WO2013155528A3 - Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels - Google Patents

Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels Download PDF

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Publication number
WO2013155528A3
WO2013155528A3 PCT/US2013/036639 US2013036639W WO2013155528A3 WO 2013155528 A3 WO2013155528 A3 WO 2013155528A3 US 2013036639 W US2013036639 W US 2013036639W WO 2013155528 A3 WO2013155528 A3 WO 2013155528A3
Authority
WO
WIPO (PCT)
Prior art keywords
reducing
formula
methods
insulin sensitivity
increasing insulin
Prior art date
Application number
PCT/US2013/036639
Other languages
French (fr)
Other versions
WO2013155528A2 (en
Inventor
Joseph William MCFADDEN
Gabriele Valeria RONNETT
Susan Aja SLOAN
Original Assignee
Fasgen, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasgen, Inc. filed Critical Fasgen, Inc.
Publication of WO2013155528A2 publication Critical patent/WO2013155528A2/en
Publication of WO2013155528A3 publication Critical patent/WO2013155528A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels in a subject including by administering one or more compounds of Formula I, Formula II, or both are provided. The present disclosure provides for, and includes the use of a compound of Formula I, Formula II, or both for the manufacture of a medicine for reducing inflammation. In certain aspects, the compound of Formula I is FSG67 and the compound of Formula II is C75. The present disclosure also provides for, and includes, the use of a compound of Formula I, Formula II, or both for the manufacture of a medicine for the activation of palmitate oxidation in a subject in need.
PCT/US2013/036639 2012-04-13 2013-04-15 Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels WO2013155528A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261623896P 2012-04-13 2012-04-13
US61/623,896 2012-04-13

Publications (2)

Publication Number Publication Date
WO2013155528A2 WO2013155528A2 (en) 2013-10-17
WO2013155528A3 true WO2013155528A3 (en) 2013-12-05

Family

ID=49328292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/036639 WO2013155528A2 (en) 2012-04-13 2013-04-15 Methods for reducing brain inflammation, increasing insulin sensitivity, and reducing ceramide levels

Country Status (1)

Country Link
WO (1) WO2013155528A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160231334A1 (en) * 2013-10-28 2016-08-11 The Forsyth Institute Compositions and Methods for Evaluating Metabolic Syndrome and Related Diseases
PE20160901A1 (en) 2013-12-18 2016-08-27 Astex Therapeutics Ltd NRF2 REGULATORS
KR101705253B1 (en) * 2014-10-06 2017-02-22 울산과학기술원 Pharmaceutical composition for prevention or treatment of inflammatory diseases comprising cerulenin or cerulenin derivative as an active ingredient
EP3220901B1 (en) 2014-11-20 2020-02-19 VIB vzw Means and methods for treatment of early-onset parkinson's disease
WO2016202253A1 (en) 2015-06-15 2016-12-22 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulators
KR20180018684A (en) 2015-06-15 2018-02-21 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 NRF2 modulator
EP3359532A1 (en) 2015-10-06 2018-08-15 GlaxoSmithKline Intellectual Property Development Limited Biaryl pyrazoles as nrf2 regulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033506A1 (en) * 2001-11-30 2004-02-19 Dennis Farrelly Polynucleotides encoding novel human mitochondrial and microsomal glycerol-3-phosphate acyl-transferases and variants thereof
US20050106217A1 (en) * 2002-02-08 2005-05-19 Johns Hopkins University Licensing And Technology Development Stimulation of CPT-1 as a means to reduce weight
US20110274654A1 (en) * 2010-05-05 2011-11-10 Bahadoor Adilah Triazoles as inhibitors of fatty acid synthase
US20120083471A1 (en) * 2008-07-07 2012-04-05 Townsend Craig A Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040033506A1 (en) * 2001-11-30 2004-02-19 Dennis Farrelly Polynucleotides encoding novel human mitochondrial and microsomal glycerol-3-phosphate acyl-transferases and variants thereof
US20050106217A1 (en) * 2002-02-08 2005-05-19 Johns Hopkins University Licensing And Technology Development Stimulation of CPT-1 as a means to reduce weight
US20120083471A1 (en) * 2008-07-07 2012-04-05 Townsend Craig A Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same
US20110274654A1 (en) * 2010-05-05 2011-11-10 Bahadoor Adilah Triazoles as inhibitors of fatty acid synthase

Also Published As

Publication number Publication date
WO2013155528A2 (en) 2013-10-17

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