WO2011091131A3 - Eslicarbazepine acetate and its polymorphs - Google Patents

Eslicarbazepine acetate and its polymorphs Download PDF

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Publication number
WO2011091131A3
WO2011091131A3 PCT/US2011/021852 US2011021852W WO2011091131A3 WO 2011091131 A3 WO2011091131 A3 WO 2011091131A3 US 2011021852 W US2011021852 W US 2011021852W WO 2011091131 A3 WO2011091131 A3 WO 2011091131A3
Authority
WO
WIPO (PCT)
Prior art keywords
eslicarbazepine acetate
polymorphs
preparation
eslicarbazepine
acetate
Prior art date
Application number
PCT/US2011/021852
Other languages
French (fr)
Other versions
WO2011091131A2 (en
Inventor
Srinivas Katkam
Rajeshwar Reddy Sagyam
Ravinder Buchikonda
Murali Mohan Muttavarapu
Sridhar Munagala
Rambabu Chikka
Original Assignee
Dr. Reddy's Laboratories Ltd.
Dr. Reddy's Laboratories, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Reddy's Laboratories Ltd., Dr. Reddy's Laboratories, Inc. filed Critical Dr. Reddy's Laboratories Ltd.
Publication of WO2011091131A2 publication Critical patent/WO2011091131A2/en
Publication of WO2011091131A3 publication Critical patent/WO2011091131A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Processes for the preparation of eslicarbazepine acetate and intermediates thereof. Also provided are polymorphic forms of eslicarbazepine acetate and methods for their preparation.
PCT/US2011/021852 2010-01-23 2011-02-08 Eslicarbazepine acetate and its polymorphs WO2011091131A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN155/CHE/2010 2010-01-23
IN155CH2010 2010-01-23
US32016010P 2010-04-01 2010-04-01
US61/320,160 2010-04-01

Publications (2)

Publication Number Publication Date
WO2011091131A2 WO2011091131A2 (en) 2011-07-28
WO2011091131A3 true WO2011091131A3 (en) 2011-12-22

Family

ID=44307578

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/021852 WO2011091131A2 (en) 2010-01-23 2011-02-08 Eslicarbazepine acetate and its polymorphs

Country Status (1)

Country Link
WO (1) WO2011091131A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011138795A2 (en) * 2010-05-03 2011-11-10 Msn Laboratories Limited Process for preparing (s)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f] azepine-5-carboxamide
WO2012121701A1 (en) * 2011-03-07 2012-09-13 Watson Laboratories, Inc. Process for the resolution of racemic (±)-10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide
US9346760B2 (en) 2011-03-08 2016-05-24 Jubilant Life Sciences Limited Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy dihydrodibenz[B,F]azepines by enantioselective reduction of 10,11-dihydro-10-OXO-5H-dibenz[B,F]azepines and polymorphs thereof
WO2012156987A2 (en) * 2011-05-19 2012-11-22 Glenmark Generics Limited A novel process for the preparation of eslicarbazepine
US20150065704A1 (en) * 2011-07-13 2015-03-05 Ketan Hirpara Process for the preparation and purification of eslicarbazepine acetate and intermediates thereof
WO2013158473A1 (en) * 2012-04-16 2013-10-24 Shell Oil Company Lubricant compositions containing ionic liquids
IN2015DN02296A (en) 2012-09-26 2015-08-21 Ranbaxy Lab Ltd
US9409913B2 (en) * 2012-11-21 2016-08-09 Enaltec Labs Private Limited Polymorphic forms of alcaftadine
EP3064490A1 (en) 2015-03-06 2016-09-07 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
WO2006005951A1 (en) * 2004-07-13 2006-01-19 Portela & C.A. S.A. Method for chiral inversion of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
US7119197B2 (en) * 2001-05-11 2006-10-10 Portela & C.A., S.A. Method for preparation of (s)-(+)-and(r)-(-)10,11-dihydro-10-hydrodoxy-5h-dibenz/b,f/azephine-5-carboxamide
WO2007012793A1 (en) * 2005-07-29 2007-02-01 Portela & C.A., S.A. Asymmetric catalytic reduction of oxcarbazepine
WO2007117166A1 (en) * 2006-04-11 2007-10-18 Bial - Portela & C.A., S.A. Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753646A (en) * 1995-06-30 1998-05-19 Portela & Ca., S.A. Substituted dihydrodibenzo/b,f/azepines, method of their preparation, their use in the treatment of some central nervous system disorders, and pharmaceutical compositions containing them
US7119197B2 (en) * 2001-05-11 2006-10-10 Portela & C.A., S.A. Method for preparation of (s)-(+)-and(r)-(-)10,11-dihydro-10-hydrodoxy-5h-dibenz/b,f/azephine-5-carboxamide
WO2006005951A1 (en) * 2004-07-13 2006-01-19 Portela & C.A. S.A. Method for chiral inversion of (s)-(+)- and (r)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof
WO2007012793A1 (en) * 2005-07-29 2007-02-01 Portela & C.A., S.A. Asymmetric catalytic reduction of oxcarbazepine
WO2007117166A1 (en) * 2006-04-11 2007-10-18 Bial - Portela & C.A., S.A. Preparation of eslicarbazepine and related compounds by asymmetric hydrogenation
WO2010113179A2 (en) * 2009-04-02 2010-10-07 Glenmark Generics Limited A process for the purification of eslicarbazepine acetate

Also Published As

Publication number Publication date
WO2011091131A2 (en) 2011-07-28

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