WO2012090219A3 - Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors - Google Patents

Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors Download PDF

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Publication number
WO2012090219A3
WO2012090219A3 PCT/IN2011/000884 IN2011000884W WO2012090219A3 WO 2012090219 A3 WO2012090219 A3 WO 2012090219A3 IN 2011000884 W IN2011000884 W IN 2011000884W WO 2012090219 A3 WO2012090219 A3 WO 2012090219A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutically acceptable
acceptable salts
acc
acetyl
coa carboxylase
Prior art date
Application number
PCT/IN2011/000884
Other languages
French (fr)
Other versions
WO2012090219A2 (en
Inventor
Pakala Kumara Savithru Sarma
Vinod Parameshwaran ACHARYA
Srinivas Rao Kasibhatla
Vellarkad Narayana Viswanadhan
Atul Tiwari
Rakesh Kumar SINGHA
Alexander Bischoff
Original Assignee
Jubilant Biosys Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jubilant Biosys Ltd. filed Critical Jubilant Biosys Ltd.
Publication of WO2012090219A2 publication Critical patent/WO2012090219A2/en
Publication of WO2012090219A3 publication Critical patent/WO2012090219A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention provides thiazole compounds of Formula I or its pharmaceutically acceptable salts, prodrugs, solvates, N-oxide thereof; solvates of pharmaceutically acceptable salts and N-oxides; pharmaceutically acceptable salts of N-oxides, or prodrugs; or combination or mixtures thereof; (I) The present invention further provides a method for preventing or treating a condition that responds to an Acetyl-CoA Carboxylase (ACC) inhibitor by using compounds of formula (I) or ), its pharmaceutically acceptable salts, prodrugs, solvates, N-oxide thereof; solvates of pharmaceutically acceptable salts and N-oxides; pharmaceutically acceptable salts of N-oxides, or prodrugs; or combination or mixtures thereof.
PCT/IN2011/000884 2010-12-31 2011-12-21 Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors WO2012090219A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN4057/CHE/2010 2010-12-31
IN4057CH2010 2010-12-31

Publications (2)

Publication Number Publication Date
WO2012090219A2 WO2012090219A2 (en) 2012-07-05
WO2012090219A3 true WO2012090219A3 (en) 2012-10-04

Family

ID=46383588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000884 WO2012090219A2 (en) 2010-12-31 2011-12-21 Thiazole compounds useful as acetyl-coa carboxylase (acc) inhibitors

Country Status (1)

Country Link
WO (1) WO2012090219A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2519517B1 (en) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
US9169205B2 (en) 2012-10-08 2015-10-27 Boehringer Ingelheim International Gmbh Pyrrolidine derivatives, pharmaceutical compositions and uses thereof
BR112015015250A2 (en) * 2013-01-25 2017-07-11 Boehringer Ingelheim Int pyrrolidine derivatives, pharmaceutical compositions and uses thereof
US8962641B2 (en) * 2013-04-17 2015-02-24 Boehringer Ingelheim International Gmbh Pyrimidine-substituted pyrrolidine derivatives, pharmaceutical compositions and uses thereof
CA2923884A1 (en) 2013-09-12 2015-03-19 Pfizer Inc. Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris
WO2015089800A1 (en) * 2013-12-19 2015-06-25 Eli Lilly And Company Fluorophenyl pyrazol compounds
CN107207444B (en) * 2014-11-26 2020-07-24 武田药品工业株式会社 Bicyclic compounds
CA2972919A1 (en) * 2015-01-09 2016-07-14 Gilead Apollo, Llc Acc inhibitor combination therapy for the treatment of non-alcoholic fatty liver disease
US10550121B2 (en) 2015-03-27 2020-02-04 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2016159049A1 (en) * 2015-03-31 2016-10-06 武田薬品工業株式会社 Monocyclic compound
EP4019515A1 (en) * 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
TW202400605A (en) 2016-03-02 2024-01-01 美商基利阿波羅有限責任公司 Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
AU2018243719B2 (en) 2017-03-28 2021-01-21 Gilead Sciences, Inc. Therapeutic combinations for treating liver diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008079610A2 (en) * 2006-12-21 2008-07-03 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
US20090048298A1 (en) * 2006-02-15 2009-02-19 Abbott Laboratories Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome
US20090155815A1 (en) * 2007-10-26 2009-06-18 Grasberger Bruce L Crystal structure of the carboxyl transferase domain of human acetyl-coa carboxylase 2 protein (acc2 ct) and uses thereof
WO2010127208A1 (en) * 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibitors of acetyl-coa carboxylase

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090048298A1 (en) * 2006-02-15 2009-02-19 Abbott Laboratories Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome
WO2008079610A2 (en) * 2006-12-21 2008-07-03 Abbott Laboratories Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome
US20090155815A1 (en) * 2007-10-26 2009-06-18 Grasberger Bruce L Crystal structure of the carboxyl transferase domain of human acetyl-coa carboxylase 2 protein (acc2 ct) and uses thereof
WO2010127208A1 (en) * 2009-04-30 2010-11-04 Forest Laboratories Holdings Limited Inhibitors of acetyl-coa carboxylase

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLARK ET AL.: "Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituents.", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, 2007, pages 1961 - 1965 *

Also Published As

Publication number Publication date
WO2012090219A2 (en) 2012-07-05

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