WO2011125073A1 - Dispositif d'administration de stérilisant dans l'utérus d'une chienne pour une stérilisation transcervicale - Google Patents
Dispositif d'administration de stérilisant dans l'utérus d'une chienne pour une stérilisation transcervicale Download PDFInfo
- Publication number
- WO2011125073A1 WO2011125073A1 PCT/IN2011/000239 IN2011000239W WO2011125073A1 WO 2011125073 A1 WO2011125073 A1 WO 2011125073A1 IN 2011000239 W IN2011000239 W IN 2011000239W WO 2011125073 A1 WO2011125073 A1 WO 2011125073A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sterilant
- uterus
- cuffs
- delivery
- contraceptive
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12027—Type of occlusion
- A61B17/1204—Type of occlusion temporary occlusion
- A61B17/12045—Type of occlusion temporary occlusion double occlusion, e.g. during anastomosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12136—Balloons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
- A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
- A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
- A61F6/18—Inserters or removers ; Apparatus for loading an intra-uterine device into an insertion tube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00535—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated
- A61B2017/00557—Surgical instruments, devices or methods, e.g. tourniquets pneumatically or hydraulically operated inflatable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/12127—Double occlusion, e.g. for creating blood-free anastomosis site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22051—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation
- A61B2017/22054—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation with two balloons
Definitions
- the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization.
- More particularly it relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization not only by overcoming difficulties of two right angles and mucous plug in the female dog cervix, but also by overcoming difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- the main difficulty in sterilization, particularly the transcervical sterilization of female dogs is due to impossible approach to uterus due to two right angles and mucus plug in the female dog cervix. These problems are further enhanced due to very tighten muscles of cervical canal. Additionally, the spasmodic contraction of muscles of cervical canal adds further to these difficulties. Therefore, delivery of a sterilant, be. it a liquid, past these obstacles posses a very serious problem in transcervical sterilization of female dogs.
- present inventions aims to solve above-described problems by providing a device for delivery of sterilant in uterus of female dog for transcervical sterilization which should be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- main object of present inventions is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of overcoming difficulties of two right angles, mucus plug in the female dog cervix, as well as difficulties of very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- Another object of present invention is to provide a device for delivery of sterilant in uterus of female dog for transcervical sterilization which has been found to be capable of delivering a liquid sterilant or semi-solid liquid sterilant or liquid of high viscosity sterilant upto uterus by overcoming difficulties posed by two right angle turns and mucus plug in the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- Figure 1 is schematic representation of the female dog's reproductive system showing interconnections of its uterus, cervical canal and vagina.
- Figure 2 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with one of the preferred embodiments of present invention.
- Figure 3 is a schematic representation of device for delivery of sterilant in uterus of female dog for transcervical sterilization in accordance with another preferred embodiment of present invention.
- Figure 4 illustrates a prototype manufactured in accordance with one of the preferred embodiments of the present invention, wherein the device in accordance with Figure x 3 further comprises an inflating means, a vibrating means, a vacuum means, and a sterilant injecting (or supply) means.
- Figure 5 illustrates X-ray of uterus region of sterilized female dog after injecting the sterilant with the help of prototype of Figure 4.
- the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes and at least one projection provided with inflatable and vibratable cuffs.
- a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube having a hole running through its length and provided with one or more vertical holes, and at least two projections each provided with corresponding inflatable and vibratable cuffs, wherein at least one vacuum suction ring is provided in-between two projections.
- the device further comprises a vacuum means, a vibrating means, an inflating means and a sterilant injecting (or supply) means.
- the inventor confirms that the presently provided devices of above embodiments have been found to be capable of overcoming difficulties of two right angle turns, mucous plug in the cervix, as well as difficulties of tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal in the reproductive system of female dog during injecting sterilant.
- a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallopian tubes.
- the reproductive system of female dog [Figure 1 ] comprises vagina 1 , cervical canal 2, uterine horn'3, mucous plug 4 which blocks the cervical canal, cervix-vaginal junction 5, and uterine horn-cervical canal junction ' 6.
- the mucus plug 4 causes total blockage in cervical canal 2, and hence, blocks way of sterilant from vagina to uterus.
- the muscles of cervical canal 2 are very tighten and continuously cause spasmodic contraction which have been found to cause reversal of sterilant if injected in the vagina, and hence, the sterilant does not flow from vagina to uterus.
- the present invention relates to a device for delivery of sterilant in uterus of female dog for transcervical sterilization comprising a cylindrical tube 1 1 having a hole 12 running through its length and provided with one or more vertical holes 13 and at least one projection 14 provided with inflatable and vibratable cuffs 15 [Figure ?].
- the device comprises at least two projections 14 each provided with corresponding inflatable and vibratable cuffs 15, wherein at least one vacuum suction ring 16 is provided in-between two projections 14 [Figure 3].
- the device further comprises an inflating means 21 , a vibrating means 22, a vacuum means 23, and a sterilant injecting (or supply) means 24 [Figure 4].
- the inventor confirms that the presently disclosed devices of above embodiments have overcome above-described difficulties caused by two right angles (90° angle) turns 5 and 6, mucous plug 4 in the cervix 2, as well as tighten muscles of cervical canal 2, and spasmodic contraction of muscles of cervical canal 2 in flow of sterilant, and hence, have demonstrated advantages of causing free flow of sterilant in reproductive system of female dog.
- the cuffs 15 are inflatable cuffs which have been found to have advantage of causing seal in vagina, and hence, avoiding reversal of sterilant once injected.
- the cuffs are connectable to inflating means for causing inflation thereof.
- the inflating means may be provided at any location which is convenient for construction of device, preferably the inflating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
- the cuffs 15 are inflatable cuffs as well as capable of vibrating which not only have advantage of causing seal in vagina, but also have advantage of causing vibration in the vagina.
- the cuffs are inflated by means of inflating means, and their vibration is caused by means of vibrating means. Accordingly, in one embodiment, the cuffs are connectable to inflating means for causing inflation thereof and vibrating means for causing vibration thereof.
- the vibrating means may be provided at any location which is convenient for construction of device, preferably the vibrating means are provided on one end of the device or may also be provided on or around the cuffs as illustrated in accompanying Figure 4.
- the vibrating means is electromechanical vibrator which not only causes vibration in cuffs, but also inflates the cuffs. Therefore, in accordance with this preferred embodiment of present invention, the inflating means and vibrating means are one means.
- the vibrating means which may also be capable of causing inflation of cuffs, is embedded within the sterilant or contraceptive source, or is provided on one end of the device or may also be provided on or around the cuffs.
- vibration of cuffs also cause expansion of joining point 5 of cervical canal 2 and vagina 1, and joining point 6 of cervical canal 2 and uterus 3, which results in a comfortable and easy way for sterilant being injected through hole 12 and passing through holes 13 of present device to pass through the vagina 1 , cervical canal 2 and uterine horn 3 to yterus.
- vibration of cuffs also results in loosening of muscles of cervical canal 2, and thereby effects of spasmodic contraction are greatly reduced, meaning thereby, reversal of sterilant injected in vagina is totally avoided, and hence, sterilant flows freely from vagina to uterus through cervical canal.
- the vacuum suction ring
- the opposite end 18 of present device is closed which has advantage of avoiding flow of sterilant without having caused dislodgement of mucous plug and expansion of junctions 5 and 6, and relaxing of muscles of cervical canal, because any such advance flow of sterilant causes hindrance in functioning of present device.
- present device is capable of delivering a sterilant selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity upto uterus for transcervical sterilization by overcoming difficulties posed by two right angle turns and mucous plug in; the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- a sterilant selected from a group comprising liquid sterilant, semi-solid liquid sterilant and liquid sterilant of high viscosity upto uterus for transcervical sterilization by overcoming difficulties posed by two right angle turns and mucous plug in; the female dog cervix, as well as by very tighten muscles of cervical canal, and spasmodic contraction of muscles of cervical canal.
- present device has been described for application in delivering a liquid sterilant in uterus of a female dog.
- the present device may also be employed to deliver a contraceptive selected from a group comprising a solid contraceptive, wire form contraceptive and a contraceptive capable of forming a plug in uterus.
- present device may be employed to deliver any contraceptive in desired region of any animal or human being provided the dimensions of hole 12, holes 13 and cuffs 14 are made in accordance with animal and human being and the contraceptive to be injected.
- the opposite end 18 may be kept open.
- the device further comprises an endoscope so that its insertion and movement can be controlled for efficient delivery of sterilant.
- the sterilant is a liquid polymer sterilant which is styrene maleic anhydride (SMA) complexed with dimethyl sulfoxide (DMSO) [RISUGTM], which is in Phase III trials as a human male contraceptive and already tested for toxicology and during the animal trials has also been found to be suitable as female contraceptive, or its modified form having diluted styrene maleic anhydride complexed with dimethyl sulfoxide (DMSO), or further modified form having magnetic particles.
- SMA styrene maleic anhydride
- DMSO dimethyl sulfoxide
- the cuffs 15 are inflated by applying pressure through inflating means so as to cause seal in vagina, and thereafter, vibrating means is switched on so as to cause vibration of inflated cuffs, which results in relaxing of muscles of cervical canal, and expansion of junctions 5 and 6, and loosening of mucous plug, which slowly gets dislodged.
- present device when present device is operated with pulsed alternating pressure it comfortably, easily and successfully forced the sterilant through the cervical canal.
- This embodiment permits delivery of even thicker fluids than with continuous pressure. Alternating pulsed pressure with pulsed suction from the vacuum seal managed to dislodge the mucous plug more conveniently, which is a vital step in transcervical sterilization and has been achieved by present invention.
- a reference to 'uterus' or 'uterus region' is intended to include the uterus, uterine horns and fallop an tubes.
- the sterilant passes via uterus to the fallopian tubes.
- the long term contraceptive action is achieved when sterilant reaches and lodges in the fallopian tubes.
- the sterilant delivered through present device has been found to reach and lodge in the fallopian tubes as it is observed from the X-ray scan [ Figure 5].
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Public Health (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
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Abstract
L'invention concerne un dispositif d'administration de stérilisant dans l'utérus d'une chienne pour une stérilisation transcervicale qui comprend un tube cylindrique (11) possédant un trou (12) traversant toute la longueur du tube et comportant un ou plusieurs trous verticaux (13) et au moins une saillie (14) munie de ballonnets gonflables et vibrants (15). Dans l'un des modes de réalisation, le dispositif comprend au moins deux saillies (14) chacune munie de ballonnets gonflables et vibrants (15), au moins un anneau d'aspiration sous vide (16) placé entre les saillies (14). Dans l'un des modes de réalisation, le dispositif comprend, en outre, des moyens de gonflage (21), des moyens de vibration (22), des moyens de mise sous vide (23), et des moyens d'injection (ou d'administration) du stérilisant (24).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN881/DEL/2010 | 2010-04-09 | ||
IN881DE2010 | 2010-04-09 |
Publications (1)
Publication Number | Publication Date |
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WO2011125073A1 true WO2011125073A1 (fr) | 2011-10-13 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IN2011/000239 WO2011125073A1 (fr) | 2010-04-09 | 2011-04-06 | Dispositif d'administration de stérilisant dans l'utérus d'une chienne pour une stérilisation transcervicale |
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WO (1) | WO2011125073A1 (fr) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013061341A1 (fr) * | 2011-10-28 | 2013-05-02 | Sujoy Kumar Guha | Dispositif contraceptif intra-utérin amélioré |
CN104127954A (zh) * | 2014-08-18 | 2014-11-05 | 梁季鸿 | 一种一次性自助式人工助孕装置 |
CN104665954A (zh) * | 2013-12-02 | 2015-06-03 | 绍兴万佳器械有限公司 | 一种高效型兽用注射枪 |
EP2723673B1 (fr) * | 2011-06-24 | 2020-01-22 | Heidi Hall | Mors et système pour envoyer une substance visqueuse et/ou liquide dans la bouche d'un animal |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050245902A1 (en) * | 2002-02-08 | 2005-11-03 | Brian Cornish | Substance delivery device |
US20070015965A1 (en) * | 2005-07-13 | 2007-01-18 | Usgi Medical Inc. | Methods and apparatus for colonic cleaning |
US20100022947A1 (en) * | 2007-02-12 | 2010-01-28 | Noam Hassidov | Inflatable chamber device for motion through a passage |
-
2011
- 2011-04-06 WO PCT/IN2011/000239 patent/WO2011125073A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050245902A1 (en) * | 2002-02-08 | 2005-11-03 | Brian Cornish | Substance delivery device |
US20070015965A1 (en) * | 2005-07-13 | 2007-01-18 | Usgi Medical Inc. | Methods and apparatus for colonic cleaning |
US20100022947A1 (en) * | 2007-02-12 | 2010-01-28 | Noam Hassidov | Inflatable chamber device for motion through a passage |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2723673B1 (fr) * | 2011-06-24 | 2020-01-22 | Heidi Hall | Mors et système pour envoyer une substance visqueuse et/ou liquide dans la bouche d'un animal |
WO2013061341A1 (fr) * | 2011-10-28 | 2013-05-02 | Sujoy Kumar Guha | Dispositif contraceptif intra-utérin amélioré |
CN104665954A (zh) * | 2013-12-02 | 2015-06-03 | 绍兴万佳器械有限公司 | 一种高效型兽用注射枪 |
CN104127954A (zh) * | 2014-08-18 | 2014-11-05 | 梁季鸿 | 一种一次性自助式人工助孕装置 |
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