WO2011141823A3 - Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17 - Google Patents

Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17 Download PDF

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Publication number
WO2011141823A3
WO2011141823A3 PCT/IB2011/001448 IB2011001448W WO2011141823A3 WO 2011141823 A3 WO2011141823 A3 WO 2011141823A3 IB 2011001448 W IB2011001448 W IB 2011001448W WO 2011141823 A3 WO2011141823 A3 WO 2011141823A3
Authority
WO
WIPO (PCT)
Prior art keywords
antagonists
methods
treating
cell proliferation
proliferation disorders
Prior art date
Application number
PCT/IB2011/001448
Other languages
English (en)
Other versions
WO2011141823A2 (fr
Inventor
Jérémy BASTID
Nathalie Bonnefoy-Berard
Agnès DOREAU-BASTID
Jean-François ELIAOU
Original Assignee
Orega Biotech
Institut National De La Sante Et De La Recherche Medicale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orega Biotech, Institut National De La Sante Et De La Recherche Medicale filed Critical Orega Biotech
Priority to EP11743614.7A priority Critical patent/EP2569335B1/fr
Publication of WO2011141823A2 publication Critical patent/WO2011141823A2/fr
Publication of WO2011141823A3 publication Critical patent/WO2011141823A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne en général des méthodes de traitement et/ou de prévention de troubles prolifératifs, notamment les cancers, à l'aide d'antagonistes de IL-17. L'invention concerne également des méthodes et des trousses pour identifier des patients qui sont susceptibles de répondre au traitement et/ou à la prévention de troubles prolifératifs à l'aide d'antagonistes de IL-17.
PCT/IB2011/001448 2010-05-14 2011-05-13 Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17 WO2011141823A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP11743614.7A EP2569335B1 (fr) 2010-05-14 2011-05-13 Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33497910P 2010-05-14 2010-05-14
US61/334,979 2010-05-14

Publications (2)

Publication Number Publication Date
WO2011141823A2 WO2011141823A2 (fr) 2011-11-17
WO2011141823A3 true WO2011141823A3 (fr) 2012-01-05

Family

ID=44583192

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/001448 WO2011141823A2 (fr) 2010-05-14 2011-05-13 Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17

Country Status (3)

Country Link
US (2) US20110293629A1 (fr)
EP (1) EP2569335B1 (fr)
WO (1) WO2011141823A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106687135A (zh) * 2014-09-15 2017-05-17 豪夫迈·罗氏有限公司 使用pd‑1轴结合拮抗剂和il‑17结合拮抗剂治疗癌症的方法

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US8597239B2 (en) * 2011-03-01 2013-12-03 Sanovas, Inc. Abrading balloon catheter for extravasated drug delivery
US20160074581A1 (en) 2014-09-17 2016-03-17 Lawrence J. Gerrans Modulated Drug Delivery
WO2013070563A1 (fr) * 2011-11-07 2013-05-16 Merck Sharp & Dohme Corp. Traitement de troubles auto-immuns et inflammatoires par inhibition de blimp-1
US9284283B2 (en) 2012-02-02 2016-03-15 Ensemble Therapeutics Corporation Macrocyclic compounds for modulating IL-17
AR090626A1 (es) 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos
EP3417878A1 (fr) * 2012-06-12 2018-12-26 Orega Biotech Antagonistes d'isoformes il-17 et leurs utilisations
WO2013186236A1 (fr) * 2012-06-12 2013-12-19 Orega Biotech Antagonistes d'isoformes d'il-17 et leurs utilisations
WO2014001368A1 (fr) 2012-06-25 2014-01-03 Orega Biotech Anticorps antagonistes de l'il-17
ES2923942T3 (es) * 2013-11-06 2022-10-03 Us Health Procedimiento para el subtipado de tipos de linfoma por medio de perfiles de expresión
WO2016098041A1 (fr) 2014-12-18 2016-06-23 Saarum Sciences Private Ltd Établissement et utilisation d'une plateforme in vitro pour transition épithélio-mésenchymateuse (emt)
US20190151346A1 (en) * 2016-05-10 2019-05-23 INSERM (Institute National de la Santé et de la Recherche Médicale) Combinations therapies for the treatment of cancer
CN110551215A (zh) * 2018-05-30 2019-12-10 中山康方生物医药有限公司 抗白细胞介素-17a抗体、其药物组合物及其用途
US10846964B2 (en) 2018-06-01 2020-11-24 Sentrilock, Llc Electronic lockbox with interface to other electronic locks
GB201810327D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to IL-17
GB201820316D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for IL-17
US11753849B2 (en) 2019-03-27 2023-09-12 Sentrilock, Llc Electronic lockbox
EP4007775A1 (fr) 2019-08-02 2022-06-08 Orega Biotech Nouveaux anticorps il-17b
JP2023506083A (ja) 2019-12-16 2023-02-14 バイスクルテクス・リミテッド Ｉｌ－１７に特異的な二環式ペプチドリガンド
WO2023069510A1 (fr) * 2021-10-19 2023-04-27 The United States Government As Represented By The Department Of Veterans Affairs Compositions à base de cannabinoïdes pour des troubles gastro-intestinaux

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106687135A (zh) * 2014-09-15 2017-05-17 豪夫迈·罗氏有限公司 使用pd‑1轴结合拮抗剂和il‑17结合拮抗剂治疗癌症的方法

Also Published As

Publication number Publication date
US20140023650A1 (en) 2014-01-23
EP2569335B1 (fr) 2018-08-22
WO2011141823A2 (fr) 2011-11-17
US20110293629A1 (en) 2011-12-01
EP2569335A2 (fr) 2013-03-20

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