WO2012091518A3 - Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same - Google Patents
Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same Download PDFInfo
- Publication number
- WO2012091518A3 WO2012091518A3 PCT/KR2011/010378 KR2011010378W WO2012091518A3 WO 2012091518 A3 WO2012091518 A3 WO 2012091518A3 KR 2011010378 W KR2011010378 W KR 2011010378W WO 2012091518 A3 WO2012091518 A3 WO 2012091518A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diagnosis
- intensity focused
- phospholipid nanoparticles
- induced high
- ultrasonic treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1809—Micelles, e.g. phospholipidic or polymeric micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
Abstract
The present invention relates to phospholipid nanoparticles for MR-induced high-intensity focused ultrasonic treatment and diagnosis, and to a method for producing same. More particularly, the present invention relates to phospholipid nanoparticles for MR-induced high-intensity focused ultrasound treatment and diagnosis, in which an MRI contrast agent is bonded to gas-containing phospholipid nanoparticles to enable high-intensity focused ultrasound treatment and monitoring by MR to be simultaneously performed. The present invention also relates to a method for producing the phospholipid nanoparticles.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020100140070A KR101292939B1 (en) | 2010-12-31 | 2010-12-31 | A phospholipid nanoparticle for theragnostics of MR-guided high-intensity focused ultrasound and a method for preparation thereof |
KR10-2010-0140070 | 2010-12-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012091518A2 WO2012091518A2 (en) | 2012-07-05 |
WO2012091518A3 true WO2012091518A3 (en) | 2012-08-23 |
Family
ID=46383771
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2011/010378 WO2012091518A2 (en) | 2010-12-31 | 2011-12-30 | Phospholipid nanoparticles for mr-induced high-intensity focused ultrasonic treatment and diagnosis, and method for producing same |
Country Status (2)
Country | Link |
---|---|
KR (1) | KR101292939B1 (en) |
WO (1) | WO2012091518A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9877699B2 (en) | 2012-03-26 | 2018-01-30 | Teratech Corporation | Tablet ultrasound system |
US10667790B2 (en) | 2012-03-26 | 2020-06-02 | Teratech Corporation | Tablet ultrasound system |
KR101991912B1 (en) * | 2013-01-04 | 2019-06-24 | 주식회사 인벤테라제약 | Mri contrast agent including t1 contrast material coated on surface of nanoparticle support |
CN103449530A (en) * | 2013-09-06 | 2013-12-18 | 南京东纳生物科技有限公司 | Preparation method of high-performance magnetic manganese zinc ferrite nanostars and nanoclusters |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030039613A1 (en) * | 1993-11-30 | 2003-02-27 | Unger Evan C. | Novel therapeutic delivery systems |
US20030216638A1 (en) * | 2002-05-16 | 2003-11-20 | Rohan Dharmakumar | Microbubble construct for sensitivity enhanced MR manometry |
US20070081946A1 (en) * | 2003-12-22 | 2007-04-12 | Bracco Research S.A. | Assembly of gas-filled microvesicle with active component for contrast imaging |
WO2008130137A1 (en) * | 2007-04-20 | 2008-10-30 | Korea Research Institute Of Chemical Technology | Anionic lipid nanosphere and preparation method of the same |
US20090117052A1 (en) * | 2005-01-10 | 2009-05-07 | Zhibiao Wang | Enhancement agent for high intensity focused ultrasound treatment and method for screening the same |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0811856D0 (en) | 2008-06-27 | 2008-07-30 | Ucl Business Plc | Magnetic microbubbles, methods of preparing them and their uses |
-
2010
- 2010-12-31 KR KR1020100140070A patent/KR101292939B1/en active IP Right Grant
-
2011
- 2011-12-30 WO PCT/KR2011/010378 patent/WO2012091518A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030039613A1 (en) * | 1993-11-30 | 2003-02-27 | Unger Evan C. | Novel therapeutic delivery systems |
US20030216638A1 (en) * | 2002-05-16 | 2003-11-20 | Rohan Dharmakumar | Microbubble construct for sensitivity enhanced MR manometry |
US20070081946A1 (en) * | 2003-12-22 | 2007-04-12 | Bracco Research S.A. | Assembly of gas-filled microvesicle with active component for contrast imaging |
US20090117052A1 (en) * | 2005-01-10 | 2009-05-07 | Zhibiao Wang | Enhancement agent for high intensity focused ultrasound treatment and method for screening the same |
WO2008130137A1 (en) * | 2007-04-20 | 2008-10-30 | Korea Research Institute Of Chemical Technology | Anionic lipid nanosphere and preparation method of the same |
Non-Patent Citations (2)
Title |
---|
A. M. CHOW ET AL.: "Enhancement of gas-filled microtubule R2* by iron oxide nanoparticles for MRI", MAGNETIC RESONANCE IN MEDICINE, vol. 3, January 2010 (2010-01-01), pages 224 - 229 * |
F. YANG ET AL.: "The preparation and application of microbubble contrast agent combining ultrasound imaging and magnetic resonance imaging", CHINESE SCIENCE BULLETIN, vol. 54, 2009, pages 2934 - 2939 * |
Also Published As
Publication number | Publication date |
---|---|
KR20120077931A (en) | 2012-07-10 |
KR101292939B1 (en) | 2013-08-02 |
WO2012091518A2 (en) | 2012-07-05 |
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