WO2012085936A3 - Recombinant respiratory syncytial virus plasmids and vaccines - Google Patents
Recombinant respiratory syncytial virus plasmids and vaccines Download PDFInfo
- Publication number
- WO2012085936A3 WO2012085936A3 PCT/IN2011/000871 IN2011000871W WO2012085936A3 WO 2012085936 A3 WO2012085936 A3 WO 2012085936A3 IN 2011000871 W IN2011000871 W IN 2011000871W WO 2012085936 A3 WO2012085936 A3 WO 2012085936A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- respiratory syncytial
- syncytial virus
- vaccines
- mva
- genes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The present invention relates to novel recombinant plasmids comprising a cassette of at least one, or at least two, or at least three or most preferably at least four foreign genes from Respiratory syncytial virus (RSV) wherein the said genes are inserted at a non-essential site preferably Del III, within the modified vaccinia Ankara (MVA) genome. The invention further relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneous expression of a cassette comprising of at least one, or at least two, or at least three or most preferably at least four foreign genes from Respiratory syncytial virus (RSV), wherein the said genes are inserted at a non-essential site preferably Del III, within the modified vaccinia Ankara (MVA) genome. The invention further provides compositions and method of treatment using the novel recombinant virus.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3028/DEL/2010 | 2010-12-20 | ||
IN3028DE2010 | 2010-12-20 |
Publications (4)
Publication Number | Publication Date |
---|---|
WO2012085936A2 WO2012085936A2 (en) | 2012-06-28 |
WO2012085936A8 WO2012085936A8 (en) | 2012-08-16 |
WO2012085936A3 true WO2012085936A3 (en) | 2012-10-11 |
WO2012085936A4 WO2012085936A4 (en) | 2012-12-27 |
Family
ID=45757038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2011/000871 WO2012085936A2 (en) | 2010-12-20 | 2011-12-19 | Recombinant respiratory syncytial virus plasmids and vaccines |
Country Status (2)
Country | Link |
---|---|
AR (1) | AR084439A1 (en) |
WO (1) | WO2012085936A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7317896B2 (en) | 2012-08-01 | 2023-07-31 | バヴァリアン・ノルディック・アクティーゼルスカブ | Recombinant modified vaccinia virus Ankara (MVA) respiratory syncytial virus (RSV) vaccine |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2869841B1 (en) * | 2012-07-05 | 2021-08-25 | GlaxoSmithKline Biologicals SA | Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides |
WO2014005643A1 (en) * | 2012-07-05 | 2014-01-09 | Okairos Ag | Novel prime-boosting regimens involving immunogenic polypeptides encoded by polynucleotides |
JP6523955B2 (en) * | 2012-08-01 | 2019-06-05 | バヴァリアン・ノルディック・アクティーゼルスカブ | Recombinant modified vaccinia virus Ankara (MVA) RS virus (RSV) vaccine |
MX2016016533A (en) | 2014-06-13 | 2017-05-01 | Glaxosmithkline Biologicals Sa | Immunogenic combinations. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004335A2 (en) * | 1999-07-09 | 2001-01-18 | The Government Of The United States Of America, As Represented By The Department Of Health And Humanservices | Human-bovine chimeric respiratory syncytial virus vaccines |
WO2010075491A2 (en) * | 2008-12-24 | 2010-07-01 | University Of Rochester | Recombinant expression of self-folding neutralizing epitope-bearing subdomains of the respiratory syncytial virus attachment and fusion proteins |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA201171436A1 (en) | 2009-05-18 | 2012-04-30 | Панацеа Биотек Лтд. | UNIVERSAL ANTI-GRIPPOSOUS VACCINE ON THE BASIS OF A RECOMBINANT MODIFIED VIRUS OF ANKARA COW-SPEAK (MVA) |
-
2011
- 2011-12-19 WO PCT/IN2011/000871 patent/WO2012085936A2/en active Application Filing
- 2011-12-20 AR ARP110104823A patent/AR084439A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001004335A2 (en) * | 1999-07-09 | 2001-01-18 | The Government Of The United States Of America, As Represented By The Department Of Health And Humanservices | Human-bovine chimeric respiratory syncytial virus vaccines |
WO2010075491A2 (en) * | 2008-12-24 | 2010-07-01 | University Of Rochester | Recombinant expression of self-folding neutralizing epitope-bearing subdomains of the respiratory syncytial virus attachment and fusion proteins |
Non-Patent Citations (1)
Title |
---|
TECHAARPORNKUL S ET AL: "Functional analysis of recombinant respiratory syncytial virus deletion mutants lacking the small hydrophobic and/or attachment glycoprotein gene", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 75, no. 15, 1 August 2001 (2001-08-01), pages 6825 - 6834, XP002301669, ISSN: 0022-538X, DOI: 10.1128/JVI.75.15.6825-6834.2001 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7317896B2 (en) | 2012-08-01 | 2023-07-31 | バヴァリアン・ノルディック・アクティーゼルスカブ | Recombinant modified vaccinia virus Ankara (MVA) respiratory syncytial virus (RSV) vaccine |
Also Published As
Publication number | Publication date |
---|---|
WO2012085936A8 (en) | 2012-08-16 |
WO2012085936A2 (en) | 2012-06-28 |
AR084439A1 (en) | 2013-05-15 |
WO2012085936A4 (en) | 2012-12-27 |
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