WO2012136873A3 - Antagonistes de trpv1 et leurs utilisations - Google Patents

Antagonistes de trpv1 et leurs utilisations Download PDF

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Publication number
WO2012136873A3
WO2012136873A3 PCT/ES2012/070234 ES2012070234W WO2012136873A3 WO 2012136873 A3 WO2012136873 A3 WO 2012136873A3 ES 2012070234 W ES2012070234 W ES 2012070234W WO 2012136873 A3 WO2012136873 A3 WO 2012136873A3
Authority
WO
WIPO (PCT)
Prior art keywords
trpv1
triazine derivatives
trpv1 inhibitors
inhibitors
specifically
Prior art date
Application number
PCT/ES2012/070234
Other languages
English (en)
Spanish (es)
Other versions
WO2012136873A2 (fr
WO2012136873A8 (fr
Inventor
Antonio Ferrer Montiel
Asia Fernández Carvajal
José Manuel GONZÁLEZ ROS
Carlos BELMONTE MARTÍNEZ
Félix VIANA DE LA IGLESIA
Ana GOMIS GARCÍA
Ángel MESSEGUER PEYPOCH
Jordi BUJONS VILAS
Miquel VIDAL MOSQUERA
Rosa Planells Cases
Original Assignee
Universidad Miguel Hernández De Elche
Consejo Superior De Investigaciones Científicas C.S.I.C.
Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad Miguel Hernández De Elche, Consejo Superior De Investigaciones Científicas C.S.I.C., Fundación De La Comunidad Valenciana Centro De Investigación Príncipe Felipe filed Critical Universidad Miguel Hernández De Elche
Publication of WO2012136873A2 publication Critical patent/WO2012136873A2/fr
Publication of WO2012136873A3 publication Critical patent/WO2012136873A3/fr
Publication of WO2012136873A8 publication Critical patent/WO2012136873A8/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • C07D251/52—Two nitrogen atoms with an oxygen or sulfur atom attached to the third ring carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C07D251/70—Other substituted melamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des composés dérivés de la triazine qui présentent la capacité de bloquer l'activité de TRPV1, et leurs utilisations thérapeutiques. Plus concrètement, les auteurs de la présente invention ont synthétisé des triazines trisubstituées qui sont capables d'inhiber spécifiquement le thermorécepteur TRPV1 à l'état activé.
PCT/ES2012/070234 2011-04-05 2012-04-04 Antagonistes de trpv1 et leurs utilisations WO2012136873A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES201130537A ES2390326B1 (es) 2011-04-05 2011-04-05 Antagonistas de trpv1 y sus usos.
ESP201130537 2011-04-05
ESEP201130537 2011-04-05

Publications (3)

Publication Number Publication Date
WO2012136873A2 WO2012136873A2 (fr) 2012-10-11
WO2012136873A3 true WO2012136873A3 (fr) 2012-11-29
WO2012136873A8 WO2012136873A8 (fr) 2013-03-28

Family

ID=46208612

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2012/070234 WO2012136873A2 (fr) 2011-04-05 2012-04-04 Antagonistes de trpv1 et leurs utilisations

Country Status (2)

Country Link
ES (1) ES2390326B1 (fr)
WO (1) WO2012136873A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104003897A (zh) * 2014-06-19 2014-08-27 南京麦思德餐饮管理有限公司 一种辣椒素的制备方法
CN114874107B (zh) * 2022-07-12 2022-11-29 中山大学附属第七医院(深圳) 一种氨基脂质及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040258636A1 (en) * 2003-03-03 2004-12-23 Societe L'oreal S.A. Novel s-triazine compounds bearing at least one para-aminobenzalmalonic salt substituent and photoprotective cosmetic compositions comprised thereof
WO2005007646A1 (fr) * 2003-07-10 2005-01-27 Neurogen Corporation Analogues de diarylamine heterocycliques substitues
WO2005009980A1 (fr) * 2003-07-22 2005-02-03 Neurogen Corporation Analogues de pyridin-2-ylamine substitues
WO2006026135A2 (fr) * 2004-08-13 2006-03-09 Neurogen Corporation Analogues de biaryle pipérazinyl-pyridine substitués
WO2011115677A1 (fr) * 2010-03-17 2011-09-22 New York University Composés de s-triazine, compositions pharmaceutiques et procédés d'utilisation associés

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3627734A (en) * 1968-10-15 1971-12-14 Toray Industries Polyester fiber improved in dyeability, and process for the preparation thereof
WO2003032903A2 (fr) * 2001-10-12 2003-04-24 New York University Composes de triazine trisubstitues a activite anti-tubuline, procedes d'elaboration et d'utilisation correspondants
JP2007523875A (ja) * 2003-07-15 2007-08-23 ニューロジェン・コーポレーション バニロイド受容体リガンドとしての置換ピリミジン−４−イルアミン類縁体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040258636A1 (en) * 2003-03-03 2004-12-23 Societe L'oreal S.A. Novel s-triazine compounds bearing at least one para-aminobenzalmalonic salt substituent and photoprotective cosmetic compositions comprised thereof
WO2005007646A1 (fr) * 2003-07-10 2005-01-27 Neurogen Corporation Analogues de diarylamine heterocycliques substitues
WO2005009980A1 (fr) * 2003-07-22 2005-02-03 Neurogen Corporation Analogues de pyridin-2-ylamine substitues
WO2006026135A2 (fr) * 2004-08-13 2006-03-09 Neurogen Corporation Analogues de biaryle pipérazinyl-pyridine substitués
WO2011115677A1 (fr) * 2010-03-17 2011-09-22 New York University Composés de s-triazine, compositions pharmaceutiques et procédés d'utilisation associés

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MENG, JUN-CAI ET AL: "Cleavable linkers for porous silicon-based mass spectrometry", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION , 43(10), 1255-1260 CODEN: ACIEF5; ISSN: 1433-7851, 2004, XP002683214 *
MOON H-S ET AL: "A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of a Triazine Library and Zebrafish Embryo Screening", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ACS PUBLICATIONS, US, vol. 124, 1 January 2002 (2002-01-01), pages 11608 - 11609, XP002297373, ISSN: 0002-7863, DOI: 10.1021/JA026720I *
VIDAL-MOSQUERA, MIQUEL ET AL: "Triazine-Based Vanilloid 1 Receptor Open Channel Blockers: Design, Synthesis, Evaluation, and SAR Analysis", JOURNAL OF MEDICINAL CHEMISTRY , 54(21), 7441-7452 CODEN: JMCMAR; ISSN: 0022-2623, 2011, XP002683215 *

Also Published As

Publication number Publication date
WO2012136873A2 (fr) 2012-10-11
WO2012136873A8 (fr) 2013-03-28
ES2390326B1 (es) 2013-08-14
ES2390326A1 (es) 2012-11-12

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