WO2011114343A1 - Système d'administration de médicament parental multidose doté d'une cartouche de verre échangeable - Google Patents

Système d'administration de médicament parental multidose doté d'une cartouche de verre échangeable Download PDF

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Publication number
WO2011114343A1
WO2011114343A1 PCT/IN2010/000305 IN2010000305W WO2011114343A1 WO 2011114343 A1 WO2011114343 A1 WO 2011114343A1 IN 2010000305 W IN2010000305 W IN 2010000305W WO 2011114343 A1 WO2011114343 A1 WO 2011114343A1
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
drug delivery
dose
piston
delivery system
Prior art date
Application number
PCT/IN2010/000305
Other languages
English (en)
Inventor
Pawan Trilokchand Agrawal
Zameer Pawan Agarwal
Original Assignee
Pawan Trilokchand Agrawal
Zameer Pawan Agarwal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pawan Trilokchand Agrawal, Zameer Pawan Agarwal filed Critical Pawan Trilokchand Agrawal
Publication of WO2011114343A1 publication Critical patent/WO2011114343A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member

Definitions

  • This invention relates to an injection device or drug delivery system with exchangeable glass cartridge.
  • This invention specially adapted to provide multiple measured injections of preset dose of all homogeneous liquid formulations which are very frequent used in the hospitals, (e.g: Amicacin).
  • This invention also uses simple, comfort and novel mechanism to deliver multiple injectable doses.
  • the subject matter in the European Patent Application No. 058536 discloses device in which by rotating the drive member of a gear mechanism which is constituted by a threaded sleeve in contact with plunger, the later of the pre filled syringe of this device is advanced.
  • the rotating motion of the drive member is limited by a stop, and a coupling means takes care that the drive member can be turned backwards away from the stop without engagement with the gear mechanism.
  • the drive member is in each case turned backward to select desired amount of liquid and then it turned forward for dispensing the pre selected amount of liquid to the patient through the needle.
  • Such conventional device requires one more person other than the user for injection of the drug because during injection the device must be held with one hand, and the drive member must be turned with the other hand. Furthermore, when the turning step is limited by a stop, there is the danger that the device and thus also the needle are tilted.
  • An especially grave drawback resides in that only a small amount of liquid can be injected with one turning motion, and, for injection of a relatively large amount of liquid, the drive member-with the needle having been inserted-would have to be turned back and forth repeatedly.
  • a window in the cap permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected.
  • the overall length of the pen diminishes.
  • a collar is rotatably coupled to, but is not longitudinally adjustable with respect to, the syringe housing.
  • a liquid filled cap coupled by threads to the plunger rod is selectively adjustable to vary the desired dosage.
  • Indicia in the form of a dose-indicating scale situated on the cap is hidden by the collar except for a window in the collar which permits only a portion of the scale to be viewed, the visible portion being indicative of the dose selected.
  • the overall length of the pen remains substantially unchanged with repeated use.
  • Both the above embodiment involves some what complicated mechanical steps during charging of the desired amount of dose as well as during injection of the dose through needle which increase the cumbersome during manufacturing as well as operation and in the above mentioned device once drug holding container is empty the whole device is to be thrown and one is to purchase the new device for use which increases the medical waste other materials and there by increase the cost.
  • a disposable multi-dose device or with exchangeable liquid filled container having simple working mechanism during the operation and less medical wastages, more economical and capable of use with the user J himself.
  • the present invention over comes all the disadvantages and fulfils all the above requirements by providing an injection device wherein exactly preset or pre selected amount of liquid is being administered repeatedly through needle by means of single pushing pressure exerted on the lever.
  • This invention further objects to provide simple mechanical arrangement, comfort and novel mechanical steps during operation; it also objects to provide reduction of 80% medical waste and thereby provides more economical than the conventional system.
  • Regular syringes that available in the market uses 10 glass ampoule of 22 grams, 10 needles of 1.5 grams, 20 individual packing (10 ampoule +10 syringe) and 10 syringe and 10 needle cover of 39 grams for the same formulation of liquid quantity as used in the present multi dose drug delivery device within the cartridge, while our present system or device only uses 1 cartridge of 8 grams, 10 needles of 0.3 grams, 11 individual packing (10 needles + 1 cartridge cover) and 1 syringe and 10 needle cover of 2 grams respectively and thereby saves 175% of glass materials, 400% SS (Stainless steel) materials and 1850% of plastic materials respectively.
  • the present multi dose drug delivery system would helps to reduce 80% of medical waste and provides more economical than the conventional devices or syringes.
  • the main object of the invention is to provide portable pen like multi dose parental drug delivery system enable to use for longer term by providing exchangeable long glass cartridge, injecting assembly, rotatable knob, compressing spring and lever.
  • This invention also objects to provide the system that uses novel screw mechanism with the help of compression spring and said mechanical screw drive assembly and this invention also object to provide reduction of nearly 80% of the medical waste and more economical than the conventional parental drug delivery system.
  • Multi dose parental drug delivery system comprises two protecting housing at the distal and proximal sections of the ' system mated with teethed clip like structure.
  • the distal protecting housing encompasses glass cartridge while the proximal one encompasses mechanical screw drive assembly, compression spring, reverse mechanism knob, fixed rod.
  • Such system except cartridge is made up from plastic polymers of (PP) grade works on a novel screw mechanism principle with the help of compression spring.
  • the drug delivery has to be made it can be charged 0.5 ml to 2 ml at a time by twisting the knob which is on the other end of the drug delivery system.
  • the compression spring plays very important role. Consequence to this when lever is pushed to eject the dose which have been set or charged already, the delivery of drug is possible as the injecting assembly distally advances in the longitudinal direction and pushes in the cartridge.
  • Figure 1 is a cross - sectional view of the multi dose drug delivery system of the present invention in stable or static condition prior to mounting of needle assembly.
  • Figure 2 is the cross sectional view of the bottom or rear part of the system.
  • Figure 3 is the cross sectional view of the state of whole system just later to rotating the bottom knob.
  • Figure 4 is the cross sectional view of state of the whole system just later to pushing mechanism of lever in the direction of the arrow shown.
  • Figure 5 is the cross sectional view of the system during the exchange of the cartridge. Best mode for carrying out invention
  • Injection pen (15) includes external cap (1), external protective housing (13) of the proximal section of the system mating with the external cartridge holder (2) fixedly secured together through the teethed clip like structure as diagrammatically shown in fig. 1, and such an external protecting made up of plastic polymers is extending from outer proximal end to a distal end of the system, within the liquid filled interior of tubular body of glass cartridge (10) a multi dose quantity of fluid (liquid) medicine being sealed to deliver by operation of pen (15).
  • Medicine may be of any homogeneous liquid drug variety, * ⁇ which do not react with the external glass structure; at the distal end of cartridge (10) head like tubular hub (16) is disposed and such hub is made up of external aluminium covering and synthetic rubber or septum inside the covering on which hyperdermic needle of known design is to be mounted by piercing the membrane or septum and entering and communicating with the interior of the cartridge.
  • the glass_cartridge (10) may be transparent to allow the contained medicine to be visible to let a user to estimate the amount remaining.
  • Whole device except cartridge is made up from plastic polymers of (PP) grade.
  • Screw holder (7) being mechanically disposed over fixed rod (4) to provide mechanical support for the screw drive assembly (18) as diagrammatically shown in fig. 1 and 2, clip trigger (11) being operably disposed with the leg like portion of the screw holder (7) and at the proximal end of clip trigger spring holder (12) being connected through washer ring (8) to provide mechanical support to the spring (14) during operation.
  • Reverse mechanism knob (9) projecting from the proximal end of cartridge provides holding support for piston (17) during initial equilibrium state of the system and it also helps to bring the screw drive (18) into initial stable equilibrium position by rotating it manually, once when all the liquid contents have been dispensed by it.
  • the said piston like structure (17) axially slides within liquid filled interior of cartridge (2) along a middle interior section of the cartridge length and further the piston (17) has sealing periphery in a fluid tight engagement with the liquid filled interior-defining internal surface of cartridge to contain the fluid medication.
  • these components Positioned proximally of piston (17) are the components that function, in a preferred embodiment, to allow any one of a number of quantities of medicine to be selected and expelled from the pen by a user.
  • these components include a manually operable dosage knob (6) that projects from the proximal end of the protective housing (13); a fixed rod (4) with slidable plunger rod (5) and spring (14) is operably connected to knob (6), this fixed rod extending in an axial or longitudinal direction within the centre of the proximal section of the system over which movable plunger rod (5) slides: The advancing height of the plunger rod (5) depends on the potential energy stored inside the compression spring (14) during rotation of the knob (6).
  • Dosage knob (6) is rotatable in a conventional clock wise direction to set the dose to be injected, which rotation causes the spring (14) to compress in the downward direction that results into detachment of washer ring (8) from spring holder (12) as diagrammatically shown in figure (3) and due this compressing operation potential energy is stored inside the spring (14). This action causes the desired amount of dose to be set. Consequence to this the pushing employment of lever in the direction as shown in fig.4, triggers the clip trigger (11) to cause plunger rod (5) to advance in the distal direction to shift piston (17) distally forward for dispensing the set dose of medicine through needle.
  • the longitudinal advancing height of the plunger rod (5) depends on the potential energy stored inside the spring which in turn depends on number of rotating turns of knob (6).
  • the drive assembly (18) overall is axially secured within the volume of the proximal part of the system. Such securement may be achieved by attaching, such as via compression spring (14), the screw drive assembly (18) to the interior wall of fixed rod (4).

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un système d'administration de médicament parental multidose. Ledit système, à l'exception de la cartouche, est constitué de polymères plastiques de catégorie polypropylène, et fonctionne sur un nouveau principe de mécanisme à levier avec l'aide d'un ressort de compression. Lorsque l'administration de médicament doit avoir lieu, le système peut être chargé de 0,5 ml à 2 ml en une fois par torsion de la poignée qui se situe sur l'autre extrémité du système d'administration de médicament. En conséquence, lorsque le levier est poussé pour éjecter la dose qui a déjà été réglée ou chargée, l'administration du médicament est possible à mesure que l'ensemble d'injection avance distalement dans le sens de la longueur et pousse la cartouche.
PCT/IN2010/000305 2010-03-19 2010-05-13 Système d'administration de médicament parental multidose doté d'une cartouche de verre échangeable WO2011114343A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN751MU2010 2010-03-19
IN751/MUM/2010 2010-03-19

Publications (1)

Publication Number Publication Date
WO2011114343A1 true WO2011114343A1 (fr) 2011-09-22

Family

ID=44648500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000305 WO2011114343A1 (fr) 2010-03-19 2010-05-13 Système d'administration de médicament parental multidose doté d'une cartouche de verre échangeable

Country Status (1)

Country Link
WO (1) WO2011114343A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114681326A (zh) * 2022-02-23 2022-07-01 罗文悦 结直肠癌患者多基因多因素定量给药***及其使用方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338806A2 (fr) * 1988-04-18 1989-10-25 Turner, Robert Charles Seringues
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
CN2774544Y (zh) * 2004-11-29 2006-04-26 纪柏 适用卡式瓶胰岛素笔式注射器
WO2007063342A1 (fr) * 2005-12-02 2007-06-07 Owen Mumford Limited Méthode d’injection et appareil
US20080147005A1 (en) * 2004-10-21 2008-06-19 Novo Nordisk A/A Dial-Down Mechanism for Wind-Up Pen

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0338806A2 (fr) * 1988-04-18 1989-10-25 Turner, Robert Charles Seringues
US5320609A (en) * 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
US20080147005A1 (en) * 2004-10-21 2008-06-19 Novo Nordisk A/A Dial-Down Mechanism for Wind-Up Pen
CN2774544Y (zh) * 2004-11-29 2006-04-26 纪柏 适用卡式瓶胰岛素笔式注射器
WO2007063342A1 (fr) * 2005-12-02 2007-06-07 Owen Mumford Limited Méthode d’injection et appareil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114681326A (zh) * 2022-02-23 2022-07-01 罗文悦 结直肠癌患者多基因多因素定量给药***及其使用方法

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