WO2012151289A3 - Method and system to detect aggregate formation on a substrate - Google Patents

Method and system to detect aggregate formation on a substrate Download PDF

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Publication number
WO2012151289A3
WO2012151289A3 PCT/US2012/036139 US2012036139W WO2012151289A3 WO 2012151289 A3 WO2012151289 A3 WO 2012151289A3 US 2012036139 W US2012036139 W US 2012036139W WO 2012151289 A3 WO2012151289 A3 WO 2012151289A3
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
aggregate formation
detect
sample
detect aggregate
Prior art date
Application number
PCT/US2012/036139
Other languages
French (fr)
Other versions
WO2012151289A2 (en
Inventor
James P. Landers
Jingyi Li
Qian Liu
Original Assignee
University Of Virginia Patent Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Virginia Patent Foundation filed Critical University Of Virginia Patent Foundation
Publication of WO2012151289A2 publication Critical patent/WO2012151289A2/en
Publication of WO2012151289A3 publication Critical patent/WO2012151289A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays

Abstract

The invention provides methods to detect or determine the presence or amount of a polymeric analyte in a sample, which employ magnetic particles and subjects the sample and the magnetic substrate to forms of energy so as to induce aggregate formation, which is then detected on a substrate, e.g., filter paper.
PCT/US2012/036139 2011-05-02 2012-05-02 Method and system to detect aggregate formation on a substrate WO2012151289A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161481594P 2011-05-02 2011-05-02
US61/481,594 2011-05-02

Publications (2)

Publication Number Publication Date
WO2012151289A2 WO2012151289A2 (en) 2012-11-08
WO2012151289A3 true WO2012151289A3 (en) 2013-03-07

Family

ID=46208759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/036139 WO2012151289A2 (en) 2011-05-02 2012-05-02 Method and system to detect aggregate formation on a substrate

Country Status (1)

Country Link
WO (1) WO2012151289A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009114709A2 (en) 2008-03-12 2009-09-17 Uva Patent Foundation Detection of polymeric analytes
WO2014113598A2 (en) * 2013-01-16 2014-07-24 The Regents Of The University Of California Microfluidic devices to extract, concentrate and isolate molecules
CN107328931A (en) * 2017-05-16 2017-11-07 中山大学 A kind of quick continuous detection technique based on nano-probe and magnetic micro-nano granules
US11207677B2 (en) 2018-03-07 2021-12-28 University Of Virginia Patent Foundation Devices, systems, and methods for detecting substances

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081714A1 (en) * 2000-05-05 2002-06-27 Maneesh Jain Devices and methods to form a randomly ordered array of magnetic beads and uses thereof
WO2003096014A2 (en) * 2002-05-08 2003-11-20 Yissum Research Development Company Of The Hebrew University Of Jerusalem Magneto-controlled method and system for determining an analyte in a liquid medium
WO2009114709A2 (en) * 2008-03-12 2009-09-17 Uva Patent Foundation Detection of polymeric analytes
WO2011056215A1 (en) * 2009-11-03 2011-05-12 Landers James P Versatile, visible method for detecting polymeric analytes

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