WO2013065805A1 - 角膜撮影装置 - Google Patents
角膜撮影装置 Download PDFInfo
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- WO2013065805A1 WO2013065805A1 PCT/JP2012/078397 JP2012078397W WO2013065805A1 WO 2013065805 A1 WO2013065805 A1 WO 2013065805A1 JP 2012078397 W JP2012078397 W JP 2012078397W WO 2013065805 A1 WO2013065805 A1 WO 2013065805A1
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- light
- optical system
- cornea
- illumination
- photographing apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
- A61B3/15—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing
- A61B3/152—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing for aligning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
- A61B3/15—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing
- A61B3/156—Arrangements specially adapted for eye photography with means for aligning, spacing or blocking spurious reflection ; with means for relaxing for blocking
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/56—Cameras or camera modules comprising electronic image sensors; Control thereof provided with illuminating means
Definitions
- the present invention relates to a cornea imaging apparatus that images an image of a corneal region of a subject's eye.
- a cornea photographing apparatus for example, there is an apparatus that irradiates illumination light from an illumination light source obliquely toward the cornea and receives a reflected light beam from the cornea by an imaging device to obtain a cell image of the corneal endothelium in a non-contact manner It is known (see Patent Document 1).
- the circular diaphragm and the rectangular diaphragm are arranged symmetrically with respect to the optical axis of the optical system.
- the above-described apparatus is an optical system having a special object surface for observing an object from an oblique direction, and therefore passes through the periphery of the lens due to the influence of aberration. It became clear that some light fluxes had an adverse effect on image formation and contributed to the deterioration of image quality.
- the aperture of the circular diaphragm or rectangular diaphragm is simply reduced, the influence of aberration is reduced, but as a result, the image becomes dark and the resolution is lowered.
- an object of the present invention is to provide a corneal endothelial cell imaging apparatus that can secure an image brightness and resolving power and can acquire an endothelial image suitable for observation and analysis.
- the present invention is characterized by having the following configuration.
- An illumination optical system that irradiates an illumination light beam toward the cornea, and a light receiving optical system that is arranged with an inclination with respect to the optical axis of the illumination optical system and that receives a reflected light beam from the cornea by a photodetector.
- the cornea photographing apparatus provided with an optical system for photographing the corneal region of A cornea photographing apparatus, comprising: a light restricting means provided in an optical path of an optical system for photographing the corneal part of the eye, and restricting a light beam asymmetrically with respect to an optical axis.
- the light limiting means allows light passing through a central portion of an objective lens provided in the light receiving optical system to pass toward the photodetector and limits light passing through a peripheral portion of the objective lens asymmetrically.
- the cornea photographing device according to any one of (1) to (2).
- the optical system for photographing the corneal region is an optical system for photographing endothelial cells of the cornea, and the illumination optical system irradiates the cornea with an illumination light beam from an oblique direction, and the light receiving optical system
- the corneal imaging device according to any one of (1) to (3), wherein the reflected light beam from the cornea is received from the regular reflection direction at the cornea.
- the illumination optical system and the light receiving optical system are arranged symmetrically with respect to a central axis,
- the light limiting means is Passing light passing through the center of an objective lens provided in the light receiving optical system toward the photodetector; Of the light passing through the peripheral portion of the objective lens, the light on the central axis side is allowed to pass, and the light in the direction opposite to the central axis side is limited. apparatus.
- the illumination optical system and the light receiving optical system are arranged symmetrically with respect to a central axis,
- the light limiting means is Passing light passing through the center of an objective lens provided in the light receiving optical system toward the photodetector; Of the light passing through the periphery of the objective lens, the light in the direction opposite to the central axis side is allowed to pass and the light on the central axis side is limited.
- apparatus. 4 The cornea photographing apparatus according to claim 1, wherein the cornea is irradiated with an illumination light beam from an oblique direction, and the light receiving optical system receives a reflected light beam from the cornea from a regular reflection direction on the cornea.
- the illumination optical system and the light receiving optical system are arranged symmetrically with respect to a central axis,
- the corneal imaging device according to any one of (1) to (7), wherein the observation optical axis of the observation optical system is the central axis.
- the light restricting means is disposed in the light receiving optical system and restricts a reflected light beam from the cornea asymmetrically.
- the light restricting means is disposed in the illumination optical system and restricts the illumination light flux asymmetrically.
- the light limiting means includes an opening in which an opening asymmetric with respect to the optical axis is formed, and a light-shielding portion formed outside the opening.
- (1) to (9) Shooting device.
- (11) The cornea photographing device according to any one of (1) to (10), wherein the light limiting means is any one of an asymmetric aperture, a lens holder having an asymmetric aperture, and an asymmetric coating on the optical member.
- An apparatus relates to an apparatus that captures an image of a corneal region of a subject's eye, an illumination optical system that irradiates an illumination light beam toward the cornea, and a reflected light beam from the cornea is received by a photodetector. It has a light receiving optical system, and includes an optical system for photographing the cornea portion of the eye in a non-contact manner.
- the optical axes of the illumination optical system and the light receiving optical system are not coaxial but have a relationship that intersects on the eye to be examined.
- this device uses an optical system that irradiates the cornea with light from an oblique direction and receives reflected light from the regular reflection direction of the cornea, like a general specular microscope (corneal endothelial cell imaging device).
- the illumination optical system and the light receiving optical system are advantageously arranged symmetrically with respect to a certain central axis.
- This device cuts the light beam that adversely affects the image formation while ensuring the brightness of the image by restricting the illumination light beam or the reflected light beam asymmetrically with respect to the optical axis. This improves the quality of the corneal image.
- an asymmetric aperture As means for limiting the reflected light flux asymmetrically, an asymmetric aperture, a lens holder having an asymmetric aperture, an asymmetric coating on an optical member, or the like is used.
- the light limiting means only needs to be able to limit light, and it is advantageous to use a light blocking member that blocks light.
- an attenuation member that attenuates light (for example, an optical member that is coated with 10% transmission / 90% light shielding) is used.
- Asymmetrical light limiting means is provided in the optical path of the illumination optical system or the light receiving optical system.
- the asymmetric light restricting means restricts in advance the component that adversely affects the image formation in the reflected light beam from the cornea in the illumination light path by restricting the illumination light beam asymmetrically.
- the asymmetric light restricting member restricts a part of the reflected light beam to restrict a component that adversely affects image formation in the reflected light beam from the cornea in the light receiving light path.
- the asymmetrical light limiting means is disposed in the vicinity of a condenser lens (objective lens, relay lens, imaging lens, etc.) having a function of condensing light. Further, it is advantageous that the asymmetric light limiting means is disposed between a plurality of lenses forming the condensing optical system. In other words, it is advantageous that the asymmetrical light limiting means is arranged at a position away from the light beam condensing point (imaging point). With such an arrangement, the luminous flux is uniformly restricted over a wide observation range. In this case, an asymmetric light restricting means may be arranged so as to obtain such an effect.
- the asymmetrical light limiting means advantageously allows light passing through the central portion of the objective lens in the light receiving optical system to pass toward the photodetector and restricts light passing through the peripheral portion asymmetrically.
- the light on the central axis side is passed toward the photodetector, and the light on the opposite side is limited.
- Such means is advantageous when the light on the opposite side adversely affects image formation due to aberration or the like. Since the light on the central axis side contributes to image formation, it is possible to satisfy both image formation performance and image brightness.
- the light passing through the periphery of the objective lens in the light receiving optical system may be asymmetrically limited by providing means for restricting the generation of reflected light that has an adverse effect in the optical path of the illumination optical system. .
- the asymmetry of the asymmetrical light limiting means is formed in reverse. It is.
- This apparatus is advantageously provided with an observation optical system for observing the front image of the anterior segment.
- the observation optical axis of the observation optical system is advantageously used as the central axis of the illumination optical system and the light receiving optical system arranged symmetrically with respect to each other.
- the illumination optical system and the light receiving optical system are advantageously arranged symmetrically with respect to the observation optical axis, and the asymmetrical light restricting means allows the reflected light beam from the cornea to be horizontally oriented with respect to the optical axis of the light receiving optical system. Restrict to asymmetric with respect to.
- FIG. 1 is an external side configuration diagram of a cornea photographing apparatus according to the present embodiment.
- the device 100 is a so-called stationary device, and is a base 1, a face support unit 2 attached to the base 1, and a movable base provided so as to be movable on the base 1 by a sliding mechanism not shown. 3 and a photographing unit (device main body) 4 that is provided so as to be movable with respect to the movable table 3 and accommodates a photographing system and an optical system described later.
- the imaging unit 4 is moved in the left-right direction (X direction), the up-down direction (Y direction), and the front-rear direction (Z direction) with respect to the eye E by an XYZ driving unit 6 provided on the moving table 3.
- the movable table 3 is moved in the XZ direction on the base 1 by operating the joystick 5. Further, when the examiner rotates the rotary knob 5 a, the photographing unit 4 is moved in the Y direction by the Y drive of the XYZ drive unit 6.
- a start switch 5 b is provided on the top of the joystick 5.
- the display monitor 95 is provided on the examiner side of the imaging unit 4. In this embodiment, the photographing unit 4 is moved relative to the eye E by a sliding mechanism (not shown) or the XYZ driving unit 6.
- FIG. 2 is a schematic configuration diagram illustrating an example of an optical arrangement and a control system configuration when the optical system housed in the photographing unit 4 is viewed from above.
- FIG. 3 is a view of the first projection optical system and the second projection optical system as viewed from the subject side.
- the overall configuration of the optical system is such that the illumination optical system 10 that irradiates illumination light from the illumination light source 12 toward the cornea Ec obliquely and the reflected light from the cornea Ec including endothelial cells is received by the first imaging device 44.
- First projection optical systems 60a and 60b for projecting the indices, second projection optical systems 65a to 65d (see FIG.
- the illumination optical system 10 includes an illumination light source (eg, visible LED, flash lamp) 12 that emits visible light for endothelium imaging, a condensing lens 14, a slit plate 16, a dichroic mirror 18 that reflects and transmits infrared light, and light projection.
- a lens 20 The light emitted from the illumination light source 12 illuminates the slit plate 16 via the condenser lens 14. Then, the slit light that has passed through the slit plate 16 is converged by the light projecting lens 20 via the dichroic mirror 18 and irradiated onto the cornea.
- the slit plate 16 and the cornea Ec are disposed at a substantially conjugate position with respect to the objective lens 20.
- the imaging optical system 30 is symmetrical with the illumination optical system 10 with respect to the optical axis L1, and includes an objective lens 32, a visible light reflecting / infrared transmitting dichroic mirror 34, a mask 35, a first imaging lens 36, and a total reflection mirror 38. , A second imaging lens 42, an asymmetrical slit 43, and a first two-dimensional imaging device (for example, a two-dimensional CCD, CMOS, etc.) 44.
- the mask 35 is disposed at a position substantially conjugate with the cornea Ec with respect to the objective lens 32.
- the first imaging lens (relay lens) 36 and the second imaging lens (imaging lens) 42 form an imaging optical system that forms an endothelial image on the imaging device 44.
- the imaging element 44 is disposed at a position substantially conjugate with the cornea Ec with respect to the lens system of the imaging optical system 30.
- hatching H indicates a light beam that adversely affects the image formation of the endothelial image and contributes to a reduction in image quality.
- This light beam is a central axis (light beam) in the periphery of the objective lens 32. It passes through the opposite side of the axis L1).
- FIG. 4 is a front view for explaining the configuration of the asymmetric diaphragm 43.
- the asymmetric diaphragm 43 is a diaphragm that shields light acquired by reflection of light from the illumination optical system 10 on the cornea asymmetrically.
- the diaphragm 43 includes an opening 43a that has a longitudinal direction in the horizontal direction and is asymmetric in the horizontal direction with respect to the optical axis L3, and a light-shielding portion 43b that is formed outside the opening 43a.
- the diaphragm 43 is arranged such that the opening 43a is decentered in the horizontal direction with respect to the optical axis L3 of the light receiving optical system.
- the opening 43a allows the light in the central region including the optical axis L3 to pass toward the image sensor 44, and the light corresponding to the hatching H with respect to the optical axis L3 among the light in the peripheral region away from the optical axis L3. And symmetric light are transmitted toward the image sensor 44.
- the light shielding portion 43b includes a portion that shields the light corresponding to the hatching H, and shields the light of the hatching H and the upper and lower light among the light in the peripheral area away from the optical axis L3. That is, the asymmetrical diaphragm 43 in FIG. 4 also serves as a light blocking unit that blocks light passing through the upper and lower regions in the light receiving optical system 30. Note that the portion of the light shielding portion 43b may be a member having a dimming action that transmits part of the light.
- the shape of the opening 43a is not limited to a rectangle as shown in FIG. 4, and may be asymmetric in the horizontal direction with respect to the optical axis L3.
- the shape may be polygonal, circular, elliptical, etc.
- the cornea-reflected light from the illumination optical system 10 is directed in the direction of the optical axis L3 (diagonal direction), converged by the objective lens 32, reflected by the dichroic mirror 34, temporarily imaged by the mask 35, and an endothelial cell image is obtained. Light that becomes noise during acquisition is blocked.
- the light that has passed through the mask 35 is imaged on the two-dimensional imaging device 44 through the first imaging lens 36, the total reflection mirror 38, the second imaging lens 42, and the asymmetric aperture 43. Thereby, a high-magnification corneal endothelial cell image is acquired.
- the output of the image sensor 44 is connected to the control unit 90, and the acquired image is stored in the memory 92.
- the cell image is displayed on the monitor 95.
- the mask 35 shields noise light other than the endothelial reflection, whereas the asymmetric aperture 43 asymmetrically shields light that adversely affects image formation including light corresponding to the hatching H out of light from the corneal endothelium. .
- the brightness of the endothelial image can be ensured by forming an image on the image pickup element 44 without cutting light having a symmetrical relationship with the light corresponding to the hatching H, and the imaging performance can be improved.
- the imaging performance can be improved.
- the asymmetric diaphragm 43 is disposed between the second imaging lens 42 and the image sensor 44, but is not limited thereto.
- the asymmetric diaphragm 43 is disposed in the optical path of the photographing optical system 30 and restricts the reflected light from the cornea including the light beam corresponding to the hatching H, while the light having the symmetrical relationship with the light corresponding to the hatching H. Let it pass. More specifically, between the cornea and the objective lens 32, between the objective lens 32 and the first imaging point (mask 35), between the first imaging point and the first imaging lens 36, the first Arranged between the imaging lens 36 and the second imaging lens 42.
- the size of the opening 43a / light-shielding part 43b is appropriately set.
- the asymmetric diaphragm 43 is disposed in the optical path of the illumination optical system 10 and restricts the generation of reflected light from the cornea including light rays corresponding to the hatching H in advance by limiting the illumination light to the cornea. To do. More specifically, the asymmetric diaphragm 43 is disposed between the light source 12 and the slit 16, between the slit 16 and the objective lens 20, and between the objective lens 20 and the cornea.
- the asymmetric diaphragm 43 is disposed in the vicinity of the condenser lens (for example, the objective lens 32, the first imaging lens 36, the second imaging lens 42, the objective lens 20, and the condenser lens 14), thereby forming an image.
- a light beam (hatching H) that adversely affects the entire imaging region on the cornea can be shielded uniformly.
- the condensing lens is composed of a plurality of lens groups, it may be arranged in the lens group (for example, between the first imaging lens 36 and the second imaging lens 42 in the imaging optical system). In other words, it is advantageous if the asymmetric diaphragm 43 is placed at a position away from the light condensing point (image forming point). *
- the front projection optical system 50 includes an infrared light source 51, a light projection lens 53, and a half mirror 55, and projects infrared light for XY alignment detection onto the cornea Ec from the direction of the observation optical axis L1. Infrared light emitted from the light source 51 is converted into a parallel light beam by the light projecting lens 53, then reflected by the half mirror 55, and projected onto the center of the cornea Ec to form an index i10 (see FIG. 5). ).
- the first projection optical systems 60a and 60b are disposed so as to be inclined at a predetermined angle with respect to the optical axis L1.
- the first projection optical systems 60a and 60b have infrared light sources 61a and 61b and collimator lenses 63a and 63b, respectively, are arranged symmetrically with respect to the optical axis L1, and are infinite with respect to the eye E.
- An index is projected (see FIG. 2).
- the first projection optical systems 60a and 60b are disposed on substantially the same meridian as the horizontal direction passing through the optical axis L1 (see FIG. 3).
- the lights emitted from the light sources 61a and 61b are collimated by the collimator lenses 63a and 63b, respectively, and then projected onto the cornea Ec to form the indices i20 and i30 (see FIG. 5).
- the second projection optical systems 65a to 65d are arranged so as to be inclined with respect to the optical axis L1.
- the second projection optical systems 65a to 65d have infrared light sources 66a to 66d, are arranged symmetrically with respect to the optical axis L1, and project a finite index to the eye E.
- the second projection optical systems 65a and 65b are disposed above the optical axis L1 and are disposed at the same height with respect to the Y direction.
- the second projection optical systems 65c and 65d are disposed below the optical axis L1 and are disposed at the same height with respect to the Y direction.
- the second projection optical systems 65a and 65b and the second projection optical systems 65c and 65d are arranged in a vertically symmetrical relationship with the optical axis L1 in between.
- light from the light sources 66a and 66b is irradiated obliquely upward toward the upper part of the cornea Ec, and indexes i40 and i50 which are virtual images of the light sources 66a and 66b are formed.
- light from the light sources 66c and 66d is irradiated obliquely downward toward the lower portion of the cornea Ec, and indexes i60 and i70 that are virtual images of the light sources 66c and 66d are formed (see FIG. 5).
- the index i10 is formed at the apex of the cornea of the eye E (see FIG. 5).
- the indices i20 and i30 by the first projection optical systems 60a and 60b are formed symmetrically with respect to the index i10 at the same horizontal position as the index i10.
- the indices i40 and i50 by the second projection optical systems 65a and 65b are formed symmetrically with respect to the index i10 above the index i10.
- the indices i60 and i70 by the second projection optical systems 65c and 65d are formed symmetrically with respect to the index i10 below the index i10.
- the internal fixation optical system 70 includes a visible light source (fixation lamp) 71, a light projecting lens 73, and a visible reflection / infrared transmission dichroic mirror 74, and emits light for fixing the eye E in the front direction. Project to eye E. Visible light emitted from the light source 71 is converted into a parallel light beam by the light projection lens 73, reflected by the dichroic mirror 75, and projected onto the fundus of the eye E.
- An external fixation optical system (not shown) is disposed in the vicinity of the first projection optical system and the second projection optical system.
- the anterior ocular segment observation optical system 80 includes an objective lens 82 and a two-dimensional image sensor 84 for acquiring an anterior ocular segment front image, and includes a second image sensor 84, and an anterior ocular segment image and an alignment index. Is imaged by the second image sensor 84.
- the two-dimensional imaging device 84 include a two-dimensional CCD image sensor (Charge coupled device image sensor), a two-dimensional CMOS (Complementary Metal). Oxide Semiconductor Image Sensor) is used.
- photography optical path and an anterior ocular segment observation optical path is provided, and the 1st image sensor for imaging a corneal endothelium acquires an anterior ocular segment front image. Therefore, the configuration may also be used as the second imaging element.
- the anterior segment illuminated by an anterior segment illumination light source (not shown) is imaged by the two-dimensional imaging device 84 via the dichroic mirror 75, the half mirror 55, and the objective lens 82.
- the corneal reflection images by the front projection optical system 50, the first projection optical systems 60a and 60b, and the second projection optical systems 65a to 65d are received by the two-dimensional imaging device 84.
- the output of the image sensor 84 is connected to the controller 90, and the anterior segment image captured by the image sensor 84 is displayed on the monitor 95 as shown in FIG.
- the reticle LT displayed electronically on the monitor 95 indicates a reference for XY alignment.
- the observation optical system 80 also serves as a detection optical system for detecting the alignment state of the imaging unit 4 with respect to the eye E (alignment deviation direction / deviation amount).
- the Z alignment detection optical system 85 includes a light projecting optical system 85a that projects a detection light beam from an oblique direction toward the cornea Ec, and a light receiving optical system 85b that receives a corneal reflected light beam by the light projecting optical system 85a. .
- the optical axis L2 of the light projecting optical system 85a and the optical axis L3 of the light receiving optical system 85b are arranged at positions symmetrical with respect to the observation optical axis L1.
- the light projecting optical system 85 a includes, for example, an illumination light source 86 that emits infrared light, a condensing lens 87, a pinhole plate 88, and a lens 20.
- the pinhole plate 88 and the cornea Ec are disposed at a substantially conjugate position with respect to the lens 20.
- the light receiving optical system 85 b includes, for example, a lens 32 and a one-dimensional light receiving element (line sensor) 89.
- the one-dimensional light receiving element 89 and the cornea Ec are disposed at a substantially conjugate position with respect to the lens 32.
- the infrared light emitted from the light source 86 illuminates the pinhole plate 88 via the condenser lens 87. Then, the light that has passed through the opening of the pinhole plate 88 is projected onto the cornea Ec through the lens 20. The corneal reflection light is received by the light receiving element 89 via the lens 32 and the dichroic mirror 34.
- the output of the light receiving element 89 is connected to the control unit 90 and used for Z alignment detection for the eye E.
- the light receiving position of the alignment light beam received on the light receiving element 89 is changed depending on the positional relationship between the imaging unit 4 and the eye E in the Z direction.
- the control unit 90 detects the position of the corneal reflected light in the detection signal from the light receiving element 89 and detects the alignment state in the Z direction.
- the alignment detection using the light receiving element 89 is used for precise alignment with the eye E.
- the control unit 90 controls the entire apparatus.
- the control unit 90 is connected to the rotary knob 5a, the start switch 5b, the XYZ driving unit 6, the two-dimensional imaging devices 44 and 84, each light source, a memory 92 as a storage unit, and a monitor 95.
- FIG. It is a schematic block diagram which shows an example of the optical arrangement
- FIG. It is a figure which shows an example of the anterior ocular segment observation screen at the time of imaging
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Abstract
Description
照明光束を角膜に向けて照射する照明光学系と、照明光学系の光軸に対して傾斜して配置され,角膜からの反射光束を光検出器により受光する受光光学系とを有し、眼の角膜部位を撮影するための光学系を備える角膜撮影装置において、
前記眼の角膜部位を撮影するための光学系の光路中に設けられ、光束を光軸に関して非対称に制限する光制限手段を備えることを特徴とする角膜撮影装置。
(2)
前記光制限手段は、光束の集光点から離れた位置に配置される(1)の角膜撮影装置。
(3)
前記光制限手段は、前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させると共に、前記対物レンズの周辺部を通過する光を非対称に制限する(1)~(2)のいずれかの角膜撮影装置。
(4)
前記角膜部位を撮影するための光学系は、角膜の内皮細胞を撮影するための光学系であって、前記照明光学系は、角膜に対して斜め方向から照明光束を照射し、前記受光光学系は、角膜からの反射光束を角膜での正反射方向から受光する(1)~(3)のいずれかの角膜撮影装置。
(5)
前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記光制限手段は、
前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させ、
前記対物レンズの周辺部を通過する光のうち、前記中心軸側の光を通過させ、前記中心軸側とは反対の方向の光を制限する
(1)~(4)のいずれかの角膜撮影装置。
(6)
前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記光制限手段は、
前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させ、
前記対物レンズの周辺部を通過する光のうち、前記中心軸側とは反対の方向の光を通過させ、前記中心軸側の光を制限する
(1)~(4)のいずれかの角膜撮影装置。
は、角膜に対して斜め方向から照明光束を照射し、前記受光光学系は、角膜からの反射光束を角膜での正反射方向から受光する請求項1~3のいずれかの角膜撮影装置。
(7)
被検眼の前眼部正面像を観察する観察光学系を有し、
前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記観察光学系の観察光軸は、前記中心軸である(1)~(7)のいずれかの角膜撮影装置。
(8)
前記光制限手段は、前記受光光学系に配置され、前記角膜からの反射光束を非対称に制限する(1)~(7)のいずれかの角膜撮影装置。
(9)
前記光制限手段は、前記照明光学系に配置され、前記照明光束を非対称に制限する(1)~(7)のいずれかの角膜撮影装置。
(10)
前記光制限手段は、前記光軸に対して非対称な開口が形成された開口部と、前記開口部の外側に形成された遮光部と、を備える(1)~(9)のいずれかの角膜撮影装置。
(11)
光制限手段は、非対称な絞り、非対称な開口を持つレンズホルダ、光学部材への非対称なコーティングのいずれかである(1)~(10)のいずれかの角膜撮影装置。
本発明の実施形態に係る装置は、被検者眼の角膜部位の画像を撮影する装置に関し、照明光束を角膜に向けて照射する照明光学系、角膜からの反射光束を光検出器により受光する受光光学系を有し、眼の角膜部位を非接触にて撮影するための光学系を備える。
以下、図面に沿って、本実施形態に係る装置の実施例を具体的に説明する。図1は、本実施例に係る角膜撮影装置の外観側方構成図である。
図2において、ハッチングHは、内皮画像の結像に対して悪影響を及ぼし、像の質の低下に寄与する光束を示しており、この光束は、対物レンズ32の周辺部において、中心軸(光軸L1)側とは反対側を通過する。
図2に戻る。照明光学系10による角膜反射光は、光軸L3方向(斜め方向)に向かい、対物レンズ32によって収束された後、ダイクロイックミラー34によって反射され、マスク35にて一旦結像され、内皮細胞像を取得する際にノイズとなる光が遮光される。そして、マスク35を通過した光は、第1結像レンズ36、全反射ミラー38、第2結像レンズ42、非対称絞り43を介して二次元撮像素子44に結像される。これにより、高倍率の角膜内皮細胞像が取得される。なお、撮像素子44の出力は、制御部90に接続され、取得された画像は、メモリ92に記憶される。また、細胞像はモニタ95に表示される。
Oxide Semiconductor Image Sensor)が用いられる。なお、上記構成に限定されず、内皮撮影光路と前眼部観察光路とを結合する光路結合部材を設け、角膜内皮を撮像するための第1の撮像素子が、前眼部正面像を取得するための第2の撮像素子を兼用する構成であってもよい。
6 駆動部
10 照明光学系
12 照明光源
30 撮像光学系
43 非対称スリット
60a,60b 第1投影光学系
65a~65d 第2投影光学系
80 前眼部観察光学系
85 Zアライメント検出光学系
85a 投光光学系
85b 受光光学系
90 制御部
92 メモリ
95 モニタ
Claims (11)
- 照明光束を角膜に向けて照射する照明光学系と、照明光学系の光軸に対して傾斜して配置され,角膜からの反射光束を光検出器により受光する受光光学系とを有し、眼の角膜部位を撮影するための光学系を備える角膜撮影装置において、
前記眼の角膜部位を撮影するための光学系の光路中に設けられ、光束を光軸に関して非対称に制限する光制限手段を備えることを特徴とする角膜撮影装置。 - 前記光制限手段は、光束の集光点から離れた位置に配置される請求項1の角膜撮影装置。
- 前記光制限手段は、前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させると共に、前記対物レンズの周辺部を通過する光を非対称に制限する請求項1~2のいずれかの角膜撮影装置。
- 前記角膜部位を撮影するための光学系は、角膜の内皮細胞を撮影するための光学系であって、前記照明光学系は、角膜に対して斜め方向から照明光束を照射し、前記受光光学系は、角膜からの反射光束を角膜での正反射方向から受光する請求項1~3のいずれかの角膜撮影装置。
- 前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記光制限手段は、
前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させ、
前記対物レンズの周辺部を通過する光のうち、前記中心軸側の光を通過させ、前記中心軸側とは反対の方向の光を制限する
請求項1~4のいずれかの角膜撮影装置。 - 前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記光制限手段は、
前記受光光学系に設けられた対物レンズの中心部を通過する光を前記光検出器に向けて通過させ、
前記対物レンズの周辺部を通過する光のうち、前記中心軸側とは反対の方向の光を通過させ、前記中心軸側の光を制限する
請求項1~4のいずれかの角膜撮影装置。
は、角膜に対して斜め方向から照明光束を照射し、前記受光光学系は、角膜からの反射光束を角膜での正反射方向から受光する請求項1~3のいずれかの角膜撮影装置。 - 被検眼の前眼部正面像を観察する観察光学系を有し、
前記照明光学系と前記受光光学系は、中心軸に対して対称に配置されており、
前記観察光学系の観察光軸は、前記中心軸である請求項1~7のいずれかの角膜撮影装置。 - 前記光制限手段は、前記受光光学系に配置され、前記角膜からの反射光束を非対称に制限する請求項1~7のいずれかの角膜撮影装置。
- 前記光制限手段は、前記照明光学系に配置され、前記照明光束を非対称に制限する請求項1~7のいずれかの角膜撮影装置。
- 前記光制限手段は、前記光軸に対して非対称な開口が形成された開口部と、前記開口部の外側に形成された遮光部と、を備える請求項1~9のいずれかの角膜撮影装置。
- 光制限手段は、非対称な絞り、非対称な開口を持つレンズホルダ、光学部材への非対称なコーティングのいずれかである請求項1~4項1~10のいずれかの角膜撮影装置。
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US9986908B2 (en) | 2014-06-23 | 2018-06-05 | Visunex Medical Systems Co. Ltd. | Mechanical features of an eye imaging apparatus |
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