WO2012050892A3 - Methods for stimulating, increasing or enhancing killing of a cell that expresses luteinizing hormone releasing hormone (lhrh) receptors - Google Patents
Methods for stimulating, increasing or enhancing killing of a cell that expresses luteinizing hormone releasing hormone (lhrh) receptors Download PDFInfo
- Publication number
- WO2012050892A3 WO2012050892A3 PCT/US2011/053684 US2011053684W WO2012050892A3 WO 2012050892 A3 WO2012050892 A3 WO 2012050892A3 US 2011053684 W US2011053684 W US 2011053684W WO 2012050892 A3 WO2012050892 A3 WO 2012050892A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lhrh
- stimulating
- increasing
- methods
- expresses
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1808—Epidermal growth factor [EGF] urogastrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
The disclosure relates to compositions and methods for stimulating, increasing, or enhancing luteinizing hormone-releasing hormone (LHRH) receptor (LHRH-R) expression on cells with a first agent, to target cells for arrest, inhibition, reduction or decrease of cell growth, survival, or proliferation, or increased, stimulated, induced or enhanced cell killing, lysis or apoptosis with a second agent that binds to LHRH-R.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38790410P | 2010-09-29 | 2010-09-29 | |
US61/387,904 | 2010-09-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012050892A2 WO2012050892A2 (en) | 2012-04-19 |
WO2012050892A3 true WO2012050892A3 (en) | 2014-04-03 |
Family
ID=45938868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/053684 WO2012050892A2 (en) | 2010-09-29 | 2011-09-28 | Methods for stimulating, increasing or enhancing killing of a cell that expresses luteinizing hormone releasing hormone (lhrh) receptors |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012050892A2 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2889475A1 (en) | 2012-10-30 | 2014-05-08 | Esperance Pharmaceuticals, Inc. | Antibody/drug conjugates and methods of use |
CA2910311A1 (en) * | 2012-11-15 | 2014-05-22 | Esperance Pharmaceuticals, Inc. | Follicle-stimulating hormone (fsh)/lytic domain fusion constructs and methods of making and using same |
CN107106638A (en) * | 2014-10-14 | 2017-08-29 | 激流生物科学有限公司 | Peptide with anti-inflammatory property |
US10130717B2 (en) | 2015-12-04 | 2018-11-20 | Eastern Kentucky University | LHRH-platinum conjugates for treating reproductive cancers |
US10413584B1 (en) | 2018-08-29 | 2019-09-17 | Riptide Bioscience, Inc. | Peptides having immunomodulatory properties |
US10548944B1 (en) | 2018-10-19 | 2020-02-04 | Riptide Bioscience, Inc. | Antimicrobial peptides and methods of using the same |
EP4051693A4 (en) * | 2019-10-31 | 2023-11-15 | Worcester Polytechnic Institute | Lhrh-prodigiosin conjugates and methods of use |
EP4051309A4 (en) * | 2019-10-31 | 2023-11-08 | Worcester Polytechnic Institute | Lhrh-paclitaxel conjugates and methods of use |
CN117003898B (en) * | 2023-09-27 | 2023-12-29 | 贝格探索(成都)科技有限公司 | LHRH4-CRM197-LF multimeric recombinant protein and preparation method and application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060281685A1 (en) * | 1999-03-17 | 2006-12-14 | Michael Bernd | Methods of treatment using novel lhrh antagonists having improved solubility properties |
US20080027003A1 (en) * | 2004-05-27 | 2008-01-31 | Curepeptide Ltd. | Peptides Useful for Treating Gnrh Associated Diseases |
US20090087494A1 (en) * | 2006-09-12 | 2009-04-02 | Board Of Regents Of The University Of Nebraska | Methods and Compositions for Targeted Delivery of Therapeutic Agents |
US20090269341A1 (en) * | 2008-01-24 | 2009-10-29 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
-
2011
- 2011-09-28 WO PCT/US2011/053684 patent/WO2012050892A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060281685A1 (en) * | 1999-03-17 | 2006-12-14 | Michael Bernd | Methods of treatment using novel lhrh antagonists having improved solubility properties |
US20080027003A1 (en) * | 2004-05-27 | 2008-01-31 | Curepeptide Ltd. | Peptides Useful for Treating Gnrh Associated Diseases |
US20090087494A1 (en) * | 2006-09-12 | 2009-04-02 | Board Of Regents Of The University Of Nebraska | Methods and Compositions for Targeted Delivery of Therapeutic Agents |
US20090269341A1 (en) * | 2008-01-24 | 2009-10-29 | Esperance Pharmaceuticals | Lytic domain fusion constructs and methods of making and using same |
Non-Patent Citations (6)
Also Published As
Publication number | Publication date |
---|---|
WO2012050892A2 (en) | 2012-04-19 |
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