WO2013038016A3 - Monoclonal antibodies for detection of high-risk human papillomavirus oncoprotein e7 - Google Patents
Monoclonal antibodies for detection of high-risk human papillomavirus oncoprotein e7 Download PDFInfo
- Publication number
- WO2013038016A3 WO2013038016A3 PCT/EP2012/068271 EP2012068271W WO2013038016A3 WO 2013038016 A3 WO2013038016 A3 WO 2013038016A3 EP 2012068271 W EP2012068271 W EP 2012068271W WO 2013038016 A3 WO2013038016 A3 WO 2013038016A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- monoclonal antibodies
- detection
- human papillomavirus
- risk human
- oncoprotein
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57411—Specifically defined cancers of cervix
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Disclosed herein are monoclonal antibodies for an improved detection of HPV-associated pre-malignant lesions, malignant lesions and invasive cancer. Furthermore, methods and uses of the monoclonal antibodies for the detection, diagnosis and/or prognosis HPV-associated pre-malignant lesions, malignant lesions and invasive cancer are disclosed.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161535815P | 2011-09-16 | 2011-09-16 | |
US61/535,815 | 2011-09-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013038016A2 WO2013038016A2 (en) | 2013-03-21 |
WO2013038016A3 true WO2013038016A3 (en) | 2013-05-10 |
Family
ID=46851522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/068271 WO2013038016A2 (en) | 2011-09-16 | 2012-09-17 | Monoclonal antibodies for detection of high-risk human papillomavirus oncoprotein e7 |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2013038016A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105504049B (en) | 2014-09-26 | 2019-07-05 | 艾托金生物医药(苏州)有限公司 | The relevant HPV E7 protein monoclonal antibody of cervical carcinoma and its application |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026731A1 (en) * | 2003-09-17 | 2005-03-24 | Amynon Biotech Gmbh | Combination of anti-hpv-16 and 18 antibodies and uses thereof |
WO2006085822A1 (en) * | 2005-02-10 | 2006-08-17 | Canag Diagnostics Ab | Site-specific immunization in order to establish antibodies with specificity for the e7 oncoprotein of high-risk hpvs |
WO2011101122A1 (en) * | 2010-02-16 | 2011-08-25 | Österreichische Akademie der Wissenschaften | Anti-hpv e7 antibodies |
-
2012
- 2012-09-17 WO PCT/EP2012/068271 patent/WO2013038016A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005026731A1 (en) * | 2003-09-17 | 2005-03-24 | Amynon Biotech Gmbh | Combination of anti-hpv-16 and 18 antibodies and uses thereof |
WO2006085822A1 (en) * | 2005-02-10 | 2006-08-17 | Canag Diagnostics Ab | Site-specific immunization in order to establish antibodies with specificity for the e7 oncoprotein of high-risk hpvs |
WO2011101122A1 (en) * | 2010-02-16 | 2011-08-25 | Österreichische Akademie der Wissenschaften | Anti-hpv e7 antibodies |
Non-Patent Citations (3)
Title |
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KRCHNAK V ET AL: "IDENTIFICATION OF SEROREACTIVE EPITOPES OF HUMAN PAPILLOMAVIRUS TYPE 18 E7 PROTEIN BY SYNTHETIC PEPTIDES", ACTA VIROLOGICA, ACADEMIA PRAGUE, PRAGUE, CS, vol. 37, no. 5, 1 October 1993 (1993-10-01), pages 395 - 402, XP009050452, ISSN: 0001-723X * |
KRCHNAK V ET AL: "SYNTHETIC PEPTIDES DERIVED FROM E7 REGION OF HUMAN PAPILLOMAVIRUS TYPE 16 USED AS ANTIGENS IN ELISA", JOURNAL OF GENERAL VIROLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, SPENCERS WOOD, GB, vol. 71, no. 11, 1 January 1990 (1990-01-01), pages 2719 - 2724, XP002635493, ISSN: 0022-1317, DOI: 10.1099/0022-1317-71-11-2719 * |
M. LIDQVIST ET AL: "Detection of human papillomavirus oncoprotein E7 in liquid-based cytology", JOURNAL OF GENERAL VIROLOGY, vol. 93, no. 2, 1 February 2012 (2012-02-01), pages 356 - 363, XP055045456, ISSN: 0022-1317, DOI: 10.1099/vir.0.034884-0 * |
Also Published As
Publication number | Publication date |
---|---|
WO2013038016A2 (en) | 2013-03-21 |
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