WO2012083840A1 - Système de détection de glucose et d'alerte, basé sur un téléphone mobile - Google Patents

Système de détection de glucose et d'alerte, basé sur un téléphone mobile Download PDF

Info

Publication number
WO2012083840A1
WO2012083840A1 PCT/CN2011/084288 CN2011084288W WO2012083840A1 WO 2012083840 A1 WO2012083840 A1 WO 2012083840A1 CN 2011084288 W CN2011084288 W CN 2011084288W WO 2012083840 A1 WO2012083840 A1 WO 2012083840A1
Authority
WO
WIPO (PCT)
Prior art keywords
mobile system
blood glucose
subject
data signal
wireless data
Prior art date
Application number
PCT/CN2011/084288
Other languages
English (en)
Inventor
Feng Xiao
Lu Wang
Patrick M. EAVES
Alex Y. NIE
Original Assignee
Beijing Metis Biomed Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Metis Biomed Ltd filed Critical Beijing Metis Biomed Ltd
Publication of WO2012083840A1 publication Critical patent/WO2012083840A1/fr

Links

Classifications

    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04L—TRANSMISSION OF DIGITAL INFORMATION, e.g. TELEGRAPHIC COMMUNICATION
    • H04L67/00—Network arrangements or protocols for supporting network services or applications
    • H04L67/01—Protocols
    • H04L67/12—Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks
    • H04L67/125—Protocols specially adapted for proprietary or special-purpose networking environments, e.g. medical networks, sensor networks, networks in vehicles or remote metering networks involving control of end-device applications over a network
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6887—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient mounted on external non-worn devices, e.g. non-medical devices
    • A61B5/6898—Portable consumer electronic devices, e.g. music players, telephones, tablet computers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient ; user input means
    • A61B5/7465—Arrangements for interactive communication between patient and care services, e.g. by using a telephone network
    • A61B5/747—Arrangements for interactive communication between patient and care services, e.g. by using a telephone network in case of emergency, i.e. alerting emergency services
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04W—WIRELESS COMMUNICATION NETWORKS
    • H04W4/00—Services specially adapted for wireless communication networks; Facilities therefor
    • H04W4/90—Services for handling of emergency or hazardous situations, e.g. earthquake and tsunami warning systems [ETWS]

Definitions

  • the disclosure relates systems and methods for monitoring a person's blood glucose level and alerting the person or appropriate contacts when the person's blood glucose level indicates a need for health care attention.
  • Type I diabetes previously known as juvenile diabetes, in this particularly severe form, the body does not produce insulin, and Type I diabetes is fatal without insulin treatment.
  • Intensive insulin therapy is key to managing this condition, and studies have shown that it significantly delays and prevents the progression of microvascular diseases such as retinopathy and
  • hypoglycemia pose a substantial hurdle to effective and safe intensive insulin therapy.
  • An additional benefit of frequent blood glucose measurements is that they provide critical data for determining the appropriate insulin dosage, and many algorithms that attempt to use continuously monitored glucose data to determine insulin dosage have been developed thus far, and these algorithm invariably relies on near- continuous glucose concentration data. Therefore, a sensor that is capable of providing frequent, near-continuous monitoring of glucose concentration is necessary for improving diabetes management, especially for those with Type I diabetes. It has been well established that concentration of subcutaneous interstitial fluid closely follows the glucose concentration in the blood; therefore, a minimally invasive, subcutaneous glucose sensor can be used as a continuous glucose monitoring modality.
  • CGiVIS subcutaneous continuous glucose monitoring systems
  • the present disclosure provides a mobile system, such as a smart phone equipped with appropriate components and software.
  • the mobile system receives data from a blood glucose sensor attached to a patient and processes the data and makes determination or prediction as to whether the patient's blood glucose level is or will be too high (hyperglycemia) or too low (hypoglycemia), both of which indicate needs for health care attention.
  • hyperglycemia or hypoglycemia is detected or predicted, the mobile system will alert to the patient that appropriate actions are required. In the event the alert is not responded to by the patient, the mobile system will transmit a warning signal to one or more preselected contacts.
  • the mobile system will then check whether the contact responds to the warning signal and if he does not, then transmit a warning signal to another contact, or an emergency health care center, until it receives appropriate attention.
  • the mobile system further transmits a global positioning system (GPS) to the contact to facilitate locating of the patient.
  • GPS global positioning system
  • the present disclosure provides a mobile system comprising a processor, a receiver, a transmitter and a storage medium in communication with the processor, the storage medium containing a set of processor executable instructions that, when executed by the processor, configure the receiver to receive a wireless data signal from a blood glucose sensor attached to a subject, determine whether the subject is in need of health care attention, and cause the transmitter to wirelessiy transmit a warning signal to a remote wireless receiver if the subject is in need to health care attention.
  • the wireless data signal is a Bluetooth data signal.
  • the wireless data signal comprises a blood glucose level.
  • the wireless data signal comprises raw blood glucose measurement data such as a raw electrical signal.
  • a raw electrical signal can be an electrical signal or an actual glucose reading.
  • the wireless data signal further comprises body temperature.
  • the receiver receives wireless data signals at a regular interval.
  • the interval is from about 10 seconds to 10 minutes. In some aspects, the interval is about 1 minute.
  • a subject in need of health care attention can be a subject having a hyperglycemia level.
  • a subject in need of health care attention is a subject having a hypoglycemia level.
  • the executable instructions are configured to predict a blood glucose level at a future time point. The health care attention, then, can be based on the predicted blood glucose level.
  • the executable instructions are configured to process raw blood glucose measurement data or to improve the accuracy of a blood glucose measurement.
  • the mobile system can further comprise a database for storing the wireless data signal or data converted from the wireless data signal.
  • the transmitting comprises voice calling.
  • the transmitting comprises text messaging or a wireless web-based communication, in some aspects, the transmitter also transmits a global positioning system (GPS) signal to the remote receiver.
  • GPS global positioning system
  • the remote receiver in one aspect, comprises a phone, such as a home phone or a ceil phone of a family member or a friend, a social networking site or a research network.
  • the remote receiver is part of an emergency response system or a clinical database. In the event a remote receiver does not respond, the mobile system transmits an additional warning signal to a different remote server.
  • the mobile system further comprises a display for displaying blood glucose levels.
  • the mobile system can be configured to alert the subject when the blood glucose level that needs attention is determined.
  • the alerting comprises a voice or vibration generator.
  • the transmitter wirelessiy transmits the warning signal to a remote receiver.
  • the mobile system further comprises a blood glucose sensor for generating the wireless data signal.
  • the blood glucose sensor comprises a wireless transmitter.
  • the wireless transmitter generates Bluetooth radio signal.
  • Another embodiment of the present disclosure provides a method for monitoring the blood glucose level in a subject with a mobile device comprising a processor, a receiver and a transmitter, the method comprising: receiving, through the receiver, a wireless data signal from a blood glucose sensor attached to a subject, determining whether the subject is in need of health care attention, and wirelessly transmitting, through the transmitter, a warning signal to a remote wireless receiver if the subject is in need of health care attention.
  • the wireless data signal is a Bluetooth data signal.
  • the wireless data signal comprises a blood glucose level.
  • the wireless data signal comprises raw blood glucose measurement data such as a raw electrical signal.
  • a raw electrical signal can be an electrical signal or an actual glucose reading.
  • the wireless data signal further comprises body temperature.
  • the wireless data signals are received at a regular interval.
  • Such an interval in one aspect, is from about 10 seconds to 10 minutes and in another aspect, is about 1 minute.
  • a subject in need of health care attention is a subject in hyperglycemia.
  • a subject in need of health care attention is a subject in hypoglycemia.
  • the determining of the method can also comprise predicting a blood glucose level at a future time point.
  • the prediction can be the basis for determining the need for health care attention is.
  • the determining comprises processing raw blood glucose measurement data or improving the accuracy of a biood glucose measurement,
  • the method further comprises storing the wireless data signal or data converted from the wireless data signal in a database.
  • the transmitting comprises voice calling, in another aspect, the transmitting comprises text messaging or a wireless web-based communication, in yet another aspect, the method further comprises transmitting a global positioning system (GPS) signal to the remote receiver.
  • GPS global positioning system
  • the remote receiver comprises a phone of a family member or a friend, in another aspect, the remote receiver is part of an emergency response system. In some aspects, the method further comprises transmitting an additional warning signal to a different remote server if the remote server does not respond.
  • the method further comprises displaying blood glucose levels on a display.
  • the method further comprises alerting the subject when the blood glucose level that needs attention is determined.
  • the alert component in one aspect, comprises a voice or vibration generator. In another aspect, if the subject fails to respond to the alert, then the transmitter wireiessly transmits the warning signal to a remote receiver.
  • FIG. 1 is a flow chart showing components and control of one embodiment of the presently disclosed mobile system.
  • FIG. 2 illustrates the components of certain embodiments of the mobile system of the present disclosure and how the mobile system is used to provide monitoring and alerting.
  • a glucose sensor (100) is attached to a patient's skin, or preferably placed subcutaneous!y.
  • a glucose sensor further includes controller 200 for providing a power source and retrieve electric signal from the sensor.
  • the glucose sensor 100 along with controller 200 are also known as a continuous glucose monitoring system (CGMS) although the present disclosure provides embodiments of such a CGMS with unique features and
  • a glucose sensor typically includes two or three electrodes coated with glucose oxidase.
  • the glucose sensor of the present disclosure further includes a thermistor for measuring local body temperature.
  • the glucose sensor is directly fixed on controller 200 of the CGMS.
  • controller 200 can be affixed to the skin with an adhesive base.
  • the glucose sensor is connected to controller 200 through a wire so that controller 200 can be conveniently anchored on a belt.
  • controller includes one or more of the following components: a potentiostat with an optional automatic density control (ADC) (201 ), a wireless, e.g., Bluetooth, radio generator and transmitter (202) and a microcontroller (203).
  • ADC automatic density control
  • the potentiostat 201 is used to maintain suitable potentials on electrodes on the glucose sensor.
  • the wireless/Bluetooth radio 202 generate a wireless/Bluetooth radio that includes data collected from the glucose sensor and transmits them to suitable receivers.
  • the microcontroller 203 can be connected to both potentiostat 201 and wireless/Bluetooth radio 202 and contains processor and program code to operate the controller.
  • the controller further includes a storage unit such that raw data or processed data can be stored. This is useful in particular when the mobile system is temporarily out of range or out of battery. With the storage unit, the mobile system can retrieve the data that it has failed to retrieve.
  • a dual charger that can simultaneously charge the glucose sensor and the mobile system.
  • the charger can be battery-powered and thus portable, in one aspect, the charger charges the glucose sensor wireless or with a wire attached to the sensor, such as to the controller. In another aspect, the charger also charges the mobile system to avoid power outage especially when the patient is potentially suffering an abnormal blood glucose level.
  • the CMGS can generate a wireless signal for transmission to remote wireless receivers.
  • the transmission can be continuous, at a pre-determined interval, at an interval determined by the microcontroller, or upon request by a remote receiver.
  • the transmission is regular, from about every 1 second to about every 10 minutes, or alternatively from about every 2 seconds to about every 5 minutes, or alternatively from about every 3 seconds to about 3 minutes.
  • the transmission takes place about every 1 , 2, 3, 4, 5, 8, 7, 8, 9, 10, 15, 20, 25, 30, 40, 45, 50, or 60 seconds, or every 1 , 2, 3, 4, 5, 6, 7, 8, 9 or 10 minutes.
  • An example of a remote receive that receives the wireless signal from the CGMS is a mobile system such as a cellular phone (300).
  • the mobile system includes a processor, a receiver, a transmitter and a storage medium in communication with the processor, the storage medium containing a set of processor executable instructions that, when executed by the processor, configure the receiver to receive a wireless data signal from a CGMS attached to a subject, determine whether the subject is in need of health care attention.
  • a subject in need of health care attention can be a subject having a hyperglycemia level or alternatively a hypoglycemia level.
  • the mobile system is configured to process the wireless signal received from the CGMS. Depending on the type of data, there are a wide range of algorithms available to conduct signal processing. In one embodiment, the mobile system is also configured to make a prediction based on historical data and/or dietary or other type of information entered into the mobile system by the subject. When a prediction is made, therefore, the need of health care attention can be based on the predicted glucose level, in order to prevent occurrence of adverse health conditions.
  • the mobile system includes a database for storing the wireless data signal or data converted from the wireless data signal.
  • a database will be useful in making predictions or when presented to the subject or a health care professional, useful for assessing the subject's health condition or make future health care recommendations.
  • Data stored in the database can be wirelessiy transmitted to a clinical database (500) to facilitate emergency response or future health care.
  • the mobile system in the event an abnormal glucose level, either hyperglycemia or hypoglycemia, is determined or predicted, the mobile system can display a warning signal or otherwise alert the subject that suitable care is needed.
  • the alert for example, can be in the form of a visual display, a flashing light, a warning sound, or a vibration signal.
  • the mobile system allows a certain period for the subject to respond. In case no proper response is received from the subject, the mobile system is configured to transmit a warning signal to a remote receiver to seek help.
  • the transmitting includes voice calling.
  • the transmitting includes text messaging or a wireless web-based communication.
  • the remote receiver for example, is a phone (400) of a friend or family member and the contact can be stored in the mobile system and pre-selected by the subject.
  • the remote receiver will be given a time period to respond to the warning, either by answering the call or a return text or email message. In the event a proper response is not received by the mobile system, the mobile system will attempt to transmit a warning signal to another contact until a response is received.
  • Any of remote receivers can also be a medical professional or an emergency service center (401 ) so that health care attention is ensured.
  • any of the remote receivers can be at a social networking site (402) so that the personal network of the subject can be properly notified, who can then provide appropriate help or contact emergency service center.
  • the receiver can be a research network (403) or a clinical database (404) which collect such data for the purpose of conducting clinical research for benefit of the public and/or for the subject itself.
  • the transmitter also transmits a global positioning system (GPS) signal that is determined by a satellite or cellular tower (800) to the remote receiver.
  • GPS global positioning system
  • a GPS signal will enable the friend, family member, medical professional or emergency service center to easily locate the subject. This is particularly useful when the subject is in serious medical condition can not himself or herself provide location information,
  • the transmission can further include glucose level data received by the mobile system or data stored in the database of the mobile system. Such data will be useful in assessing the situation of the subject.
  • the mobile system in the event the mobile system fails to receive a signal from the glucose sensor, such as when the subject is out of range reachable by the wireless signal, the mobile system automatically starts a time out period. If during the time out period the mobile system fails to
  • the duration of the time out period can be preset or adjusted by the subject.
  • the time out can be disabled or terminated by the subject if the subject determines that he or she is safe without the monitoring, such as in a swimming pool.
  • ail ranges disclosed herein also encompass any and all possible subranges and combinations of subranges thereof. Any listed range can be easily recognized as sufficiently describing and enabling the same range being broken down into at least equal halves, thirds, quarters, fifths, tenths, etc. As a non-limiting example, each range discussed herein can be readily broken down into a lower third, middle third and upper third, etc.
  • ail language such as “up to,” “at least,” “greater than,” “less than,” and the like include the number recited and refer to ranges which can be subsequently broken down into subranges as discussed above.
  • a range includes each individual member.
  • a group having 1 -3 particles refers to groups having 1 , 2, or 3 particles.
  • a group having 1 -5 particles refers to groups having 1 , 2, 3, 4, or 5 particles, and so forth.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Business, Economics & Management (AREA)
  • Emergency Management (AREA)
  • Emergency Medicine (AREA)
  • Signal Processing (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • General Business, Economics & Management (AREA)
  • Computing Systems (AREA)
  • Multimedia (AREA)
  • Environmental & Geological Engineering (AREA)
  • Critical Care (AREA)
  • Nursing (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

L'invention porte sur un système mobile, tel qu'un téléphone intelligent, qui est équipé de composants appropriés et d'un logiciel approprié. Le système mobile reçoit des données à partir d'un glucomètre attaché à un patient et traite les données et réalise une détermination ou une prédiction quant au niveau de glycémie sang du patient. Lorsqu'un niveau anormal de niveau de glycémie est détecté ou prédit, le système mobile alertera le patient. Dans le cas où le patient ne répond pas à l'alerte, le système mobile transmettra un signal d'avertissement à un ou plusieurs contacts présélectionnés, lequel signal d'avertissement comprend éventuellement un signal GPS.
PCT/CN2011/084288 2010-12-21 2011-12-20 Système de détection de glucose et d'alerte, basé sur un téléphone mobile WO2012083840A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061425245P 2010-12-21 2010-12-21
US61/425,245 2010-12-21

Publications (1)

Publication Number Publication Date
WO2012083840A1 true WO2012083840A1 (fr) 2012-06-28

Family

ID=46313168

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/084288 WO2012083840A1 (fr) 2010-12-21 2011-12-20 Système de détection de glucose et d'alerte, basé sur un téléphone mobile

Country Status (1)

Country Link
WO (1) WO2012083840A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036212A2 (fr) * 2004-04-22 2006-04-06 Medtox Scientific, Inc. Edulcorants sans sucre a utiliser dans des dispositifs d'essai
CN1877335A (zh) * 2005-06-11 2006-12-13 乐金电子(中国)研究开发中心有限公司 一种具备血糖量测定功能的移动通信终端及其操作方法
CN101841561A (zh) * 2010-04-06 2010-09-22 四川东林科技有限公司 智能移动个人健康数据监控***及监控方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036212A2 (fr) * 2004-04-22 2006-04-06 Medtox Scientific, Inc. Edulcorants sans sucre a utiliser dans des dispositifs d'essai
CN1877335A (zh) * 2005-06-11 2006-12-13 乐金电子(中国)研究开发中心有限公司 一种具备血糖量测定功能的移动通信终端及其操作方法
CN101841561A (zh) * 2010-04-06 2010-09-22 四川东林科技有限公司 智能移动个人健康数据监控***及监控方法

Similar Documents

Publication Publication Date Title
US9293023B2 (en) Techniques for emergency detection and emergency alert messaging
US9927305B2 (en) Method and apparatus for accurate detection of fever
US20220392601A1 (en) Systems for tracking medications
US8164461B2 (en) Monitoring task performance
US20040199056A1 (en) Body monitoring using local area wireless interfaces
RU2602676C2 (ru) Устройство для обнаружения лихорадки
US20150173674A1 (en) Detecting and communicating health conditions
US20100056878A1 (en) Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject
JP2012514799A (ja) 摂取に関連するバイオフィードバックおよび個別薬物療法の方法およびシステム
JP6476124B2 (ja) 身体機能および／または身体特性をモニタするための装置ならびに方法
WO2015143085A1 (fr) Techniques pour le suivi de santé et la messagerie d'alerte d'urgence
CN111372506B (zh) 使用可穿戴设备预测甲状腺毒症的***和计算机程序
JP2014230207A (ja) 転倒時通報システム及び転倒時通報システム用プログラム
US20170014028A1 (en) Medical monitoring and treatment devices, systems, and methods
KR20150061195A (ko) 모바일 응급 관리 시스템
EP1163877A1 (fr) Dispositif pour mesurer l' activité du corps et procédé
AU2018400229B2 (en) Method and system of providing an emergency response notification
US20170249823A1 (en) System for Tracking Wellness and Scheduling of Caregiving
CN108986409B (zh) 一种智慧养老预警***
WO2012083840A1 (fr) Système de détection de glucose et d'alerte, basé sur un téléphone mobile
WO2018042084A1 (fr) Procédé de déclenchement d'une alarme médicale auprès d'un centre de surveillance et un système médical de surveillance
KR20170060211A (ko) 사용자의 응급 상황 정보 전송 및 수면 시간 알람 방법
JP2006081838A (ja) 生体情報データ測定機能付き腕時計
US20240194316A1 (en) Facilitating adherence to tasks designed to maintain or improve health
CN115666385A (zh) 用于监测患者的生理特征的装置、***和方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11852078

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 13/11/2013)

122 Ep: pct application non-entry in european phase

Ref document number: 11852078

Country of ref document: EP

Kind code of ref document: A1