WO2012074202A3 - Method of screening material for improving dry skin using bleomycin hydrolase - Google Patents

Method of screening material for improving dry skin using bleomycin hydrolase Download PDF

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Publication number
WO2012074202A3
WO2012074202A3 PCT/KR2011/007937 KR2011007937W WO2012074202A3 WO 2012074202 A3 WO2012074202 A3 WO 2012074202A3 KR 2011007937 W KR2011007937 W KR 2011007937W WO 2012074202 A3 WO2012074202 A3 WO 2012074202A3
Authority
WO
WIPO (PCT)
Prior art keywords
dry skin
screening
skin
improving dry
bleomycin hydrolase
Prior art date
Application number
PCT/KR2011/007937
Other languages
French (fr)
Korean (ko)
Other versions
WO2012074202A2 (en
Inventor
손의동
김윤경
주경미
김형준
이은경
남개원
김지현
안수미
김한곤
Original Assignee
(주)아모레퍼시픽
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주)아모레퍼시픽 filed Critical (주)아모레퍼시픽
Publication of WO2012074202A2 publication Critical patent/WO2012074202A2/en
Publication of WO2012074202A3 publication Critical patent/WO2012074202A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/007—Preparations for dry skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/148—Screening for cosmetic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96466—Cysteine endopeptidases (3.4.22)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/20—Dermatological disorders

Abstract

The present invention relates to a method of screening material for improving dry skin and provides a method of screening material for improving dry skin comprising screening on the basis of a change in gene expression of bleomycin hydrolase by a candidate material, and a material for improving dry skin found by screening. In addition, provided is a composition for a skin preparation for external use, containing a liver X receptor activator which increases the gene expression of bleomycin hydrolase as an active ingredient. The screening method of the present invention can find an effective material for improving dry skin, and the composition improves dry skin and prevents loss of skin moisture, thereby restoring the skin barrier of the stratum corneum.
PCT/KR2011/007937 2010-11-30 2011-10-24 Method of screening material for improving dry skin using bleomycin hydrolase WO2012074202A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020100120370A KR101766393B1 (en) 2010-11-30 2010-11-30 Screening method for materials improving dry skin using bleomycin hydrolase
KR10-2010-0120370 2010-11-30

Publications (2)

Publication Number Publication Date
WO2012074202A2 WO2012074202A2 (en) 2012-06-07
WO2012074202A3 true WO2012074202A3 (en) 2012-07-26

Family

ID=46172339

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/007937 WO2012074202A2 (en) 2010-11-30 2011-10-24 Method of screening material for improving dry skin using bleomycin hydrolase

Country Status (2)

Country Link
KR (1) KR101766393B1 (en)
WO (1) WO2012074202A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6462437B2 (en) 2014-05-08 2019-01-30 花王株式会社 Evaluation method of skin dryness

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127223A1 (en) * 1984-07-17 2002-09-12 Matsumura Kenneth N. Method for reducing side effects of a drug
US20020187157A1 (en) * 2000-02-21 2002-12-12 Jensen Martin Roland Novel method for down-regulation of amyloid
US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US20080070883A1 (en) * 2006-09-19 2008-03-20 Wyeth Use of LXR modulators for the prevention and treatment of skin aging
WO2009142268A1 (en) * 2008-05-23 2009-11-26 株式会社資生堂 Method for evaluation of the state of skin barrier function by natural moisturizing factor of employing the activity of bleomycin hydrolase as measure

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127223A1 (en) * 1984-07-17 2002-09-12 Matsumura Kenneth N. Method for reducing side effects of a drug
US20030153541A1 (en) * 1997-10-31 2003-08-14 Robert Dudley Novel anticholesterol compositions and method for using same
US20020187157A1 (en) * 2000-02-21 2002-12-12 Jensen Martin Roland Novel method for down-regulation of amyloid
US20080070883A1 (en) * 2006-09-19 2008-03-20 Wyeth Use of LXR modulators for the prevention and treatment of skin aging
WO2009142268A1 (en) * 2008-05-23 2009-11-26 株式会社資生堂 Method for evaluation of the state of skin barrier function by natural moisturizing factor of employing the activity of bleomycin hydrolase as measure

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HARINI SAMPATH, B.SC. ET AL.: "Polyunsaturated Fatty Acid Regulation of Gene Expression.", NUTRITION REVIEWS., vol. 62, no. 9, 2004, pages 333 - 339 *

Also Published As

Publication number Publication date
WO2012074202A2 (en) 2012-06-07
KR101766393B1 (en) 2017-08-10
KR20120058863A (en) 2012-06-08

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