WO2013065017A3 - Platelet rich plasma (prp) and prominin-1 derived peptides stimulate lymphangiogenesis - Google Patents

Platelet rich plasma (prp) and prominin-1 derived peptides stimulate lymphangiogenesis Download PDF

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Publication number
WO2013065017A3
WO2013065017A3 PCT/IB2012/056110 IB2012056110W WO2013065017A3 WO 2013065017 A3 WO2013065017 A3 WO 2013065017A3 IB 2012056110 W IB2012056110 W IB 2012056110W WO 2013065017 A3 WO2013065017 A3 WO 2013065017A3
Authority
WO
WIPO (PCT)
Prior art keywords
prominin
prp
peptide
rich plasma
platelet rich
Prior art date
Application number
PCT/IB2012/056110
Other languages
French (fr)
Other versions
WO2013065017A2 (en
Inventor
Paolo ERBA
Original Assignee
Centre Hospitalier Universitaire Vaudois (C.H.U.V.)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Hospitalier Universitaire Vaudois (C.H.U.V.) filed Critical Centre Hospitalier Universitaire Vaudois (C.H.U.V.)
Publication of WO2013065017A2 publication Critical patent/WO2013065017A2/en
Publication of WO2013065017A3 publication Critical patent/WO2013065017A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere

Abstract

The present invention relates to an isolated prom-1 peptide derived from a prominin-, a conservative amino acid substitution variant of said prominin-1 peptide, or a fragment of 5 said prominin-1 peptide, as well as to isolated Platelet Rich Plasma (PRP), or a combination of PRP and said prominin-1 peptide for use in the treatment and/or prevention of lymphedema, lymphatic fistula, lymphorrea or lymphocele/seroma formation, any chronic wound not healing because of lymphorrhea or lymph secretions in surgical wounds.
PCT/IB2012/056110 2011-11-03 2012-11-02 Platelet rich plasma (prp) and prominin-1 derived peptide stimulate lymphangiogenesis WO2013065017A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161555098P 2011-11-03 2011-11-03
US61/555,098 2011-11-03

Publications (2)

Publication Number Publication Date
WO2013065017A2 WO2013065017A2 (en) 2013-05-10
WO2013065017A3 true WO2013065017A3 (en) 2013-08-08

Family

ID=47178796

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/056110 WO2013065017A2 (en) 2011-11-03 2012-11-02 Platelet rich plasma (prp) and prominin-1 derived peptide stimulate lymphangiogenesis

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WO (1) WO2013065017A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10711068B2 (en) 2015-03-26 2020-07-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-CD133 monoclonal antibodies and related compositions and methods
WO2016158756A1 (en) * 2015-03-31 2016-10-06 テルモ株式会社 Intradermal formulation for regenerative medicine
RU2698866C9 (en) * 2018-11-09 2020-01-09 Федеральное Государственное Бюджетное Образовательное Учреждение Высшего Образования "Московский государственный медико-стоматологический университет имени А.И. Евдокимова" Министерства здравоохранения Российской Федерации (ФГБОУ ВО МГМСУ имени А.И. Евдокимова Минздрава России) Method for intraoperative photodynamic prevention of postoperative lymphorrhoea
CN109453419A (en) * 2018-11-26 2019-03-12 广州新诚生物科技有限公司 Absorbable hemostasis bone wax of one kind and preparation method thereof
CN111647045B (en) * 2020-06-17 2022-05-27 清华大学深圳国际研究生院 CD133 antagonistic polypeptide, derivative and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014616A2 (en) * 2008-07-28 2010-02-04 Children's Medical Center Corporation Prominin-1 peptide fragments and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014616A2 (en) * 2008-07-28 2010-02-04 Children's Medical Center Corporation Prominin-1 peptide fragments and uses thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ANONYMOUS: "Abstracts - 46. Jahreskongress SGH", 6 November 2012 (2012-11-06), pages 1 - 44, XP055058990, Retrieved from the Internet <URL:http://www.congress-info.ch/sgh-sghr2012/upload/File/SGH_Abstractheft.pdf> [retrieved on 20130410] *
ANONYMOUS: "Hauptprogramm/Programme principal 46. Jahreskongress SGH", 23 August 2012 (2012-08-23), pages 1 - 48, XP055058984, Retrieved from the Internet <URL:http://web.archive.org/liveweb/http://www.congress-info.ch/sgh-sghr2012/upload/File/SGH_HP_2012.pdf> [retrieved on 20130410] *
CATARINA HADAMITZKY ET AL: "Regeneration of Autotransplanted Avascular Lymph Nodes in the Rat Is Improved by Platelet-Rich Plasma", JOURNAL OF VASCULAR RESEARCH, vol. 46, no. 5, 2009, pages 389 - 396, XP055059016, ISSN: 1018-1172, DOI: 10.1159/000194269 *
KATHLEEN M LACCI ET AL: "Platelet-Rich Plasma: Support for Its Use in Wound Healing", YALE JOURNAL OF BIOLOGY AND MEDICINE, vol. 83, 2010, pages 1 - 9, XP055059137 *
PAULIINA HARTIALA ET AL: "Growth Factor Therapy and Autologous Lymph Node Transfer in Lymphedema", TRENDS IN CARDIOVASCULAR MEDICINE, vol. 20, no. 8, 1 November 2010 (2010-11-01), pages 249 - 253, XP055059036, ISSN: 1050-1738, DOI: 10.1016/j.tcm.2011.11.008 *

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