WO2013066839A3 - Compounds and methods - Google Patents

Compounds and methods Download PDF

Info

Publication number
WO2013066839A3
WO2013066839A3 PCT/US2012/062514 US2012062514W WO2013066839A3 WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3 US 2012062514 W US2012062514 W US 2012062514W WO 2013066839 A3 WO2013066839 A3 WO 2013066839A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
methods
hdac
enzymes
inhibition
Prior art date
Application number
PCT/US2012/062514
Other languages
French (fr)
Other versions
WO2013066839A2 (en
Inventor
Shomir Ghosh
Mercedes Lobera
Ryan Paul Trump
Cunyu Zhang
Original Assignee
Glaxosmithkline Llc
Tempero Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Llc, Tempero Pharmaceuticals, Inc. filed Critical Glaxosmithkline Llc
Publication of WO2013066839A2 publication Critical patent/WO2013066839A2/en
Publication of WO2013066839A3 publication Critical patent/WO2013066839A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Abstract

The present invention relates to compounds that inhibit histone deacetylase (HDAC) enzymes, the preparation of these compounds or salts of said compound, the use of these compounds in the treatment of neurodegenerative diseases or conditions ameliorated by inhibition of HDAC activity and pharmaceutical compositions that are comprised of these compounds.
PCT/US2012/062514 2011-10-31 2012-10-30 Compounds and methods WO2013066839A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161553757P 2011-10-31 2011-10-31
US61/553,757 2011-10-31
US201261596269P 2012-02-08 2012-02-08
US61/596,269 2012-02-08

Publications (2)

Publication Number Publication Date
WO2013066839A2 WO2013066839A2 (en) 2013-05-10
WO2013066839A3 true WO2013066839A3 (en) 2015-06-25

Family

ID=48193011

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/062514 WO2013066839A2 (en) 2011-10-31 2012-10-30 Compounds and methods

Country Status (1)

Country Link
WO (1) WO2013066839A2 (en)

Cited By (2)

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CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi
CN108368098B (en) * 2015-12-18 2022-01-28 先正达参股股份有限公司 Microbicidal oxadiazole derivatives

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WO2013004332A1 (en) * 2011-07-07 2013-01-10 Merck Patent Gmbh Substituted azaheterocycles for the treatment of cancer
ES2556822T3 (en) 2011-07-08 2016-01-20 Novartis Ag Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease
US10179790B2 (en) 2014-06-04 2019-01-15 Thomas Helledays Stiftelse For Medicinsk Forskning MTH1 inhibitors for treatment of cancer
JP6635949B2 (en) 2014-06-04 2020-01-29 トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング MTH1 inhibitors for the treatment of inflammatory and autoimmune diseases
JP6556146B2 (en) * 2014-08-26 2019-08-07 武田薬品工業株式会社 Heterocyclic compounds
WO2017014170A1 (en) * 2015-07-17 2017-01-26 武田薬品工業株式会社 Heterocyclic compound
CA2992700A1 (en) 2015-07-17 2017-01-26 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as hdac inhibitors
PL3330259T3 (en) 2015-07-27 2021-02-08 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole amide derivative compound as histone deacetylase 6 inhibitor, and pharmaceutical composition containing same
MY197262A (en) 2015-07-27 2023-06-08 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole sulfonamide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
EP3328844B1 (en) 2015-07-27 2019-11-27 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole sulfamide derivatives as histone deacetylase 6 inhibitor and pharmaceutical composition comprising the same
MY197738A (en) 2015-08-04 2023-07-12 Chong Kun Dang Pharmaceutical Corp 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
EP3342772A4 (en) 2015-08-25 2019-03-27 Takeda Pharmaceutical Company Limited Heterocyclic compound
JP6864673B2 (en) * 2015-10-02 2021-04-28 シンジェンタ パーティシペーションズ アーゲー Microbial oxadiazole derivative
WO2017055473A1 (en) 2015-10-02 2017-04-06 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
NZ740809A (en) 2015-10-12 2019-04-26 Chong Kun Dang Pharmaceutical Corp Oxadiazole amine derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
CR20180310A (en) 2015-11-05 2018-11-30 Basf Se OXADIAZOLS REPLACED TO COMBAT HONGOD PHYTOOPATHOGENS
WO2017085098A1 (en) 2015-11-19 2017-05-26 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US10640497B2 (en) 2015-12-02 2020-05-05 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
JP2019507110A (en) * 2015-12-17 2019-03-14 シンジェンタ パーティシペーションズ アーゲー Microbicidal oxadiazole derivative
UY37062A (en) 2016-01-08 2017-08-31 Syngenta Participations Ag DERIVATIVES OF ARYL OXADIAZOL FUNGICIDAS
EP3433252B1 (en) 2016-03-24 2021-10-27 Syngenta Participations AG Microbicidal oxadiazole derivatives
CA3020532A1 (en) 2016-04-11 2017-10-19 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN109071522B (en) * 2016-04-12 2022-04-12 先正达参股股份有限公司 Microbicidal oxadiazole derivatives
WO2017211649A1 (en) 2016-06-09 2017-12-14 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
US11066396B2 (en) * 2016-06-23 2021-07-20 Merck Sharp & Dohme Corp. 3-aryl- heteroaryl substituted 5-trifluoromethyl oxadiazoles as histonedeacetylase 6 (HDAC6) inhibitors
CN106243083B (en) * 2016-07-12 2018-10-30 浙江宏冠生物药业有限公司 A kind of Imatinib preparation method
WO2018165520A1 (en) 2017-03-10 2018-09-13 Vps-3, Inc. Metalloenzyme inhibitor compounds
CN113979962A (en) 2017-03-31 2022-01-28 先正达参股股份有限公司 Fungicidal compositions
WO2018177880A1 (en) 2017-03-31 2018-10-04 Syngenta Participations Ag Fungicidal compositions
US20210101874A1 (en) 2017-04-03 2021-04-08 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
BR112019020819B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag COMPOUND OF FORMULA (I), AGROCHEMICAL COMPOSITION, METHOD FOR CONTROLLING OR PREVENTING INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS AND USE OF A COMPOUND OF FORMULA (I)
BR112019020735B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag COMPOUNDS DERIVED FROM OXADIAZOLE MICROBIOCIDES AND THEIR USE, AGROCHEMICAL COMPOSITION AND METHOD TO CONTROL OR PREVENT INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS
BR112019020756B1 (en) 2017-04-05 2023-11-28 Syngenta Participations Ag COMPOUNDS DERIVED FROM OXADIAZOLE MICROBICIDES, AGROCHEMICAL COMPOSITION COMPRISING THE SAME, METHOD FOR CONTROLLING OR PREVENTING INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS AND USE OF THESE COMPOUNDS
BR112019021019B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag Microbiocidal oxadiazole-derived compounds, agricultural composition, method for controlling or preventing infestation of useful plants by phytopathogenic microorganisms and use of an oxadiazole-derived compound
BR112019020734B1 (en) 2017-04-05 2023-12-05 Syngenta Participations Ag Compounds derived from oxadiazole, agrochemical composition, method for controlling or preventing infestation of useful plants by phytopathogenic microorganisms and use of said compounds
BR112019020739B1 (en) 2017-04-05 2023-12-19 Syngenta Participations Ag COMPOUNDS DERIVED FROM OXADIAZOLE MICROBIOCIDES AND THEIR USE, AGROCHEMICAL COMPOSITION, METHOD TO CONTROL OR PREVENT INFESTATION OF USEFUL PLANTS BY PHYTOPATHOGENIC MICROORGANISMS
TWI829634B (en) * 2017-04-06 2024-01-21 美商富曼西公司 Fungicidal oxadiazoles
TW201910328A (en) 2017-07-31 2019-03-16 日商武田藥品工業股份有限公司 Heterocyclic compound
WO2019110663A1 (en) * 2017-12-05 2019-06-13 Oryzon Genomics, S.A. 1,2,4-oxadiazole derivatives as histone deacetylase 6 inhibitors
WO2019207062A1 (en) 2018-04-26 2019-10-31 Syngenta Participations Ag Microbiocidal oxadiazole derivatives
KR102316234B1 (en) 2018-07-26 2021-10-22 주식회사 종근당 1,3,4-Oxadiazole Derivative Compounds as Histone Deacetylase 6 Inhibitor, and the Pharmaceutical Composition Comprising the same
CN111285861B (en) * 2018-12-10 2021-08-17 浙江省化工研究院有限公司 Trifluoromethyl oxadiazole substituted pyrimidinamine compound, and preparation method and application thereof
AR118673A1 (en) 2019-04-18 2021-10-20 Syngenta Crop Protection Ag PROCEDURE FOR THE PREPARATION OF OXADIAZOLE DERIVATIVES MICROBIOCIDES
US20230079386A1 (en) 2019-05-31 2023-03-16 Chong Kun Dang Pharmaceutical Corp. 1,3,4-oxadiazole homophthalimide derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same
WO2020254494A1 (en) * 2019-06-21 2020-12-24 Bayer Aktiengesellschaft Fungicidal oxadiazoles
MX2022003490A (en) 2019-09-27 2022-04-25 Takeda Pharmaceuticals Co 2-isoindol-1,3,4-oxadiazole derivatives useful as hdac6 inhibitors.

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Patent Citations (4)

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US20080227834A1 (en) * 2005-09-29 2008-09-18 Sanofi-Aventis Derivatives of 2-aminothiazoles and 2-amino-oxazoles, processes for their preparation and their use as pharmaceutical compositions
US20090062252A1 (en) * 2007-08-27 2009-03-05 Helicon Therapeutics, Inc. Therapeutic isoxazole compounds
WO2011088192A1 (en) * 2010-01-13 2011-07-21 Tempero Pharmaceuticals, Inc. Compounds and methods

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108289449A (en) * 2015-11-19 2018-07-17 巴斯夫欧洲公司 Qu Dai oxadiazoles for preventing and kill off plant pathogenic fungi
CN108368098B (en) * 2015-12-18 2022-01-28 先正达参股股份有限公司 Microbicidal oxadiazole derivatives

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