WO2012142615A3 - Auranofin and auranofin analogs useful to treat proliferative disease and disorders - Google Patents
Auranofin and auranofin analogs useful to treat proliferative disease and disorders Download PDFInfo
- Publication number
- WO2012142615A3 WO2012142615A3 PCT/US2012/033837 US2012033837W WO2012142615A3 WO 2012142615 A3 WO2012142615 A3 WO 2012142615A3 US 2012033837 W US2012033837 W US 2012033837W WO 2012142615 A3 WO2012142615 A3 WO 2012142615A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- auranofin
- disorders
- treat proliferative
- proliferative disease
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Auranofin analogs and pharmaceutical compositions which inhibit p-STAT3 are provided together methods of synthesizing and methods of using the compounds. Also provided are methods of treating p-STAT3 diseases and disorders in a patient in need thereof by administering a therapeutically effective amount of one or more of these compounds, alone or in combination with another drug therapy. The compounds and pharmaceutical compositions disclosed are useful to treat proliferative diseases and disorders including, but not limited to, cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161475600P | 2011-04-14 | 2011-04-14 | |
US61/475,600 | 2011-04-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012142615A2 WO2012142615A2 (en) | 2012-10-18 |
WO2012142615A3 true WO2012142615A3 (en) | 2013-01-31 |
Family
ID=47010040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2012/033837 WO2012142615A2 (en) | 2011-04-14 | 2012-04-16 | Auranofin and auranofin analogs useful to treat proliferative disease and disorders |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012142615A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010005799A2 (en) | 2008-07-11 | 2010-01-14 | Board Of Regents, The University Of Texas System | Novel acetates of 2-deoxy monosaccharides with anticancer activity |
HUE056881T2 (en) | 2013-04-05 | 2022-03-28 | Univ Texas | Esters of 2-deoxy-monosaccharides with anti proliferative activity |
WO2015127234A1 (en) * | 2014-02-20 | 2015-08-27 | Board Of Regents, The University Of Texas System | Use of ibrutinib to treat egfr mutant cancer |
CN103980330B (en) * | 2014-04-04 | 2017-02-01 | 济南圣泉唐和唐生物科技有限公司 | Preparation method of isothiourea dihydrobromide |
CN107043404B (en) * | 2016-11-24 | 2020-08-11 | 中山大学肿瘤防治中心 | Novel phosphine gold complex and anti-tumor application thereof |
TW202106676A (en) | 2019-04-05 | 2021-02-16 | 美商凱麥拉醫療公司 | Stat degraders and uses thereof |
CN112206238A (en) * | 2019-07-09 | 2021-01-12 | 厦门大学 | Application of auranofin in lung cancer treatment |
AT523662B1 (en) | 2020-03-16 | 2023-07-15 | Aurovir Pharma Gmbh | Gold-containing medicines used to treat lung infections |
WO2023242100A1 (en) | 2022-06-13 | 2023-12-21 | KHR Biotec GmbH | Novel ras inhibitors |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003018598A2 (en) * | 2001-08-30 | 2003-03-06 | University College Dublin | Monosaccharide derivatives |
US20050043250A1 (en) * | 2000-05-01 | 2005-02-24 | Lampidis Theodore J. | Cancer treatment including glycolytic inhibitors |
US20050143336A1 (en) * | 2003-12-30 | 2005-06-30 | Board Of Regents, The University Of Texas System | Methods and compositions for improved non-viral gene therapy |
WO2010005799A2 (en) * | 2008-07-11 | 2010-01-14 | Board Of Regents, The University Of Texas System | Novel acetates of 2-deoxy monosaccharides with anticancer activity |
US20100130434A1 (en) * | 2006-02-24 | 2010-05-27 | Board Of Regents, The University Of Texas System | Hexose Compounds to Treat Cancer |
US20110003758A1 (en) * | 2006-04-27 | 2011-01-06 | Waldemar Priebe | Inhibitors of Glycolysis Useful In the Treatment of Brain Tumors |
-
2012
- 2012-04-16 WO PCT/US2012/033837 patent/WO2012142615A2/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050043250A1 (en) * | 2000-05-01 | 2005-02-24 | Lampidis Theodore J. | Cancer treatment including glycolytic inhibitors |
WO2003018598A2 (en) * | 2001-08-30 | 2003-03-06 | University College Dublin | Monosaccharide derivatives |
US20050143336A1 (en) * | 2003-12-30 | 2005-06-30 | Board Of Regents, The University Of Texas System | Methods and compositions for improved non-viral gene therapy |
US20100130434A1 (en) * | 2006-02-24 | 2010-05-27 | Board Of Regents, The University Of Texas System | Hexose Compounds to Treat Cancer |
US20110003758A1 (en) * | 2006-04-27 | 2011-01-06 | Waldemar Priebe | Inhibitors of Glycolysis Useful In the Treatment of Brain Tumors |
WO2010005799A2 (en) * | 2008-07-11 | 2010-01-14 | Board Of Regents, The University Of Texas System | Novel acetates of 2-deoxy monosaccharides with anticancer activity |
Non-Patent Citations (1)
Title |
---|
KIM, N. H. ET AL.: "Auranofin blocks interleukin-6 signalling by inhibiting p hosphorylation of JAK1 and STAT3.", IMMUNOLOGY., vol. 122, no. 4, 2007, pages 6 07 - 614, XP055237295, DOI: doi:10.1111/j.1365-2567.2007.02679.x * |
Also Published As
Publication number | Publication date |
---|---|
WO2012142615A2 (en) | 2012-10-18 |
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