酯、 卵磷脂、 肉豆蔻酸、 聚甲基苯基 硅氧烷、 聚乙烯吡咯烷酮、 透明质酸， 混合， 加热至 90°C， 使物料熔化、 溶解均匀。 然后 在搅拌下将水慢慢加入到油相物质中， 继续搅拌， 当温度降至 50°C时， 加入防腐剂山梨酸 钾， 静置、 冷却至白色乳状护肤霜后添加印加果油和沙棘油， 调均， 即得美白护肤霜。 制 备得到的护肤品为类白色稀泥状， 颗粒分散均匀、 粘稠的霜体， 涂在皮肤上容易展开， 使 用后对皮肤没有刺激， 放置几天后， 不变色， 不霉变， 不干燥。 Preparation method: glyceryl monostearate, lecithin, myristic acid, polymethylphenylsiloxane, polyvinylpyrrolidone, hyaluronic acid are weighed according to the amount in the formula, and mixed, heated to 90 ° C, The material is melted and dissolved evenly. Then slowly add water to the oil phase material with stirring, continue to stir, when the temperature drops to 50 ° C, add the preservative potassium sorbate, let stand, cool to white milky skin cream, add inca fruit oil and sea buckthorn Oil, tune, that is, whitening skin cream. The prepared skin care product is a white-like muddy body, and the particles are uniformly dispersed and viscous. It is easy to spread on the skin, and is not irritating to the skin after use. After being placed for a few days, it does not change color, is mildewed, and is not dry.
实施例 9: 抗氧化功能动物实验 Example 9: Antioxidant function animal experiment
本实施例采用的试验品由实施例 1制备得到。 The test article used in this example was prepared in the same manner as in Example 1.
实验目的： 观察喂伺本发明组合物对老龄小鼠抗氧化功能的影响。 Experimental Objective: To observe the effect of the composition of the present invention on the antioxidant function of aged mice.
实验方法： 设实验对照组 （含维生素 C和 E的食用油）和 0.34、 0.67、 2.00g/kg本发明 组合物 3个剂量组， 每组 10只 12月龄雄性小鼠， 每日经口给样品 1次， 连续给予 30 do 于第 31d摘眼球采血，离心，取血清，分别测定小鼠血清中过氧化脂质降解产物-丙二醛 (MDA) 含量、 超氧化物歧化酶 (SOD)活力、 以及谷胱甘肽过氧化物酶 (GSH-Px)水平。 Experimental method: The experimental control group (edible oil containing vitamins C and E) and 0.34, 0.67, 2.00 g/kg of the composition of the present invention were administered in three dose groups, each group of 10 male mice of 12 months old, daily oral Give the sample once, continue to give 30 do on the 31st day, take the blood, centrifuge, take serum, and determine the lipid peroxide degradation product - malondialdehyde (MDA) content and superoxide dismutase (SOD) in the serum of mice. Vitality, as well as glutathione peroxidase (GSH-Px) levels.
实验结果：小鼠喂养 30d，一般情况好，毛色光洁，进食稳定，实验期内体重增长平稳，
未见明显异常表现， 无自然死亡。 实验开始、 中期、 末期体重各剂量组与对照组比较无显 著性差异 (P〉0.05)。经口给予小鼠不同剂量的本发明组合物， 2.00 g/kg组 MDA水平较对照 组显著降低， 差异有统计学意义 (P<0.05); SOD 活力较对照组显著升高， 差异有统计学意 义 (P<0.05); GSH-Px水平较对照组有所升高， 差异无统计学意义 (P〉0.05)。 Experimental results: The mice were fed for 30 days, the general condition was good, the coat color was smooth, the food was stable, and the weight gain was stable during the experiment period. No obvious abnormal performance was observed, and no natural death occurred. There was no significant difference between the experimental groups at the beginning, middle and end of the experiment, and the control group (P>0.05). The doses of the present invention were orally administered to mice in different doses. The MDA level in the 2.00 g/kg group was significantly lower than that in the control group (P<0.05); the SOD activity was significantly higher than that in the control group, and the difference was statistically significant. Significance (P<0.05); GSH-Px level was higher than the control group, the difference was not statistically significant (P>0.05).
实验结论： 本发明组合物对小鼠具有抗氧化功能。 Experimental Conclusion: The composition of the present invention has an antioxidant function in mice.
实施例 10: 本发明组合物抗氧化功能的人体试验 Example 10: Human test of antioxidant function of the composition of the present invention
试验品： 本实施例的软胶囊由实施例 3制备得到。 Test article: The soft capsule of this example was prepared in the same manner as in Example 3.
实验目的： 观察试食本发明组合物对人体抗氧化作用及安全性的影响。 Experimental purpose: To observe the effect of the composition of the present invention on the antioxidant activity and safety of human body.
实验方法： 双盲设样品组和安慰剂组， 每组 51例， 每日口服软胶囊 2次， 每次 2粒， 连续服用 150天， 检测服用前后的 MDA、 SOD, GSH-Px水平及生理生化指标。 Experimental methods: Double-blind sample group and placebo group, 51 cases in each group, daily oral soft capsules 2 times, 2 capsules each time, continuous administration for 150 days, detection of MDA, SOD, GSH-Px levels and physiology before and after taking. Biochemical Indicators.
实验结果： 样品组试食后血清中 SOD显著增高， 较试食前提高 21.17%， 差异有统计 学意义 (P<0.05); 与对照组相比， 差异有统计学意义 (P<0.05); 血清中 MDA、 GSH-Px水 平在试食前后的变化无差异 (P〉0.05)， 心电图、胸片、血液学等检查结果未发现异常情况。 Experimental results: After treatment, the serum SOD of the sample group increased significantly, which was 21.17% higher than that before the test, and the difference was statistically significant (P<0.05). Compared with the control group, the difference was statistically significant (P<0.05); serum There was no difference in the changes of MDA and GSH-Px levels before and after the test (P>0.05). No abnormalities were found in the results of electrocardiogram, chest X-ray and hematology.
实施例 11: 抗氧化、 延缓衰老、 美容养颜护肤等作用 Example 11: Antioxidation, anti-aging, beauty and skin care
本是实施例的软胶囊由实施例 5制备得到。 The soft capsules of the examples were prepared in the same manner as in Example 5.
为验证本发明组合物的抗氧化延缓衰老、美容养颜护肤等作用，选用 160例女性试用， 参加者为 33〜56岁， 均为皮肤粗糙， 面部有色斑、 或粉刺等症状的女性。 In order to verify the anti-oxidation anti-aging, beauty and skin care effects of the composition of the present invention, 160 female trials were used, and the participants were 33 to 56 years old, all of whom were rough skin, facial spots, or acne.
试用组： 服用本实施例的软胶囊 2次， 每次 400mg; Trial group: Take the soft capsule of this embodiment twice, 400mg each time;
对照组 1：服用维生素 E软胶囊 2次，每次 400mg(北京同仁堂健康药业股份有限公司）； 对照组 2: 不服用任何软胶囊或其他药物或保健食品； 实验结果见表 1。
Control group 1: Take vitamin E soft capsule 2 times, each time 400mg (Beijing Tongrentang Health Pharmaceutical Co., Ltd.); Control group 2: Do not take any soft capsules or other drugs or health foods; the experimental results are shown in Table 1.
表 1 Table 1
效果很好 延缓衰老， 面部色斑消退， 皮肤细腻白皙; The effect is very good, delaying aging, facial stains subsiding, skin delicate and fair;
效果明显 ΔΔ: 肌肤较以前白嫩， 面部色斑变淡， 脸色较红润有光泽； The effect is obviously ΔΔ : the skin is whiter than before, the facial spots become lighter, and the face is more rosy and shiny;
效果可见 ΔΔΔ： 改善皮肤粗糙及粉刺， 皮肤较以前有弹性； The effect can be seen ΔΔΔ : Improve skin roughness and acne, the skin is more elastic than before;
无效 ΔΔΔΔ: 看不出有任何改变。 Invalid ΔΔΔΔ : No change is seen.
结论： 进一步验证了本发明组合物对人体具有抗氧化、 延缓衰老、 美容养颜护肤的功 能， 并且安全性高。 在本说明书的描述中， 参考术语"一个实施例"、 "一些实施例"、 "示例"、 "具体示例"、 或"一些示例"等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含 于本发明的至少一个实施例或示例中。 在本说明书中， 对上述术语的示意性表述不一定指 的是相同的实施例或示例。 而且， 描述的具体特征、 结构、 材料或者特点可以在任何的一 个或多个实施例或示例中以合适的方式结合。 Conclusion: It has been further verified that the composition of the present invention has the functions of anti-oxidation, anti-aging, beauty and skin care, and has high safety. In the description of the present specification, the description of the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" and the like means a specific feature described in connection with the embodiment or example. A structure, material or feature is included in at least one embodiment or example of the invention. In the present specification, the schematic representation of the above terms does not necessarily mean the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples.
尽管上面已经示出和描述了本发明的实施例，可以理解的是，上述实施例是示例性的， 不能理解为对本发明的限制， 本领域的普通技术人员在不脱离本发明的原理和宗旨的情况 下在本发明的范围内可以对上述实施例进行变化、 修改、 替换和变型。
Although the embodiments of the present invention have been shown and described, it is understood that the foregoing embodiments are illustrative and not restrictive Variations, modifications, alterations and variations of the above-described embodiments are possible within the scope of the invention.
Claims
1、 一种组合物， 其特征在于， 包括： 1. A composition, characterized in that it includes:
10〜30重量份的印加果油； 以及 10 to 30 parts by weight of sacha inchi oil; and
5〜25重量份的沙棘油。 5 to 25 parts by weight of sea buckthorn oil.
2、 根据权利要求 1 所述的组合物， 其特征在于， 包括： 2. The composition according to claim 1, comprising:
16〜24重量份的印加果油； 以及 16 to 24 parts by weight of sacha inchi oil; and
8-20重量份的沙棘油。 8-20 parts by weight of sea buckthorn oil.
3、 根据权利要求 1 所述的组合物， 其特征在于， 包括： 3. The composition according to claim 1, comprising:
20重量份的印加果油； 以及 20 parts by weight of sacha inchi oil; and
10重量份的沙棘油。 10 parts by weight of sea buckthorn oil.
4、 根据权利要求 1-3任意一项所述的组合物， 其特征在于， 进一步包括： 4. The composition according to any one of claims 1-3, further comprising:
50-65重量份的甘油； 50-65 parts by weight of glycerol;
20〜40重量份的明胶； 以及 20 to 40 parts by weight of gelatin; and
50-70重量份的水。 50-70 parts by weight of water.
5、 根据权利要求 1-3任意一项所述的组合物， 其特征在于， 进一步包括： 5. The composition according to any one of claims 1 to 3, further comprising:
60重量份的甘油； 60 parts by weight of glycerin;
25重量份的明胶； 以及 25 parts by weight of gelatin; and
55重量份的水。 55 parts by weight of water.
6、 根据权利要求 1-3任意一项所述的组合物， 其特征在于， 进一步包括： 6. The composition according to any one of claims 1-3, further comprising:
20重量份的单硬脂酸甘油酯； 20 parts by weight of glyceryl monostearate;
5重量份的卵磷脂； 5 parts by weight of lecithin;
15重量份的肉豆蔻酸； 15 parts by weight of myristic acid;
3重量份的聚甲基苯基硅氧烷； 3 parts by weight of polymethylphenylsiloxane;
3重量份的聚乙烯吡咯烷酮； 3 parts by weight of polyvinylpyrrolidone;
3重量份的透明质酸 ； 以及 3 parts by weight of hyaluronic acid; and
1重量份的山梨酸钾。 1 part by weight of potassium sorbate.
7、 根据权利要求 1-6任意一项所述的组合物， 其特征在于， 所述组合物为功能食品、 保健食品或化妆品。 7. The composition according to any one of claims 1 to 6, characterized in that the composition is functional food, health food or cosmetics.
8、 根据权利要求 1-6任意一项所述的组合物， 其特征在于， 所述组合物呈胶囊剂、 片 剂、 颗粒剂、 丸剂、 软膏剂、 乳膏剂或霜剂的形式。 8. The composition according to any one of claims 1 to 6, characterized in that the composition is in the form of capsules, tablets, granules, pills, ointments, creams or creams.
9、 一种食品， 其特征在于， 包含权利要求 1-8任意一项所述的组合物。
9. A food, characterized in that it contains the composition according to any one of claims 1-8.
10、 一种化妆品， 其特征在于， 包含权利要求 1-8任意一项所述的组合物。 10. A cosmetic, characterized in that it contains the composition according to any one of claims 1-8.
11、 一种制备权利要求 10所述的化妆品的方法， 其特征在于， 包括： 11. A method for preparing the cosmetics according to claim 10, characterized in that it includes:
将预定比例的单硬脂酸甘油酯、 卵磷脂、 肉豆蔻酸、 聚甲基苯基硅氧烷、 聚乙烯吡咯 烷酮和透明质酸混合加热至 90摄氏度， 以便得到第一混合物； Mix and heat a predetermined proportion of glyceryl monostearate, lecithin, myristic acid, polymethylphenylsiloxane, polyvinylpyrrolidone and hyaluronic acid to 90 degrees Celsius to obtain a first mixture;
将所述第一混合物降温至 50摄氏度时加入山梨酸钾并搅拌均匀；以便得到第二混合物； 将所述第二混合物中加入印加果油和沙棘油， 以便得到所述化妆品。 When the temperature of the first mixture is cooled to 50 degrees Celsius, potassium sorbate is added and stirred evenly to obtain the second mixture; Inchi inchi oil and sea buckthorn oil are added to the second mixture to obtain the cosmetics.
12、 权利要求 1-8任意一项所述的组合物在制备制剂中的用途， 所述制剂用于抗氧化、 抗衰老、 美容护肤和治疗肥胖的至少之一。
12. Use of the composition of any one of claims 1 to 8 in preparing a preparation for at least one of antioxidant, anti-aging, beauty and skin care, and obesity treatment.
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