WO2011091410A8 - Trpv4 antagonists - Google Patents
Trpv4 antagonists Download PDFInfo
- Publication number
- WO2011091410A8 WO2011091410A8 PCT/US2011/022380 US2011022380W WO2011091410A8 WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8 US 2011022380 W US2011022380 W US 2011022380W WO 2011091410 A8 WO2011091410 A8 WO 2011091410A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trpv4 antagonists
- trpv4
- antagonists
- indole
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
The present invention relates to indole or benzothiophene analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29786410P | 2010-01-25 | 2010-01-25 | |
| US61/297,864 | 2010-01-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2011091410A1 WO2011091410A1 (en) | 2011-07-28 |
| WO2011091410A8 true WO2011091410A8 (en) | 2011-11-24 |
Family
ID=44307279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2011/022380 WO2011091410A1 (en) | 2010-01-25 | 2011-01-25 | Trpv4 antagonists |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2011091410A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9499533B2 (en) | 2012-03-27 | 2016-11-22 | Shionogi & Co., Ltd. | Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity |
| JPWO2015046193A1 (en) | 2013-09-25 | 2017-03-09 | 塩野義製薬株式会社 | Aromatic heterocyclic amine derivatives having TRPV4 inhibitory activity |
| MA40538A (en) * | 2014-08-28 | 2021-04-07 | X Chem Inc | SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND USES OF THEM |
| ES2883938T3 (en) | 2014-12-29 | 2021-12-09 | Us Health | Small Molecule Lactate Dehydrogenase Inhibitors and Methods of Using Them |
| BR112022024553A2 (en) | 2020-07-16 | 2023-01-24 | Raqualia Pharma Inc | COMPOUND WITH TRPV4 INHIBITORY ACTIVITY OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND THEIR USE, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT OF DISEASE OF THE RETIN ACCOMPANIED BY DISORDERS OF BLOOD FLOW OR CELL DISORDERS, KIT FOR USE IN THE PREVENTION OR TREATMENT OF DISEASES, DISEASE FOR A DISEASE OF THE RETINA, METHOD FOR DETECTING A DISEASE OF THE RETINA, METHODS OF SCREENING FOR A SUBSTANCE THAT SUPPRESSES EXPRESSION OF THE TRPV4 GENE, ONE THAT DECREASES THE EXPRESSION LEVEL OF A TRPV4 PROTEIN, AND ONE THAT INHIBITS THE ACTIVITY OF A TRPV4 PROTEIN. TRPV4 AND AN AGENT TO PREVENT OR TREAT DISEASE OF THE RETINA |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006029154A2 (en) * | 2004-09-07 | 2006-03-16 | Smithkline Beecham Corporation | Novel compounds |
| WO2007070865A2 (en) * | 2005-12-15 | 2007-06-21 | Smithkline Beecham Corporation | Piperazine compounds as agonists of trpv4 channel receptors |
-
2011
- 2011-01-25 WO PCT/US2011/022380 patent/WO2011091410A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011091410A1 (en) | 2011-07-28 |
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