WO2013171907A1 - Aiguille d'injection et trousse de préparation - Google Patents

Aiguille d'injection et trousse de préparation Download PDF

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Publication number
WO2013171907A1
WO2013171907A1 PCT/JP2012/062854 JP2012062854W WO2013171907A1 WO 2013171907 A1 WO2013171907 A1 WO 2013171907A1 JP 2012062854 W JP2012062854 W JP 2012062854W WO 2013171907 A1 WO2013171907 A1 WO 2013171907A1
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WO
WIPO (PCT)
Prior art keywords
needle
injection needle
tube
injection
needle tube
Prior art date
Application number
PCT/JP2012/062854
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English (en)
Japanese (ja)
Inventor
徳夫 金山
Original Assignee
大勝 明
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大勝 明 filed Critical 大勝 明
Priority to PCT/JP2012/062854 priority Critical patent/WO2013171907A1/fr
Publication of WO2013171907A1 publication Critical patent/WO2013171907A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Definitions

  • the present invention relates to an injection needle, particularly an injection needle suitable for subcutaneous injection, and a kit preparation having such an injection needle.
  • drug solution a drug solution and drug that cannot be administered orally (in the present invention, these are collectively referred to as “drug solution”).
  • Such injections are more or less painful due to needle penetration. There is a strong demand for alleviating such pain, particularly in those who need to be administered daily by injection, such as diabetic patients.
  • FIG. 6 (a) A cross-sectional view of this injection needle is shown in FIG. 6 (a), and a front view is shown in FIG. 6 (b) as a model.
  • three thin needle tubes 20c are embedded on the distal end side of a plastic needle base 20a.
  • the distal end 20b of the needle tube 20c is exposed from the distal end of the right needle base 20a in the drawing, and can pierce the skin surface.
  • the proximal end side of the needle tube 20c is exposed to a female luer taper portion 20d provided on the needle base 20a, and the needle tube 20c and the female luer taper portion 20d are in communication with each other, and therefore connected to the female luer taper portion 20d.
  • the drug solution discharged from the syringe passes through the needle tube 20c and is supplied subcutaneously from the tip 20b.
  • the injection needle 20 has three needle tubes 20c, so that a sufficient amount of drug solution can be injected relatively easily even with an extremely fine needle tube.
  • Such a needle is difficult to manufacture.
  • a thin needle tube is difficult to manufacture, and a high-level molding technique and an expensive molding die are required for forming a needle base using such a fine needle tube as an insert.
  • a short needle tube cannot be manufactured, and the length of the needle tube is much longer than the original length required for injection. Therefore, there is a demerit that the pressure loss at the time of injection increases and the force required for the injection increases.
  • the present invention improves the above-mentioned conventional problems, i.e., reduces the pain at the time of piercing, is easy to manufacture, has a short needle tube, and has such a needle. It is an object of the present invention to provide an injection needle with a needle base that is easy to mold and a kit preparation.
  • the injection needle of the present invention is characterized in that, as described in claim 1, a cylindrical needle tube is provided so as to protrude from one surface of a flat plate portion. It is a needle.
  • the injection needle according to the present invention is characterized in that, as described in claim 2, in the injection needle according to claim 1, the needle tube is provided so as to be closer to a tip of the needle tube.
  • the injection needle of the present invention is the injection needle according to claim 1 or 2, wherein the needle tube is provided so as to protrude from the flat plate portion.
  • the step portion having a step portion plane parallel to the step portion is provided so as to protrude from the step portion plane.
  • the injection needle of the present invention is characterized in that, as described in claim 4, in the injection needle according to any one of claims 1 to 3, a plurality of the needle tubes are provided.
  • the injection needle of this invention is a syringe needle in any one of Claim 1 thru
  • a hood-shaped hood portion is provided.
  • a syringe needle according to any one of the first to fourth aspects, and a cylindrical needle communicating with the needle tube of the syringe needle.
  • An injection needle with a needle base configured such that the needle tube protrudes from one end of the cylinder by a base, and an opening at one end of the cylinder is covered by the flat plate portion, and A female luer taper-shaped taper portion is formed in the opening at the other end of the tube.
  • the needle in the injection needle of the sixth aspect, is separated from the tip of the needle tube and covers one end of the tube to protect the needle tube.
  • the cap to be attached is detachably attached.
  • the injection needle of the present invention is characterized in that, as described in claim 8, the injection needle according to any one of claims 1 to 7 is an injection needle for subcutaneous injection.
  • the kit preparation of this invention has the injection needle of any one of Claim 1 thru
  • the kit preparation of the present invention is characterized in that in the kit preparation according to claim 9, the chemical solution is housed in an openable sealed container.
  • the kit preparation of the present invention is the kit preparation according to claim 9 or 10, wherein the kit lumber has a planar or substantially planar shape, as defined in claim 11.
  • the injection tube is provided on one surface of a shape or a substantially planar shape so that the needle tube protrudes from the one surface, and an adhesive is provided on at least a part of the periphery of the injection needle on the one surface It has the adhesive surface formed by apply
  • the kit preparation of the present invention is the kit preparation according to any one of claims 9 to 11, wherein the kit preparation is spaced apart from the tip of the needle tube, and the injection needle A cap that covers the one surface and protects the needle tube is detachably mounted.
  • the kit preparation of the present invention is characterized in that in the kit preparation according to any one of claims 9 to 12, the kit preparation is for subcutaneous administration.
  • kit preparation of the present invention is any one of the influenza vaccine, tetanus vaccine, and antidiabetic agent in the kit preparation according to any one of claims 9 to 13.
  • a needle tube forming step of removing and forming a cylindrical needle tube in order
  • the method of manufacturing an injection needle according to the present invention is the first convex part as described in claim 16, wherein the first convex part protrudes from one surface of the flat plate by pressing, and the top is a plane parallel to the flat plate.
  • An injection needle manufacturing method comprising: a forming step, and a needle tube forming step of forming a cylindrical needle tube by removing a tip of the second convex portion.
  • the configuration in which the cylindrical needle tube is provided so as to protrude from one surface of the flat plate portion is easy to manufacture and a short needle tube can be realized. It is possible to realize an injection needle that can reduce the pain and requires less force for injection.
  • the configuration in which the needle tube is so thin that it is closer to the tip of the needle tube causes less pain during piercing and the needle tube is less likely to break.
  • the needle tube is provided so as to protrude from the flat plate portion and protrudes from the stepped plane of the stepped portion having a stepped plane parallel to the flat plate portion on the top, manufacture is easy. At the same time, the strength of the needle tube is high and it is difficult to break.
  • the injection needle of the present invention is provided with a plurality of needle tubes, the injection of a necessary amount of medicinal solution can be completed in a short time even if a thin needle tube that can reduce pain during piercing is used. Furthermore, since a plurality of needle tubes can be administered subcutaneously over a wide range by arranging them at intervals, immunity can be effectively imparted during vaccine administration.
  • the injection needle of the present invention is provided with a hood-like hood part that protrudes from the other surface of the flat part at the edge of the flat part, the drug solution can be held in the hood part. It can be made the most suitable as an injection needle for use.
  • the injection needle of the present invention is a needle configured such that the needle tube projects from one end of the cylinder by the above-described injection needle and a cylindrical needle base communicating with the needle tube of the injection needle.
  • An injection needle with a base, wherein an opening at one end of the tube is covered with the flat plate portion, and a female luer taper-shaped tapered portion is formed at the opening at the other end of the tube According to the configuration, it is possible to connect with a syringe. At this time, since it is compact, handling becomes easy, and as a result, unforeseen accidents such as medical accidents are prevented in advance.
  • the needle tube is separated from the tip of the needle tube, and a cap for covering the one end of the tube and protecting the needle tube is detachably attached. It is protected and can prevent damage to the needle tube and medical accidents.
  • the injection needle of the present invention is optimal as an injection needle for subcutaneous injection.
  • the kit preparation of the present invention has the above-described injection needle, and has a drug solution on the other surface side of the flat plate portion, thereby reducing pain during piercing and being easy to manufacture. Kit preparation.
  • the chemical solution when the chemical solution is stored in an openable sealed container, the chemical solution is prevented from being contaminated, and accidents such as accidents are prevented in advance.
  • the kit preparation of the present invention is the kit preparation described above, wherein the kit lumber has a planar or substantially planar shape, and the one surface of the planar or substantially planar shape is on one surface.
  • the needle tube protrudes from the side, the injection needle is provided, and at least a portion other than the portion from which the needle tube protrudes on one side has an adhesive surface formed by applying an adhesive. It is as easy and safe to administer subcutaneously as it is to treat agents and gauze bandages.
  • kit preparation of the present invention in the above-described kit preparation, a cap that is separated from the tip of the needle tube and covers the one surface of the injection needle to protect the needle tube is detachably mounted. As a result, the needle tube is protected, and damage to the needle tube and medical accidents can be prevented.
  • kit preparation of the present invention is optimal as a kit preparation for subcutaneous administration.
  • kit preparation of the present invention is particularly suitable as a kit preparation for subcutaneous administration of any one of influenza vaccine, tetanus vaccine, and antidiabetic agent in the above kit preparation.
  • the manufacturing method of the injection needle of the present invention has the above-described excellent injection by a structure having a step of forming a convex portion by pressing and a step of forming a cylindrical needle tube by removing the tip of the convex portion.
  • the needle can be manufactured inexpensively and efficiently.
  • FIG. 1 is a model diagram showing an example 1 of an injection needle according to the present invention.
  • FIG. 1A is a perspective view.
  • FIG. 1B a cross-sectional view.
  • FIG. 1C is an enlarged cross-sectional view near the needle tube.
  • FIG. 1 (d) is an enlarged cross-sectional view of the vicinity of a needle tube 1a 'of another example of the injection needle 1'.
  • FIG. 2 is a model diagram showing an example of a needle base having the injection needle and needle base of FIG.
  • FIG. 2B is a cross-sectional view.
  • FIG. 3 is a model diagram showing another example of the injection needle according to the present invention and an example of a kit preparation having this injection needle.
  • FIG. 3A is a perspective view of the injection needle 5.
  • FIG. 3B is a cross-sectional view of the injection needle 5.
  • FIG. 3 (c) is a perspective view of an example 7 of a kit preparation having an injection needle 5.
  • Fig. 3 (e): Fig. 3 (f) is a perspective view showing another example 5 'of the injection needle according to the present invention.
  • FIG. 4 is a model diagram showing a process for manufacturing an example of an injection needle according to the present invention.
  • FIG. 4A is a cross-sectional view showing a convex forming process by press working.
  • FIG. 4B is a cross-sectional view at the end of the convex forming process.
  • FIG. 4C is a cross-sectional view showing a state after the needle tube forming step.
  • FIG. 5 is a model diagram showing a process for manufacturing another example of the injection needle according to the present invention.
  • FIG. 5B is a cross-sectional view showing a second protrusion forming step by press working.
  • FIG. 5C is a cross-sectional view at the end of the second convex portion forming step.
  • FIG. 5D is a cross-sectional view showing a state after the needle tube forming step. It is a model figure which shows the injection needle concerning a prior art.
  • FIG. 6A is a cross-sectional view.
  • FIG. 1 is a diagram schematically showing an example 1 of an injection needle according to the present invention.
  • 1A is a perspective view
  • FIG. 1B is a cross-sectional view
  • FIG. 1C is an enlarged cross-sectional view near the needle tube
  • FIG. 1D is a needle tube 1a of another example of the injection needle 1 ′. It is an enlarged sectional view of the vicinity.
  • Example 1 of the injection needle four cylindrical needle tubes 1a are provided so as to protrude from the upper surface of the disk-shaped flat plate portion 1d.
  • an annular edge 1c which is perpendicular to the flat plate portion 1d and is parallel to the flat plate portion 1d via a cylindrical step 1b on the opposite side (lower surface side) of the needle tube 1a. It is connected.
  • these needle tubes 1a they are cut at an angle of 45 degrees in the same direction, but they may be cut in different directions or in the same direction two by two, and the angle of the cut is also necessary. Can be changed according to the same (the same applies hereinafter).
  • the material constituting the flat plate portion needs to be formed from a material that can be used medically and pharmacologically.
  • a metal such as stainless steel, brass, titanium, nickel is preferable.
  • the thickness of the flat plate portion is determined in consideration of workability and the required strength of the needle tube, but it is usually preferably 0.03 mm or more and 0.3 mm or less.
  • the injection needle of the present invention is provided with a cylindrical needle tube protruding from one surface of a flat plate portion.
  • a sufficient amount of drug solution can be easily administered subcutaneously while reducing pain during piercing.
  • the cylindrical needle tube 1a of the injection needle 1 is provided so as to approach the tip. Further, the thickness of the needle tube 1a is reduced as it approaches the tip. Such a shape is preferable because the needle tube is less likely to be broken, so that the number of accidents caused by the breakage of the needle tube is reduced and pain during piercing is reduced.
  • This injection needle 1 is provided with four needle tubes. For this reason, the swell of the skin surface between the needle tubes at the time of puncture of the skin surface can be prevented, and safer and more stable puncture is possible. Furthermore, administration with a small liquid volume, for example, 1/10 liquid volume, is possible by using a chemical solution having a high active ingredient compared to conventional subcutaneous injection (using a single needle needle). At this time, the viscosity of the drug solution is increased. However, since the injection needle according to the present invention can realize a short needle tube, the pressure loss is small, and as a result, the force required for injection is reduced.
  • the injection can be completed in a short time even if a thin needle tube that can reduce pain during piercing is used.
  • medical solution can be subcutaneously administered to a wide range by arrange
  • FIG. 1 (d) shows an enlarged cross-sectional view of the vicinity of the needle tube 1a 'of another example of the injection needle 1'.
  • the needle tube 1 a ′ is provided via a step portion 1 e ′ having a step portion plane whose top is parallel to the flat plate portion 1 d in the injection needle 1.
  • the size of the step portion 1e ′ is larger than the size of the base portion of the needle tube 1a ′ and is preferably 2 mm or less
  • the height of the step portion 1e ′ is 0.1 mm or more. It is preferably 1 mm or less, more preferably 0.5 mm or less.
  • FIG. 2 shows another example of an injection needle (an injection needle with a needle base) 2 of the present invention having a needle base while having the above-described injection needle 1 that enables connection to a drug solution administration system such as a syringe.
  • a model is a perspective view
  • FIG. 2 (b) is a cross-sectional view
  • FIG. 2 (c) is a perspective view showing a state where an injection needle 2 with a needle base is mounted on a syringe using the needle base.
  • FIG. 2D is a perspective view showing a state where a cap is attached to the injection needle 2 with a needle base.
  • the injection needle 2 includes a needle base 1a having a cylindrical shape with a needle base 1a shown in FIG. 1 and a cylindrical needle base (in this example, made of plastic) 2a communicating with the needle tube 1a of the injection needle 1.
  • 2a is an injection needle with a needle base which is configured to protrude from one end 2c of the cylinder and integrally molded, and an opening of one end 2c of the cylinder of the cylindrical needle base 2a is formed of the injection needle 1
  • a female luer taper-shaped tapered portion 2b is formed in the opening at the other end of the cylinder, which is covered with the flat plate portion 1d.
  • the injection needle 2 is an injection needle with a needle base in which the injection needle 1 according to the present invention is installed at the tip of a plastic needle base 2a having a general shape.
  • Such an injection needle is connected to the syringe 3 by a male luer (not shown) at the tip of the syringe 3 and a tapered portion 2b, as shown in FIG. Can be used for the subcutaneous administration of the drug solution 4.
  • reference numeral 3b denotes a sliding valve
  • 3c denotes a plunger.
  • a cap 15 that is separated from the tip of the needle tube 1a and covers the tip of the injection needle 2 with a needle base and protects the needle tube 1a is detachably mounted. Since the step portion 15a of the cap 15 abuts against the tip of the injection needle 2 with a needle base when the cap 15 is mounted, the space 15b is formed and the needle tube 1a is separated from the inner bottom surface of the cap 15. Therefore, the needle tube 1a is safely protected.
  • FIG. 3 shows an example 5 (and 5 ′) of an injection needle provided with a hood-shaped hood portion protruding from the other surface of the flat portion at the edge of the flat portion, and a kit using the injection needle 5 Formulation Example 7 is shown as a model.
  • 3 (a) is a perspective view of the injection needle 5
  • FIG. 3 (b) is a sectional view of the injection needle 5
  • FIG. 3 (c) is a perspective view of an example 7 of a kit preparation having the injection needle 5
  • FIG. ) Is a cross-sectional view of the kit preparation 7
  • FIG. 3 (e) is a cross-sectional view when the cap 12 protecting the needle tube 5a is attached to the kit preparation 7
  • FIG. 3 (f) is an injection with a hood according to the present invention. It is a perspective view which shows other examples 5 'of a needle
  • cylindrical needle tubes 5a are provided so as to protrude from the upper surface of the rectangular flat plate portion 5d.
  • the shape of the cylindrical needle tube 5a is the same as that of the needle tube 1a of the injection needle 1.
  • a hood-shaped hood portion 5b that protrudes from the lower surface of the flat surface portion 5c is provided at the edge of the flat surface portion 5d, and a space 5c is formed on the lower surface side of the flat surface portion 5c. In manufacturing the kit preparation, the space 5c can be used to hold the chemical solution.
  • Example 7 of the kit preparation having the injection needle 5 has a substantially planar shape, and the needle portion 5a is projected to the outside and exposed, and the injection needle 5 is housed inside.
  • an adhesive surface 7a coated with an adhesive is provided around the exposed surface of the injection needle 5 in the same manner as a bandage with absorbent cotton or a patch.
  • a drug solution hermetically held in an openable soft capsule is stored.
  • the adhesive surface 7a is used to fix the injection needle 5 so that it is located at the skin injection site, and then from the back side of the kit preparation 7, that is, from the space 5c side of the injection needle 5, for example, a finger
  • the drug solution is released to the outside of the capsule by an operation such as pressing it strongly with the needle etc., and administered subcutaneously via the needle tube 5a of the injection needle 5.
  • the kit preparation 7 is detachably mounted with a cap 12 that is separated from the tip of the needle tube 5a and covers the surface of the injection needle 5 on the needle tube 5a side to protect the needle tube. Since the cap 12 and the needle tube 5a are separated from each other at the inner end of the cap 12 against the surface having the injection needle 5 of the kit preparation, the needle tube 5a is prevented from being damaged by the contact with the cap 12 in advance. ing.
  • the injection needle 5 having eight needle tubes and the kit preparation having such an injection needle 5 have been described.
  • the injection needle 5 ′ shown in FIG. It may be a kit preparation using an injection needle having a larger number of needle tubes.
  • kit preparations include kit preparations for subcutaneous administration of any one of influenza vaccines, tetanus vaccines, and antidiabetics.
  • the injection needle according to the present invention can be manufactured easily and inexpensively.
  • the tip of the convex portion is removed by a known means such as a cutting means or a cutting means to form a cylinder
  • the needle tube is formed (needle tube forming step). At this time, pain at the time of injection can be reduced by making the cut surface an acute angle and making the needle tube the tip of which is inclined. Then clean, sterilize, and package as necessary.
  • the needle tube 1a 'whose cross section is modeled in FIG. 1D can be manufactured as shown in FIG. 5, for example.
  • one of the flat plates 10 is formed on the flat plate 10 by press working using a first convex portion forming press die 8 ′ (having the first convex portion forming convex portion 8 a ′).
  • the second convex portion forming step (see FIGS.
  • the injection needle and kit formulation of this invention are not limited to the structure of the said embodiment.
  • the injection needle of the present invention is an injection needle particularly suitable for subcutaneous injection, but can also be applied to the field of use of general injection needles by providing a long needle tube.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention vise à proposer une aiguille d'injection qui comprend un tube d'aiguille court, ladite aiguille d'injection diminuant une douleur de ponction et étant facile à fabriquer ; une aiguille d'injection comprenant l'aiguille d'injection mentionnée ci-dessus et comprenant un raccord d'aiguille qui peut être facilement moulé ; et une trousse de préparation. A cet effet, la présente invention concerne une aiguille d'injection qui comprend un tube d'aiguille cylindrique qui fait saillie à partir d'une surface d'une partie de plaque plate.
PCT/JP2012/062854 2012-05-18 2012-05-18 Aiguille d'injection et trousse de préparation WO2013171907A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2012/062854 WO2013171907A1 (fr) 2012-05-18 2012-05-18 Aiguille d'injection et trousse de préparation

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015177976A1 (fr) * 2014-05-20 2015-11-26 凸版印刷株式会社 Procédé de production de corps en forme d'aiguille, et corps en forme d'aiguille
WO2017170815A1 (fr) * 2016-03-31 2017-10-05 花王株式会社 Outil saillant creux fin
WO2019070077A1 (fr) * 2017-10-06 2019-04-11 シンクランド株式会社 Capuchon de seringue d'injection et injecteur
JP2020127892A (ja) * 2020-06-04 2020-08-27 花王株式会社 微細中空突起具

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JP2003501163A (ja) * 1999-06-09 2003-01-14 ザ プロクター アンド ギャンブル カンパニー 皮内用刃状ミクロ針構造体
JP2001149485A (ja) * 1999-09-22 2001-06-05 Becton Dickinson & Co 物質の経皮投与の方法及び装置
JP2003238347A (ja) * 2002-02-18 2003-08-27 Nano Device & System Research Inc 機能性マイクロパイル及びその製造方法
JP2007532245A (ja) * 2004-04-12 2007-11-15 アラーガン、インコーポレイテッド マルチサイト注射システム
JP2008521610A (ja) * 2004-11-26 2008-06-26 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ 微細構造製造方法および微細構造製造装置
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JP2009039171A (ja) * 2007-08-06 2009-02-26 Dai Ichi Kasei Kk 微細針形状突起物及びその成形金型及びその製造方法
JP2010057704A (ja) * 2008-09-04 2010-03-18 Toppan Printing Co Ltd 針状体製造方法、針状体、および研削刃

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WO2015177976A1 (fr) * 2014-05-20 2015-11-26 凸版印刷株式会社 Procédé de production de corps en forme d'aiguille, et corps en forme d'aiguille
JPWO2015177976A1 (ja) * 2014-05-20 2017-04-20 凸版印刷株式会社 針状体の製造方法、及び針状体
US10471245B2 (en) 2014-05-20 2019-11-12 Toppan Printing Co., Ltd. Manufacturing method of needle-shaped body, and needle-shaped body
WO2017170815A1 (fr) * 2016-03-31 2017-10-05 花王株式会社 Outil saillant creux fin
JP2017176652A (ja) * 2016-03-31 2017-10-05 花王株式会社 微細中空突起具
CN108883263A (zh) * 2016-03-31 2018-11-23 花王株式会社 微细中空突起器具
US11129974B2 (en) 2016-03-31 2021-09-28 Kao Corporation Fine hollow protrusion implement
CN108883263B (zh) * 2016-03-31 2022-01-07 花王株式会社 微细中空突起器具
WO2019070077A1 (fr) * 2017-10-06 2019-04-11 シンクランド株式会社 Capuchon de seringue d'injection et injecteur
JP2019068897A (ja) * 2017-10-06 2019-05-09 シンクランド株式会社 麻酔シリンジ本体用のキャップ、インジェクタ及び表面麻酔薬剤の塗布方法
JP7037026B2 (ja) 2017-10-06 2022-03-16 シンクランド株式会社 麻酔シリンジ本体用のキャップ及びアプリケータ
JP2020127892A (ja) * 2020-06-04 2020-08-27 花王株式会社 微細中空突起具

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