WO2012156805A1 - Fils, fibres ou filaments comprenant des charges minerales; article textile dispositif medical obtenus a partir desdits fils pour la cicatrisation de la peau - Google Patents
Fils, fibres ou filaments comprenant des charges minerales; article textile dispositif medical obtenus a partir desdits fils pour la cicatrisation de la peau Download PDFInfo
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- WO2012156805A1 WO2012156805A1 PCT/IB2012/000954 IB2012000954W WO2012156805A1 WO 2012156805 A1 WO2012156805 A1 WO 2012156805A1 IB 2012000954 W IB2012000954 W IB 2012000954W WO 2012156805 A1 WO2012156805 A1 WO 2012156805A1
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- Prior art keywords
- fibers
- yarns
- filaments
- mineral fillers
- skin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/04—Non-resorbable materials
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F6/00—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof
- D01F6/58—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products
- D01F6/60—Monocomponent artificial filaments or the like of synthetic polymers; Manufacture thereof from homopolycondensation products from polyamides
Definitions
- YARNS, FIBERS OR FILAMENTS COMPRISING MINERAL CHARGES; TEXTILE ARTICLE AND MEDICAL DEVICE OBTAINED FROM SAID THREADS FOR SKIN HEALING
- the subject of the present invention is yarns, fibers or filaments as well as textile articles and medical devices obtained from said yarns for improving the healing of the skin, in particular by stimulating the functioning of keratinocytes and fibroblasts, inter alia by activating the synthesis of collagen on the surface of the injured skin.
- Human skin consists of three superimposed tissues: the epidermis, the outermost, the dermis, and the hypodermis, the deepest.
- the natural human epidermis is composed mainly of three types of cells, which are the keratinocytes, a very large majority, melanocytes and Langerhans cells. Each of these cell types contributes by its own functions to the essential role played in the body by the skin.
- the dermis provides the epidermis with a solid support. It is also its nourishing element because it contains a vascuiarisation whose epidermis is free. It consists mainly of fibroblasts and an extracellular matrix itself composed of various extracellular proteins including among others collagen fibers, elastin and various glycoproteins.
- the hypodermis which is invaginated in the dermis and is attached to the overlying dermis by collagen and elastin fibers, consists essentially of a type of cell specialized in the accumulation and storage of fats, adipocytes. It is the energy reservoir of the body.
- Adipocytes are mature cells resulting from a process of differentiation of fibroblasts into pre-adipocytes and adipocytes; this process is called adipogenesis and / or adipocyte differentiation.
- Collagen is the main protein of the extracellular matrix (ECM) and is the most abundant protein in mammals, comprising 25% of total protein and 70% to 80% of skin (dry weight). Collagen acts as a structural scaffold in tissues. The main characteristic of all collagen molecules is their rigidity due to the three-stranded helical structure. Types I, II and III of collagen are the main types of collagen found in connective tissues and make up 90% of all collagen in the body.
- ECM extracellular matrix
- the biosynthesis of collagen begins in the endoplasmic reticulum, where polypeptide chains are synthesized. These polypeptides pass through the endoplasmic reticulum of the fibroblasts that synthesize the proline and lysine which are hydroxylated and glycosylated. It follows the conformation of the polypeptides in the form of triple helix, called "procollagen". The procollagen molecules then pass through the Golgi apparatus where they are encapsulated in secretory granules and secreted to the extracellular space in the connective tissue.
- the skin can suffer lesions or wounds.
- the lesion can be of several types, it is for example the result of a mechanical trauma (cutting, contusion, laceration, scratching, bite), thermal (burn), electrical (electrocution) or chemical (burn). It can also be wounds caused for example by venous ulcers (in people with diabetes, for example, or post-thrombotic or related to chronic venous insufficiency) or bedsores.
- Collagen is a key component in wound healing, which is a complex process that can be divided into 5 phases:
- Blood vessels are the structures most likely to be damaged in case of injury.
- the first goal of the body repair process is to stop the bleeding. Platelet aggregation and activation of the coagulation cascade cause blood clotting. Platelets release aA-granules, which release several growth factors (FGs) and cytokines, which "attract" a variety of inflammatory cells (neutrophils, eosinophils, and monocytes) to the wound site and initiate the inflammatory phase.
- FGs growth factors
- cytokines which "attract" a variety of inflammatory cells (neutrophils, eosinophils, and monocytes)
- exudate contains a variety of essential substances such as enzymes, antibodies and inflammatory cells, all of which are necessary for the healing process.
- Inflammatory cells secrete proteolytic enzymes including neutrophils, eosinophils and macrophages.
- proteolytic enzymes include neutrophils, eosinophils and macrophages.
- the action of proteolytic enzymes on the macromolecular constituents of ECM gives rise to many peptides (protein fragments) during wound healing. These degradation products have a chemotactic effect in the recruitment of other cells, such as mononuclear cells, additional neutrophils, and macrophages.
- TNF- ⁇ and IL-1b are key to pro-inflammatory cytokines that directly affect collagen formation in the wound by stimulating collagen synthesis by fibroblasts. Inflammatory cells also secrete growth factors that continue to stimulate the migration of fibroblasts, epithelial cells and vascular endothelial cells into the wound. As a result, the cellularity of the wound increases.
- the new tissue is called granulation tissue. It fills the wound from below and has a bright red appearance.
- the construction of the new tissue is performed by the fibroblasts (the main cells of the dermis) through the synthesis of the collagen fibers that form the connective tissue matrix. During this phase there are fibroblasts, vascular endothelial cells and also keratinocytes. Vascular endothelial cells secrete a variety of FGs that promote angiogenesis. Granulation is reached by the vascularization of the ECM.
- the granulation tissue fills the wound and creates the basis for re-epithelialization: building a new layer of skin. Reepithelialization of the wound completes the healing process. The epithelial cells divide and migrate from the edges of the wound and close it again. Once the crustal epithelium is renewed, the crust is detached and the new pink epithelial tissue beneath becomes visible.
- the re-epithelialization phase of the wound is followed by the maturation phase during which the collagen fibers are rearranged to give more resistance to the skin.
- the new fabric is not identical to the original fabric, it is sometimes uneven and less elastic.
- significant color variations are possible and in up to 15% of wounds, one can observe the formation of a hypertrophic scar.
- the process of remodeling scar tissue can last for years.
- the types of existing dressings are numerous and vary according to the nature of the wounds.
- One of the most common forms of the dressing is a thin compress held on the wound by an adhesive.
- the semi-permeable adhesive film allows the passage of air and water vapor. It is very flexible and can be used at joints for example. he can be combined with a gel layer of hydrocolloids, alginates or a hydrogel, allowing a better hydration of the wound and a favored cicatrization.
- the gel may be impregnated with certain products such as antiseptics or corticosteroids to limit infections or inflammation of the wound.
- the dressings use fibers, for example in the form of textile.
- a wide variety of fibers can be used for the production of textile materials for various applications such as clothing.
- the fibers For the production of textile materials, the fibers must have certain properties such as toughness, elasticity, spinnability, etc. However, not all fibers are suitable for the manufacture of medical products.
- the fibers for medical use must also have properties such as non-toxicity, be sterilizable, have good biocompatibility, biodegradability, good absorbability, and have a soft touch.
- Medical textiles means non-implantable, implantable, extracorporeal devices, health products and personal care products. Dressings are considered non-implantable devices.
- One of the aims of the present invention is therefore to propose a new, highly effective product which makes it possible to improve the wound healing process.
- polymeric threads, fibers or filaments which have a capacity for emitting and / or absorbing infrared radiation in the wavelength range of between 2 ⁇ m and 20 ⁇ m make it possible to to improve the healing of the skin, in particular via the activation of collagen synthesis.
- the yarns, fibers or filaments according to the invention also make it possible to increase the proliferation of fibroblasts and keratinocytes, as well as their migration.
- the yarns, fibers or filaments according to the invention make it possible to improve both the process (in particular the speed and efficiency) of the cicatrization and the quality thereof.
- the invention relates to yarns, fibers or filaments comprising a polymeric matrix and mineral fillers which are uniformly dispersed in the polymeric matrix and have absorption and / or emission properties in the far-infrared region ranging from from 2 ⁇ to 20 ⁇ m to improve the healing of the skin.
- the present invention also relates to a textile article comprising yarns, fibers or filaments of the invention, for improving the healing of the skin.
- Another object of the present invention is a non-implantable medical device, such as a dressing or a suture, comprising yarns, fibers or filaments according to the invention.
- the present invention also relates to a method for improving the healing of the skin, using the son, fibers or filaments, textile articles or non-implantable medical devices as described in the present application.
- This method consists in particular in putting the skin having one or more lesions in contact with threads, fibers or filaments, a textile article or a non-implantable medical device according to the invention.
- the invention uses yarns, fibers or filaments comprising a polymeric matrix.
- the polymer matrix may be chosen from the group comprising polyesters, polyolefins, cellulose-ester-based polymers such as cellulose acetate, cellulose propionate, rayon, viscose and polymers of the same family. acrylic polymers and copolymers, polyamides, polyhexamethylene adipamide (PA66) or polycaproamide (PA6), or copolymers thereof in all proportions, or mixtures of any of the polymers mentioned above.
- polyesters polyolefins
- cellulose-ester-based polymers such as cellulose acetate, cellulose propionate, rayon, viscose and polymers of the same family.
- acrylic polymers and copolymers polyamides, polyhexamethylene adipamide (PA66) or polycaproamide (PA6), or copolymers thereof in all proportions, or mixtures of any of the polymers mentioned above.
- the polymeric matrix is based on polyamide, chosen between polyamide 6, polyamide 66 and copolymers of polyamide 6 / polyamide 66 in all proportions.
- the yarns, fibers or filaments according to the invention comprise mineral fillers having absorption and / or emission properties in the far-infrared region ranging from 2 to 20 ⁇ m.
- the mineral fillers have absorption and / or emission properties in the far-infrared region ranging from 3 to 20 ⁇ , and even more preferably from 3 to 15 ⁇ m.
- the mineral fillers are dispersed uniformly in the polymeric matrix.
- uniformly dispersed it is meant that the mineral fillers are homogeneously incorporated within the polymer itself, in particular that they have been incorporated during the synthesis of the polymer or into the melt polymer during the spinning phase, or by means of a concentrate of particles in the form of a masterbatch. These are not mineral fillers deposited in the form of a coating on the surface of the wires ("coating").
- the yarns, fibers or filaments according to the invention comprise mineral fillers having absorption and / or emission properties in the far-infrared region ranging from 2 to 20 ⁇ m, that is to say that is, at least two types of mineral fillers having such properties are present in said yarns, fibers or filaments. In a particularly preferred manner, at least three types of mineral fillers having such properties are present in said yarns, fibers or filaments.
- the mineral fillers may be chosen from oxides, sulphates, carbonates, phosphates and silicates.
- the oxide is selected from titanium dioxide, silicon dioxide and magnesium oxide.
- the sulphate may be selected from alkali metal and alkaline earth metal sulphates, preferably from barium sulphate, calcium sulphate and strontium sulphate.
- the carbonate is advantageously chosen from calcium carbonate or sodium carbonate.
- the silicate is selected from actinolite, tourmaline, serpentine and kaolin.
- the phosphate may be chosen from zirconium phosphates, apatite or their mixtures.
- the mineral fillers are chosen from oxides, sulphates, carbonates, phosphates and silicates.
- the yarns, fibers or filaments of the invention contain at least two types of mineral fillers chosen from the following types: oxides, sulphates, carbonates, phosphates and silicates.
- the fibers or filaments of the invention contain at least two mineral fillers of different types, preferably at least three mineral fillers of different types, chosen from the following types: oxides, sulphates, and silicates.
- the yarns, fibers or filaments of the invention contain three different mineral fillers, the three fillers being an oxide, a sulphate, and a silicate.
- the yarns, fibers or filaments of the invention contain at least two mineral fillers chosen from titanium dioxide, an alkali metal or alkaline earth metal sulphate and a silicate.
- At least two mineral fillers selected from titanium dioxide, barium sulfate, and tourmaline are present in the yarns, fibers or filaments of the invention.
- the yarns, fibers or filaments of the invention comprise three mineral fillers of different types.
- the combination of the three mineral fillers is preferably the combination of titanium dioxide / alkaline earth metal sulphate / silicate; preferably titanium dioxide / barium sulfate / tourmaline.
- the proportion by weight of the three mineral fillers is preferably between 80:10:10 and 10:30:60, and more specifically in proportion of 50:25:25.
- the yarns, fibers or filaments contain at least two mineral fillers of different types, preferably at least three mineral fillers of different types, chosen from the following types: oxides, phosphates, and silicates.
- the combinations of three mineral fillers of different types are particularly preferred, the three fillers being an oxide, a phosphate, and a silicate.
- the proportion by weight of the combination of mineral fillers relative to the total weight of the polymeric composition is greater than 1.0%, preferably greater than or equal to 1 , 5% and more preferably still greater than or equal to 2.5%.
- the proportion by weight of the combination of inorganic fillers relative to the total weight of the polymeric composition is less than 9%, preferably less than 6%, advantageously less than 4.5%.
- the inorganic fillers according to the invention are in the form of particles, which advantageously have an average size by weight of less than or equal to 2 ⁇ m, measured according to the laser diffraction particle size distribution method (using, for example, MALVERN granulometers. or CILAS).
- the inorganic fillers used in the present invention have a particle size which is neither too small, to prevent any risk that the particles can not leave the polymeric matrix and to enter the wounds and enter the body. human body or dispersing in the environment, and not too large, which would make it more difficult to incorporate the particles into the polymer matrix and make the material more abrasive on contact with the skin, which could be detrimental to the process of healing.
- the mineral fillers according to the invention are in the form of particles which advantageously have a weight average size, measured according to the laser diffraction particle size distribution method, ranging from 0.1 to 2 ⁇ m, and more preferably from 0 to , 2 to 1, 5 pm.
- the mineral fillers advantageously have a particle size distribution with 99% by weight of the particles having a size less than 1.0 ⁇ m, preferably 90% by weight of the particles having a size less than 0.5 ⁇ m.
- the particle size distribution is also measured by the laser diffraction particle size analysis method (using, for example, MALVERN or CILAS granulometers).
- the ratio between the particle size of the mineral fillers and the diameter of the filament is advantageously optimized to avoid the problems described above.
- the ratio between the average equivalent diameter of the filaments according to the invention and the average size by weight of the mineral fillers, measured according to the laser diffraction particle size distribution method, is advantageously greater than or equal to 10.
- This ratio between the equivalent mean diameter filament and the average size by weight of the mineral fillers is preferably less than or equal to 200.
- the yarns, fibers or filaments according to the invention are characterized in that the filaments preferably have a linear mass (or titre) ranging from 0.2 to 20 dtex, advantageously from 0.5 to 8 dtex, and even more preferentially from 0.5 to 3.5 dtex.
- the title of the filaments may vary depending on the chosen application.
- the filaments advantageously have a titre ranging from 0.5 to 1.5 dtex, whereas for applications for compression garments of the "postoperative" type, the filaments may exhibit title ranging from 2 to 8 dtex.
- the filaments according to the invention preferably have an equivalent mean diameter ranging from 4 to 50 ⁇ m, preferably from 6 to 30 ⁇ m.
- the mineral fillers are in the form of particles having a weight average size, measured according to the laser diffraction particle size distribution method, ranging from , 1 ⁇ to 0.4 ⁇ , and more preferably from 0.2 ⁇ to 0.4 ⁇ .
- the mineral fillers are advantageously in the form of particles having a weight average size, measured according to the laser diffraction particle size distribution method, ranging from 0.25 ⁇ m to 2 ⁇ , and more preferably from 1 to 2 ⁇ .
- the mineral fillers are incorporated during the synthesis phase of the polymer, or by direct mixing with the polymer during the spinning phase of the filaments, or by means of a concentrate of particles in the form of a mixture masterbatch), which can be subsequently diluted to predetermined concentrations in the polymer mass during the spinning phase.
- the son, fibers or filaments according to the invention preferably have a number of infrared radiation absorption peaks greater than 10 in the following ten frequency ranges: 3.00 +/- 0.30pm, 6.20 +/- 0.50pm, 8.00 +/- 0.25pm, 8.50 +/- 0.25pm, 9.00 +/- 0.25pm, 9.50 +/- 0.25pm, 10.00 +/- 0.25pm, 10.50 +/- 0.25pm, 11.00 +/- 0.25pm, 14.60 +/- 2.10pm, with at least one peak occurring in at least 7 of these 10 frequency ranges .
- the infrared radiation absorption spectrum may be determined by any method known to those skilled in the art.
- One possible method is the use of a Bruker device Equinox 55, with a resolution of 4 cm -1, in which case the spectrum obtained is in ATR ("Atenuated Total Reflectance") form, using a ZnSe crystal.
- the son, fibers or filaments according to the invention may advantageously have additional functionalities, different from the far infrared emission / absorption (FIR) functionality.
- FIR far infrared emission / absorption
- This can include yarns, fibers, or filaments that combine FIR functionality with one or more of the following features: moisture control,
- additives / active ingredients may be provided by additives / active ingredients, added to the yarn, fiber or filament according to the invention during its preparation.
- the process for obtaining such fibers according to the invention may consist in producing one or more suspensions of mineral fillers, for example a silicate, titanium dioxide and an alkali or alkaline-earth metal sulphate, stabilized by surfactants. .
- the suspension (s) is (are) then added to the synthesis of the polyamide.
- An alternative is to introduce a part of the mineral fillers, previously put in the form of a masterbatch in the molten polymer at the time of spinning.
- the polyamide obtained is cooled, cut and remelted before passing through an extruder to form the wire.
- the polyamide yarns, fibers or filaments according to the invention contain the mineral fillers uniformly dispersed in the polymer matrix.
- the mineral fillers can be introduced into the molten polymer by means of a mixing device, for example upstream of a spinning device.
- a mixing device for example upstream of a spinning device.
- By spinning the additive polymer composition continuous multifilament yarns, monofilaments, short and long fibers, or mixtures thereof can be obtained.
- the term "son” means all the son, fibers and filaments that can be obtained by spinning.
- the yarns obtained from the compositions charged polymers presented above can be subjected to all textile treatments known to those skilled in the art, such as extrusion, drawing, texturing, dyeing, finishing etc.
- the textile article can be obtained from a single type of yarn, fibers or filaments according to the invention, or from a mixture of yarns, fibers or filaments according to the invention with different threads, fibers or filaments. those of the invention.
- the son, fibers or filaments of different of those of the invention may advantageously have different functionalities and / or complementary functionality of emission / absorption in the far infrared (FIR). This may include threads, fibers, or filaments with one or more of the following features:
- additives / actives added to the wires; fibers or filaments different from those of the invention during their preparation.
- textile article is meant in particular a fabric, a knit or a nonwoven.
- the textile article is manufactured by known techniques using the yarns, fibers or filaments of the invention as a raw material, and optionally other yarns, fibers or filaments natural (for example cotton) or synthetic (for example the viscose). These additional yarns, fibers or filaments may in particular have good hygroscopicity, which may be advantageous in the application.
- the textile article is in the form of a bandage or a garment, such as, for example, a bermuda, a t-shirt, a tights, a pair of trousers, a compression stockings or a postoperative compression garment (of the type used in conventional or cosmetic surgery).
- a bandage or a garment such as, for example, a bermuda, a t-shirt, a tights, a pair of trousers, a compression stockings or a postoperative compression garment (of the type used in conventional or cosmetic surgery).
- the non-implantable medical device is in particular a dressing or a suture.
- the dressing may be a gauze, an adhesive bandage, a plaster, a bandage such as a compression bandage or absorbent bandage, adhesive tape or tissue scaffold.
- the non-implantable medical device comprises the yarns, fibers or filaments defined above, for example in the form of textile articles such as gauze. It may also be a combination of the yarns, fibers, filaments or textile articles of the invention with other textile bases (for example, non-woven felts or meshes) or with plastics.
- the non-implantable medical device may also include a combination of yarns, fibers, filaments, textile articles and combinations thereof with other textile or plastic bases:
- fibers such as alginate, chitosan, chitin, or collagen fibers ... and / or
- the interaction between the yarns, fibers or filaments and the skin improves the healing of the damaged skin, in particular by stimulating the synthesis of collagen.
- the lesion can be of several types, it is for example the result of a mechanical trauma (cutting, contusion, laceration, scratching, bite), thermal (burn), electrical (electrocution) or chemical (burn).
- the method according to the invention consists in applying the son, fibers, filaments, textile article or non-implantable medical device against the injured part of the skin, which is optionally previously disinfected.
- the recommended application may range from a few hours to several days depending on the severity, type and depth of the lesion.
- the son, fibers, filaments textile article or non-implantable medical device can be sterilized before use.
- the invention makes it possible to obtain a high efficiency in cicatrization.
- the present invention also has the advantage of having a high resistance to washing / cleaning of the mineral fillers of the textile article by incorporating these fillers into the polymeric matrix. Examples of embodiments of the invention are given below. These examples are given for illustrative purposes and without limitation.
- a masterbatch of polyamide 66 is prepared by incorporating 20% by weight of infrared emitting inorganic charges in powder form into polyamide 66 of relative viscosity (RV) 43, measured in a 90% formic acid solution. % in water.
- RV relative viscosity
- the masterbatch thus obtained is extruded, cooled and granulated.
- the granules thus obtained are melted and then introduced during spinning in molten polyamide 66 of relative viscosity (RV) 43, measured in a solution of 90% formic acid in water, in a proportion which makes it possible to obtain the desired quantity.
- RV relative viscosity
- the obtained molten polymeric composition is spun at a temperature between 280 ° C and 300 ° C (measured in the die), cooled in air (20 ° C, relative humidity 65%) and wound at a speed of 4200 m / min to obtain a multifilament continuous wire.
- the multifilament yarn formed of 68 filaments of circular section was subsequently textured.
- the title of the filament in the finished product is 1, 2 dtex.
- the yarn thus obtained is then converted into knits by using a circular knitter.
- a multifilament yarn was also made from a virgin polyamide 66 (containing only 1.5% by weight TiO 2 of average particle size by 0.3 ⁇ m) of relative viscosity (RV). 43, measured in a solution of 90% formic acid in water.
- the comparative yarn is also formed of 68 filaments of circular section and has been subsequently textured.
- the title of the filament in the finished product is 1, 2 dtex.
- the yarn thus obtained is also transformed into knits by using the same circular knitter.
- Bermudas were then made from said knits.
- the bermudas have a surface density of 305 g / m 2 , and contain 12% elastane. These articles were then used to evaluate the performance in the intended application (see in vivo tests below).
- a solution of type I collagen and primary fibroblasts is added to a cell culture. This solution polymerizes at physiological pH and temperature of 37 ° C giving rise to a gel, then the medium supplemented with growth factors or serum is added.
- the fibroblasts were obtained from the normal skin of 5 volunteers. The evaluation of the fibroblast samples of each volunteer was carried out 8 times. The results given below are an average of these evaluations.
- the fibroblasts were maintained under defined conditions of temperature and oxygen saturation (37 ° C and 5% CO 2 ) for 7 days.
- the same model was built in the presence of outdoor light.
- the Petri dishes were photographed using the UTSCSA Image Tool for Windows Version 3 software, the surface of each gel was measured, to calculate the level of contraction of the gel.
- the previously described method makes it possible to observe the degree of contraction of the gel, which makes it possible to evaluate the collagen synthesis activity by the fibroblasts. Indeed, the greater the contraction of the gel, the greater the collagen synthesis is important.
- Table 1 The results of contraction of the gel after 7 days are described in Table 1 below.
- Human skin has a maximum level of excitation of fluorescence at the wavelength of 295 nm and fluorescence emission at 360 nm. This fluorescence is attributed to the aromatic side chain of the amino acid tryptophan present in the protein structures of the skin. Another excitation maximum is observed at 340 nm wavelength and fluorescence emission at 400 nm. This other maximum is attributed to cross-links of type I collagen.
- the method chosen is the fluorescence spectroscopy measurement which makes it possible to quantify the presence of collagen type I in the skin, by comparing the amount of tryptophan (reference measured at 360 nm) with the amount of cross-links of collagen (measured at 400 nm ).
- the signal intensity of tryptophan in the excitation spectrum at 295 nm is strongly related to cell proliferation. A reduction in signal strength at 295 nm indicates a reduction in epidermal proliferation associated with aging of the skin.
- the internal (intrinsic) aging of the skin shows a 10 to 20% reduction in the tryptophan and collagen type I signal every 10 years.
- the tryptophan signal was considered as a virtually constant internal reference during the study.
- the ratio between the signal intensities at 340 nm and 295 nm indicates the increase in the number of cross-links of type I collagen, resulting from the increase in the synthesis of this molecule.
- the statistical test shows that there is a statistically significant difference between the tissue according to the invention and the comparative tissue from the point of view of the increase in collagen synthesis in vivo. (p ⁇ 0.0001)
- the two in vitro and in vivo tests above confirm that the contact of the additive yarn according to the invention with the skin makes it possible to observe a significant increase in collagen synthesis.
- collagen synthesis plays an important role in the healing process of the skin and the increase in its synthesis contributes significantly to the quality and speed of healing.
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Abstract
Description
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Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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BR112013029399A BR112013029399B8 (pt) | 2011-05-18 | 2012-05-16 | Fios, fibras ou filamentos incluindo cargas minerais e artigo têxtil |
US14/116,778 US9814798B2 (en) | 2011-05-18 | 2012-05-16 | Yarns, fibers or filaments, textile article, and medical device obtained from said yarns for skin cicatrization |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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FR1154333 | 2011-05-18 | ||
FR1154333 | 2011-05-18 |
Publications (1)
Publication Number | Publication Date |
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WO2012156805A1 true WO2012156805A1 (fr) | 2012-11-22 |
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PCT/IB2012/000954 WO2012156805A1 (fr) | 2011-05-18 | 2012-05-16 | Fils, fibres ou filaments comprenant des charges minerales; article textile dispositif medical obtenus a partir desdits fils pour la cicatrisation de la peau |
Country Status (5)
Country | Link |
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US (1) | US9814798B2 (fr) |
AR (1) | AR086429A1 (fr) |
BR (1) | BR112013029399B8 (fr) |
TW (1) | TW201300593A (fr) |
WO (1) | WO2012156805A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2999613A1 (fr) * | 2012-12-19 | 2014-06-20 | Sophie Beauge-Duguet | Materiau textile impregne de principes actifs et comprenant des particules de ceramique |
EP3031431A1 (fr) | 2014-12-11 | 2016-06-15 | Skin'up | Article textile massant |
WO2016091316A1 (fr) | 2014-12-11 | 2016-06-16 | Skin'up | Article textile massant |
EP2992907A4 (fr) * | 2013-05-02 | 2016-11-30 | José Zavala | Serviettes hygiéniques pour femmes et protections pour l'incontinence urinaire, gazes/bandes et pansements chirurgicaux pour le traitement de blessures, à base de tourmaline |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20190047732A (ko) * | 2016-09-26 | 2019-05-08 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | 인체 냉각을 위한 적외선-투과, 폴리머 섬유-기반 우븐 텍스타일 |
TWI766268B (zh) * | 2020-04-29 | 2022-06-01 | 財團法人工業技術研究院 | 纖維與其製備方法與人工韌帶/肌腱 |
CN115896971A (zh) * | 2021-09-30 | 2023-04-04 | 财团法人工业技术研究院 | 纤维与其制备方法与人工韧带/肌腱 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004588A (en) * | 1995-12-25 | 1999-12-21 | Torii; Kazuyuki | Far-infrared radiation material |
JP2004131453A (ja) * | 2002-10-15 | 2004-04-30 | Graffiti Twenty One:Kk | 超微粉末化されたマイナスイオン発生素材、遠赤外線発生素材を有効成分とする製剤及び機能性食品 |
CN1506026A (zh) * | 2002-12-09 | 2004-06-23 | 郑州时代纳米生物技术有限公司 | 抗菌、抗过敏、快愈合医用纱布或绷带 |
WO2009077834A2 (fr) | 2007-12-14 | 2009-06-25 | Rhodia Poliamida E Especialidades Ltda | Composition polymérique, procédé pour la fabrication de la composition polymérique, articles à base de cette composition polymérique et utilisation de ces articles |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2934598B1 (fr) | 2008-07-30 | 2012-11-30 | Rhodia Poliamida E Especialidades Ltda | Procede de fabrication de matrice polymerique thermoplastique |
FR2967573B1 (fr) | 2010-11-23 | 2012-11-09 | Rhodia Poliamida E Especialidades Ltda | Kit cosmetique et utilisation pour ameliorer l'aspect de la peau |
-
2012
- 2012-05-16 WO PCT/IB2012/000954 patent/WO2012156805A1/fr active Application Filing
- 2012-05-16 BR BR112013029399A patent/BR112013029399B8/pt active IP Right Grant
- 2012-05-16 US US14/116,778 patent/US9814798B2/en active Active
- 2012-05-17 TW TW101117632A patent/TW201300593A/zh unknown
- 2012-05-17 AR ARP120101744A patent/AR086429A1/es not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6004588A (en) * | 1995-12-25 | 1999-12-21 | Torii; Kazuyuki | Far-infrared radiation material |
JP2004131453A (ja) * | 2002-10-15 | 2004-04-30 | Graffiti Twenty One:Kk | 超微粉末化されたマイナスイオン発生素材、遠赤外線発生素材を有効成分とする製剤及び機能性食品 |
CN1506026A (zh) * | 2002-12-09 | 2004-06-23 | 郑州时代纳米生物技术有限公司 | 抗菌、抗过敏、快愈合医用纱布或绷带 |
WO2009077834A2 (fr) | 2007-12-14 | 2009-06-25 | Rhodia Poliamida E Especialidades Ltda | Composition polymérique, procédé pour la fabrication de la composition polymérique, articles à base de cette composition polymérique et utilisation de ces articles |
Non-Patent Citations (5)
Title |
---|
CARLSON, MA; LONGAKER, MT, WOUND REPAIR AND REGENERATION, vol. 12, no. 2, March 2004 (2004-03-01), pages 134 - 47 |
DATABASE WPI Week 200432, Derwent World Patents Index; AN 2004-344767, XP002665573 * |
DATABASE WPI Week 200476, Derwent World Patents Index; AN 2004-767175, XP002665574 * |
YING WANG ET AL: "INFLUENCE OF TOURMALINE ON NEGATIVE AIR ION EMITTING PROPERTY OF POLY(ETHYLENE TEREPHTHALATE)", JOURNAL OF MACROMOLECULAR SCIENCE , PART A - PURE AND APPLIED CHEMISTRY, MARCEL DEKKER INC, US, vol. 43, no. 11, 1 January 2006 (2006-01-01), pages 1749 - 1756, XP009097463, ISSN: 1060-1325, DOI: 10.1080/10601320600939452 * |
YING WANG ET AL: "Surface modification of superfine tourmaline powder with titanate coupling agent", COLLOID AND POLYMER SCIENCE ; KOLLOID-ZEITSCHRIFT UND ZEITSCHRIFT FÜR POLYMERE, SPRINGER, BERLIN, DE, vol. 284, no. 12, 24 June 2006 (2006-06-24), pages 1465 - 1470, XP019425964, ISSN: 1435-1536, DOI: 10.1007/S00396-006-1510-Y * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2999613A1 (fr) * | 2012-12-19 | 2014-06-20 | Sophie Beauge-Duguet | Materiau textile impregne de principes actifs et comprenant des particules de ceramique |
EP2992907A4 (fr) * | 2013-05-02 | 2016-11-30 | José Zavala | Serviettes hygiéniques pour femmes et protections pour l'incontinence urinaire, gazes/bandes et pansements chirurgicaux pour le traitement de blessures, à base de tourmaline |
EP3031431A1 (fr) | 2014-12-11 | 2016-06-15 | Skin'up | Article textile massant |
WO2016091316A1 (fr) | 2014-12-11 | 2016-06-16 | Skin'up | Article textile massant |
EP3031431B1 (fr) | 2014-12-11 | 2018-09-19 | Skin'up | Article textile massant |
EP3403633A1 (fr) | 2014-12-11 | 2018-11-21 | Skin'up | Article textile massant |
Also Published As
Publication number | Publication date |
---|---|
TW201300593A (zh) | 2013-01-01 |
US20140065092A1 (en) | 2014-03-06 |
AR086429A1 (es) | 2013-12-11 |
US9814798B2 (en) | 2017-11-14 |
BR112013029399B8 (pt) | 2022-12-06 |
BR112013029399B1 (pt) | 2021-03-02 |
BR112013029399A2 (pt) | 2017-01-31 |
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