WO2014118099A1 - Naphtoquinones fongicides et dérivés - Google Patents

Naphtoquinones fongicides et dérivés Download PDF

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WO2014118099A1
WO2014118099A1 PCT/EP2014/051461 EP2014051461W WO2014118099A1 WO 2014118099 A1 WO2014118099 A1 WO 2014118099A1 EP 2014051461 W EP2014051461 W EP 2014051461W WO 2014118099 A1 WO2014118099 A1 WO 2014118099A1
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alkyl
compounds
meaning
cycloalkyl
substituents
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PCT/EP2014/051461
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Christine WIEBE
Joachim Rheinheimer
Doris KREMZOW-GRAW
Franz Röhl
Sonia SCHWOLOW
Till Opatz
Anja SCHÜFFLER
Horst Kunz
Eckhard Thines
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Basf Se
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings

Definitions

  • the present invention relates to fungicidal naphthoquinones and derivatives, compositions comprising them, to their use and to methods for combating
  • the present invention also relates to seeds treated with at least one such compound.
  • the fungicidal activity of known fungicidal compounds is unsatisfactory. Based on this, it was an object of the present invention to provide compounds having improved activity and/or a broader activity spectrum against phytopathogenic fungi on field crops. This objective is achieved by the use of substituted naphthoquinones and derivatives of formula I having good fungicidal activity against phytopathogenic fungi on field crops.
  • phytopathogenic fungi with mollisin or its derivatives on field crops as defined herein differ from those described in the abovementioned publications in that they are characterized by specific substituents R 1 at the acyl group.
  • R Ya is halogen, CN, N0 2 , OH, SH, NH 2 , Ci-C 6 -alkyl, Ci-Ce-haloalkyl,
  • R YN is independently selected from hydrogen, OH, NH 2 , Ci-C6-alkyl, C 2 -C6-alk- enyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 ,
  • R b is halogen, CN, OH, SH, NH 2 , Ci-C 6 -alkyl, Ci-Ce-haloalkyl,
  • R1c is fluorine, Ci-C6-alkyl, C 2 -C6-alkenyl or C 2 -C6-alkynyl; wherein the aliphatic moieties are substituted by 1 , 2, 3, 4 or up to the maximum possible number of fluorine atoms; fluorine, Ci-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; is halogen, CN, N0 2 , OH, SH, Ci-C 6 -alkyl, Ci-C 6 -alkoxy, Ci-C 6 -alkylthio, Ci-C 6 - alkylsulfinyl, Ci-C6-alkylsulfonyl, C2-C6-alkenyl, C2-C6-alkynyl, Ca-Cs-cycloalkyl, Ca-Cs-cycloalkoxy, NH 2 , NH(Ci-C 4 -alkyl),
  • R 2a is halogen, CN, N0 2 , OH, SH, NH 2 , Ci-Cs-alkyl, Ci-C 6 -haloalkyl,
  • R 3a is halogen, CN, NO2, OH, SH, NH 2 , Ci-Cs-alkyl, Ci-C 6 -haloalkyl,
  • Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or C 3 - Cs-cycloalkyl; is hydrogen, halogen, CN, N0 2 , OH, SH, Ci-C 6 -alkyl, Ci-C 6 -alkoxy, Ci-C 6 - alkylthio, Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, C2-C6-alkenyl, C2-C6-alkynyl, C 3 - Ce-cycloalkyl, C 3 -C 8 -cycloalkoxy, NH 2 , NH(Ci-C -alkyl), N(Ci-C -alkyl) 2 ,
  • R 6 is hydrogen, halogen, CN, N0 2 , OH, SH, Ci-C 6 -alkyl, Ci-C 6 -alkoxy, Ci-C 6 - alkylthio, Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, C2-C6-alkenyl, C2-C6-alkynyl, C 3 - Cs-cycloalkyl, C 3 -C 8 -cycloalkoxy, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 ,
  • R 6a is halogen, CN, N0 2 , OH, SH, NH 2 , Ci-C 5 -alkyl, Ci-C 6 -haloalkyl,
  • R 5a is halogen, CN, N0 2 , OH, SH, NH 2 , Ci-C 6 -alkyl, Ci-C 6 -haloalkyl,
  • the present invention also provides a use of compounds of the formula I and/or their agriculturally useful salts for controlling phytopathogenic fungi on field crops and to methods for combating phytopathogenic fungi on field crops, which process comprises treating the fungi or the materials, plants, the soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula I or of an N-oxide or an agriculturally acceptable salt thereof.
  • the invention further provides compositions comprising these compounds I and/or their agriculturally acceptable salts.
  • the present invention also relates to seeds treated with at least one such compound or seeds comprising at least one such compound.
  • Agriculturally useful salts of the compounds I encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of the compounds I.
  • Suitable cations are thus in particular the ions of the alkali metals, preferably sodium and potassium, of the alkaline earth metals, preferably calcium, magnesium and barium, of the transition metals, preferably manganese, copper, zinc and iron, and also the ammonium ion which, if desired, may carry one to four Ci-C4-alkyl substituents and/or one phenyl or benzyl substituent, preferably diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, furthermore phosphonium ions, sulfonium ions, preferably tri(Ci-C4-alkyl)sulfonium, and sulfoxonium
  • Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of Ci-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate. They can be formed by reacting a compound I with an acid of the
  • anion preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid or nitric acid.
  • Compounds I can exist as one or more stereoisomers.
  • the various stereoisomers include enantiomers, diastereomers, atropisomers arising from restricted rotation about a single bond of asymmetric groups and geometric isomers.
  • one stereoisomer may be more active and/or may exhibit beneficial effects when enriched relative to the other stereoisomer(s) or when separated from the other stereoisomer(s). Additionally, the skilled artisan knows how to separate, enrich, and/or to selectively prepare said stereoisomers.
  • the compounds of the invention may be present as a mixture of stereoisomers, e.g. a racemate, individual stereoisomers, or as an optically active form.
  • Compounds I can be present in different crystal modifications whose biological activity may differ. They also form part of the subject matter of the present invention.
  • the compounds of formula I can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention.
  • C n -C m indicates the number of carbon atoms possible in each case in the substituent or substituent moiety in question.
  • halogen refers to fluorine, chlorine, bromine and iodine.
  • Ci-C6-alkyl refers to a straight-chained or branched saturated hydrocarbon group having 1 to 6 carbon atoms, for example methyl, ethyl, propyl, 1 -methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, and 1 ,1-dimethylethyl.
  • Ci-C6-haloalkyl refers to a straight-chained or branched alkyl group having 1 to 6 carbon atoms (as defined above), wherein some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as mentioned above, for example chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoro- methyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl,
  • Ci-C6-alkoxy refers to a straight-chain or branched alkyl group having 1 to 6 carbon atoms (as defined above) which is bonded via an oxygen, at any position in the alkyl group, for example methoxy, ethoxy, n-propoxy, 1 -methylethoxy, butoxy, 1-meth- yhpropoxy, 2-methylpropoxy or 1 ,1 -dimethylethoxy.
  • Ci-C6-hydroxyalkyl refers to a straight-chained or branched alkyl group having 1 to 6 carbon atoms (as defined above), wherein one hydrogen atom in these groups may be replaced by one hydroxy group, for example hydroxym ethyl,
  • Ci-C6-haloalkoxy refers to a Ci-C6-alkoxy group as defined above, wherein some or all of the hydrogen atoms may be replaced by halogen atoms as mentioned above, for example, OCH 2 F, OCHF 2 , OCF 3 , OCH 2 CI, OCHCI 2 , OCCI 3 , chlorofluoro- methoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 2-fluoroethoxy, 2-chloro- ethoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, OC2F5, 2-fluoropropoxy, 3-fluoropropoxy,
  • phenyl-Ci-C4-alkyl or heteroaryl-Ci-C4-alkyl refer to alkyl having 1 to 4 carbon atoms (as defined above), wherein one hydrogen atom of the alkyl radical is replaced by a phenyl or hetereoaryl radical respectively.
  • Ci-C4-alkoxy-Ci-C4-alkyl refers to alkyl having 1 to 4 carbon atoms (as defined above), wherein one hydrogen atom of the alkyl radical is replaced by a
  • Ci-C4-alkoxy group (as defined above).
  • Ci-C6-alkoxy-Ci-C4-alkyl refers to alkyl having 1 to 6 carbon atoms (as defined above), wherein one hydrogen atom of the alkyl radical is replaced by a Ci-C6-alkoxy group (as defined above).
  • Ci-C6-alkylthio refers to straight-chain or branched alkyl groups having 1 to 6 carbon atoms (as defined above) bonded via a sulfur atom.
  • Ci-C6-haloalkylthio refers to straight-chain or branched haloalkyl group having 1 to 6 carbon atoms (as defined above) bonded through a sulfur atom, at any position in the haloalkyl group.
  • C2-C6-alkenyl refers to a straight-chain or branched unsaturated
  • hydrocarbon radical having 2 to 6 carbon atoms and a double bond in any position such as ethenyl, 1-propenyl, 2-propenyl (allyl), 1 -methylethenyl, 1-butenyl, 2-butenyl,
  • C2-C6-alkynyl refers to a straight-chain or branched unsaturated
  • C 3 -C8-cycloalkyl refers to monocyclic saturated hydrocarbon radicals having 3 to 8 carbon ring members such as cyclopropyl (C3H5), cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl.
  • C3-C8-cycloalkyl-Ci-C4-alkyl refers to a cycloalkyi radical having 3 to 8 carbon atoms (as defined above), which is bonded via a Ci-C4-alkyl group (as defined above).
  • C 3 -C8-cycloalkyl-C 3 -C8-cycloalky refers to a cycloalkyi radical having 3 to 8 carbon atoms (as defined above), which is substituted by a further cycloalkyi radical having 3 to 8 carbon atoms.
  • C 3 -C8-cycloalkyloxy refers to a cycloalkyi radical having 3 to 8 carbon atoms (as defined above), which is bonded via an oxygen.
  • the number of valence of carbon is 4, that of nitrogen is 3.
  • saturated or partially unsaturated 3-, 4- 5-, 6- or 7-membered carbocycle is to be understood as meaning both saturated or partially unsaturated carbocycles having 3, 4, 5, 6 or 7 ring members.
  • Examples include cyclopropyl, cyclopentyl, cyclopentenyl, cyclopentadienyl, cyclohexyl, cyclohexenyl, cyclohexadienyl, cycloheptyl, cycloheptenyl, cycloheptadienyl, and the like.
  • saturated or partially unsaturated 3-, 4-, 5-, 6-, or 7-membered heterocycle wherein the ring member atoms of the heterocycle include besides carbon atoms 1 , 2, 3 or 4 heteroatoms independently selected from the group of N, O and S
  • saturated and partially unsaturated heterocycles for example: a 3- or 4-membered saturated heterocycle which contains 1 or 2 heteroatoms from the group consisting of N, O and S as ring members such as oxirane, aziridine, thiirane, oxetane, azetidine, thiethane, [1 ,2]dioxetane, [1 ,2]dithietane, [1 ,2]diazetidine; and a 5- or 6-membered saturated or partially unsaturated heterocycle which contains
  • heteroatoms from the group consisting of N, O and S as ring members such as 2-tetrahydrofuranyl, 3-tetrahydrofuranyl, 2-tetrahydrothienyl, 3- tetrahydrothienyl, 2-pyrrolidinyl, 3-pyrrolidinyl, 3-isoxazolidinyl, 4-isoxazolidinyl, 5- isoxazolidinyl, 3-isothiazolidinyl, 4-isothiazolidinyl, 5-isothiazolidinyl, 3- pyrazolidinyl, 4-pyrazolidinyl, 5-pyrazolidinyl, 2-oxazolidinyl, 4-oxazolidinyl, 5- oxazolidinyl, 2-thiazolidinyl, 4-thiazolidinyl, 5-thiazolidinyl, 2-imidazolidinyl, 4- imidazolidinyl, 1 ,2,4-oxadiazolidin-3-y
  • 5-membered heteroaryl refers to aromatic ring systems incuding besides carbon atoms, 1 , 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S, for example, a 5-membered heteroaryl such as pyrrol-1-yl, pyrrol-2-yl, pyrrol-3-yl, thien-2-yl, thien-3-yl, furan-2-yl, furan-3-yl, pyrazol-1 -yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5- yl, imidazol-1-yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4- yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5
  • Q 1 and Q 2 are to be understood as representing two oxidation states of the aromatic system.
  • R Q0 are independently selected from hydrogen, Ci-C6-alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl,
  • R QO are independently selected from hydrogen, d-Ce-alkyl, C 2 -C 3 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl,
  • R Q0 wherein the aliphatic, alicyclic moieties of R Q0 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Qa as defined or preferably defined below.
  • R QO are independently selected from hydrogen, Ci-C6-alkyl and C 2 -C6-alkenyl; wherein the aliphatic moieties of R Q0 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Qa as defined or preferably defined below.
  • R QO is independently selected from hydrogen, C1-C6- alkyl, in particular methyl, ethyl, 1 -methyl-ethyl, n-propyl, and C2-C6-alkenyl, in particular 2-propenyl (allyl).
  • R Q0 is hydrogen.
  • R QN are independently selected from hydrogen, OH , N H2, d-Ce-alkyl, C 2 -C 5 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, NH(Ci-C 4 -alkyl), N(Ci-C - alkyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalk
  • R QN are independently selected from hydrogen, OH, N H2, d-Ce-alkyl, C 2 -C 5 -alkenyl, C 2 -C 5 -alkynyl, C 3 -C 8 -cycloalkyl, NH(d-d-alkyl),
  • N(d-C 4 -alkyl) 2 N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 ,
  • R QN wherein the aliphatic and alicyclic moieties of R QN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Qa as defined or preferably defined below.
  • R QN are independently selected from hydrogen, OH, d-Ce-alkyl, C 2 -C 3 -alkenyl, C 2 -C 3 -alkynyl, C 3 -C 8 -cycloalkyl, wherein the aliphatic and alicyclic moieties of R QN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Qa as defined or preferably defined below.
  • R QN are independently selected from hydrogen, OH , Ci-C6-alkyl, C2-C6-alkenyl; wherein the aliphatic moieties of R QN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Qa as defined or preferably defined below.
  • R QN are independently selected from hydrogen, Ci-C6-alkyl, in particular methyl, ethyl, 1 -methyl-ethyl, n-propyl, and C2-C6-alkenyl, in particular 2-propenyl (allyl).
  • R QN is hydrogen.
  • R Qa according to the invention is halogen, CN , NO2, OH, SH, N H 2 , Ci-C6-alkyl,
  • Ci-C6-haloalkyl Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or d-Ce-cycloalkyl.
  • R Qa is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl,
  • R Qa is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R Qa is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R Qa is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R Qa is fluorine. In another preferred aspect thereof R Qa is chlorine.
  • R Y0 are independently selected from hydrogen, Ci-C6-alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl,
  • R Y0 are independently selected from hydrogen, d-Ce-alkyl, C 2 -C 3 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl,
  • R Y0 wherein the aliphatic, alicyclic moieties of R Y0 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YO are independently selected from hydrogen, Ci-C6-alkyl and C2-C6-alkenyl; wherein the aliphatic moieties of R Y0 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R Y0 is independently selected from hydrogen, C1-C6- alkyl, in particular methyl, ethyl, 1 -methyl-ethyl, n-propyl, and C 2 -C6-alkenyl, in particular 2-propenyl (allyl).
  • R Y0 is hydrogen.
  • R YN aliphatic, alicyclic and aromatic moieties of R YN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YN are independently selected from hydrogen, OH, NH 2 , C1-C6- alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 ,
  • R YN aliphatic and alicyclic moieties of R YN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YN are independently selected from hydrogen, OH, NH 2 , d-Ce-alkyl, C 2 -C 3 -alkenyl, C 2 -C 3 -alkynyl, C 3 -C 8 -cycloalkyl, NH(Ci-C -alkyl),
  • R YN wherein the aliphatic and alicyclic moieties of R YN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YN are independently selected from hydrogen, OH, Ci-Ce-alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, wherein the aliphatic and alicyclic moieties of R YN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YN are independently selected from hydrogen, OH, Ci-C6-alkyl, C2-C6-alkenyl; wherein the aliphatic moieties of R YN are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R Ya as defined or preferably defined below.
  • R YN are independently selected from hydrogen, Ci-C6-alkyl, in particular methyl, ethyl, 1 -methyl-ethyl, n-propyl, and C 2 -C6-alkenyl, in particular 2-propenyl (allyl).
  • R YN is hydrogen.
  • R Ya is halogen, CN , NO2, OH , SH , NH2, d-Ce-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or C3-C8-cycloalkyl.
  • R Ya is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl,
  • Ci-C6-alkoxy Ci-C6-haloalkoxy or Ca-Ce-cycloalkyl.
  • R Ya is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R Ya is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R Ya is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R Ya is fluorine. In another preferred aspect thereof R Ya is chlorine.
  • R 1 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties of R 1 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R a as defined or preferably defined below; or Ci-C6-alkyl, which is substituted by one, two, three or four or up to the maximum possible number of fluorine atoms.
  • R 1 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties of R 1 are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R a as defined or preferably defined below.
  • R 1 is phenyl, which is unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 1a as defined or preferably defined below.
  • R 1 is selected from 2-F-phenyl, 3-F-phenyl, 4-F-phenyl, 2-CI-phenyl, 3-CI-phenyl, 4-CI-phenyl, 4-Br-phenyl, 4-l-phenyl, 4-CH 3 -phenyl, 4-OCH 3 - phenyl, 2-CF 3 -phenyl, 3-CF 3 -phenyl, 4-CF 3 -phenyl, 2-CHF 2 -phenyl, 3-CHF 2 -phenyl, 4-CHF 2 -phenyl, 2,4-F 2 -phenyl, 2,3-F 2 -phenyl, 2,5-F 2 -phenyl, 2,6-F 2 -phenyl,
  • R 1 is a is 5- or 6-membered heteroaryl which is unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 1a as defined or preferably defined below.
  • R 1 is selected from thien-2-yl, thien-3-yl, pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, 1 ,2,4-triazolyl-1-yl, 1 ,2,4-triazol-3-yl 1 ,2,4-triazol-5-yl, pyridine-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2
  • R 1 is selected from thien-2-yl, thien-3-yl, pyrazol-1 -yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, imidazol-1 -yl, imidazol-2-yl, imidazol-4-yl, imidazol-5-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl; wherein the aromatic moieties of R 1 are unsubstituted or substituted by 1 , 2 or 3 independently selected substituents R 1a as defined or preferably defined below
  • R 1 is Ci-C6-alkyl, in particular methyl and ethyl, which is unsubsbtituted or substituted by 1 , 2, 3 or up to the maximum possible number of halogen atoms.
  • R 1 is Ci-C6-alkyl, in particular methyl and ethyl, which is substituted by 1 , 2, 3 or up to the maximum possible number of fluorine atoms.
  • R 1a is halogen, CN , N0 2 , OH , SH, NH 2 , Ci-C 6 -alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio, C3-C8-cycloalkyl, phenyl, phenoxy, heteroaryl or heteroaryloxy; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moiety of R 1a is unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 1b as defined or preferably defined below.
  • R 1a is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy or C3-C8-cycloalkyl.
  • R 1a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 1a is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R 1a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 1a is fluorine. In another preferred aspect thereof R 1a is chlorine.
  • R 1b according to the invention is halogen, CN , OH, SH , N H2, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio or Ci-C6-haloalkylthio.
  • R 1b is fluorine, CN , OH, SH , N H 2 , Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio or Ci-C6-haloalkylthio.
  • R 1 is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy.
  • R 1 b is fluorine, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy or Ci-C6-haloalkoxy.
  • R 1 b is halogen, in particular fluorine or chlorine, CN , Ci-C6-alkyl, in particular methyl, ethyl, n-propyl or 1 -methylethyl, or Ci-C6-alkoxy, in particular methoxy, ethoxy or 1-methylethoxy.
  • R 1 is halogen, in particular fluorine, chlorine or bromine.
  • R 1 b is fluorine.
  • R 1 b is chlorine.
  • R 1c is hydrogen, halogen, Ci-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of halogen atoms.
  • R 1 c according to the invention is fluorine, Ci-C6-alkyl,
  • R 1 c is fluorine or Ci-C6-alkyl, in particular methyl, ethyl, n- propyl and 1-methylethyl; wherein the aliphatic moieties are substituted by 1 , 2, 3, 4 or up to the maximum possible number of fluorine atoms.
  • R 1d according to the invention is hydrogen, halogen, Ci-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl.
  • R 1 d is fluorine, Ci-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl.
  • R d is fluorine or Ci-C6-alkyl, preferably methyl, ethyl, n-propyl and 1-methylethyl. More preferably R 1d is fluorine or chlorine, most preferably fluorine.
  • R 2 is halogen, CN, NO2, OH, SH , Ci-C6-alkyl, Ci-C6-alkoxy, C 2 -C6-alkenyl, C2-C6-alkynyl, C 3 -C8-cycloalkyl, C 3 -C8-cycloalkoxy, N H 2 , N H(Ci-C 4 -alkyl), N(Ci-C -alkyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 2a as defined or preferably defined below.
  • R 2 is halogen, CN, OH, Ci-C6-alkyl, Ci-C6-alkoxy,
  • R 2 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 2a as defined or preferably defined below.
  • R 2 is halogen, CN, OH, Ci-C6-alkyl, Ci-C6-alkoxy,
  • R 2 is halogen, CN, Ci-C6-alkyl or Ci-C6-alkoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 2a as defined or preferably defined below.
  • R 2 is Ci-C6-alkyl in particular methyl, ethyl, n-propyl and 1-methylethyl, or Ci-C6-alkoxy, in particular methoxy, ethoxy, n-propoxy and 1- methylethoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 2a as defined or preferably defined below.
  • R 2 is Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1 -methylethyl, which are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 2a as defined or preferably defined below.
  • R 2 is CH 3 , CH 2 CI, CHCI2 or CCI3.
  • R 2a according to the invention is halogen, CN, NO2, OH, SH, NH 2 , Ci-C6-alkyl,
  • Ci-C6-haloalkyl Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or Cs-Ce-cycloalkyl.
  • R 2a is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl,
  • Ci-C6-alkoxy Ci-Cs-haloalkoxy or Ca-Cs-cycloalkyl.
  • R 2a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 2a is halogen, in particular fluorine and chlorine
  • R 2a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 2a is fluorine. In another preferred aspect thereof R 2a is chlorine.
  • R 3 is halogen, CN , NO2, OH, SH , Ci-C6-alkyl, Ci-C6-alkoxy, Ci-C6-alkylthio, Ci-C6-alkylsulfinyl, Ci-C6-alkylsulfonyl, C2-C6-alkenyl, C2-C6-alkynyl, Cs-Cs-cycloalkyl, C 3 -C 8 -cycloalkoxy, N H 2 , N H(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 3 -C 6 - cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 ,
  • R 3 is halogen, CN, N0 2 , OH, SH , Ci-C6-alkyl, Ci-C6-alkoxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl, C 3 -C8-cycloalkyl, Ca-Ce-cycloalkoxy, N H 2 , N H(Ci-C 4 -alkyl), N(Ci-C -alkyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 -cycloalkyl) 2 , phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is halogen, CN, OH, Ci-C6-alkyl, Ci-C6-alkoxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl, C 3 -C8-cycloalkyl, phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is halogen, CN, OH , Ci-Cs-alkyl, Ci-C6-alkoxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl or C 3 -Cs-cycloalkyl; wherein the aliphatic and alicyclic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is halogen, CN , Ci-C6-alkyl or Ci-C6-alkoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is Ci-C6-alkyl in particular methyl, ethyl, n-propyl and 1-methylethyl, or Ci-C6-alkoxy, in particular methoxy, ethoxy, n-propoxy and 1- methylethoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1 -methylethyl, which are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 3a as defined or preferably defined below.
  • R 3 is CH3, CH2CI, CHC or CCI3.
  • R 3a is halogen, CN , NO2, OH , SH, NH2, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or C3-C8-cycloalkyl.
  • R 3a is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl,
  • Ci-C6-alkoxy Ci-C6-haloalkoxy or C 3 -C8-cycloalkyl.
  • R 3a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 3a is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R 3a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 3a is fluorine. In another preferred aspect thereof R 3a is chlorine.
  • R 4 is hydrogen, halogen, CN , NO2, OH, SH , Cr C6-alkyl, Ci-C6-alkoxy, C2-C6-alkenyl, C2-C6-alkynyl, Cs-Cs-cycloalkyl, C 3 -Ce- cycloalkoxy, N H 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , N H(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 - cycloalkyl)2, phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is hydrogen, halogen, CN, OH , Ci-C6-alkyl, Ci-C6-alk- oxy, C2-C6-alkenyl, C2-C6-alkynyl, C 3 -C8-cycloalkyl, phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is hydrogen, halogen, CN , OH , Ci-C6-alkyl, Ci-C6-alk- oxy, C2-C6-alkenyl, C2-C6-alkynyl or Ca-Ce-cycloalkyl; wherein the aliphatic and alicyclic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is hydrogen, halogen, CN, Ci-C6-alkyl or Ci-C6-alk- oxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is Ci-C6-alkyl in particular methyl, ethyl, n-propyl and 1-methylethyl, or Ci-C6-alkoxy, in particular methoxy, ethoxy, n-propoxy and 1- methylethoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1 -methylethyl, which are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 4a as defined or preferably defined below.
  • R 4 is hydrogen, CH3 or chlorine.
  • R 4 is hydrogen
  • R 4a according to the invention is halogen, CN , NO2, OH , SH, NH 2 , Ci-Ce-alkyl,
  • Ci-C6-haloalkyl Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or Cs-Ce-cycloalkyl.
  • R 4a is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl,
  • Ci-C6-alkoxy Ci-Cs-haloalkoxy or Ca-Cs-cycloalkyl.
  • R 4a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 4a is halogen, in particular fluorine and chlorine
  • Ci-C6-alkyl in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R 4a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 4a is fluorine. In another preferred aspect thereof R 4a is chlorine.
  • R 6 is hydrogen, halogen, CN, N0 2 , OH, SH, Ci- C6-alkyl, Ci-C6-alkoxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl, C 3 -C8-cycloalkyl, C 3 -C 3 - cycloalkoxy, NH 2 , NH(Ci-C 4 -alkyl), N(Ci-C 4 -alkyl) 2 , NH(C 3 -C 6 -cycloalkyl), N(C 3 -C 6 - cycloalkyl) 2 , phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below
  • R 6 is hydrogen, halogen, CN, OH, Ci-C6-alkyl, Ci-C6-alk- oxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl, C 3 -C8-cycloalkyl, phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aliphatic, alicyclic and aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below.
  • R 6 is phenyl or heteroaryl; wherein the heteroaryl radical is 5- or 6-membered; and wherein the aromatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below.
  • R 6 is hydrogen, halogen, CN, OH, Ci-C6-alkyl, Ci-C6-alk- oxy, C 2 -C6-alkenyl, C 2 -C6-alkynyl or C 3 -C8-cycloalkyl; wherein the aliphatic and alicyclic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below.
  • R 6 is hydrogen, halogen, CN, Ci-C6-alkyl or Ci-C6-alk- oxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 5a as defined or preferably defined below.
  • R 6 is Ci-C6-alkyl in particular methyl, ethyl, n-propyl and 1-methylethyl, or Ci-C6-alkoxy, in particular methoxy, ethoxy, n-propoxy and 1- methylethoxy; wherein the aliphatic moieties are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below.
  • R 6 is Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1 -methylethyl, which are unsubstituted or substituted by 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 6a as defined or preferably defined below.
  • R 6 is hydrogen, CH3 or chlorine.
  • R 6 is hydrogen
  • R 6a is halogen, CN , NO2, OH , SH, NH 2 , d-Ce-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or C3-C8-cycloalkyl.
  • R 6a is halogen, CN , Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy or Ca-Cs-cycloalkyl.
  • R 6a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 6a is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1-methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1-methylethoxy.
  • R 6a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 6a is fluorine. In another preferred aspect thereof R 6a is chlorine.
  • R 5 is hydrogen, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, Ci-C6-alkylsulfonyl, phenylsulfonyl,
  • R 5 is hydrogen, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, Ci-C6-alkylsulfonyl, phenylsulfonyl,
  • R 5 is hydrogen, Ci-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, d-Ce-alkylsulfonyl, phenylsulfonyl, or phenyl-Ci-C4-alkyl; wherein the aliphatic and aromatic moieties are unsubstituted or carry 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 5a as defined or preferably defined below.
  • R 5 is Ci-C6-alkylsulfonyl, in particular methylsulfonyl (mesyl), or phenylsulfonyl, in particular para-tolylsulfonyl (tosyl); wherein the aliphatic and aromatic moieties are unsubstituted or carry 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 5a as defined or preferably defined below.
  • R 5 is phenyl-Ci-C4-alkyl, in particular phenyl-CH 2 - (benzyl), or heteroaryl-Ci-C4-alkyl; wherein the heteroaryl group is 5- or 6-membered; and wherein the aliphatic and aromatic moieties are unsubstituted or carry 1 , 2, 3, 4 or up to the maximum possible number of independently selected substituents R 5a as defined or preferably defined below.
  • R 5 is hydrogen, Ci-C6-alkyl, C 2 -C6-alkenyl or C 2 - C6-alkynyl.
  • R 5 is Ci-C6-alkyl, in particular methyl, ethyl, n- propyl and 1 -methylethyl, or C 2 -C6-alkenyl, in particular 2-propenyl.
  • R 5 is hydrogen, methylsulfonate, para- tolylsulfonate or acetyl.
  • R 5 is hydrogen.
  • R 5a according to the invention is halogen, CN, N0 2 , OH, SH, NH 2 , Ci-C 6 -alkyl,
  • Ci-C6-haloalkyl Ci-C6-alkoxy, Ci-C6-haloalkoxy, Ci-C6-alkylthio, Ci-C6-haloalkylthio or C 3 -C8-cycloalkyl.
  • R 5a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl,
  • Ci-C6-alkoxy Ci-C6-haloalkoxy or C 3 -C8-cycloalkyl.
  • R 5a is halogen, CN, Ci-C6-alkyl, Ci-C6-haloalkyl, Ci-C6-alkoxy, Ci-C6-haloalkoxy.
  • R 5a is halogen, in particular fluorine and chlorine, CN, Ci-C6-alkyl, in particular methyl, ethyl, n-propyl and 1 -methylethyl or Ci-C6-alkoxy, in particular methoxy, ethoxy and 1 -methylethoxy.
  • R 5a is halogen, in particular fluorine, chlorine and bromine. In a preferred aspect thereof R 5a is fluorine. In another preferred aspect thereof R 5a is chlorine.
  • R 1 has in each case one of the following meanings in lines A-1 to A-57 in table A.
  • R 2 , R 3 , R 4 , R 5 and R 6 in each case is one of the following combinations in lines B-1 to B-576 in table B.
  • Table 1 Compounds I . A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 in Table A (compounds I . A.a1 .b1 to
  • Table 2 Compounds I . A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-2 in Table A (compounds I .A.a2.b1 to
  • Table 4 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-4 in Table A (compounds I.A.a4.b1 to
  • Table 5 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-5 in Table A (compounds I.A.a5.b1 to
  • Table 7 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-7 in Table A (compounds I.A.a7.b1 to
  • Table 8 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-8 in Table A (compounds I.A.a8.b1 to
  • Table 9 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-9 in Table A (compounds I.A.a9.b1 to
  • Table 10 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-10 in Table A (compounds I.A.a10.b1 to
  • Table 1 1 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 1 in Table A (compounds I.A.al 1.b1 to
  • Table 12 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-12 in Table A (compounds I.A.a12.b1 to
  • Table 13 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-13 in Table A (compounds I.A.a13.b1 to
  • Table 14 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-14 in Table A (compounds I.A.a14.b1 to
  • Table 15 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-15 in Table A (compounds I.A.a15.b1 to
  • Table 16 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-16 in Table A (compounds I.A.a16.b1 to
  • Table 17 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-17 in Table A (compounds I.A.a17.b1 to
  • Table 18 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-18 in Table A (compounds I.A.a18.b1 to
  • Table 19 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-19 in Table A (compounds I.A.a19.b1 to
  • Table 20 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-20 in Table A (compounds I.A.a20.b1 to
  • Table 21 Compounds I.A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-21 in Table A (compounds I.A.a21.b1 to
  • Table 22 Compounds I.A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-22 in Table A (compounds I.A.a22.b1 to
  • Table 23 Compounds I.A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-23 in Table A (compounds I.A.a23.b1 to
  • Table 25 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-25 in Table A (compounds I.A.a25.b1 to
  • Table 26 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-26 in Table A (compounds I.A.a26.b1 to
  • Table 27 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-27 in Table A (compounds I.A.a27.b1 to
  • Table 28 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-28 in Table A (compounds I.A.a28.b1 to
  • Table 29 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-29 in Table A (compounds I.A.a29.b1 to
  • Table 30 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-30 in Table A (compounds I.A.a30.b1 to
  • Table 31 Compounds I .A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-31 in Table A (compounds I.A.a31.b1 to
  • Table 32 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-32 in Table A (compounds I.A.a32.b1 to
  • Table 33 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-33 in Table A (compounds I.A.a33.b1 to
  • Table 34 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-34 in Table A (compounds I.A.a34.b1 to
  • Table 35 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-35 in Table A (compounds I.A.a35.b1 to
  • Table 36 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-36 in Table A (compounds I.A.a36.b1 to
  • Table 37 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-37 in Table A (compounds I.A.a37.b1 to
  • Table 38 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-38 in Table A (compounds I.A.a38.b1 to
  • Table 39 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-39 in Table A (compounds I.A.a39.b1 to
  • Table 40 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-40 in Table A (compounds I.A.a40.b1 to
  • Table 41 Compounds I .A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-41 in Table A (compounds I.A.a41.b1 to
  • Table 42 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-42 in Table A (compounds I.A.a42.b1 to
  • Table 43 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-43 in Table A (compounds I.A.a43.b1 to
  • Table 44 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-44 in Table A (compounds I.A.a44.b1 to
  • Table 46 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-46 in Table A (compounds I.A.a46.b1 to
  • Table 47 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-47 in Table A (compounds I.A.a47.b1 to
  • Table 48 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-48 in Table A (compounds I.A.a48.b1 to
  • Table 49 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-49 in Table A (compounds I.A.a49.b1 to
  • Table 50 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-50 in Table A (compounds I.A.a50.b1 to
  • Table 51 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-51 in Table A (compounds I.A.a51.b1 to
  • Table 52 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-52 in Table A (compounds I.A.a52.b1 to
  • Table 53 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-53 in Table A (compounds I.A.a53.b1 to
  • Table 54 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-54 in Table A (compounds I.A.a54.b1 to
  • Table 55 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-55 in Table A (compounds I.A.a55.b1 to
  • Table 56 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-56 in Table A (compounds I.A.a56.b1 to
  • Table 57 Compounds I. A, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-57 in Table A (compounds I.A.a57.b1 to
  • Table 58 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 in Table A (compounds I.B.al .b1 to
  • Table 59 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-2 in Table A (compounds I.B.a2.b1 to
  • Table 60 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-3 in Table A (compounds I.B.a3.b1 to
  • Table 61 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-4 in Table A (compounds I.B.a4.b1 to
  • Table 62 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-5 in Table A (compounds I.B.a5.b1 to
  • Table 63 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-6 in Table A (compounds I.B.a6.b1 to
  • Table 64 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-7 in Table A (compounds I.B.a7.b1 to
  • Table 65 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-8 in Table A (compounds I.B.a8.b1 to
  • Table 67 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-10 in Table A (compounds I.B.a10.b1 to
  • Table 68 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 1 in Table A (compounds I.B.al 1 .b1 to
  • Table 69 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-12 in Table A (compounds I.B.a12.b1 to
  • Table 70 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-13 in Table A (compounds I.B.al 3. b1 to
  • Table 71 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-14 in Table A (compounds I.B.a14.b1 to
  • Table 72 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-15 in Table A (compounds I.B.al 5. b1 to
  • Table 73 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-16 in Table A (compounds I.B.al 6. b1 to
  • Table 74 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-17 in Table A (compounds I.B.al 7. b1 to
  • Table 75 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-18 in Table A (compounds I.B.al 8. b1 to
  • Table 76 Compounds I .B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-19 in Table A (compounds I.B.a19.b1 to
  • Table 77 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-20 in Table A (compounds I.B.a20.b1 to
  • Table 78 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-21 in Table A (compounds I.B.a21.b1 to
  • Table 79 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-22 in Table A (compounds I.B.a22.b1 to
  • Table 80 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-23 in Table A (compounds I.B.a23.b1 to
  • Table 81 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-24 in Table A (compounds I.B.a24.b1 to
  • Table 82 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-25 in Table A (compounds I.B.a25.b1 to
  • Table 83 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-26 in Table A (compounds I.B.a26.b1 to
  • Table 84 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-27 in Table A (compounds I.B.a27.b1 to
  • Table 85 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-28 in Table A (compounds I.B.a28.b1 to
  • Table 86 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-29 in Table A (compounds I.B.a29.b1 to
  • Table 88 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-31 in Table A (compounds I.B.a31.b1 to
  • Table 90 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-33 in Table A (compounds I.B.a33.b1 to
  • Table 91 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-34 in Table A (compounds I.B.a34.b1 to
  • Table 92 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-35 in Table A (compounds I.B.a35.b1 to
  • Table 93 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-36 in Table A (compounds I.B.a36.b1 to
  • Table 94 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-37 in Table A (compounds I.B.a37.b1 to
  • Table 95 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-38 in Table A (compounds I.B.a38.b1 to
  • Table 96 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-39 in Table A (compounds I.B.a39.b1 to
  • Table 97 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-40 in Table A (compounds I.B.a40.b1 to
  • Table 98 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-41 in Table A (compounds I.B.a41.b1 to
  • Table 100 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-43 in Table A (compounds I.B.a43.b1 to
  • Table 101 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-44 in Table A (compounds I.B.a44.b1 to
  • Table 102 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-45 in Table A (compounds I.B.a45.b1 to
  • Table 103 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-46 in Table A (compounds I.B.a46.b1 to
  • Table 104 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-47 in Table A (compounds I.B.a47.b1 to
  • Table 105 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-48 in Table A (compounds I.B.a48.b1 to
  • Table 106 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-49 in Table A (compounds I.B.a49.b1 to
  • Table 107 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-50 in Table A (compounds I.B.a50.b1 to
  • Table 108 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-51 in Table A (compounds I.B.a51.b1 to
  • Table 109 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-52 in Table A (compounds I.B.a52.b1 to
  • Table 1 10 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-53 in Table A (compounds I.B.a53.b1 to
  • Table 1 1 1 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-54 in Table A (compounds I.B.a54.b1 to
  • Table 1 12 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-55 in Table A (compounds I.B.a55.b1 to
  • Table 1 13 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-56 in Table A (compounds I.B.a56.b1 to
  • Table 1 14 Compounds I.B, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-57 in Table A (compounds I.B.a57.b1 to
  • Table 1 15 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 in Table A (compounds I.C.al .b1 to
  • Table 1 16 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-2 in Table A (compounds I.C.a2.b1 to
  • Table 1 17 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-3 in Table A (compounds I.C.a3.b1 to
  • Table 1 18 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-4 in Table A (compounds I.C.a4.b1 to
  • Table 1 19 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-5 in Table A (compounds I.C.a5.b1 to
  • Table 120 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-6 in Table A (compounds I.C.a6.b1 to
  • Table 121 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-7 in Table A (compounds I.C.a7.b1 to
  • Table 122 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-8 in Table A (compounds I.C.a8.b1 to
  • Table 123 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-9 in Table A (compounds I.C.a9.b1 to
  • Table 124 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-10 in Table A (compounds I.C.a10.b1 to
  • Table 125 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 1 in Table A (compounds I.C.al 1.b1 to
  • Table 126 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-12 in Table A (compounds I.C.a12.b1 to
  • Table 127 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-13 in Table A (compounds I.C.al 3. b1 to
  • Table 128 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-14 in Table A (compounds I.C.al 4.b1 to
  • Table 129 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-15 in Table A (compounds I.C.a15.b1 to
  • Table 130 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-16 in Table A (compounds I.C.a16.b1 to
  • Table 131 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-17 in Table A (compounds I.C.a17.b1 to
  • Table 132 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-18 in Table A (compounds I.C.a18.b1 to
  • Table 133 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-19 in Table A (compounds I.C.a19.b1 to
  • Table 134 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-20 in Table A (compounds I.C.a20.b1 to
  • Table 135 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-21 in Table A (compounds I.C.a21.b1 to
  • Table 136 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-22 in Table A (compounds I.C.a22.b1 to
  • Table 137 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-23 in Table A (compounds I.C.a23.b1 to
  • Table 138 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-24 in Table A (compounds I.C.a24.b1 to
  • Table 139 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-25 in Table A (compounds I.C.a25.b1 to
  • Table 140 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-26 in Table A (compounds I.C.a26.b1 to
  • Table 141 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-27 in Table A (compounds I.C.a27.b1 to
  • Table 142 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-28 in Table A (compounds I.C.a28.b1 to
  • Table 143 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-29 in Table A (compounds I.C.a29.b1 to
  • Table 144 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-30 in Table A (compounds I.C.a30.b1 to
  • Table 145 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-31 in Table A (compounds I.C.a31.b1 to
  • Table 146 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-32 in Table A (compounds I.C.a32.b1 to
  • Table 147 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-33 in Table A (compounds I.C.a33.b1 to
  • Table 148 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-34 in Table A (compounds I.C.a34.b1 to
  • Table 149 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-35 in Table A (compounds I.C.a35.b1 to
  • Table 150 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-36 in Table A (compounds I.C.a36.b1 to
  • Table 151 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-37 in Table A (compounds I.C.a37.b1 to
  • Table 152 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-38 in Table A (compounds I.C.a38.b1 to
  • Table 153 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-39 in Table A (compounds I.C.a39.b1 to
  • Table 154 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-40 in Table A (compounds I.C.a40.b1 to
  • Table 155 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-41 in Table A (compounds I.C.a41.b1 to
  • Table 156 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-42 in Table A (compounds I.C.a42.b1 to
  • Table 157 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-43 in Table A (compounds I.C.a43.b1 to
  • Table 158 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-44 in Table A (compounds I.C.a44.b1 to
  • Table 159 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-45 in Table A (compounds I.C.a45.b1 to
  • Table 160 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-46 in Table A (compounds I.C.a46.b1 to
  • Table 161 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-47 in Table A (compounds I.C.a47.b1 to
  • Table 162 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-48 in Table A (compounds I.C.a48.b1 to
  • Table 163 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-49 in Table A (compounds I.C.a49.b1 to
  • Table 164 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-50 in Table A (compounds I.C.a50.b1 to
  • Table 165 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-51 in Table A (compounds I.C.a51.b1 to
  • Table 166 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-52 in Table A (compounds I.C.a52.b1 to
  • Table 167 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-53 in Table A (compounds I.C.a53.b1 to
  • Table 168 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-54 in Table A (compounds I.C.a54.b1 to
  • Table 169 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-55 in Table A (compounds I.C.a55.b1 to
  • Table 170 Compounds I.C, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-56 in Table A (compounds I.C.a56.b1 to
  • Table 172 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 in Table A (compounds I.D.al .b1 to
  • Table 173 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-2 in Table A (compounds I.D.a2.b1 to
  • Table 174 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-3 in Table A (compounds I.D.a3.b1 to
  • Table 175 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-4 in Table A (compounds I.D.a4.b1 to
  • Table 176 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-5 in Table A (compounds I.D.a5.b1 to
  • Table 177 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-6 in Table A (compounds I.D.a6.b1 to
  • Table 178 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-7 in Table A (compounds I.D.a7.b1 to
  • Table 179 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-8 in Table A (compounds I.D.a8.b1 to
  • Table 180 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-9 in Table A (compounds I.D.a9.b1 to
  • Table 181 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-10 in Table A (compounds I.D.a10.b1 to
  • Table 182 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-1 1 in Table A (compounds I.D.al 1.b1 to
  • Table 183 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-12 in Table A (compounds I.D.a12.b1 to
  • Table 184 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-13 in Table A (compounds I.D.al 3. b1 to
  • Table 185 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-14 in Table A (compounds I.D.a14.b1 to
  • Table 186 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-15 in Table A (compounds I.D.al 5. b1 to
  • Table 187 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-16 in Table A (compounds I.D.al 6. b1 to
  • Table 188 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-17 in Table A (compounds I.D.al 7. b1 to
  • Table 189 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-18 in Table A (compounds I.D.al 8. b1 to
  • Table 190 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-19 in Table A (compounds I.D.al 9. b1 to
  • Table 191 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-20 in Table A (compounds I.D.a20.b1 to
  • Table 192 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-21 in Table A (compounds I.D.a21.b1 to
  • Table 193 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-22 in Table A (compounds I.D.a22.b1 to
  • Table 194 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-23 in Table A (compounds I.D.a23.b1 to
  • Table 195 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-24 in Table A (compounds I.D.a24.b1 to
  • Table 196 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-25 in Table A (compounds I.D.a25.b1 to
  • Table 197 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-26 in Table A (compounds I.D.a26.b1 to
  • Table 198 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-27 in Table A (compounds I.D.a27.b1 to
  • Table 199 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-28 in Table A (compounds I.D.a28.b1 to
  • Table 200 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-29 in Table A (compounds I.D.a29.b1 to
  • Table 201 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-30 in Table A (compounds I.D.a30.b1 to
  • Table 202 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-31 in Table A (compounds I.D.a31.b1 to
  • Table 203 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-32 in Table A (compounds I.D.a32.b1 to
  • Table 204 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-33 in Table A (compounds I.D.a33.b1 to
  • Table 205 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-34 in Table A (compounds I.D.a34.b1 to
  • Table 206 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-35 in Table A (compounds I.D.a35.b1 to
  • Table 207 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-36 in Table A (compounds I.D.a36.b1 to
  • Table 208 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-37 in Table A (compounds I.D.a37.b1 to
  • Table 209 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-38 in Table A (compounds I.D.a38.b1 to
  • Table 210 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-39 in Table A (compounds I.D.a39.b1 to
  • Table 21 1 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-40 in Table A (compounds I.D.a40.b1 to
  • Table 212 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-41 in Table A (compounds I.D.a41.b1 to
  • Table 214 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-43 in Table A (compounds I.D.a43.b1 to
  • Table 215 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-44 in Table A (compounds I.D.a44.b1 to
  • Table 216 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-45 in Table A (compounds I.D.a45.b1 to
  • Table 217 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-46 in Table A (compounds I.D.a46.b1 to
  • Table 218 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-47 in Table A (compounds I.D.a47.b1 to
  • Table 219 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-48 in Table A (compounds I.D.a48.b1 to
  • Table 220 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-49 in Table A (compounds I.D.a49.b1 to
  • Table 221 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-50 in Table A (compounds I.D.a50.b1 to
  • Table 222 Compounds I.D, wherein the meaning of the combination of substituents R 2 , R 3 , R 4 , R 5 and R 6 are selected from lines B-1 to B-576 in Table B and wherein the meaning of R 1 corresponds to line A-51 in Table A (compounds I.D.a51.b1 to

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Abstract

La présente invention concerne des naphtoquinones fongicides et leurs dérivés de formule I, des compositions contenant celles-ci, leur utilisation et des procédés pour lutter contre les champignons phytopathogènes des cultures. La présente invention concerne également des semences traitées avec au moins un de ces composés.
PCT/EP2014/051461 2013-01-30 2014-01-27 Naphtoquinones fongicides et dérivés WO2014118099A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109879732A (zh) * 2019-02-27 2019-06-14 上海卡洛化学有限公司 一种1-(5-异丙基-2,4-二甲氧基苯基)乙酮的制备方法

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