WO2013151666A3 - Modified polynucleotides for the production of biologics and proteins associated with human disease - Google Patents
Modified polynucleotides for the production of biologics and proteins associated with human disease Download PDFInfo
- Publication number
- WO2013151666A3 WO2013151666A3 PCT/US2013/030062 US2013030062W WO2013151666A3 WO 2013151666 A3 WO2013151666 A3 WO 2013151666A3 US 2013030062 W US2013030062 W US 2013030062W WO 2013151666 A3 WO2013151666 A3 WO 2013151666A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- biologics
- production
- human disease
- proteins associated
- modified polynucleotides
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
Abstract
Priority Applications (32)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18208097.8A EP3520821A1 (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
AU2013243949A AU2013243949A1 (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
CA2868391A CA2868391A1 (en) | 2012-04-02 | 2013-03-09 | Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same |
JP2015504565A JP2015518705A (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human diseases |
CN201380028773.4A CN104411338A (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
EP13712973.0A EP2833920A2 (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
US14/390,106 US9221891B2 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
EP13713306.2A EP2833922B1 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
CA2868418A CA2868418A1 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
CN201380028186.5A CN104870022A (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
EP18204317.4A EP3520820A1 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
CN202010645626.3A CN112390871A (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
PCT/US2013/031821 WO2013151736A2 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
AU2013243834A AU2013243834A1 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
JP2015504587A JP6348482B2 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
HK15107125.6A HK1206601A1 (en) | 2012-04-02 | 2015-07-27 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
HK15107400.2A HK1206639A1 (en) | 2012-04-02 | 2015-08-03 | In vivo production of proteins |
US14/824,247 US9572896B2 (en) | 2012-04-02 | 2015-08-12 | In vivo production of proteins |
US15/403,517 US10493167B2 (en) | 2012-04-02 | 2017-01-11 | In vivo production of proteins |
JP2017012947A JP6953135B6 (en) | 2012-04-02 | 2017-01-27 | In vivo production of proteins |
AU2017232121A AU2017232121B2 (en) | 2012-04-02 | 2017-09-21 | In vivo production of proteins |
AU2018200374A AU2018200374B2 (en) | 2012-04-02 | 2018-01-19 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
AU2019202835A AU2019202835A1 (en) | 2012-04-02 | 2019-04-23 | In vivo production of proteins |
US16/442,168 US10583203B2 (en) | 2012-04-02 | 2019-06-14 | In vivo production of proteins |
JP2019225097A JP2020072670A (en) | 2012-04-02 | 2019-12-13 | In vivo production of protein |
US16/811,648 US20210077634A1 (en) | 2012-04-02 | 2020-03-06 | In vivo production of proteins |
AU2020257150A AU2020257150A1 (en) | 2012-04-02 | 2020-10-23 | In vivo production of proteins |
AU2021200507A AU2021200507A1 (en) | 2012-04-02 | 2021-01-28 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
JP2022020499A JP2022078081A (en) | 2012-04-02 | 2022-02-14 | In vivo production of proteins |
AU2023214237A AU2023214237A1 (en) | 2012-04-02 | 2023-08-08 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
AU2023263451A AU2023263451A1 (en) | 2012-04-02 | 2023-11-07 | In vivo production of proteins |
JP2024018721A JP2024063025A (en) | 2012-04-02 | 2024-02-09 | In vivo production of proteins |
Applications Claiming Priority (100)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261618878P | 2012-04-02 | 2012-04-02 | |
US201261618911P | 2012-04-02 | 2012-04-02 | |
US201261618922P | 2012-04-02 | 2012-04-02 | |
US201261618866P | 2012-04-02 | 2012-04-02 | |
US201261618896P | 2012-04-02 | 2012-04-02 | |
US201261618953P | 2012-04-02 | 2012-04-02 | |
US201261618868P | 2012-04-02 | 2012-04-02 | |
US201261618945P | 2012-04-02 | 2012-04-02 | |
US201261618961P | 2012-04-02 | 2012-04-02 | |
US201261618873P | 2012-04-02 | 2012-04-02 | |
US201261618957P | 2012-04-02 | 2012-04-02 | |
US201261618885P | 2012-04-02 | 2012-04-02 | |
US201261618870P | 2012-04-02 | 2012-04-02 | |
US201261618862P | 2012-04-02 | 2012-04-02 | |
US61/618,866 | 2012-04-02 | ||
US61/618,911 | 2012-04-02 | ||
US61/618,878 | 2012-04-02 | ||
US61/618,873 | 2012-04-02 | ||
US61/618,896 | 2012-04-02 | ||
US61/618,870 | 2012-04-02 | ||
US61/618,945 | 2012-04-02 | ||
US61/618,885 | 2012-04-02 | ||
US61/618,862 | 2012-04-02 | ||
US61/618,953 | 2012-04-02 | ||
US61/618,961 | 2012-04-02 | ||
US61/618,922 | 2012-04-02 | ||
US61/618,957 | 2012-04-02 | ||
US61/618,868 | 2012-04-02 | ||
US201261648244P | 2012-05-17 | 2012-05-17 | |
US201261648286P | 2012-05-17 | 2012-05-17 | |
US61/648,286 | 2012-05-17 | ||
US61/648,244 | 2012-05-17 | ||
US201261668157P | 2012-07-05 | 2012-07-05 | |
US61/668,157 | 2012-07-05 | ||
US201261681687P | 2012-08-10 | 2012-08-10 | |
US201261681648P | 2012-08-10 | 2012-08-10 | |
US201261681658P | 2012-08-10 | 2012-08-10 | |
US201261681720P | 2012-08-10 | 2012-08-10 | |
US201261681704P | 2012-08-10 | 2012-08-10 | |
US201261681654P | 2012-08-10 | 2012-08-10 | |
US201261681712P | 2012-08-10 | 2012-08-10 | |
US201261681650P | 2012-08-10 | 2012-08-10 | |
US201261681696P | 2012-08-10 | 2012-08-10 | |
US201261681649P | 2012-08-10 | 2012-08-10 | |
US201261681647P | 2012-08-10 | 2012-08-10 | |
US201261681667P | 2012-08-10 | 2012-08-10 | |
US201261681742P | 2012-08-10 | 2012-08-10 | |
US201261681645P | 2012-08-10 | 2012-08-10 | |
US201261681675P | 2012-08-10 | 2012-08-10 | |
US201261681661P | 2012-08-10 | 2012-08-10 | |
US61/681,675 | 2012-08-10 | ||
US61/681,704 | 2012-08-10 | ||
US61/681,667 | 2012-08-10 | ||
US61/681,647 | 2012-08-10 | ||
US61/681,661 | 2012-08-10 | ||
US61/681,648 | 2012-08-10 | ||
US61/681,687 | 2012-08-10 | ||
US61/681,658 | 2012-08-10 | ||
US61/681,654 | 2012-08-10 | ||
US61/681,712 | 2012-08-10 | ||
US61/681,645 | 2012-08-10 | ||
US61/681,742 | 2012-08-10 | ||
US61/681,696 | 2012-08-10 | ||
US61/681,649 | 2012-08-10 | ||
US61/681,720 | 2012-08-10 | ||
US61/681,650 | 2012-08-10 | ||
US201261696381P | 2012-09-04 | 2012-09-04 | |
US61/696,381 | 2012-09-04 | ||
US201261709303P | 2012-10-03 | 2012-10-03 | |
US61/709,303 | 2012-10-03 | ||
US201261712490P | 2012-10-11 | 2012-10-11 | |
US61/712,490 | 2012-10-11 | ||
US201261737160P | 2012-12-14 | 2012-12-14 | |
US201261737203P | 2012-12-14 | 2012-12-14 | |
US201261737174P | 2012-12-14 | 2012-12-14 | |
US201261737184P | 2012-12-14 | 2012-12-14 | |
US201261737139P | 2012-12-14 | 2012-12-14 | |
US201261737147P | 2012-12-14 | 2012-12-14 | |
US201261737134P | 2012-12-14 | 2012-12-14 | |
US201261737191P | 2012-12-14 | 2012-12-14 | |
US201261737168P | 2012-12-14 | 2012-12-14 | |
US201261737152P | 2012-12-14 | 2012-12-14 | |
US201261737135P | 2012-12-14 | 2012-12-14 | |
US201261737213P | 2012-12-14 | 2012-12-14 | |
US201261737130P | 2012-12-14 | 2012-12-14 | |
US201261737155P | 2012-12-14 | 2012-12-14 | |
US61/737,174 | 2012-12-14 | ||
US61/737,147 | 2012-12-14 | ||
US61/737,135 | 2012-12-14 | ||
US61/737,203 | 2012-12-14 | ||
US61/737,184 | 2012-12-14 | ||
US61/737,213 | 2012-12-14 | ||
US61/737,160 | 2012-12-14 | ||
US61/737,134 | 2012-12-14 | ||
US61/737,130 | 2012-12-14 | ||
US61/737,152 | 2012-12-14 | ||
US61/737,191 | 2012-12-14 | ||
US61/737,168 | 2012-12-14 | ||
US61/737,139 | 2012-12-14 | ||
US61/737,155 | 2012-12-14 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/030063 Continuation WO2013151667A1 (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/390,106 Continuation US9221891B2 (en) | 2012-04-02 | 2013-03-15 | In vivo production of proteins |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013151666A2 WO2013151666A2 (en) | 2013-10-10 |
WO2013151666A3 true WO2013151666A3 (en) | 2014-01-09 |
Family
ID=49301149
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/030062 WO2013151666A2 (en) | 2012-04-02 | 2013-03-09 | Modified polynucleotides for the production of biologics and proteins associated with human disease |
Country Status (6)
Country | Link |
---|---|
JP (5) | JP2015518705A (en) |
CN (2) | CN108949772A (en) |
AU (4) | AU2013243949A1 (en) |
CA (1) | CA2868391A1 (en) |
HK (1) | HK1206612A1 (en) |
WO (1) | WO2013151666A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11850305B2 (en) | 2010-07-06 | 2023-12-26 | Glaxosmithkline Biologicals Sa | Method of making lipid formulations with RNA encoding immunogens |
US11851660B2 (en) | 2010-07-06 | 2023-12-26 | Glaxosmithkline Biologicals Sa | Immunisation of large mammals with low doses of RNA |
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ES2713852T3 (en) | 2009-12-01 | 2019-05-24 | Translate Bio Inc | Derived from steroids for the administration of mRNA in human genetic diseases |
EP2590670B1 (en) | 2010-07-06 | 2017-08-23 | GlaxoSmithKline Biologicals SA | Methods of raising an immune response by delivery of rna |
EP2600901B1 (en) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
PL3970742T3 (en) | 2010-08-31 | 2022-09-19 | Glaxosmithkline Biologicals S.A. | Pegylated liposomes for delivery of immunogen-encoding rna |
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JP2023130471A (en) | 2023-09-20 |
CN108949772A (en) | 2018-12-07 |
AU2021200507A1 (en) | 2021-04-01 |
AU2018200374A1 (en) | 2018-03-22 |
WO2013151666A2 (en) | 2013-10-10 |
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JP2021192606A (en) | 2021-12-23 |
AU2018200374B2 (en) | 2020-11-19 |
AU2023214237A1 (en) | 2023-08-31 |
JP2015518705A (en) | 2015-07-06 |
JP2019030327A (en) | 2019-02-28 |
JP6430552B2 (en) | 2018-11-28 |
AU2013243949A1 (en) | 2014-10-30 |
CN104411338A (en) | 2015-03-11 |
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JP2017121244A (en) | 2017-07-13 |
JP6921797B2 (en) | 2021-08-18 |
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