WO2011150663A1

WO2011150663A1 - Bellows-type heat exchanger for body cavity hyperthermic perfusion

Info

Publication number: WO2011150663A1
Application number: PCT/CN2011/000168
Authority: WO
Inventors: 崔书然
Original assignee: 广州保瑞医疗技术有限公司
Priority date: 2010-06-03
Filing date: 2011-01-30
Publication date: 2011-12-08
Also published as: CN201772773U

Abstract

A bellows-type heat exchanger (68) for body cavity hyperthermic perfusion comprises a housing (1) having two separate inner chambers (11, 12) provided therein. A bellows (3) is arranged between the housing (1) and the inner chambers (11, 12). An inlet and an outlet (10, 20) for hot water and an inlet and an outlet (30, 40) for medical liquid are arranged on the housing (1). A lead-in port (50) for hot water is provided on the side wall of the inner chamber (11) corresponding to the inlet (10) for hot water, and a lead-out port (60) for hot water is provided on the side wall of the inner chamber (12) corresponding to the outlet (20) for hot water. The bellows (3) is made of aluminium alloy and hermetically connected to the housing (1) by adhesive. The heat exchanger (68) has the advantages of simple structure, good reliability and easy implementation.

Description

说明书波紋管式体腔热灌注热交换器技术领域 Description book bellows body cavity heat perfusion heat exchanger

本实用新型涉及热交换装置，具体通过加热作用而增强化疗药物对肿瘤细胞的杀伤效果，预防和治疗各类肿瘤术后腹膜种植转移和肿瘤复发而进行体腔热灌注治疗的一种波紋管式体腔热灌注热交换器。背景技术 The utility model relates to a heat exchange device, which specifically enhances the killing effect of a chemotherapeutic drug on tumor cells by heating, and prevents and treats various types of tumors, such as peritoneal implantation metastasis and tumor recurrence, and a bellows type body cavity for treating body cavity heat perfusion. Hot perfusion heat exchanger. Background technique

体腔热灌注技术是将化疗药物稀释液或癌性积液吸引到治疗机的无菌容器内加热后，通过植入体腔的两根导管注入体腔，使化疗药物稀释液或癌性积液在人体体腔与无菌容器间形成循环，通过计算机全程动态监测和反馈调节，使治疗液或癌性积液保持恒定的温度，稳定流量、流速，循环灌注，扩大药物在体腔内的作用面积，促进药物的吸收, 减少营养物质丟失，并以其显著的疗效正被人们逐渐接受，临床应用也日益广泛。体腔热灌注疗法可以有效地解决恶水越抽越涨的 "回潮" 问题，临床见效快，无反复，远期疗效较好，且无明显副作用及禁忌。然而，现有的体腔热灌注治疗仪也并非完美无缺，尤其是在进行热传递的过程中，热交换器的热传导效果以及药液在其中产生热对流效果等诸多结构因素将影响其加热效果。因此，随着科技的不断进步及产品的不断更新换代，肿瘤等引起的胸、腹水以及肿瘤手术切除以后的体腔热灌注治疗仪，尤其是其中的热交换器，还有待进一步的改进与革新才能适应患者的实际需要。发明内容 The body cavity thermal perfusion technique is to inject a chemotherapeutic drug diluent or a cancerous effusion into a sterile container of a therapeutic machine, and then inject into the body cavity through two catheters implanted in the body cavity to make a chemotherapeutic drug diluent or a cancerous effusion in the human body. The circulation between the body cavity and the aseptic container forms a constant temperature monitoring and feedback adjustment through the computer, so that the therapeutic fluid or the cancerous effusion maintains a constant temperature, stabilizes the flow rate, the flow rate, and circulates the perfusion, expands the action area of the drug in the body cavity, and promotes the drug. The absorption, the reduction of nutrient loss, and its remarkable efficacy are gradually being accepted by people, and the clinical application is also increasingly widespread. Body cavity hyperthermia therapy can effectively solve the "regaining tide" problem of rising water, and it has quick clinical effect, no repetition, good long-term effect, and no obvious side effects and contraindications. However, the existing body cavity thermal perfusion therapeutic apparatus is not perfect, especially in the process of heat transfer, the heat conduction effect of the heat exchanger and the heat convection effect of the liquid solution therein will affect the heating effect. Therefore, with the continuous advancement of technology and the continuous upgrading of products, the chest, ascites and tumor hands caused by tumors The body cavity hyperthermia therapeutic apparatus after the resection, especially the heat exchanger therein, needs further improvement and innovation to meet the actual needs of the patient. Summary of the invention

本实用新型所要解决的技术问题在于提供一种波紋管式体腔热灌注热交换器，通过加热化疗药物稀释液或癌性积液，以保持理想的恒定温度，稳定流量、流速，从而提髙治疗效果。 The technical problem to be solved by the utility model is to provide a bellows type body cavity heat perfusion heat exchanger, which can maintain the ideal constant temperature, stabilize the flow rate and the flow rate by heating the chemotherapy drug diluent or the cancerous effusion, thereby improving the treatment. effect.

本实用新型的技术问题是按如下技术方案实现的：构造一种波紋管式体腔热灌注热交换器，其特征在于，包括壳体及其分隔的两个内腔，在壳体及其内腔之间设置有波紋管，该波紋管呈波状结构，釆用铝合金材料，与壳体呈粘胶密封连接，并且，壳体分别设置有热水进、出口以及药液进、出口，而对应于热水进口的内腔的侧壁上设置有热水导入口，对应于热水出口的内腔的侧壁上设置有热水导出口。 The technical problem of the present invention is achieved according to the following technical solution: constructing a bellows type body cavity heat perfusion heat exchanger, comprising: a casing and two separated inner cavities thereof, in the casing and the inner cavity thereof A bellows is arranged between the bellows, the corrugated tube has a corrugated structure, and the aluminum alloy material is adhered to the shell by a glue seal, and the shell is respectively provided with hot water inlet and outlet, and liquid medicine inlet and outlet, and corresponding A hot water inlet is provided on a side wall of the inner chamber of the hot water inlet, and a hot water outlet is disposed on a side wall of the inner chamber corresponding to the hot water outlet.

实现本实用新型的波紋管式体腔热灌注热交换器，具有如下优点：将化疗药物稀释液或癌性积液实现了想的加热效果, 增强了化疗药物对肿瘤细胞的杀伤作用，减少耐药性的产生，有利于药物均匀分布,提高了杀灭体腔内游离恶性肿瘤细胞和残存的微小肿瘤转移病灶的效果，本实用新型构造新颖，结构简单, .可靠性好，实施容易。附图说明 The bellows type body cavity heat perfusion heat exchanger of the utility model has the following advantages: the medicinal drug diluent or the cancerous effusion achieves the desired heating effect, enhances the killing effect of the chemotherapeutic drug on the tumor cells, and reduces the drug resistance. The production of sex is beneficial to the uniform distribution of the drug, and the effect of killing the free malignant tumor cells in the body cavity and the residual microscopic tumor metastasis lesions is improved. The utility model has the advantages of novel structure, simple structure, good reliability and easy implementation. DRAWINGS

图 1为本实用新型波紋管式体腔热灌注热交换器的结构剖示图；图 2为本实用新型配套的体腔热灌注治疗仪实施例结构示意图。具体实施方式 1 is a cross-sectional view showing the structure of a bellows type body cavity heat perfusion heat exchanger according to the present invention; and FIG. 2 is a schematic structural view of an embodiment of a body cavity heat perfusion therapeutic apparatus according to the present invention. detailed description

如图 1所示的一种波紋管式体腔热灌注热交换器，包括壳体 1及其分隔的两个内腔 11、 12, 在壳体 1及其内腔之间设置有波紋管 3，并且，壳体 1分别设置有热水进口 10、热水出口 20, 以及药液进口 30、药液出口 40, 而对应于热水进口 10的腔的侧壁上设置有热水导入口 50，对应于热水出口 20的内腔的侧壁上设置有热水导出口 60。波紋管 3釆用铝合金管，且与壳体 1呈粘胶密封连接。 A bellows body cavity heat perfusion heat exchanger as shown in FIG. 1 includes a casing 1 and two compartments 11 and 12 separated therefrom, and a bellows 3 is disposed between the casing 1 and its inner cavity. Moreover, the housing 1 is provided with a hot water inlet 10, a hot water outlet 20, a chemical liquid inlet 30, and a chemical liquid outlet 40, and a hot water inlet 50 is disposed on a side wall of the cavity corresponding to the hot water inlet 10. A hot water outlet 60 is provided on a side wall corresponding to the inner cavity of the hot water outlet 20. The bellows 3 is made of an aluminum alloy tube and is adhesively sealed to the casing 1.

在进行热交换时，如图 1所示，热水从热水进口 10流进内腔 11 中, 经热水导入口 50进入波紋管 3的内侧壁流动，再从热水导出口 60流入内腔 12中，再通过热水出口 20流出；冷药液从药液进口 30 流进，经波紋管 3的外侧壁流动并充满其空间以后，热水和药液通过波紋管 3的管壁进行热交换，而再从药液出口 40流出的即为热药液。 In the heat exchange, as shown in Fig. 1, hot water flows into the inner chamber 11 from the hot water inlet 10, flows into the inner side wall of the bellows 3 through the hot water introduction port 50, and flows into the inner side of the hot water outlet 60. The chamber 12 is further discharged through the hot water outlet 20; the cold chemical liquid flows in from the chemical liquid inlet 30, flows through the outer side wall of the bellows 3 and fills the space thereof, and the hot water and the chemical liquid pass through the wall of the bellows 3 The heat is exchanged, and the hot liquid is discharged from the liquid medicine outlet 40.

在具体实施时，参考图 2所示，至少包括存储液袋 6及其呈管道连接的过滤器 66、热交换器 68以及测温接口 88, 还包括若干导管及其连接组件，热交换器 68的冷药液进口端连接过滤器 66，热交换器 68的热药液出口端连接测温接口 88，过滤器 66将药液进行过滤后流进热交换器中，热交换器 68用来进行内外循环的热交换，通过调节外循环水的温度，达到间接调节内循环温度的效果。 In a specific implementation, as shown in FIG. 2, at least the storage liquid bag 6 and its filter 66 connected to the pipe, the heat exchanger 68, and the temperature measuring interface 88 are further included, and further includes a plurality of pipes and connecting components thereof, and the heat exchanger 68 The inlet end of the cold liquid medicine is connected to the filter 66, and the hot liquid outlet end of the heat exchanger 68 is connected to the temperature measuring interface 88. The filter 66 filters the liquid and flows into the heat exchanger, and the heat exchanger 68 is used for performing The heat exchange between the inner and outer circulations achieves the effect of indirectly adjusting the inner circulation temperature by adjusting the temperature of the outer circulating water.

Claims

权利要求书 Claim

1、一种波紋管式体腔热灌注热交换器，其特征在于，包括壳体及其分隔的两个内腔，在所述壳体及其内腔之间设置有波紋管，并且, 所述壳体分别设置有热水进、出口以及药液进、出口，而对应于所述热水进口的内腔的侧壁上设置有热水导入口,对应于所述热水出口的内腔的侧壁上设置有热水导出口。 A bellows type body cavity heat perfusion heat exchanger, comprising: a housing and two compartments separated therefrom, a bellows disposed between the housing and the inner cavity thereof, and The housing is respectively provided with a hot water inlet and outlet and a chemical liquid inlet and outlet, and a side wall of the inner cavity corresponding to the hot water inlet is provided with a hot water introduction port corresponding to the inner cavity of the hot water outlet A hot water outlet is provided on the side wall.

2、根据杈利要求 1所述的波紋管式体腔热灌注热交换器，其特征在于, 所述波紋管为铝合金管，与所述壳体呈粘胶密封连接。 2. The bellows type body cavity heat infusion heat exchanger according to claim 1, wherein the bellows is an aluminum alloy tube and is in a visco-tight connection with the housing.