WO2013003373A1 - Surfaces microstructurées permettant de réduire l'adhérence de bactéries - Google Patents

Surfaces microstructurées permettant de réduire l'adhérence de bactéries Download PDF

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Publication number
WO2013003373A1
WO2013003373A1 PCT/US2012/044249 US2012044249W WO2013003373A1 WO 2013003373 A1 WO2013003373 A1 WO 2013003373A1 US 2012044249 W US2012044249 W US 2012044249W WO 2013003373 A1 WO2013003373 A1 WO 2013003373A1
Authority
WO
WIPO (PCT)
Prior art keywords
microstructures
engineered
microstructure
medical article
unit cell
Prior art date
Application number
PCT/US2012/044249
Other languages
English (en)
Inventor
G. Marco Bommarito
Matthew T. Scholz
Michael J. Svarovsky
Jeremy M. Yarwood
Scott M. Schnobrich
Robert J. Devoe
Original Assignee
3M Innovative Properties Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Company filed Critical 3M Innovative Properties Company
Publication of WO2013003373A1 publication Critical patent/WO2013003373A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/01—Non-adhesive bandages or dressings
    • A61F13/01008—Non-adhesive bandages or dressings characterised by the material
    • A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B17/00—Methods preventing fouling
    • B08B17/02—Preventing deposition of fouling or of dust
    • B08B17/06—Preventing deposition of fouling or of dust by giving articles subject to fouling a special shape or arrangement
    • B08B17/065—Preventing deposition of fouling or of dust by giving articles subject to fouling a special shape or arrangement the surface having a microscopic surface pattern to achieve the same effect as a lotus flower
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/022—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing characterised by the disposition or the configuration, e.g. dimensions, of the embossments or the shaping tools therefor
    • B29C2059/023—Microembossing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/04—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing using rollers or endless belts

Definitions

  • the present disclosure provides a method of making a biofilm adhesion resistant medical article.
  • the method includes providing a medical article having a surface comprising a polymeric material.
  • the method further includes creating a plurality of engineered microstructures on at least a portion of the surface, wherein each microstructure of the plurality of microstructures includes a base having at least one cross sectional microscale dimension, wherein the aspect ratio of each microstructure is at least 0.5 and no greater than 10, wherein the pitch between adjacent microstructures of the plurality of engineered microstructures is at least 1 time and no greater than 5 times than the smallest cross-sectional dimension, wherein no base of any microstructure includes a cross-sectional dimension greater than 5 microns, and wherein the arrangement of the microstructures on at least a portion of the surface includes a plurality of unit cells, wherein each unit cell of the plurality of unit is at least partially defined by a dimension at least approximating the pitch, and wherein each unit cell comprises a boundary and each unit cell boundary is directly adjacent
  • the engineered surface has at least one unit cell defined at least partially by the pitch between adjacent microstructures protruding from or projected into that surface.
  • Each unit cell is defined in a single plane and includes at least one microstructure having a single geometry and orientation.
  • the unit cells are arranged to be tiled or at least substantially tessellated, such that the boundary region of any one unit cell is directly adjacent to the boundary region of any neighboring unit cell (i.e., there is no deliberate space between the unit cells).
  • microorganism is generally used to refer to any prokaryotic or eukaryotic microscopic organism, including without limitation, one or more of bacteria (e.g., motile or vegetative, Gram positive or Gram negative), bacterial spores or endospores, algae, fungi (e.g., yeast, filamentous fungi, fungal spores), mycoplasmas, and protozoa, as well as combinations thereof.
  • bacteria e.g., motile or vegetative, Gram positive or Gram negative
  • bacterial spores or endospores e.g., algae, fungi (e.g., yeast, filamentous fungi, fungal spores), mycoplasmas, and protozoa, as well as combinations thereof.
  • fungi e.g., yeast, filamentous fungi, fungal spores
  • mycoplasmas e.g., mycoplasmas
  • protozoa protozoa
  • Other useful polymers may be thermoplastic or thermoset and include polyurethanes, polyolefins including metallocene polyolefins, polyesters such as elastomeric polyesters (e.g., Hytrel), biodegradable polyesters such as polylactic, polylactic/glycolic acids, copolymers of succinic acid and diols, and the like, fluoropolymers including fluoroelastomers, polyacrylates and polymethacrylates.
  • Polyurethanes may be linear and thermoplastic or thermoset.
  • suitable biodegradable, bioabsorbable, bioerodible polymers include polycarboxylic acid; polyanhydrides such as maleic anhydride polymers; polyorthoesters; poly-amino acids; polyethylene oxide; polyphosphazenes; polylactic acid, polyglycolic acid, and copolymers and mixtures thereof such as poly(L-lactic acid) (PLLA), poly(D,L,-lactide), poly(lactic acid-co-glycolic acid), and 50/50 weight ratio (D,L-lactide-co-glycolide); polydioxanone; polypropylene fumarate;
  • polyanhydrides such as maleic anhydride polymers; polyorthoesters; poly-amino acids; polyethylene oxide; polyphosphazenes; polylactic acid, polyglycolic acid, and copolymers and mixtures thereof such as poly(L-lactic acid) (PLLA), poly(D,L,-lactide), poly(lactic acid-co-
  • the microstructures may be directly adjacent to one another, such that the base of a microstructure is directly in contact with the base of an adjacent microstructure.
  • the microstructures may be further spaced apart, such that the facets or perimeters of the microstructures are not in contact and are spaced apart by a segment of engineered surface that may, for example, be flat.
  • the configuration of microstructures in any given region should be chosen, however, so that the average pitch (i.e., the centroid to centroid distance between adjacent microstructures) is at least as large as the smallest dimension of the smallest microstructure and no greater than 5 times the smallest dimension of the microstructure. Surfaces having pitches outside this range may result in topographies that reduce bioadhesion in certain areas, but at least fail to impede or potentially promote bioadhesion in other areas.
  • the arrangement of microstructures 710 on at least a portion of the engineered surface 700 comprises a plurality of unit cells740.
  • Each unit cell 740 of the plurality of unit cells 730 exists in a single plane (i.e., two dimensions), is at least partially defined by a dimension at least approximating the pitch, and contains one microstructure. In certain embodiments, the unit cell is at least partially defined by a dimension equal to the pitch. As depicted in Fig. 7a, each unit cell 740 is entirely defined by the pitch between adjacent microstructures.
  • Each unit cell includes a boundary 750 defining the perimeter of the unit cell. Each boundary 750 is directly adjacent the boundary of a neighboring unit cell, so that the plurality of unit cells resemble, e.g., a grid or tessellation.
  • Biofilm Assay(above) was conducted by analyzing at least five micrographs for each sample.
  • the micrographs were obtained using a Leica microscope (Model DM4000B, available from Leica
  • a medical article including a surface for reducing bacterial adhesion, the article comprising: an engineered surface comprising a thermoplastic or thermoset material; a plurality of engineered microstructures on at least a portion of the surface, wherein each microstructure of the plurality of microstructures comprises a base having at least one microscale cross-sectional dimension, wherein the aspect ratio of each microstructure is at least 0.5 and no greater than 10, wherein each microstructure of the plurality of engineered microstructures comprises a height greater than 0.5 microns, wherein the pitch between adjacent microstructures of the plurality of engineered microstructures is at least 1 time and no greater than 5 times than the smallest cross-sectional dimension, and wherein no base comprises a cross- sectional dimension greater than 5 microns, and wherein the arrangement of the microstructures on at least a portion of the engineered surface includes a plurality of unit cells, wherein each unit cell of the plurality of unit cells is at least partially defined by a dimension at least approximating the pitch and includes no more
  • each microstructure of the plurality of microstructures comprises an elastomeric microstructure.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

L'invention concerne des surfaces à même de résister à la formation de biofilms et de la réduire, en particulier sur des articles médicaux (100). Lesdites surfaces présentent une pluralité d'éléments de microstructure (120) agencés en fonction d'au moins une cellule unitaire (740, 840). L'invention concerne également des procédés permettant de créer des surfaces anti-adhérentes.
PCT/US2012/044249 2011-06-27 2012-06-26 Surfaces microstructurées permettant de réduire l'adhérence de bactéries WO2013003373A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161501541P 2011-06-27 2011-06-27
US61/501,541 2011-06-27

Publications (1)

Publication Number Publication Date
WO2013003373A1 true WO2013003373A1 (fr) 2013-01-03

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ID=46579312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/044249 WO2013003373A1 (fr) 2011-06-27 2012-06-26 Surfaces microstructurées permettant de réduire l'adhérence de bactéries

Country Status (1)

Country Link
WO (1) WO2013003373A1 (fr)

Cited By (29)

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Publication number Priority date Publication date Assignee Title
WO2015156658A1 (fr) * 2014-04-08 2015-10-15 Equipos Médicos Vizcarra, S.A. Sonde de foley hydrophobe texturisée à basse adhérence microbienne
WO2017014936A1 (fr) * 2015-07-17 2017-01-26 Hoowaki, Llc Surface microstructurée
WO2016199054A3 (fr) * 2015-06-10 2017-02-23 Sabic Global Technologies B.V. Surfaces en plastique ayant des structures de surface, et procédés de fabrication de ces surfaces
WO2017209993A1 (fr) * 2016-05-31 2017-12-07 Carefusion 2200, Inc. Cathéter de drainage de cavité corporelle à surface microtexturée
WO2019186312A1 (fr) * 2018-03-28 2019-10-03 BSH Hausgeräte GmbH Corps polymère thermoplastique doté d'une structure de surface, procédé pour sa fabrication et appareil électroménager comprenant le corps polymère thermoplastique
WO2020026061A1 (fr) * 2018-07-30 2020-02-06 3M Innovative Properties Company Articles en mousse antimicrobiens et procédé de fabrication correspondant
US10590899B2 (en) 2012-08-01 2020-03-17 3M Innovative Properties Company Fuel injectors with improved coefficient of fuel discharge
CN110891622A (zh) * 2017-02-17 2020-03-17 Bvw控股公司 超疏水表面的选择性终止
WO2020106945A1 (fr) * 2018-11-21 2020-05-28 Bvw Holding Ag Surface microstructurée
WO2021033162A1 (fr) 2019-08-20 2021-02-25 3M Innovative Properties Company Surface microstructurée avec élimination accrue des micro-organismes lors du nettoyage, articles et procédés
WO2021033151A1 (fr) 2019-08-20 2021-02-25 3M Innovative Properties Company Articles médicaux ayant une surface microstructurée présentant une élimination accrue des microorganismes après nettoyage et procédés associés
WO2021236429A1 (fr) 2020-05-20 2021-11-25 3M Innovative Properties Company Articles médicaux à surface microstructurée
US11219705B2 (en) 2014-07-08 2022-01-11 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
US11278941B2 (en) 2017-02-17 2022-03-22 Bvw Holding Ag Selective termination of superhydrophobic surfaces
US11357962B2 (en) 2013-02-13 2022-06-14 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
US11357965B2 (en) 2014-04-23 2022-06-14 Becton, Dickinson And Company Antimicrobial caps for medical connectors
WO2022123440A1 (fr) 2020-12-11 2022-06-16 3M Innovative Properties Company Procédé de thermoformage d'un film à surface structurée et articles
WO2022162614A1 (fr) 2021-01-28 2022-08-04 3M Innovative Properties Company Articles et compositions antimicrobiennes et procédés associés
WO2022162528A1 (fr) 2021-01-28 2022-08-04 3M Innovative Properties Company Surface microstructurée à élimination accrue des micro-organismes après nettoyage, articles et procédés
WO2022180466A1 (fr) 2021-02-23 2022-09-01 3M Innovative Properties Company Articles médicaux ayant une surface microstructurée ayant une élimination accrue de micro-organismes lorsqu'ils sont nettoyés et procédés associés
US20220378622A1 (en) * 2021-05-26 2022-12-01 Tiburon Technologies, LLC Biomimetic wound dressing with articulating micropattern
WO2023042072A1 (fr) 2021-09-14 2023-03-23 3M Innovative Properties Company Articles comprenant une surface incurvée microstructurée et leurs méthodes de fabrication
WO2023105372A1 (fr) 2021-12-07 2023-06-15 3M Innovative Properties Company Surface microstructurée et articles présentant une moindre visibilité des rayures et procédés associés
US11744708B2 (en) 2016-02-16 2023-09-05 Koninklijke Philips N.V. Surface topographies for altering the physiology of living cells
US11766822B2 (en) 2019-08-20 2023-09-26 3M Innovative Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
US11871745B2 (en) 2021-03-08 2024-01-16 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US11904114B2 (en) 2015-10-28 2024-02-20 Becton, Dickinson And Company Extension tubing strain relief
WO2024030828A3 (fr) * 2022-08-01 2024-04-04 The Regents Of The University Of California Système, dispositif et procédé de capteur d'endoprothèse bioélectronique auto-alimenté
US11965120B2 (en) 2018-04-05 2024-04-23 3M Innovative Properties Company Gel adhesive comprising crosslinked blend of polydiorganosiloxane and acrylic polymer

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US10590899B2 (en) 2012-08-01 2020-03-17 3M Innovative Properties Company Fuel injectors with improved coefficient of fuel discharge
US11357962B2 (en) 2013-02-13 2022-06-14 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
WO2015156658A1 (fr) * 2014-04-08 2015-10-15 Equipos Médicos Vizcarra, S.A. Sonde de foley hydrophobe texturisée à basse adhérence microbienne
US11357965B2 (en) 2014-04-23 2022-06-14 Becton, Dickinson And Company Antimicrobial caps for medical connectors
US11219705B2 (en) 2014-07-08 2022-01-11 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
CN107848073B (zh) * 2015-06-10 2019-04-19 沙特基础工业全球技术有限公司 在固体塑料零件上形成表面结构的方法和包含由该方法形成的固体塑料零件的照明产品
CN107848073A (zh) * 2015-06-10 2018-03-27 沙特基础工业全球技术有限公司 具有表面结构的塑料表面和制备它们的方法
WO2016199054A3 (fr) * 2015-06-10 2017-02-23 Sabic Global Technologies B.V. Surfaces en plastique ayant des structures de surface, et procédés de fabrication de ces surfaces
WO2017014936A1 (fr) * 2015-07-17 2017-01-26 Hoowaki, Llc Surface microstructurée
US11904114B2 (en) 2015-10-28 2024-02-20 Becton, Dickinson And Company Extension tubing strain relief
US11744708B2 (en) 2016-02-16 2023-09-05 Koninklijke Philips N.V. Surface topographies for altering the physiology of living cells
CN107441568A (zh) * 2016-05-31 2017-12-08 康尔福盛2200有限公司 具有微纹理化表面的体腔引流导管
WO2017209993A1 (fr) * 2016-05-31 2017-12-07 Carefusion 2200, Inc. Cathéter de drainage de cavité corporelle à surface microtexturée
US10610665B2 (en) 2016-05-31 2020-04-07 Carefusion 2200, Inc. Body cavity drainage catheter with microtextured surface
US11278941B2 (en) 2017-02-17 2022-03-22 Bvw Holding Ag Selective termination of superhydrophobic surfaces
CN110891622A (zh) * 2017-02-17 2020-03-17 Bvw控股公司 超疏水表面的选择性终止
US11697141B2 (en) 2017-02-17 2023-07-11 Bvw Holding Ag Selective termination of superhydrophobic surfaces
WO2019186312A1 (fr) * 2018-03-28 2019-10-03 BSH Hausgeräte GmbH Corps polymère thermoplastique doté d'une structure de surface, procédé pour sa fabrication et appareil électroménager comprenant le corps polymère thermoplastique
US11965120B2 (en) 2018-04-05 2024-04-23 3M Innovative Properties Company Gel adhesive comprising crosslinked blend of polydiorganosiloxane and acrylic polymer
WO2020026061A1 (fr) * 2018-07-30 2020-02-06 3M Innovative Properties Company Articles en mousse antimicrobiens et procédé de fabrication correspondant
WO2020106945A1 (fr) * 2018-11-21 2020-05-28 Bvw Holding Ag Surface microstructurée
CN113164655A (zh) * 2018-11-21 2021-07-23 Bvw控股公司 微结构化表面
US11766822B2 (en) 2019-08-20 2023-09-26 3M Innovative Properties Company Microstructured surface with increased microorganism removal when cleaned, articles and methods
CN114650887A (zh) * 2019-08-20 2022-06-21 3M创新有限公司 具有在清洁时微生物去除增加的微结构化表面、制品及方法
WO2021033151A1 (fr) 2019-08-20 2021-02-25 3M Innovative Properties Company Articles médicaux ayant une surface microstructurée présentant une élimination accrue des microorganismes après nettoyage et procédés associés
WO2021033162A1 (fr) 2019-08-20 2021-02-25 3M Innovative Properties Company Surface microstructurée avec élimination accrue des micro-organismes lors du nettoyage, articles et procédés
WO2021236429A1 (fr) 2020-05-20 2021-11-25 3M Innovative Properties Company Articles médicaux à surface microstructurée
WO2022123440A1 (fr) 2020-12-11 2022-06-16 3M Innovative Properties Company Procédé de thermoformage d'un film à surface structurée et articles
WO2022162614A1 (fr) 2021-01-28 2022-08-04 3M Innovative Properties Company Articles et compositions antimicrobiennes et procédés associés
WO2022162528A1 (fr) 2021-01-28 2022-08-04 3M Innovative Properties Company Surface microstructurée à élimination accrue des micro-organismes après nettoyage, articles et procédés
WO2022180466A1 (fr) 2021-02-23 2022-09-01 3M Innovative Properties Company Articles médicaux ayant une surface microstructurée ayant une élimination accrue de micro-organismes lorsqu'ils sont nettoyés et procédés associés
US11871745B2 (en) 2021-03-08 2024-01-16 Ka Shui Plastic Technology Co. Ltd. Bacteria repellant polymer composites
US20220378622A1 (en) * 2021-05-26 2022-12-01 Tiburon Technologies, LLC Biomimetic wound dressing with articulating micropattern
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WO2023105372A1 (fr) 2021-12-07 2023-06-15 3M Innovative Properties Company Surface microstructurée et articles présentant une moindre visibilité des rayures et procédés associés
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