WO2012008785A3 - 라말린의 합성방법 - Google Patents

라말린의 합성방법 Download PDF

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Publication number
WO2012008785A3
WO2012008785A3 PCT/KR2011/005206 KR2011005206W WO2012008785A3 WO 2012008785 A3 WO2012008785 A3 WO 2012008785A3 KR 2011005206 W KR2011005206 W KR 2011005206W WO 2012008785 A3 WO2012008785 A3 WO 2012008785A3
Authority
WO
WIPO (PCT)
Prior art keywords
ramalin
synthesizing
preparing
present
hydrazinylphenol
Prior art date
Application number
PCT/KR2011/005206
Other languages
English (en)
French (fr)
Other versions
WO2012008785A2 (ko
Inventor
임정한
김일찬
이성구
김덕규
한세종
이형석
김성진
김태경
강필성
박희용
박하주
고혜연
박미라
박유경
Original Assignee
한국해양연구원
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한국해양연구원 filed Critical 한국해양연구원
Priority to JP2013519604A priority Critical patent/JP5684383B2/ja
Priority to CN201180039072.1A priority patent/CN103068794B/zh
Priority to US13/810,145 priority patent/US8865934B2/en
Priority to EP11807070.5A priority patent/EP2594552B1/en
Publication of WO2012008785A2 publication Critical patent/WO2012008785A2/ko
Publication of WO2012008785A3 publication Critical patent/WO2012008785A3/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/04—Preparation of hydrazides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

본 발명은 라말린의 합성방법에 관한 것으로, 더욱 상세하게는, 2-하이드라지닐-페놀(2-Hydrazinylphenol)과, 1번탄소의 카복실기 및 2번탄소의 아미노기가 보호된 L-글루탐산을 반응시키는 것을 특징으로 하는, 라말린의 합성방법 및 상기 라말린의 분해 방지방법에 관한 것이다. 본 발명에 따르면, 항산화 및 항염증 효과가 뛰어난 라말린을 안정적인 수율로 합성할 수 있어, 라말린의 대량생산이 가능하다. 또한, 라말린을 장기간 안정적으로 유지할 수 있어 라말린을 산업상 이용하기 용이하다.
PCT/KR2011/005206 2010-07-14 2011-07-14 라말린의 합성방법 WO2012008785A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013519604A JP5684383B2 (ja) 2010-07-14 2011-07-14 ラマリンの合成方法
CN201180039072.1A CN103068794B (zh) 2010-07-14 2011-07-14 制备树花素的方法
US13/810,145 US8865934B2 (en) 2010-07-14 2011-07-14 Method for preparing ramalin
EP11807070.5A EP2594552B1 (en) 2010-07-14 2011-07-14 Method for preparing ramalin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0067710 2010-07-14
KR20100067710A KR101182334B1 (ko) 2010-07-14 2010-07-14 라말린의 합성방법

Publications (2)

Publication Number Publication Date
WO2012008785A2 WO2012008785A2 (ko) 2012-01-19
WO2012008785A3 true WO2012008785A3 (ko) 2012-05-03

Family

ID=45469947

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/005206 WO2012008785A2 (ko) 2010-07-14 2011-07-14 라말린의 합성방법

Country Status (6)

Country Link
US (1) US8865934B2 (ko)
EP (1) EP2594552B1 (ko)
JP (1) JP5684383B2 (ko)
KR (1) KR101182334B1 (ko)
CN (1) CN103068794B (ko)
WO (1) WO2012008785A2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101290745B1 (ko) 2010-06-03 2013-07-29 한국해양과학기술원 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물
KR101371045B1 (ko) * 2012-01-19 2014-03-14 한국해양과학기술원 글루탐산 유도체와 하이드록시 아닐린 또는 하이드록시기가 보호된 하이드록시 아닐린을 이용한 라말린 및 라말린 전구체의 합성방법
KR101326256B1 (ko) 2012-02-28 2013-11-11 한국해양과학기술원 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물
KR101429242B1 (ko) * 2012-03-19 2014-08-12 한국해양과학기술원 다공성 매트릭스를 이용한 라말린의 안정화 방법 및 안정화된 라말린 용액
CN113456623A (zh) 2014-10-24 2021-10-01 韩国海洋研究院 用于预防或治疗神经变性疾病的含有Ramalin的组合物
KR102048869B1 (ko) * 2017-10-31 2019-11-27 케이에스랩(주) 중금속 주석을 사용하지 않는 라말린의 합성방법
JP6811507B1 (ja) * 2019-07-12 2021-01-13 株式会社Ｒｅｓｖｏ バイオピリンの分解防止剤
KR20230070702A (ko) * 2021-11-15 2023-05-23 한국해양과학기술원 신규한 라말린 유도체 및 이의 퇴행성 뇌질환의 예방 또는 치료 용도

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2010053327A2 (ko) * 2008-11-10 2010-05-14 한국해양연구원 신규 화합물인 r a m a l i n 및 그 용도

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CA920121A (en) * 1969-03-06 1973-01-30 Otsuka Hideo Corticotropically highly active octadecapeptides intermediates therefor and production of the same
US3726881A (en) * 1970-12-28 1973-04-10 Richter Gedeon Vegyeszet N-aminoxy-acetyl-n'-isonicotinoyl-hydrazine and the pharmaceutically acceptable salts thereof
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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
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See also references of EP2594552A4 *

Also Published As

Publication number Publication date
US8865934B2 (en) 2014-10-21
CN103068794B (zh) 2015-07-22
JP2013531035A (ja) 2013-08-01
KR20120007130A (ko) 2012-01-20
WO2012008785A2 (ko) 2012-01-19
EP2594552A4 (en) 2014-02-19
CN103068794A (zh) 2013-04-24
EP2594552A2 (en) 2013-05-22
US20130211133A1 (en) 2013-08-15
JP5684383B2 (ja) 2015-03-11
EP2594552B1 (en) 2017-01-11
KR101182334B1 (ko) 2012-09-20

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