WO2014091935A1 - 医療用ガイドワイヤ - Google Patents
医療用ガイドワイヤ Download PDFInfo
- Publication number
- WO2014091935A1 WO2014091935A1 PCT/JP2013/082020 JP2013082020W WO2014091935A1 WO 2014091935 A1 WO2014091935 A1 WO 2014091935A1 JP 2013082020 W JP2013082020 W JP 2013082020W WO 2014091935 A1 WO2014091935 A1 WO 2014091935A1
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- WO
- WIPO (PCT)
- Prior art keywords
- wire
- medical guide
- guide wire
- medical
- wire body
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/105—Induction heating apparatus, other than furnaces, for specific applications using a susceptor
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/10—Induction heating apparatus, other than furnaces, for specific applications
- H05B6/105—Induction heating apparatus, other than furnaces, for specific applications using a susceptor
- H05B6/108—Induction heating apparatus, other than furnaces, for specific applications using a susceptor for heating a fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09058—Basic structures of guide wires
- A61M2025/09083—Basic structures of guide wires having a coil around a core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
- A61M2025/09108—Methods for making a guide wire
Definitions
- the present invention relates to a medical guide wire, for example, a medical guide wire used when a catheter is introduced into a body cavity such as a blood vessel or a bile duct.
- a medical guide wire is used to ensure the insertion of the catheter safely.
- This medical guide wire is inserted into a blood vessel or bile duct with its distal end protruding from the distal end of the catheter, and is pushed and pulled while rotating the proximal portion located outside the body to advance inside the blood vessel etc. At the same time, it is inserted to the vicinity of the target site. In this state, the catheter is moved along the medical guide wire, and the distal end portion of the catheter is guided to the vicinity of the target site. Therefore, medical guidewires are required to have high quality with high flexibility and flexibility, high slidability in blood vessels and catheters, and high operability at the hand.
- Patent Document 1 a medical guide wire meeting the above required quality is known as disclosed in Patent Document 1.
- the outer periphery of the tip portion including the leading portion is set as a high lubricity zone
- the slightly long outer periphery of the rear end including the proximal portion is set as a low lubricity zone.
- the outer periphery of the middle part of the low-lubricity zone is set to the medium-lubricity zone, and it is formed so as to have a three-zone outer periphery configuration with different lubricity.
- the high lubricity zone is formed by forming a lubrication film of a hydrophilic polymer (polyvinylpyrrolidone) with a thickness of 18 to 20 microns, and the medium lubricity zone is a diluted hydrophilic polymer (polyvinylpyrrolidone).
- the lubricating film having a thickness of 5 to 10 microns is formed.
- the low lubricity zone is formed by a lubricious coating of fluororesin (PTFE).
- the above-mentioned medical guide wire is intended to provide a high slip property by forming a lubricious coating made of a hydrophilic polymer on the outer periphery of the tip including the leading portion. Due to the large area, it was difficult to say that the contact resistance was large and high slipperiness could be obtained. Furthermore, in a medical guide wire having such a structure, it is difficult to say that the water-holding property of the lubricating coating is excellent and it is difficult to maintain high slipperiness, and physiological saline is resupplied during the operation. In some cases, treatment had to be stopped due to worsening of slipperiness.
- the medical guide wire is divided into three sections, and a film made of a different resin material is formed for each of the sections so that a difference in lubricity is provided.
- a film made of a different resin material is formed for each of the sections so that a difference in lubricity is provided.
- the present invention has been made to solve such a problem, and an object of the present invention is to provide a medical guide wire that can achieve both slidability and operability and is easy to manufacture.
- the object of the present invention includes a flexible long wire body and a wire structure composed of a wire disposed on the surface of the wire body.
- the wire body and the wire structure It is achieved by a medical guide wire characterized in that the object is heat-sealed.
- Such a medical guide wire is manufactured by a simple method in which, for example, a wire structure is disposed on the surface of the wire body and heat treatment is performed, the time required for manufacturing can be shortened and the cost can be reduced. It becomes possible.
- a medical guide wire is inserted into a catheter or blood vessel, the portion that comes into contact with the inner wall of the catheter is the outermost part (top) of the wire, so the contact area between the medical guide wire and the catheter or the like is reduced. It becomes possible to reduce, and it becomes possible to ensure high slidability. In particular, higher slidability can be ensured by configuring the wire structure from a wire containing easy-slip resin fibers.
- the uneven part (wire structure) formed on the surface of the medical guide wire exhibits a function of preventing slipping.
- the grip force is increased, and it becomes possible to perform delicate rotation operation and push-pull operation, and high operability can be obtained.
- a width detail smaller than the maximum width of the wire constituting the wire structure before the heat fusion is formed in the heat fusion portion between the wire body and the wire structure. It is preferred that By providing such width details, the surface of the operator's hand and fingers can easily bite into the wire structure at the proximal portion of the medical guidewire, and the gripping force against the medical guidewire can be improved. The operability of the medical guide wire can be further enhanced.
- the wire structure is configured by winding the wire in a spiral shape around the wire body.
- a medical guide wire can be manufactured very efficiently.
- a medical guide wire can be manufactured by adding further added value to the required quality of ensuring slidability and operability at the section.
- the pitch interval between adjacent wires can be ensured and the slidability can be ensured, and the structure can be configured such that the thrombus is less likely to adhere to the tip portion.
- the wire structure is configured in a mesh shape.
- the adhesion strength at the heat-sealed portion between the wire structure and the wire body can be improved, and the wire structure is peeled off from the wire body. The occurrence of a situation can be effectively suppressed.
- the main portion that contacts the inner wall of the catheter and the blood vessel is a nodule portion in the mesh, the contact area with the catheter and the blood vessel can be further reduced, so that higher slidability can be secured. it can.
- the surface of the operator's hand and fingers bite into each mesh portion during the operation of the operator, so the grip force against the hand portion of the medical guide wire
- the operability of the medical guide wire can be further improved.
- the wire has a non-circular cross section.
- the cross-section of the wire constituting the wire structure is non-circular, it is possible to enhance the slip prevention function at the hand portion, and thus the operability of the medical guide wire can be further improved.
- the distal end portion of the medical guide wire only the outermost portion (top portion) of the non-circular wire rod is in contact with the inner wall and blood vessel of the catheter, so that the slidability with respect to the catheter and blood vessel does not deteriorate.
- the wire main body is made of a conductive material, and the wire is formed of a material having lower magnetism than the wire main body, and from the outside of the wire structure disposed on the wire main body.
- the wire body is heated by electromagnetic induction, and at least one of the opposing regions of the wire structure and the wire body is melted by the heated heat of the wire body, and the wire structure heats the wire body. It is preferable to be constituted by fusing.
- FIG. 3 is a cross-sectional view taken along line AA in FIG. 2. It is explanatory drawing which shows the state which inserted the medical guide wire into the catheter. It is a principal part expanded sectional view of the medical guide wire shown in FIG. It is sectional drawing which shows the modification of the medical guide wire shown in FIG. It is sectional drawing which shows the modification of the medical guide wire shown in FIG. It is a schematic structure side view which shows the modification of the medical guide wire shown in FIG. It is explanatory drawing for demonstrating the shape of the wire which comprises a wire structure. It is a schematic structure side view which shows the modification of the medical guide wire shown in FIG.
- FIG. 1 is a schematic configuration side view of a distal end portion 1a of a medical guidewire 1 according to an embodiment of the present invention
- FIG. 2 is a schematic configuration side view of a proximal portion 1b of the medical guidewire 1.
- FIG. 3 is a cross-sectional view taken along the line AA in FIG.
- a medical guide wire 1 according to the present invention is a medical guide wire used by being inserted into a catheter, for example, and is arranged on the wire body 2 and the surface of the wire body 2 as shown in FIGS. And a wire structure 3 to be provided.
- the wire body 2 is a long and flexible wire-like member.
- the wire body 2 can be configured using various conventional materials used as a core material for medical guidewires.
- various metal materials such as stainless steel, piano wire, cobalt-based alloy, and pseudo-elastic alloys (including superelastic alloys) can be used.
- alloys showing pseudoelasticity including superelastic alloys
- superelastic alloys are more preferable.
- the superelastic alloy is relatively flexible, has a resilience, and is difficult to bend. Therefore, the medical guide wire 1 can be highly flexible and bendable by forming the wire body 2 from a superelastic alloy. Restorability can be obtained, follow-up performance with respect to blood vessels that are curved and bent in a complicated manner, etc., and better operability can be obtained. In addition, even if the medical guide wire 1 is repeatedly bent and bent, the wire body 2 is not bent due to the resilience of the wire body 2, so that the operability caused by the bending of the medical guide wire 1 during use of the medical guide wire 1 is improved. A decrease can be prevented.
- the wire body 2 is made of a cobalt-based alloy
- its elastic modulus is high and it has an appropriate elastic limit.
- the wire comprised by the cobalt type alloy is excellent in torque transferability, and problems, such as buckling, do not arise very much.
- Any cobalt-based alloy may be used as long as it contains Co as a constituent element, but it contains Co as a main component (Co-based alloy: Co content in the elements constituting the alloy) Is preferable, and a Co—Ni—Cr alloy is more preferably used. By using an alloy having such a composition, the above-described effects become more remarkable.
- an alloy having such a composition has a high elastic modulus and can be cold-formed even as a high elastic limit, and by reducing the diameter while sufficiently preventing buckling from occurring due to the high elastic limit. And can have sufficient flexibility and rigidity to be inserted into a predetermined portion.
- the wire main body 2 may be formed of a single steel material, or the wire main body 2 may be formed by folding a single linear steel material and then twisting them.
- the wire main body 2 may be formed by twisting a plurality of linear steel materials, or may be formed by twisting a linear steel material and a linear resin member.
- the central portion and the surface portion are formed of different materials (two-layer structure, for example, the surface portion is configured by coating the outer surface of the central portion made of metal with a thermosetting resin.
- the total length of the wire body 2 is not particularly limited, but is preferably about 200 to 5000 mm.
- the wire body 2 may be configured so that the outer diameter thereof is substantially constant, or the tip portion may be formed in a tapered shape in which the outer diameter decreases in the tip direction. Good.
- the distal end portion of the wire body 2 is configured to have a tapered shape whose outer diameter decreases in the distal direction, the rigidity (bending rigidity, torsional rigidity) of the wire body 2 gradually decreases in the distal direction.
- the medical guide wire 1 obtains a good stenosis part passing through and flexibility at the distal end, improves followability to blood vessels and safety, and prevents bending and the like. This is preferable.
- the wire body 2 may be configured by connecting the first wire body constituting the tip portion and the second wire body portion constituting the intermediate portion and the hand portion by welding or the like.
- the wire main body 2 is constituted by the first wire main body and the second wire main body, it is preferable to set the diameter of the first wire main body to be smaller than the diameter of the second wire main body.
- the rigidity (bending rigidity, torsional rigidity) of the wire body 2 can be gradually decreased toward the distal end.
- the medical guide wire 1 can be
- the wire structure 3 is a member disposed on the surface of the wire body 2 and is composed of a wire 31.
- the medical guide wire 1 in the present embodiment shown in FIGS. 1 to 3 is configured as a form in which a wire 31 is spirally wound around the surface of the wire body 2. Further, the wire body 2 and the wire structure 3 are integrated by heat fusion.
- the wire 31 is a wire containing a slippery resin fiber, and a wire having a maximum diameter of 10 ⁇ m or more and 200 ⁇ m or less before heat fusion to the wire body 2 can be preferably used.
- a slippery resin fiber a fluorine-based resin fiber having lubricity is preferable.
- fluororesin fibers include tetrafluoroethylene-perfluoroalkyl vinyl ether copolymer (PFA, melting point 300 to 310 ° C.), polytetrafluoroethylene (PTFE, melting point 330 ° C.), tetrafluoroethylene-hexa.
- Fluoropropylene copolymer (FEP, melting point 250-280 ° C), ethylene-tetrafluoroethylene copolymer (ETFE, melting point 260-270 ° C), polyvinylidene fluoride (PVDF, melting point 160-180 ° C), polychlorotrifluoro From fluorine resins such as ethylene (PCTFE, melting point 210 ° C.), tetrafluoroethylene-hexafluoropropylene-perfluoroalkyl vinyl ether copolymer (EPE, melting point 290-300 ° C.), and copolymers containing these polymers It can be mentioned hydrophobic resin fibers form.
- PFA, PTFE, FEP, ETFE, and PVDF are preferable because they have excellent sliding characteristics.
- a fiber made of a hydrophilic resin such as polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene oxide polymer material, maleic anhydride polymer material, acrylamide polymer material, or water-soluble nylon is used. You can also The method for producing the wire 31 with these resin fibers is not particularly limited, and for example, a conventionally known method such as a method of spinning a raw material by extrusion molding can be used.
- the wire 31 including the slippery resin fiber refers to a wire rod-like member manufactured by combining different slippery resins in addition to a wire rod-like member manufactured from the slippery resin alone, It is a concept including a wire rod-shaped member manufactured by combining a conductive resin and a metal material, and a wire rod-shaped member manufactured by combining a slippery resin and a non-metallic material.
- a fiber formed by using the above-described hydrophilic resin in combination with a thermoplastic resin can be used as the slippery resin fiber.
- the thermoplastic resin used in combination with the hydrophilic resin includes polyurethane, polyamide, EVOH and other hydrophilic thermoplastic resins having a hydrophilic group in the molecule that can be easily fiberized by melt spinning, and the fibers are melted or softened by heat treatment. It is preferable at the point made.
- the method for producing fibers using a combination of a hydrophilic resin and a thermoplastic resin is not particularly limited, either by melt-kneading and mixing, or by using a conjugate fiber such as a core-sheath, side-by-side, sea-island structure, or the like.
- conjugate fiber is preferable in that desired slipperiness can be achieved while maintaining good fusion with the wire body 2.
- the method of winding the wire 31 around the wire body 2 is not particularly limited, and examples thereof include a method of winding using a covering device used for manufacturing a covering yarn.
- the form of the wire 31 may be a single wire, or may be a stranded wire formed by twisting together the same type of single wires. Further, it may be a stranded wire formed by twisting different types of single wires.
- the wire 31 is spirally wound around the surface of the wire main body 2, and the wire 31 adjacent to each other in the direction along the longitudinal direction of the wire main body 2 is the length of the wire main body 2.
- a predetermined interval is provided in a direction along the direction.
- the adjacent wire rods 31 in the direction along the longitudinal direction of the wire body 2 are in close contact with each other (the interval between the adjacent wire rods 31 is 0).
- the wire pitch of the wire 31 in the direction along the longitudinal direction of the wire body 2 is in the range of 2 to 10 times the maximum diameter of the wire 31. It is configured as follows.
- the wire pitch of the wire 31 is a concept showing the distance between the centers of the wire 31 adjacent in the direction along the longitudinal direction of the wire main body 2, as shown in FIG. Note that the wire pitch of the wire 31 can be arbitrarily changed to constitute a medical guide wire.
- the wire structure 3 (wire 31) is heat-sealed to the outer surface of the wire body 2, as a method of heat-sealing the wire structure 3 (wire 31) to the outer surface of the wire body 2.
- a heating method for example, a chamber-type heat treatment apparatus can be used by applying heat from the outside of the wire 31 wound around the wire body 2.
- heat fusion refers to a case in which at least a part of an object is melted by heating to be softened and adhered to another object, for example, an object having no melting point (for example, an object made of a hydrophilic resin)
- an object having no melting point for example, an object made of a hydrophilic resin
- the wire body 2 is made of a conductive material (a material that can easily conduct electricity) and the wire 31 is made of a material having lower magnetism than the wire body 2, the wire body 2 is disposed on the wire body 2.
- the wire main body 2 is electromagnetically heated by an electromagnetic induction heating device from the outside of the formed wire 31, and at least one of the opposing regions of the wire 31 and the wire main body 2 is melted by the heat of the heated wire main body 2, It is preferable to fuse the wire 31 to the outer surface of the wire body 2 so that the wire 31 is fused to the wire body 2.
- the material having lower magnetism than the wire body 2 is a concept including a material having no magnetism in addition to a material having magnetism weaker than that of the wire body 2.
- Electromagnetic induction heating is a type of heating method that is also used in electromagnetic cookers (IH cooking heaters), high-frequency welding, etc., and causes a change in magnetic field (magnetic flux density) by passing an alternating current through the coil.
- This is a heating method that utilizes the principle of generating an induced current (eddy current) in a conductive substance placed in the magnetic field and generating heat by the resistance of the conductive substance itself.
- the frequency of the current flowing through the electromagnetic induction heating device (AC current flowing through the coil) high, it is possible to collect the heat generating parts in the wire body 2 on the surface, and conversely, set the frequency of the current low. By doing so, since the inside of the wire body 2 can also generate heat uniformly, it is preferable that the frequency of the current flowing through the electromagnetic induction heating device can be appropriately changed.
- the wire 31 is quickly softened or melted at and near the contact interface between the wire 31 and the wire body 2, so that the molecular orientation that contributes to the physical properties of the wire 31 can be easily maintained.
- the mechanical strength of can be kept higher.
- the outer surface of the medical guide wire 1 becomes softened or melted only at the contact interface between the wire 31 and the wire body 2 and in the vicinity thereof. The surface unevenness on the side can be easily maintained, and the slidability can be improved.
- an adhesive such as a primer is applied to the outer surface of the wire body 2, and then the outer surface of the wire body 2 is removed.
- the wire 31 is wound around the surface to form the wire structure 3, and then the adhesive and the wire structure 3 (wire 31) are melted by heating, so that the wire structure 3 (wire 31) is formed on the wire body 2.
- the material for the adhesive such as the primer is preferably a material containing the same material as that used for the wire.
- Other examples of the material contained in the primer include polyurethane, polyimide, polyamideimide, or precursors thereof. Among them, polyimide does not decrease coating film strength even during heat treatment during fusion, and has a high elastic modulus. It is preferable to include polyamide or a precursor thereof.
- the wire 31 is wound on the outer surface of the wire body 2 before the wire body 2 is wound around the surface of the wire body 2.
- Etching treatment may be performed in advance. By performing the etching process, fine irregularities are formed on the surface of the wire body 2, the adhesion between the wire body 2 and the wire 31 is improved, and the durability of the medical guide wire 1 can be improved.
- the specific method of the etching process is not particularly limited, and a physical etching process method such as sand blast etching, ion etching, plasma etching, ion milling, ECR etching, or an etching solution containing nitric acid and hydrofluoric acid is used.
- a physical etching process method such as sand blast etching, ion etching, plasma etching, ion milling, ECR etching, or an etching solution containing nitric acid and hydrofluoric acid is used.
- chemical etching methods such as wet etching using an alkaline solution, dry etching using a mixed gas for generating plasma mainly composed of a fluorine-based gas such as CF 4 and oxygen, and the like can be employed.
- the medical guide wire 1 Since the medical guide wire 1 according to the present embodiment has the above-described configuration, for example, the medical guide wire 1 is manufactured by a simple method in which the wire structure 3 is disposed on the surface of the wire body 2 and heat treatment is performed. Therefore, the time required for manufacturing can be shortened, and the cost can be reduced. In addition, since the conventional medical guide wire is configured such that a coating is formed by coating a resin material on the wire body, it is difficult to maintain the outer dimensions of the medical guide wire uniformly. Although there was also a side surface, the medical guide wire 1 of the present embodiment is formed by arranging the wire structure 3 composed of the wire 31 having a predetermined thickness on the surface of the wire body 2 having a predetermined thickness. It becomes easy to maintain the outer dimensions of the medical guide wire 1 uniformly.
- the wire 31 is not limited to perform the coating process between the wire 31 and the wire 31 (concave portion) or on the surface of the wire (convex portion) regardless of whether the wire 31 is before or after (timing). It is preferable to dispose a hydrophilic coating formed of a hydrophilic resin between the wire 31 and the wire 31. With such a configuration, the water retention of the medical guide wire 1 is increased, and slipping occurs during use. It is preferable because deterioration can be prevented as much as possible.
- the wire 31 is formed of a hydrophobic resin and a hydrophilic coating is provided in the recesses between the wires 31 so that the water retention of the recesses is effectively exhibited and high slipperiness can be exhibited.
- a material that uses polyimide, polyamideimide, or a precursor thereof together with a hydrophilic resin is adopted as a material for the hydrophilic coating, the adhesion of the wire can be made firm, and a highly durable hydrophilic coating can be obtained. It is preferable in that it can be performed.
- the portion in contact with the inner wall of the catheter Z is the outermost portion (top) of the wire 31 constituting the wire structure 3.
- the contact area between the guide wire 1 and the catheter Z can be greatly reduced as compared with a conventional medical guide wire, and the contact resistance generated between the medical guide wire 1 and the catheter Z is reduced, thereby increasing the sliding force. It becomes possible to ensure mobility.
- by configuring the wire structure 3 from the wire 31 including the slippery resin fiber higher slidability can be ensured.
- the wire 31 is formed from a fiber made of a hydrophilic resin or the like and the wire 31 itself (wire structure 3) in the medical guide wire 1 is hydrophilic, the hydrophilicity as described in the background art above. Compared with a lubricious film made of a conductive polymer, the wire 31 is easily swelled, can retain a large amount of water, and has a recess formed between the wire 31 and the wire 31 having hydrophilicity. Water retention is exhibited based on the shape, and higher slidability can be ensured. As a result, it is possible to effectively prevent slippage during use.
- the water and the recess that are effectively maintained in the wire 31 itself are effectively retained.
- the slipperiness of the hydrophilic wire 31 is effectively exhibited by the dripping water, and it becomes possible to obtain the medical guide wire 1 in which the slipperiness is sustainable over a long period of time. According to such a medical guide wire 1, a situation that has been a problem in the past, such as replenishing physiological saline during the operation, or stopping treatment due to deterioration of slipperiness occurs. This can be avoided very effectively.
- the medical guide wire 1 can achieve both high slidability and high operability.
- the medical guide wire 1 is manufactured very efficiently. Can do. In addition, it is easy to change the wire pitch (winding pitch) of the wire 31 at each of the distal end portion, the intermediate portion, and the proximal portion of the medical guide wire 1, thereby achieving high slidability at the distal end portion.
- the medical guide wire 1 can be manufactured by adding further added value to the required quality of ensuring the slidability and operability at the hand portion while ensuring the above.
- the guide wire 1 for medical use can be configured such that the wire rod pitch of the wire 31 is reduced to ensure slidability and that a stepped portion to which a thrombus easily adheres is not generated as much as possible.
- the medical guide wire 1 of the present embodiment is configured by heat-sealing a wire body 2 and a wire structure 3 provided on the surface of the wire body 2. Accordingly, as shown in the enlarged cross-sectional view of the main part of FIG. 5, the maximum width of the wire 31 constituting the wire structure 3 before the heat fusion of the wire main body 2 and the wire structure 3 before the heat fusion.
- the width detail 41 having a smaller width can be formed.
- the width detail 41 in the heat-sealed portion 4 is obtained by melting the contact portion of the wire 31 constituting the wire structure 3 with the wire body 2 when the wire structure 3 and the wire body 2 are heat-fused, and then cooling. And formed by solidification.
- the constricted portion including the width detail 41 can be formed in the heat fusion portion 4 of the wire structure 3, and thus the constricted portion (width detail 41).
- the surface of the practitioner's hand or finger can easily bite, the grip force on the medical guide wire 1 can be improved, and the operability of the medical guide wire 1 can be further enhanced.
- fusion part 4 is not a part which contacts the inner wall etc. of a catheter, this constriction part does not affect the slidability with a catheter etc. FIG. Therefore, it can be said that the medical guide wire 1 according to the present embodiment is an excellent medical guide wire that can achieve both high slidability and high operability.
- the wire 31 constituting the wire structure 3 (corresponding to a convex portion with respect to the surface of the wire body 2) ),
- the medical guide wire 1 suitable for various parts (arteries, veins, bile ducts, etc.) and catheters of the human body where the medical guide wire 1 is inserted, or slidability and operation It is possible to easily manufacture the medical guide wire 1 specialized for either sex or non-thrombogenicity.
- the medical guide wire 1 when it is desired to positively prevent the blood clot from adhering to the distal end portion of the medical guide wire 1, by supplying a large amount of thermal energy to the portion, most of the wire 31 is melted, The medical guide wire 1 in which the wires 31 arranged adjacent to each other are connected and the surface of the wire structure 3 is in a smooth state can be formed.
- the medical guide wire 1 has been described above, but the specific configuration is not limited to the above embodiment.
- the wire structure 3 that covers the outer peripheral surface of the wire body 2 is configured as a single wire layer wound around the wire body 2.
- the wire structure 3 may be configured such that the wire 31 wound spirally on the outer peripheral surface of the wire body 2 forms a plurality of layers. .
- a wire structure is formed by spirally winding a single wire 31 around the outer peripheral surface of the wire body 2.
- the wire structure 3 is formed by winding a plurality of wires 311 and 312 having different thicknesses around the outer peripheral surface of the wire body 2 in a spiral shape (double spiral shape). May be formed.
- a step D is formed between the adjacent wires 311 and 312 having different thicknesses. Therefore, at the hand portion of the medical guide wire 1, the step D has a non-slip function. Since it will be demonstrated, the grip force is further improved and the operability for the practitioner is improved. Note that, at the distal end portion of the medical guide wire 1, the wire 311 having a large diameter is in contact with the inner wall of the catheter, and the wire 312 having a small diameter is not in contact with the catheter. Sex does not decrease.
- the wire structure 3 is comprised by winding the wire 31 helically around the outer surface of the wire main body 2, as shown, for example in the schematic structure side view of FIG.
- the wire structure 3 may be formed on the outer surface of the wire body 2 so as to be a cylindrical body 32 having a network structure formed by the wire 31.
- the wire structure 3 formed as the cylindrical body 32 may be formed in any way as long as it is configured to have a network structure.
- the cylindrical body 32 may be formed by a braid manufacturing method.
- the tubular body 32 may be formed by weaving the wire 31 in the manner of forming a knitted fabric.
- the wire structure 3 is a cylindrical body 32 having a network structure formed by the wire 31 as described above, the adhesion strength at the heat-sealed portion between the wire structure 3 and the wire body 2 is improved, and the wire structure. Occurrence of a situation where 3 is peeled off from the wire body 2 can be effectively suppressed. Moreover, since the main part which contacts a catheter and a blood vessel becomes a nodule part in a mesh, since a contact area with a catheter or a blood vessel can be further reduced, higher slidability can be ensured. On the other hand, when attention is paid to the hand portion of the medical guide wire 1, the surface of the hand and fingers of the surgeon bite into each mesh portion during the operation of the operator, so A grip force improves and the operativity of the medical guide wire 1 can be improved further.
- the wire structure 3 is configured by using the wire 31 having a circular cross-sectional shape, and the wire structure 3 is formed on the outer peripheral surface of the wire body 2.
- the medical guide wire 1 is configured so as to be covered, but instead of the wire 31 having such a circular cross-sectional shape, the wire 31 having a polygonal cross-sectional shape or the wire 31 having an elliptical cross-sectional shape is used.
- the wire structure 3 may be configured by using a wire 31 having a non-circular cross section, such as a wire 31 having a fan-shaped cross section.
- the wire rod 31 having a polygonal cross-sectional shape is, for example, a triangular shape in cross-sectional view shown in FIG.
- the wire 31 having a polygonal cross section with a corner as shown in FIGS. 9D to 9F has a triangular shape with a rounded cross section, a pentagonal shape with a cross sectional view, and a cross sectional view.
- a covering member 5 that covers the tip of the wire body 2 may be provided.
- the covering member 5 is provided to prevent the inner wall of the blood vessel from being damaged when the medical guide wire 1 is inserted into a blood vessel or the like, and is formed of a flexible thermoplastic elastomer or various rubber materials.
- the shape of the covering member 5 is formed in a columnar shape with rounded tips and base ends from the viewpoint of preventing damage to blood vessels and the like.
- a filler (particles) made of a material having contrast properties (such as an X-ray opaque material) may be dispersed in the covering member 5, thereby forming a contrast portion.
- the outer surface of the covering member 5 may be coated with a hydrophilic material. Thereby, a hydrophilic material wets and produces lubricity, the friction (sliding resistance) of the medical guide wire 1 can be reduced, and slidability can be improved.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Electromagnetism (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Description
2 ワイヤ本体
3 線材構造物
31 線材
4 熱融着部
41 幅細部(くびれ部)
5 被覆部材
Claims (6)
- 可撓性を有する長尺なワイヤ本体と、前記ワイヤ本体の表面に配置される線材から構成される線材構造物とを備えており、
前記ワイヤ本体と、前記線材構造物とが熱融着されていることを特徴とする医療用ガイドワイヤ。 - 前記ワイヤ本体と前記線材構造物との熱融着部には、前記線材構造物を構成する前記線材の熱融着前の最大幅よりも幅の小さい幅細部が形成される請求項1に記載の医療用ガイドワイヤ。
- 前記線材構造物は、前記ワイヤ本体に螺旋状に前記線材を巻回して構成されることを特徴とする請求項1又は2に記載の医療用ガイドワイヤ。
- 前記線材構造物は、網目状に構成されることを特徴とする請求項1又は2に記載の医療用ガイドワイヤ。
- 前記線材は、その断面が非円形であることを特徴とする請求項1から4のいずれかに記載の医療用ガイドワイヤ。
- 前記ワイヤ本体は、導電性材料により構成されており、
前記線材は、前記ワイヤ本体よりも磁性が低い材料により形成されており、
前記ワイヤ本体上に配置された前記線材構造物の外側から前記ワイヤ本体を電磁誘導加熱し、加熱された前記ワイヤ本体の熱によって前記線材構造物と前記ワイヤ本体との対向領域の少なくともいずれか一方を溶融させて、前記線材構造物が前記ワイヤ本体に熱融着する請求項1から5のいずれかに記載の医療用ガイドワイヤ。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014551968A JP5862801B2 (ja) | 2012-12-11 | 2013-11-28 | 医療用ガイドワイヤ |
US14/649,900 US20150306354A1 (en) | 2012-12-11 | 2013-11-28 | Medical guide wire |
US15/729,756 US10974030B2 (en) | 2012-12-11 | 2017-10-11 | Medical guide wire |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012270248 | 2012-12-11 | ||
JP2012-270248 | 2012-12-11 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/649,900 A-371-Of-International US20150306354A1 (en) | 2012-12-11 | 2013-11-28 | Medical guide wire |
US15/729,756 Division US10974030B2 (en) | 2012-12-11 | 2017-10-11 | Medical guide wire |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014091935A1 true WO2014091935A1 (ja) | 2014-06-19 |
Family
ID=50934228
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2013/082020 WO2014091935A1 (ja) | 2012-12-11 | 2013-11-28 | 医療用ガイドワイヤ |
Country Status (3)
Country | Link |
---|---|
US (2) | US20150306354A1 (ja) |
JP (1) | JP5862801B2 (ja) |
WO (1) | WO2014091935A1 (ja) |
Cited By (9)
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JP2015181723A (ja) * | 2014-03-24 | 2015-10-22 | グンゼ株式会社 | 医療用ガイドワイヤ |
JP2016016098A (ja) * | 2014-07-08 | 2016-02-01 | グンゼ株式会社 | ワイヤ部材 |
JP2016017247A (ja) * | 2014-07-09 | 2016-02-01 | グンゼ株式会社 | ワイヤ部材及びその製造方法 |
USD755965S1 (en) | 2014-08-06 | 2016-05-10 | Gunze Limited | Guide wire for medical use |
WO2016072394A1 (ja) * | 2014-11-04 | 2016-05-12 | グンゼ株式会社 | ワイヤ部材 |
JP2017000661A (ja) * | 2015-06-16 | 2017-01-05 | グンゼ株式会社 | 長尺体 |
USD777916S1 (en) | 2014-08-06 | 2017-01-31 | Gunze Limited | Guide wire for medical use |
JP2019024624A (ja) * | 2017-07-26 | 2019-02-21 | 株式会社東海メディカルプロダクツ | 塞栓物質捕捉用デバイス |
JP7461753B2 (ja) | 2020-02-19 | 2024-04-04 | 朝日インテック株式会社 | ガイドワイヤ |
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US9829035B2 (en) * | 2011-09-29 | 2017-11-28 | Shimano Inc. | Bicycle control cable |
CN107847716B (zh) * | 2015-11-17 | 2021-08-24 | 郡是株式会社 | 医疗用导线 |
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WO2019016877A1 (ja) * | 2017-07-19 | 2019-01-24 | 朝日インテック株式会社 | ガイドワイヤ |
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Also Published As
Publication number | Publication date |
---|---|
US20150306354A1 (en) | 2015-10-29 |
US20180056042A1 (en) | 2018-03-01 |
US10974030B2 (en) | 2021-04-13 |
JPWO2014091935A1 (ja) | 2017-01-05 |
JP5862801B2 (ja) | 2016-02-16 |
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