WO2012081036A3 - A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione) - Google Patents

A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione) Download PDF

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Publication number
WO2012081036A3
WO2012081036A3 PCT/IN2011/000847 IN2011000847W WO2012081036A3 WO 2012081036 A3 WO2012081036 A3 WO 2012081036A3 IN 2011000847 W IN2011000847 W IN 2011000847W WO 2012081036 A3 WO2012081036 A3 WO 2012081036A3
Authority
WO
WIPO (PCT)
Prior art keywords
ethandiyl
piperazinedione
bis
methyl
preparation
Prior art date
Application number
PCT/IN2011/000847
Other languages
French (fr)
Other versions
WO2012081036A2 (en
Inventor
Thangavel Arulmoli
Ramasamy Suresh
Arunagiri Muthulingam
Annadurai Marimuthu Senthilkumar
Dhanabal Swaminathan
Kasiyappan Gurusamy Saravanakumar
Nachiappan Yogarajan
Original Assignee
Sequent Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sequent Scientific Limited filed Critical Sequent Scientific Limited
Publication of WO2012081036A2 publication Critical patent/WO2012081036A2/en
Publication of WO2012081036A3 publication Critical patent/WO2012081036A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a new method for preparing 4,4'-(1-methyl-1,2- ethandiyl)-bis-(2,6-piperazinedione) of formula (I) or its enantiomers. More specifically this invention relates to a new process for preparing 4,4'-(1-methyl- 1,2- ethandiyl)-bis-(2,6-piperazinedione), which gives better yield and purity and involves new intermediate.
PCT/IN2011/000847 2010-12-13 2011-12-12 A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione) WO2012081036A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3795CH2010 2010-12-13
IN3795/CHE/2010 2010-12-13

Publications (2)

Publication Number Publication Date
WO2012081036A2 WO2012081036A2 (en) 2012-06-21
WO2012081036A3 true WO2012081036A3 (en) 2012-10-04

Family

ID=46245171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2011/000847 WO2012081036A2 (en) 2010-12-13 2011-12-12 A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione)

Country Status (1)

Country Link
WO (1) WO2012081036A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108250094B (en) * 2018-03-09 2021-01-26 江苏奥赛康药业有限公司 Preparation method of piperazine diketone compound
CN113336661B (en) * 2020-03-03 2022-08-05 南京正大天晴制药有限公司 Preparation method of methyl tetraacetate compound

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840542A (en) * 1971-11-24 1974-10-08 Merck & Co Inc Derivatives of 3,6-bis-(2-(1-azabicyclo-(3,1,0)hexane))-2,5-piperazinedione
US4523013A (en) * 1982-01-29 1985-06-11 Sanofi, S.A. 4-Acyl-2,6-dioxo-1-phenethyl piperozines
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
US5618936A (en) * 1991-10-25 1997-04-08 Sicor Spa Process for preparing (S) (+)-4,4'-(1-methyl-1,2-ethanediyl)-bis (2,6-piperazinedione)
US20060194969A1 (en) * 2002-12-13 2006-08-31 Zimmermann Peter J 4-Substituted benzimidazoles and their uses as inhibitors of gastric secretion
US20100152447A1 (en) * 2006-11-24 2010-06-17 Cyathus Exquirere Pharmaforschungs Gmbh Novel Method for Producing 4,4-(1-Methyl-1,2-Ethanediyl)-BIS-(2,6-Piperazinedione)

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840542A (en) * 1971-11-24 1974-10-08 Merck & Co Inc Derivatives of 3,6-bis-(2-(1-azabicyclo-(3,1,0)hexane))-2,5-piperazinedione
US4523013A (en) * 1982-01-29 1985-06-11 Sanofi, S.A. 4-Acyl-2,6-dioxo-1-phenethyl piperozines
US4963679A (en) * 1988-02-17 1990-10-16 Erbamont, Inc. Process for preparing bis (3,5-dioxopiperazinyl) alkanes or alkenes
US5618936A (en) * 1991-10-25 1997-04-08 Sicor Spa Process for preparing (S) (+)-4,4'-(1-methyl-1,2-ethanediyl)-bis (2,6-piperazinedione)
US20060194969A1 (en) * 2002-12-13 2006-08-31 Zimmermann Peter J 4-Substituted benzimidazoles and their uses as inhibitors of gastric secretion
US20100152447A1 (en) * 2006-11-24 2010-06-17 Cyathus Exquirere Pharmaforschungs Gmbh Novel Method for Producing 4,4-(1-Methyl-1,2-Ethanediyl)-BIS-(2,6-Piperazinedione)

Also Published As

Publication number Publication date
WO2012081036A2 (en) 2012-06-21

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