WO2011048612A3 - Process for preparation of propargylated aminoindans or pharmaceutically acceptable salts thereof - Google Patents

Process for preparation of propargylated aminoindans or pharmaceutically acceptable salts thereof Download PDF

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Publication number
WO2011048612A3
WO2011048612A3 PCT/IN2010/000671 IN2010000671W WO2011048612A3 WO 2011048612 A3 WO2011048612 A3 WO 2011048612A3 IN 2010000671 W IN2010000671 W IN 2010000671W WO 2011048612 A3 WO2011048612 A3 WO 2011048612A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
pharmaceutically acceptable
acceptable salts
aminoindans
propargylated
Prior art date
Application number
PCT/IN2010/000671
Other languages
French (fr)
Other versions
WO2011048612A2 (en
Inventor
Amit Anant Thanedar
Shekhar Ashok Deshmukh
Sunil Sudhakar Zope
Laxmikant Madhukar Kelkar
Joseph Prabahar Koilpillai
Jitendra Maganbhai Gajera
Original Assignee
Glenmark Generics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Generics Limited filed Critical Glenmark Generics Limited
Publication of WO2011048612A2 publication Critical patent/WO2011048612A2/en
Publication of WO2011048612A3 publication Critical patent/WO2011048612A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/24—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
    • C07C209/28—Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with other reducing agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
    • C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparation of propargylated aminoindans or pharmaceutically acceptable salts thereof, comprises: a) reacting an indanone derivative or a salt thereof with propargyl amine or a salt thereof in the presence of a Lewis acid; b) subjecting the resultant reaction mixture to reduction.
PCT/IN2010/000671 2009-10-14 2010-10-08 Processes for the preparation of propargylated aminoindans or a pharmaceutically acceptable salt thereof WO2011048612A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2387/MUM/2009 2009-10-14
IN2387MU2009 2009-10-14

Publications (2)

Publication Number Publication Date
WO2011048612A2 WO2011048612A2 (en) 2011-04-28
WO2011048612A3 true WO2011048612A3 (en) 2011-08-11

Family

ID=43900759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000671 WO2011048612A2 (en) 2009-10-14 2010-10-08 Processes for the preparation of propargylated aminoindans or a pharmaceutically acceptable salt thereof

Country Status (1)

Country Link
WO (1) WO2011048612A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011092717A2 (en) * 2010-02-01 2011-08-04 Alkem Laboratories Ltd. Rasagiline mesylate having large particle size and a process for preparation thereof
CN103864646B (en) * 2014-02-21 2016-08-24 常州市第四制药厂有限公司 The impurity preparation of rasagiline mesilate and the method for analysis
CN110776429B (en) * 2018-07-30 2022-12-02 齐鲁制药有限公司 Improved preparation method of rasagiline racemic intermediate

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786390A (en) * 1990-01-03 1998-07-28 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan
CN1990455A (en) * 2005-12-29 2007-07-04 北京德众万全医药科技有限公司 Simple and novel process for preparing indenes derivatives
CN101062897A (en) * 2006-04-25 2007-10-31 重庆医药工业研究院有限责任公司 Improved process for preparing 2,3-dihydro-1H-indenes-1-amine and derivative thereof
CN101260048A (en) * 2008-04-15 2008-09-10 苏州凯达生物医药技术有限公司 Method for preparing rasagiline
WO2010059913A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of rasagiline and salts thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786390A (en) * 1990-01-03 1998-07-28 Teva Pharmaceutical Industries Ltd. Pharmaceutical compositions of the R-enantiomer of N-propargyl -1-aminoindan
CN1990455A (en) * 2005-12-29 2007-07-04 北京德众万全医药科技有限公司 Simple and novel process for preparing indenes derivatives
CN101062897A (en) * 2006-04-25 2007-10-31 重庆医药工业研究院有限责任公司 Improved process for preparing 2,3-dihydro-1H-indenes-1-amine and derivative thereof
CN101260048A (en) * 2008-04-15 2008-09-10 苏州凯达生物医药技术有限公司 Method for preparing rasagiline
WO2010059913A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of rasagiline and salts thereof

Also Published As

Publication number Publication date
WO2011048612A2 (en) 2011-04-28

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